| Entry |
|
| Symbol |
PLCB1
|
| Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1
|
| KO |
|
| Organism |
pcad Physeter macrocephalus (sperm whale)
|
| Pathway |
| pcad04070 | Phosphatidylinositol signaling system |
| pcad04261 | Adrenergic signaling in cardiomyocytes |
| pcad04613 | Neutrophil extracellular trap formation |
| pcad04621 | NOD-like receptor signaling pathway |
| pcad04723 | Retrograde endocannabinoid signaling |
| pcad04750 | Inflammatory mediator regulation of TRP channels |
| pcad04925 | Aldosterone synthesis and secretion |
| pcad04928 | Parathyroid hormone synthesis, secretion and action |
| pcad04933 | AGE-RAGE signaling pathway in diabetic complications |
| pcad04935 | Growth hormone synthesis, secretion and action |
| pcad04961 | Endocrine and other factor-regulated calcium reabsorption |
| pcad04973 | Carbohydrate digestion and absorption |
| pcad05022 | Pathways of neurodegeneration - multiple diseases |
|
| Module |
| pcad_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
| Brite |
KEGG Orthology (KO) [BR:pcad00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
102983015 (PLCB1)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
102983015 (PLCB1)
04310 Wnt signaling pathway
102983015 (PLCB1)
04371 Apelin signaling pathway
102983015 (PLCB1)
04020 Calcium signaling pathway
102983015 (PLCB1)
04070 Phosphatidylinositol signaling system
102983015 (PLCB1)
04072 Phospholipase D signaling pathway
102983015 (PLCB1)
04071 Sphingolipid signaling pathway
102983015 (PLCB1)
04022 cGMP-PKG signaling pathway
102983015 (PLCB1)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
102983015 (PLCB1)
04081 Hormone signaling
102983015 (PLCB1)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
102983015 (PLCB1)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
102983015 (PLCB1)
04613 Neutrophil extracellular trap formation
102983015 (PLCB1)
04621 NOD-like receptor signaling pathway
102983015 (PLCB1)
04062 Chemokine signaling pathway
102983015 (PLCB1)
09152 Endocrine system
04911 Insulin secretion
102983015 (PLCB1)
04922 Glucagon signaling pathway
102983015 (PLCB1)
04929 GnRH secretion
102983015 (PLCB1)
04912 GnRH signaling pathway
102983015 (PLCB1)
04915 Estrogen signaling pathway
102983015 (PLCB1)
04921 Oxytocin signaling pathway
102983015 (PLCB1)
04926 Relaxin signaling pathway
102983015 (PLCB1)
04935 Growth hormone synthesis, secretion and action
102983015 (PLCB1)
04918 Thyroid hormone synthesis
102983015 (PLCB1)
04919 Thyroid hormone signaling pathway
102983015 (PLCB1)
04928 Parathyroid hormone synthesis, secretion and action
102983015 (PLCB1)
04916 Melanogenesis
102983015 (PLCB1)
04924 Renin secretion
102983015 (PLCB1)
04925 Aldosterone synthesis and secretion
102983015 (PLCB1)
04927 Cortisol synthesis and secretion
102983015 (PLCB1)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
102983015 (PLCB1)
04270 Vascular smooth muscle contraction
102983015 (PLCB1)
09154 Digestive system
04970 Salivary secretion
102983015 (PLCB1)
04971 Gastric acid secretion
102983015 (PLCB1)
04972 Pancreatic secretion
102983015 (PLCB1)
04973 Carbohydrate digestion and absorption
102983015 (PLCB1)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
102983015 (PLCB1)
09156 Nervous system
04724 Glutamatergic synapse
102983015 (PLCB1)
04725 Cholinergic synapse
102983015 (PLCB1)
04728 Dopaminergic synapse
102983015 (PLCB1)
04726 Serotonergic synapse
102983015 (PLCB1)
04720 Long-term potentiation
102983015 (PLCB1)
04730 Long-term depression
102983015 (PLCB1)
04723 Retrograde endocannabinoid signaling
102983015 (PLCB1)
09157 Sensory system
04742 Taste transduction
102983015 (PLCB1)
04750 Inflammatory mediator regulation of TRP channels
102983015 (PLCB1)
09159 Environmental adaptation
04713 Circadian entrainment
102983015 (PLCB1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102983015 (PLCB1)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
102983015 (PLCB1)
09174 Infectious disease: parasitic
05146 Amoebiasis
102983015 (PLCB1)
05142 Chagas disease
102983015 (PLCB1)
05143 African trypanosomiasis
102983015 (PLCB1)
09164 Neurodegenerative disease
05010 Alzheimer disease
102983015 (PLCB1)
05016 Huntington disease
102983015 (PLCB1)
05017 Spinocerebellar ataxia
102983015 (PLCB1)
05022 Pathways of neurodegeneration - multiple diseases
102983015 (PLCB1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
102983015 (PLCB1)
05415 Diabetic cardiomyopathy
102983015 (PLCB1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
102983015 (PLCB1)
04934 Cushing syndrome
102983015 (PLCB1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:pcad04131]
