Physeter macrocephalus (sperm whale): 102983076 Help Entry 102983076         CDS       T06011                                  Symbol TLR4 Name (RefSeq) toll-like receptor 4 isoform X1   KO K10160   toll-like receptor 4 Organism pcad  Physeter macrocephalus (sperm whale) Pathway pcad04064   NF-kappa B signaling pathway pcad04066   HIF-1 signaling pathway pcad04145   Phagosome pcad04151   PI3K-Akt signaling pathway pcad04217   Necroptosis pcad04613   Neutrophil extracellular trap formation pcad04620   Toll-like receptor signaling pathway pcad04621   NOD-like receptor signaling pathway pcad04936   Alcoholic liver disease pcad05132   Salmonella infection pcad05133   Pertussis pcad05134   Legionellosis pcad05135   Yersinia infection pcad05140   Leishmaniasis pcad05142   Chagas disease pcad05144   Malaria pcad05145   Toxoplasmosis pcad05146   Amoebiasis pcad05152   Tuberculosis pcad05161   Hepatitis B pcad05162   Measles pcad05164   Influenza A pcad05170   Human immunodeficiency virus 1 infection pcad05171   Coronavirus disease - COVID-19 pcad05205   Proteoglycans in cancer pcad05235   PD-L1 expression and PD-1 checkpoint pathway in cancer pcad05321   Inflammatory bowel disease pcad05323   Rheumatoid arthritis pcad05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:pcad00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     102983076 (TLR4)    04066 HIF-1 signaling pathway     102983076 (TLR4)    04151 PI3K-Akt signaling pathway     102983076 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     102983076 (TLR4)   09143 Cell growth and death    04217 Necroptosis     102983076 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     102983076 (TLR4)    04620 Toll-like receptor signaling pathway     102983076 (TLR4)    04621 NOD-like receptor signaling pathway     102983076 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     102983076 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102983076 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     102983076 (TLR4)    05161 Hepatitis B     102983076 (TLR4)    05171 Coronavirus disease - COVID-19     102983076 (TLR4)    05164 Influenza A     102983076 (TLR4)    05162 Measles     102983076 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     102983076 (TLR4)    05135 Yersinia infection     102983076 (TLR4)    05133 Pertussis     102983076 (TLR4)    05134 Legionellosis     102983076 (TLR4)    05152 Tuberculosis     102983076 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     102983076 (TLR4)    05144 Malaria     102983076 (TLR4)    05145 Toxoplasmosis     102983076 (TLR4)    05140 Leishmaniasis     102983076 (TLR4)    05142 Chagas disease     102983076 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     102983076 (TLR4)    05321 Inflammatory bowel disease     102983076 (TLR4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102983076 (TLR4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     102983076 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:pcad04131]     102983076 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:pcad04054]     102983076 (TLR4)    04090 CD molecules [BR:pcad04090]     102983076 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:pcad00536]     102983076 (TLR4) Membrane trafficking [BR:pcad04131]  Endocytosis   Phagocytosis    Toll-like receptors     102983076 (TLR4) Pattern recognition receptors [BR:pcad04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    102983076 (TLR4) CD molecules [BR:pcad04090]  Proteins   102983076 (TLR4) Glycosaminoglycan binding proteins [BR:pcad00536]  Hyaluronan   Cell surface receptors    102983076 (TLR4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  LRR_8 TIR LRR_4 LRR_1 TIR_2 LRR_9 LRR_5 LRR_EndoS LRR_NXF1-5 LRR_Zer-1 