Physeter macrocephalus (sperm whale): 102985806
Help
Entry
102985806 CDS
T06011
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial isoform X2
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
pcad
Physeter macrocephalus (sperm whale)
Pathway
pcad00220
Arginine biosynthesis
pcad00330
Arginine and proline metabolism
pcad01100
Metabolic pathways
pcad04020
Calcium signaling pathway
pcad04022
cGMP-PKG signaling pathway
pcad04066
HIF-1 signaling pathway
pcad04071
Sphingolipid signaling pathway
pcad04151
PI3K-Akt signaling pathway
pcad04370
VEGF signaling pathway
pcad04371
Apelin signaling pathway
pcad04611
Platelet activation
pcad04915
Estrogen signaling pathway
pcad04921
Oxytocin signaling pathway
pcad04926
Relaxin signaling pathway
pcad04931
Insulin resistance
pcad04933
AGE-RAGE signaling pathway in diabetic complications
pcad05415
Diabetic cardiomyopathy
pcad05417
Lipid and atherosclerosis
pcad05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
pcad00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
102985806 (NOS3)
00330 Arginine and proline metabolism
102985806 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
102985806 (NOS3)
04371 Apelin signaling pathway
102985806 (NOS3)
04066 HIF-1 signaling pathway
102985806 (NOS3)
04020 Calcium signaling pathway
102985806 (NOS3)
04071 Sphingolipid signaling pathway
102985806 (NOS3)
04022 cGMP-PKG signaling pathway
102985806 (NOS3)
04151 PI3K-Akt signaling pathway
102985806 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
102985806 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
102985806 (NOS3)
04921 Oxytocin signaling pathway
102985806 (NOS3)
04926 Relaxin signaling pathway
102985806 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
102985806 (NOS3)
05418 Fluid shear stress and atherosclerosis
102985806 (NOS3)
05415 Diabetic cardiomyopathy
102985806 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
102985806 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
102985806 (NOS3)
Enzymes [BR:
pcad01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
102985806 (NOS3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
DEC-1_N
Motif
Other DBs
NCBI-GeneID:
102985806
NCBI-ProteinID:
XP_007126716
Ensembl:
ENSPCTG00005013206
UniProt:
A0A2Y9FMB5
LinkDB
All DBs
Position
5:complement(6222668..6240901)
Genome browser
AA seq
1205 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCSKQGPASPAPEPSRAPAPAPPPAPDHSPAPNSPQ
LTRPPEGPRFPRVKNWEVGTIAYDTLCAQSQQDGPCTPRRCLGSLVFPRKLQSRPSQGPP
PPEQLLSQARDFINQYYSSIKRSGSEAHKERLQEVEAEVAATGTYQLRESELVFGAKQAW
RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYVCNHIKYATNRGNLRSAITVFPQRAPGR
GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQTPDE
APELFVLPPELVLEVPLEHPTLEWFSALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYM
STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVAIV
DHHAATASFMKHLENEQRARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFRYQPD
PWKGSAAKGASITRKKTFKEVANAVKISASLMGTVMAKRVKATILYASETGRAQSYAQQL
GRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYN
SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP
HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKA
AAQDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHAHRRKMFQATVLLVENLQSSKSTRAT
ILVRLDTGGQEGLQYQPGDHIGICPPNRPGLVEALMSRVEDPPPPTESVAVEQLEKGSPG
GPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPSEQQELETLSQDPR
RYEEWKWFRCPTLLEALEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEVHLTVA
VLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGI
APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYREEVQDAQQRGVFGRVLTAFS
REPDSPKTYVQDVLRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDME
LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHMRGAVPWAFDPPGP
DTPGP
NT seq
