Physeter macrocephalus (sperm whale): 102989081
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Entry
102989081 CDS
T06011
Symbol
PLCE1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2
KO
K05860
phosphatidylinositol phospholipase C, epsilon [EC:
3.1.4.11
]
Organism
pcad
Physeter macrocephalus (sperm whale)
Pathway
pcad00562
Inositol phosphate metabolism
pcad01100
Metabolic pathways
pcad04014
Ras signaling pathway
pcad04015
Rap1 signaling pathway
pcad04020
Calcium signaling pathway
pcad04024
cAMP signaling pathway
pcad04070
Phosphatidylinositol signaling system
pcad04919
Thyroid hormone signaling pathway
pcad04933
AGE-RAGE signaling pathway in diabetic complications
pcad05205
Proteoglycans in cancer
Module
pcad_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
pcad00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
102989081 (PLCE1)
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
102989081 (PLCE1)
04015 Rap1 signaling pathway
102989081 (PLCE1)
04020 Calcium signaling pathway
102989081 (PLCE1)
04070 Phosphatidylinositol signaling system
102989081 (PLCE1)
04024 cAMP signaling pathway
102989081 (PLCE1)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
102989081 (PLCE1)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
102989081 (PLCE1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
102989081 (PLCE1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
pcad04131
]
102989081 (PLCE1)
Enzymes [BR:
pcad01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
102989081 (PLCE1)
Membrane trafficking [BR:
pcad04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
102989081 (PLCE1)
Endocytosis
Macropinocytosis
Phospholipase C
102989081 (PLCE1)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
PI-PLC-Y
RasGEF
RA
C2
EF-hand_like
GDPD
Motif
Other DBs
NCBI-GeneID:
102989081
NCBI-ProteinID:
XP_028337860
Ensembl:
ENSPCTG00005022158
UniProt:
A0A455AMJ3
LinkDB
All DBs
Position
20:52033537..52362021
Genome browser
AA seq
2314 aa
AA seq
DB search
MTSEEMAASVLRPVTQRKVISAQSAVDESNDKVSDISVAKAHPVRQSRETSHTISQLTKL
TEESSGSNLPQILSVASEKIMSDENSNEKCWEKSIPDSVKNLNINCNNILKNHQCGLPQS
QFYETCDSTTEEGLCLETGIPSSLERKVFPGIQLEIDGPPAGISPLGTQSAIIETGRAHP
DSNMAVFHFQYEVDRRMSDTFCPLSDNLILDDCGNCVLPAVGGEQKNNYMAYTCKLMELA
SNCDNKNRQLQYDHCDPLNDKYLCFEGSCPKTNVVCSSDSFCGEDFTDSPPAKTFLSHFE
DFPDNCEDVEEDLFKSKKERSTWLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLGAW
SYVDRKRNGLLLPCGRVMEQLSTVLTRQDGGQRLSEAQWYPIYSAVRRGEETEETIRSLL
HFFTKLPASETAHERISIGPCLKQCVQDTVCEYRATLQRTSISQYITGSLLEATTSLGAR
SSLLSSFGGSTGRMMLKERQPGTSMANSSALPSSSAGISKELVDLQPLIQFPEEVASVLM
EQEQNIYRRVLPVDYLCFLTRDLGTTECQRPLPCLKASISASILTSQNGEHNALEDLVMR
FNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMW
QFMDQSDLETMRGLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDGA
SGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQIIRSCSRS
LETEEEDSPSEGNSSRKNSLKDKARLQFIIGDLLDSENDIFEQPQEWDPHGSEEPQKAFD
HGTELIPWYVLSIQADVHQFLLQGATVIHYDQDMHLSARCFLQLQPDNSTLTWIKPTTAS
PASAKAKLGVLSNTSEPGKFPLLGNAGLSGLAEGVLDLFSAKAVYMGHPSIDLHTVCVQN
KLSNMSLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQ
QWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGISAKSAEKPNMQRNNTLG
ISTTKKKKKILMRGESGEATDDEMATRKAKTNKECRSRSGSDPQDVNEQEESEANAITSP
PNPLPSRRAHSLTTAGSPNLAAGTSSPIRPVSSPVLSSSNKSPSSAWSSSWHGRIKGGMK