ThsB_TIR LRR_6 ANG-1 Curto_V2 Motif Other DBs NCBI-GeneID:  102983076 NCBI-ProteinID:  XP_007112712 Ensembl:  ENSPCTG00005018929 UniProt:  A0A2Y9F2E5 LinkDB All DBs Position 9:complement(8077613..8088281) Genome browser AA seq 841 aa AA seqDB search MMPRARLAAALTPAMAFLFCLRSESWDPCVQVVPNISYQCMELNLYKIPDNIPTSTKILD LSFNHLSHLNSHSFSSFPELQMLDLSRCEIQVIEDDAYQGLNHLSTLILTGNPIQSLALG AFSGLSSLQKLVAVETNLASLEDFPIGHLKTLKELNVAHNLIHSFKFPEYFSNLPNLKHL DLSNNKIQNIYHEDLKVLHQMPLLNLSLDLSLNPLDFIEPGTFKEIKLNELTLRSNFNST HVMKICIQSLAGLKINRLVLGEFKNERTLESFDRSVLEGLCNLTFEQFRIAYFSEFPTDD TGLFNCLVNVSVISLLSLDLDSLEALPKDCRWQHLELINCHFKQFPTLKLNSLKKLVFID NKGMSTFTDLALPNLQFLDLKRNRLSFKGCCSHTNFGTIKLKHLDLSFNDVITMHSNFLG LEQLEHLDFQHSSLKQANDFSVFLSLRNLRYLDISYTNTRVVFHGIFVGLVSLQTLKMAG NSFQNNLLPDIFTELTNLIILDLSKCQLEQVSQMAFHSLPRLRVLNMSHNKLLSLDTLPY KPLHSLQILDCSFNRIMESKEQELQHLPRSLALLNLTQNDFACVCEHQSFLQWVKDKRQL LVGAEQMMCTQPLDMQDMPVLSFRNATCQMNKMIISVSLLTILLVSVAGVLVYKFYFHLM LLAGCKKYGRGESTYDAFVIYSSHDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSHAGIIFIVLQKLEKSLL RQKVELYRLLNRNTYLEWEDSVLGRHIFWRRLRKALLDGKPWRPEGTADADSRQQEATDS T NT seq 2526 nt NT seq  +upstreamnt  +downstreamnt atgatgcctcgcgcccgcctggctgcggctctgaccccagccatggccttcctcttctgc ctgaggtcggagagctgggacccttgtgtacaggtggttcctaacattagttaccaatgc atggagctgaatctctacaaaatccctgacaacatccccacatcgaccaagatactggac ctgagctttaaccacctgagtcatttaaacagccatagcttctccagcttcccagaactg cagatgttggatttatccagatgtgaaattcaggtgattgaagatgatgcgtatcagggc ctaaaccacctctccaccttgatattgacaggaaaccctatacagagtttagccctggga gccttttctgggctatcaagtttacagaagctggtagctgtggagacaaacctagcatct ctagaggacttccccattggacatctcaaaaccttgaaggagcttaatgtggctcacaat cttatccattccttcaagtttcctgaatatttttctaacctgcccaacctgaagcacttg gatctttctaataacaaaatccaaaatatttatcacgaagacttgaaggttctacatcaa atgcccctactcaacctctctttagatttgtccctgaaccctttagactttattgaacca ggtacctttaaagaaattaagctcaatgaactgactttgcgaagtaattttaatagtaca catgtaatgaaaatttgtattcaaagtctggctggtttaaaaatcaatcggttggtttta ggagaatttaaaaatgaaaggaccttggaaagttttgacagatctgtcctggagggactg tgcaatttgaccttcgaacagtttcggatagcatacttcagtgaattcccgacggatgat acaggcttatttaattgtttggtaaatgtttctgtgatttctctgttgagtctggattta gacagtctagaagcccttcctaaagattgcagatggcaacacttagaattgattaactgt cattttaaacaatttcccacattgaagctcaattctctcaaaaagcttgttttcatagac aacaaaggtatgagcacttttactgaccttgcgctaccaaaccttcagtttctagatctc aaaagaaatcgcttgagtttcaagggttgctgttctcacactaattttgggacaatcaaa ctgaagcatttagatctgagcttcaatgatgtcattactatgcattcaaacttcttgggc ttagagcaactagaacatctggattttcagcattccagtctgaaacaggccaatgatttt tcagtattcctatcactcagaaacctccgttaccttgatatttcttataccaacacccga gttgtcttccatggcatctttgttggcttggtcagcctccaaaccttgaaaatggcaggc aattcttttcagaacaacttgcttcctgacatcttcacagaactgactaacttaatcatc ctggacctctctaagtgtcaactggaacaggtatcccagatggcatttcactccctccct agacttcgggtgctaaatatgagtcacaacaaactcttgtcattggatacacttccttat aaaccactccactccctccagattctggattgcagtttcaaccgtatcatggagtccaag gagcaagaactacagcatttgccaaggagccttgctttgttaaatcttactcagaatgac tttgcttgtgtttgtgaacaccagagttttctgcagtgggtcaaggacaagaggcagctc ttggtaggagctgagcaaatgatgtgtacacaacccttagatatgcaggacatgcccgtg cttagtttcaggaatgccacttgtcagatgaacaagatgatcattagtgtgtcacttctc accatactcttggtatctgtggcaggagtcctggtctataagttctatttccacctaatg cttcttgctggctgcaaaaagtacggcagaggtgaaagcacctatgatgcttttgtaatc tactcaagccacgacgaagactgggtgaggaatgaattggtaaagaacttggaggagggg gtgcccccctttcagctctgccttcactacagagactttattcctggggtggccattgcc gccaacatcatccaggaaggtttccacaaaagccggaaggttattgtcgtggtgtcccag cacttcatccagagccgatggtgtatctttgagtatgagattgcccagacctggcagttt cttagcagccatgctggcatcatcttcatagtcctgcagaagttggagaagtccctgctg cggcagaaggtagagctgtatcgccttctcaacaggaatacctacctggagtgggaggac agtgtcctggggcggcacatcttctggagacgactcagaaaagccttgctggatggtaaa ccatggaggccagaaggaacagcagatgcagacagcagacagcaggaagcaacagactcc acttga

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