3618 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagcgtgggccaggagcctgggccaccctgcggcctggggctaggg
ctgggcctcgggctgtgcagcaagcagggcccggcctccccagcacccgagcccagccgg
gcaccggcacccgcacccccgcccgcgccagaccacagcccggctcccaacagcccacag
ctaacccggcctccagaggggcccaggttccctcgtgtgaagaattgggaggtggggacc
atcgcctacgacactctgtgtgcgcagtcacagcaggacgggccctgcacccccagacgc
tgcctgggctccctggtgtttccacggaaactgcagagccgaccctcccagggccctcca
ccccctgagcagctgctgagccaggccagggacttcatcaaccagtactacagctccatc
aagaggagcggctccgaggctcacaaggagcgccttcaggaagtggaagccgaggtagcg
gccacgggcacctaccagcttcgtgagagcgagctggtgttcggggccaagcaggcctgg
cgcaacgccccccgctgcgtgggccggatccagtgggggaagctgcaggtgtttgatgca
cgggactgcagctctgcgcaggagatgttcacctacgtctgcaaccacatcaagtacgcc
accaaccggggcaacctgcgttcggccattacagtgttcccccagcgcgccccgggccgc
ggagacttccgaatctggaacagccagctggtgcgctacgcgggctacaggcagcaggac
ggctccgtgcggggggaccccgccaacgtggagatcaccgagctctgcatccagcacggc
tggacgcccggaaacggccgctttgatgtgctgcccctgctgctccagaccccagacgag
gccccagaactcttcgttctgcctcccgaactggtcctcgaggtgcccctggagcacccc
acgctggagtggttctcggccctgggcctgcgctggtacgccctcccagcagtgtccaat
atgctgctggaaattgggggcctggagttccctgcagcccccttcagcggctggtacatg
agcacggagattggcacgcggaacctgtgtgatcctcaccgctacaacatcctggaggat
gtggccgtctgcatggacctggacacccggaccacctcatccctgtggaaagacaaggca
gccgtggaaatcaacttggctgtgctgcacagttaccagctcgccaaagtggccatcgtg
gaccaccacgctgccacagcctccttcatgaagcacctggagaacgagcagagagccagg
gggggctgccctgccgactgggcctggatcgtgccccccatctcgggcagcctcaccccc
gtcttccatcaggagatggtcaactatgtcctgtcccctgctttccgctaccagccagac
ccctggaaggggagcgcggccaagggcgccagcatcaccaggaagaagacctttaaggaa
gtggccaacgcggtgaagatctctgcctcactcatgggcaccgtgatggcgaagcgagtg
aaggcgacaattctgtacgcctccgagaccggccgggcccagagctacgcacagcagctg
gggaggctcttccggaaggccttcgaccctcgggtcctgtgcatggatgagtatgacgtg
gtgtccctggagcacgagactctggtgttggtggtgaccagcacctttgggaacggcgat
cccccagagaacggagagagttttgcagcagccctgatggagatgtcgggcccctacaac
agctcccctcggccagaacaacacaagagttacaaaatccgcttcaacagcgtctcctgc
tcagacccgctggtgtcctcctggcggcggaagaggaaggagtccagtaatacggacagc
gcaggggcgctggggaccctcaggttctgtgtgtttgggctgggctcccgggcgtacccc
catttctgcgcctttgctcgtgcggtggacacgcggctggaagagctgggaggggagcgg
ctgcttcagctgggccagggcgatgagctgtgcggccaggaggaggccttccgcggctgg
gcccaggctgccttccaggcctcctgtgagacgttctgcgtgggggaggacgccaaggcc
gcggcccaggacatcttcagccccaaacggagctggaaacgccagaggtaccggctgagc
gcccaggccgagggcctccagctgctgccaggcctgatccacgcacacaggcggaagatg
ttccaggcgacagtcctcttggtggaaaacctgcagagcagcaagtccacccgggccacg
atcctggtgcgcctggacactggaggccaggaggggctccagtaccagccgggggaccac
ataggcatctgcccgcccaaccggccggggctcgtggaggcgctgatgagccgcgtggag
gacccgccgccgcccaccgagtctgtggcagtggagcagctggagaagggcagcccaggt
ggccctcctcccggctgggtacgggacccccggctgccgccgtgtacgctgcgccaggct
ctcacctttttcctggacatcacctccccgcccagccctcaacttcttcgactgctcagc
accctggctgaagagcccagtgaacagcaggaactcgagaccctcagccaggacccccgg
cgctacgaggagtggaagtggttccgctgccccaccctgctggaggcgctcgagcagttt
ccatccgtggcgctgcctgccccgctcctcctcacccagctgcccctgctccagccccgg
tactactcggtcagctcagcacccagcgcccatccaggagaggtccacctcacagtagct
gtgctggcatacaggacccaagatgggctgggccccctgcactatggagtctgctccaca
tggctgagccagctcaagactggagaccccgtaccctgcttcatcaggggggctccctcc
ttccggctgccgcctgatcccagcctgccctgcatcctcgtgggcccgggcactggcatc
gcccccttccggggattttggcaggagcggctacacgacatcgagagcaaagggctgcag
cccgcccccatgaccttggtgttcggctgccggtgctcccagctcgaccacctctaccgc
gaggaggtgcaggatgcccagcagcgcggcgtgtttggccgcgtcctcaccgccttctcc
cgggaacccgacagccctaagacctacgtgcaggacgtcctgcggacggagctggctgct
gaggtgcaccgcgtgctgtgcctcgagcggggccacatgtttgtctgcggcgatgtcacc
atggcaaccagcgtcctgcagacggtgcagcgcatcttggcgacagagggcgacatggag
ctggatgaggccggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggac
attttcgggctcacgctgcgcacccaggaggtgacaagccgcatacgcacccagagcttt
tccttgcaggagcggcatatgcggggcgcagtgccctgggcgttcgacccgcccggccca
gacacccctggcccctga
DBGET
integrated database retrieval system
