Physeter macrocephalus (sperm whale): 102988851
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Entry
102988851 CDS
T06011
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
pcad
Physeter macrocephalus (sperm whale)
Pathway
pcad00790
Folate biosynthesis
pcad01100
Metabolic pathways
pcad01240
Biosynthesis of cofactors
pcad01523
Antifolate resistance
pcad04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
pcad00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
102988851 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
102988851 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
102988851 (FPGS)
Enzymes [BR:
pcad01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
102988851 (FPGS)
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
102988851
NCBI-ProteinID:
XP_007101844
Ensembl:
ENSPCTG00005008531
UniProt:
A0A2Y9EHU1
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Position
9:complement(64350..73065)
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AA seq
580 aa
AA seq
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MSRARCHLRAALFLAAVSSRGATTGVAARRVLSAWPAPQEPGMEYQDAVRTLNTLQTNAN
YLEQVKRQRGDPQTQLEAMRLYLARSGLQVEDLDQLNIIHITGTKGKGSTCAFTERILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKHFWRLYHRLEETKDDSSCVSMPGYFR
FLTLMAFHVFLQEKVDLAVMEVGIGGAYDCTNIVKKPVVCGVSSLGIDHTGLLGDTMEKI
AWQKGGIFKCGIPAFTVLQPDGPLAVLRDRAQQISCPLYLCPPLEALEEGGPLLTLGLEG
EHQKSNAALALQLARCWLQQKGYQDTGELKASRPSLLGQLPLAPVFQPTSHMQHGLRDTE
WPGRTQLLRRGPLTWYLDGAHTTSSMQACVRWFRQALHSREGPGGGSEVRVLLFNSTGDR
DSAALLKLLQPCQFDYTIFCPNLTEVSSVDNADQQNFTVTLDQVLLRCLAHQQHWSRLHE
DQASPEPGGPAPLLLAPRPAHTHSTSSLVFSCISHALQWISQGRDPVFQPPSPPRVLFAH
PVAGSGAIVLQEAAAIHVLVTGSLHLVGGVLKLLEPSLSQ
NT seq
1743 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcgggcacgctgccacctgcgcgcggctctcttcctggcagcggtttcttcgcgt
ggtgcaacaaccggggtcgcagcgaggcgagtattgagcgcgtggcctgcgccgcaggag
cccggcatggagtatcaggatgctgtgcgcacactcaacaccctgcagaccaatgccaac
tacctggagcaggtgaagcgccagcggggtgacccccagacgcaactggaagccatgagg
ctgtacttggcacggagtgggctgcaggtggaggacttggaccaactgaacatcatccac
atcactgggaccaaggggaagggctccacctgtgccttcactgaacgtatcctccgaagc
tatggcctgaagacgggattctttagctctccccacctggtgcaggtgcgtgagcggatc
cgaatcaatgggcagcccataagccccgagctcttcaccaagcacttctggcgcctctac
caccggctggaggagaccaaggatgacagcagctgtgtctccatgcctggctacttccgc
ttcctcacactcatggccttccatgtcttcctccaagagaaggtggacctggcagtgatg
gaagtgggcatcggcggggcttacgactgcaccaacatcgtcaagaagcctgtggtgtgt
ggggtctcctctcttggcatcgaccacactggccttctgggggacacgatggagaagatc
gcatggcagaaagggggcatttttaagtgtggcatccccgccttcaccgtgctccagcct
gacgggcccctggcagtgctgagggaccgcgctcagcagatctcatgtcccctctacctg
tgcccaccactagaagccctggaggaaggggggccactgctgaccctgggcctggagggt
gagcaccagaagtccaatgccgccttggccttgcagctggctcgctgctggctgcagcaa
aagggctaccaggatactggagagctgaaagcatccaggccaagcctcctggggcagctg
cccctggcacctgtgttccagcccacgtcccacatgcagcatgggcttcgggacacggag
tggccgggccggacgcagttgctgcggcggggccccctcacttggtacctggacggcgcg
cacaccaccagcagcatgcaggcctgcgtgcgctggttccgccaggcgctgcacagccgc
gaggggccgggcggcgggtctgaggtgcgtgtcttgctcttcaactccactggggaccgg
gattccgcggccctgctgaagctgctgcagccctgccagtttgactataccattttctgc
cctaacctgacagaggtgtcatccgtggacaatgcagaccaacagaacttcacagtgacc
ctggaccaggtgctgctccgctgccttgcacaccagcaacactggagccgcctgcacgag
gaccaggccagcccggagcctggtgggcctgcacccctgctgctggcaccccgcccagcc
cacacccacagcaccagctccctcgtcttcagctgcatttcccacgccttgcagtggatc
agccaaggccgggaccctgtctttcagccacccagtcccccacgggtcctcttcgcccac
cctgtggcaggcagtggggccatcgtcctccaggaggctgctgccatccatgtgctggtc
acaggcagcctgcacctggtgggcggcgtgctgaagctgctggagccctccctgtcccag
tag
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