GFQSFMVSDSSMSFVEFVELFKSFSVRSRKDLKDLFDIYAVPCDRAGSAAAPLYTNLTID
ENTSGLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGVESTSLGV
FGVGILQLNDFLVNCQGEHYTYDEILSIIQKFEPSVSMCHQGLMSFEGFARFLMDKDNFA
SKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCW
DGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIF
KTVFGEKLVAKFLFESDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLAS
MQAQAYNGGSANPPPANNEEEEDEEDEDDYDYESLSDDVLTASPVLNSQEDNILEDRPEN
KSCNDKLQFEYNEEIPKRIKKADNSACNKGKVYDMELGEEFYLPQNKKESRQIAPELSDL
VIYCQAVKFPGLSTLNASGSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGM
RQAWEDSPSSVNPATSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLIQHTACQLLRTY
PAATRIDSSNPSPLLFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDK
NCPMYQKFSPLERDLDNMEPAVYSLTIVSGQNVCPSNSTGSPCIEVDVLGMALDSCHFRT
KPIHRNTLNPMWNEQFLFRVHFEDLLFLRFAVVENNSSVVTAQRIIPLKALKRGYRHLQL
RNLHNEVLEISSLFINSRRMEENSSGNTMPASLMFNTEERKCLQIHRVTVHGVPGPEPFA
VFSINGGTKAKQLLQQSLTIDQDTKPIATDYFLMEEKYFISKEKNECRKQPFQRAIGPEE
EIMQILSSWFPEEGYVGRIVLKTQQENLEEKSIVQDDKEMILSSEEESFFVQVHDVSPEQ
PRTVIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPGDYVLLEEVVKDTANRKSSTPKSS
QRVLLDQECVFQAQSRWKGAGKFILKLKEQVQASREDKRKGISFASELKKLTKSTKQPRG
LTSPSQVLASENVQNKEEKPVGGLSSSDTIDYRQ
NT seq
6945 nt
NT seq
+upstream
nt +downstream
nt
atgacttctgaagaaatggcagcttctgttctcagacctgtgactcagcgaaaagtgata
tctgctcagtcggctgtagatgaaagtaatgataaggtctcggacatcagtgttgcaaag
gctcatcctgtcaggcagagcagggagacctctcataccatctcacaactgaccaaactt
acagaagaatcttctggaagcaacttgccccagattctctcagtagcaagtgagaaaata
atgagtgatgagaacagtaatgaaaagtgctgggagaaaagcataccagactctgtgaaa
aaccttaacattaactgcaacaacatactgaaaaaccatcagtgtggccttcctcagagc
cagttttatgaaacgtgtgattctaccacagaggaaggcctgtgtttggaaactggaatc
ccttcttcactggaaagaaaggtgttccctggaattcaactggaaatagatggacctccc
gcgggcattagtccactaggaactcaatcagccatcatagagacgggcagggcacaccct
gacagcaacatggcggtatttcactttcagtatgaagttgacagaagaatgtcagacact
ttctgtcccctatcagataacttgattttggatgattgtggaaactgtgtactacctgct
gttggtggggaacaaaagaacaattacatggcgtatacttgtaaactgatggaattggca
agtaactgtgacaataagaataggcagctgcagtatgatcattgtgaccccttgaatgac
aaatacttgtgctttgaaggctcttgcccgaagaccaatgtagtatgttcaagtgacagc
ttttgcggggaggattttaccgacagtccacctgccaagacctttctgagccattttgag
gacttccctgataattgtgaagatgtagaagaagatttattcaaaagcaagaaggagcgg
tccacttggttagtgaggagattttgtaaaaatgacagggaagtaaagaaatctgtatat
actgggacaagggcaattgtgagaactctgccttctggtcacattgggctgggggcttgg
agttacgttgatcggaagagaaacggtctcttactgccttgtgggagagtcatggaacag
ctgtcaacagtgctgactaggcaagatgggggccagcgtctgtcagaagcccagtggtat
ccgatctacagtgcagtgagaaggggagaagaaacagaagagacaattagatctcttctc
catttcttcacaaagcttccagcctccgagacagcccatgaaaggattagcattggtccg
tgcttaaagcaatgtgtccaagacactgtttgtgagtatcgtgccaccctccaaaggact
tccatatctcagtacatcaccggctctctcctagaagccaccacatctttaggagcaaga
agtagccttctcagttcttttggaggatccaccggacgaatgatgctgaaagaacgccaa
ccaggcacctctatggccaattccagtgccctcccttcaagttcagctgggatcagcaag
gaactggttgatctgcagcccctcatccagttcccagaggaagttgccagtgtcctgatg
gaacaggagcagaatatttaccgaagggtcctgccggttgactatctttgcttcttgacc
cgggacttgggcactacggaatgccagaggcccctgccctgcctcaaagcgtccatctca
gcatccattcttacctcccagaacggagagcataatgcccttgaagatctcgtgatgaga
tttaatgaggtgagctcctgggtgacgtggctgatcctcacggcaggctccatggaggag
aagcgggaagtcttctcgtatttggtgcacgtggccaaatgctgctggaacatgggcaac
tacaatgccgtcatggagttcttggccggcctcaggtcaagaaaagtcttaaaaatgtgg