102983015 (PLCB1)
Enzymes [BR:pcad01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
102983015 (PLCB1)
Membrane trafficking [BR:pcad04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
102983015 (PLCB1)
Endocytosis
Macropinocytosis
Phospholipase C
102983015 (PLCB1)
|
| SSDB |
|
| Motif |
|
| Other DBs |
|
| LinkDB |
|
| Position |
14:32852561..33558006
|
| AA seq |
1216 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQSKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDLIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS
GEENGVVPPEKLDLNEDMSQPLTHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPLDLMYKILVKNKKKSHKSSEGSGKK
KLSEQTSNTYSDSSSVFEPSSPGAGEADTESDDDDDEDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPALFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETQSEAPSEARTTPAENGMNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPLLLTSDPGKLNHKPPSS
EKLEGENPGKEFDTPL |
| NT seq |
3651 nt +upstreamnt +downstreamnt
atggccggggctcagcccggagtacacgctctgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgtcactcca
attattttgaggaccgaccctcagggatttttcttttactggacagatcaaagcaaggag
acggagctgttagatctcagccttgtcaaagatgccagatgtgggaaacacgccaaggct
cccaaggaccccaaattacgtgaacttctggatgtggggaacatcgggcgcctggaacat
cgcatgataacagtggtgtatgggcctgacttagttaacatctcccatttgaaccttgtg
gctttccaagaagaagtggccaaggaatggacaaatgaagttttcagtctggcaacaaac
ctgctggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaaggacgcattcctctcaaaaacatataccgcttgttctcagca
gaccggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgat
ttgatacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgt
cctcgacctgaaattgataacatcttttccgaatttggtgccaaaagcaaaccgtacctt
acggttgatcagatgatggattttatcaacctcaagcagcgagatcccaggctaaatgaa
attctttatccacctttaaagcaagagcaagtccaagtgttgattgagaagtatgaaccc
aacaacagtcttgccagaaaaggacagatatcagtggatggatttatgcgctatctgagt
ggagaagaaaatggagtcgttccacctgagaaactggatttgaatgaagatatgtctcag
ccacttactcactatttcattaattcctcacacaacacctacctcacagctggccagctg
gctggaaactcctccgtcgagatgtatcgccaggtgctcctgtctggttgtcgctgtgtg
gagttggactgctggaagggacggaccgcagaagaggagccagtcatcacccatgggttc
accatgaccacggagatatccttcaaggaagtgatagaagccattgctgagtgtgcattt
aagacttcaccttttccaattctgctttcatttgagaaccacgtggattccccaaagcag
caggccaagatggcagagtattgccgactgatcttcggggacgcccttctcatggagccc
ctggaaaagtacccactggaatctggagttcctcttccaagccctctggacttaatgtac
aaaattttggtgaaaaataagaagaaatcccacaaatcgtcagaaggaagtggcaaaaag
aagctctcagaacaaacctccaacacgtacagcgactcctccagtgtgtttgagccctcg
tccccaggagctggagaagctgatacggagagtgacgatgatgacgatgaagatgactgt
aaaaagtcttcgatggatgaggggactgctgggagcgaggccatggccacagaagagatg
tctaatctggtgaactatattcagccagtcaagttcgagtcattcgaaatttcaaaaaaa
agaaacagaagcttcgaaatgtcttcctttgtggaaaccaaaggacttgagcaacttaca
aagtctccagtggaatttgtagaatataacaaaatgcagcttagcaggatatatccaaaa
ggaacacgtgtggattcatccaactacatgccccagctcttctggaatgcaggctgccaa
atggttgcacttaatttccaaacagtggacctggctatgcaaataaacatggggatgtat
gaatacaatgggaaaagtggctacagactgaagccagaattcatgaggagacctgacaag
cactttgatccgttcaccgaaggcattgtggatgggatcgtggccaacactttatctgtt
aagattatttcaggtcagtttctctctgataagaaagtcgggacttatgtggaagtggat
atgtttggtttgcctgtggacacaaggaggaaggcatttaagacaaagacatcacaagga
aatgctgtaaatcctgtctgggaagaagaacccattgtgttcaaaaaggtagttcttcct
tctctggcctgtttgaggatagcagtttatgaagaaggaggtaaatttattggtcaccga
atcttgccagtacaagcaattcgaccaggctatcactacatctgtctgaggaatgaaagg
aaccagcctctgatgctgccagctctctttgtctacatagaggtgaaggactatgtccca
gatacatatgcagatgtgattgaagccttgtcaaatccaatccgatatgtgaatctgatg
gagcagagagctaaacaactggcagctttgacgctggaagatgaagaagaagtaaagaaa
gaggctgatcctggggaaacacagtcagaagctccaagtgaagccaggacaactccagcg
gaaaacgggatgaatcacactacatccctgacacccaaaccaccctcccaggctctccac
agccaaccagctccaggctctgtaaaggcacctgccaaaacagaagatcttattcagagt
gttttaacagaagtagaagcgcagacaattgaagagctaaagcaacagaagtcgtttgtg
aaacttcaaaagaagcactacaaagaaatgaaagacctggttaagagacatcacaagaaa
accactgaccttatcaaagaacacactacaaaatataatgaaatccagaatgactacttg
cgaaggagggcagctttggaaaagacagccaaaaaggatagtaagaaaaaatcggaaccc
agcagccctgaccatggttcatcaacaattgagcaagaccttgctgccctggatgccgaa
atgacccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcga
caagaacagtattatagcgaaaaataccagaagcgagaacatattaaactgcttattcaa
aaattgacagatgttgctgaagaatgtcagaataatcagttaaagaagcttaaagaaatt
tgtgagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagata
acagaagctaaatccaaagacaaaagccagatggaggaggaaaagacagagatgatccgg
tcatacatccaggaggtggtgcagtacatcaagaggttagaagaggcacaaagtaaacgg
caagaaaaactcgtagagaaacacaaagagatacgtcagcagatcctggacgaaaagccc
aagctgcaggtggagctagagcaggagtaccaagacaagttcaaaaggttgcccctggag
attttggaattcgtgcaggaagccatgaaagggaagatcagtgaagacagcaatcacagc
tccgcccctctcctgctgacctcagaccctggaaaactgaaccacaagcctccttccagt
gagaaactggaaggagaaaacccaggaaaagaatttgatactcccctgtga |