cagtttatggaccagtctgacctggagacgatgaggggcctgaaggacgccatggcccag
catgaatcttcctgcgagtacaggaaggtggtgactcgggcgctgcacatccccggctgt
aaggtggttccgttctgcggggtgtttctgaaggagctctgtgaggtgcttgacggagcc
tccggcctcatgaagctttgcccgaggtacaattcccaagaagaaactctagagtttgta
gctgattatagtggacaagataatttcttacaacgagtgggacagaatggcttaaagaat
tcagagaaggagtccactgtcaacagcatctttcagatcatcaggagctgcagtcgaagt
ctggagacagaggaggaggacagccccagtgaagggaacagctctaggaaaaattccttg
aaggataaagcccgactgcagttcataattggagatctgttggattctgaaaatgacatc
tttgagcagccccaagaatgggaccctcacggatcagaagagccacagaaggcctttgac
catgggacagagctcatcccgtggtacgtgctgtccatccaagctgatgtacaccagttc
ctgcttcagggggccacggtcatccactatgaccaggacatgcacctctctgcccgctgc
ttcctccagcttcagcctgacaatagtaccttgacctggataaagcccaccactgcttcc
ccagccagtgctaaagcaaaacttggtgtgcttagtaacacatccgagcctggcaaattc
ccattactgggcaatgctggattaagtggcctggcagagggggtcttggatctgttttca
gcaaaggctgtgtacatgggacaccctagcattgatttacacactgtgtgtgtccagaac
aaactgagtaacatgtctctctcagagactggtgtgacactgctctacgggcttcagacc
acggacaatagattattgcactttgtggcaccaaagcacacagctaaaatgctcttcagt
ggattgttggaactcactagagctgtgagaaagatgaggaagttccctgaccaaagacag
cagtggctgcggaaacaatacgtcagcctctaccaggaggatggacgatatgaaggccca
actttggctcacgctgtggagttgtttggcggcagacgatggagtactcgaaaccccagt
cccgggatatcagcaaagagtgctgagaagcccaacatgcagagaaacaacacgttgggt
ataagcaccaccaagaaaaagaagaaaatcctcatgaggggtgagagtggagaggccacc
gatgacgagatggccacccgcaaagccaaaacgaacaaagagtgtcggagtcggagtggt
tctgatcctcaagacgttaatgaacaagaagaatcagaggcgaacgccatcacgagccct
cctaaccctctcccttccagaagagcccactctttgaccacggctgggtcccctaacttg
gctgccgggacgtcatctcccatcaggccagtgtcctcccctgtgctgtcttcttcaaac
aagagcccgtccagtgcttggagcagcagctggcatgggcggatcaaaggaggaatgaag
ggctttcagagcttcatggtttcagacagcagcatgagttttgtggagtttgttgagctg
ttcaaatcattcagtgtgaggagccgcaaggacctgaaggatctctttgacatctatgcc
gtaccctgcgaccgagccggctccgcggcagcgcctctctacaccaacctgaccattgac
gaaaacaccagtggtcttcagcctgacctagatttgttgaccagaaatgtctccgatttg
gggttattcattaagagtaaacagcagctgtccgacaaccagaggcagatatctgatgcc
attgctgctgcaagtatcgtgacaaatggcactggggtggagagcacatccctgggcgta
tttggagttggcatcctccagctcaatgacttcctagtgaattgccaaggagaacactac
acttacgatgaaatcctcagcatcatccagaagttcgagcctagtgttagtatgtgtcat
cagggcctaatgtcgtttgaaggatttgcaaggtttctgatggataaagataattttgcc
tcgaaaaatgatgagtcccaggagaacattaaagaattgcaattgcccctctcctactat
tacattgaatcttcacacaatacctacctcacaggccatcaactcaaaggagaatcctca
gtggaactctacagccaggtcctcctgcaaggctgtaggagtgtagagttggactgctgg
gacggagatgatgggatgcccatcatttatcatggacacaccctgacaaccaagatcccc
ttcaaggaagtggttgaagccatcgatcgcagtgcctttatcaactccgacctccccatc
atcatatctattgagaaccactgttcattgcctcagcaacgaaaaatggcagaaattttc
aagactgtgtttggagaaaaactggtggctaaattcttatttgagagtgatttctcagat
gatccaatgcttccctcacctgaccaactcaggaggaaagtgcttctcaaaaataagaag
ttaaaagcccatcagacaccggtggatatattaaagcaaaaggctcatcagctggcatcc
atgcaagctcaggcttataatggtggcagtgccaaccctccacctgctaataacgaagaa
gaggaagatgaagaggacgaagatgattatgactatgaatccctctctgacgatgtcctt
actgcttctcctgttcttaacagtcaggaagacaacattctagaagacagacctgaaaat
aaatcatgtaatgacaaacttcagtttgagtataatgaagaaatccccaagaggataaag
aaagcagataactctgcttgcaacaaaggaaaggtttatgacatggaactgggagaagaa
ttttatcttcctcagaataaaaaggaaagcagacagattgcaccagagctttctgacctt
gtcatctattgccaagcagtaaagtttccaggcctgtcaactctaaatgcatctggctct
agcagaggaaaagaaaggaaaagcaggaagtccatttttggcaacaatccgggcagaatg
agccccggggagacagcatcatttaacaaaacatctggaaaaagttcctgtgaaggaatg
cgacaggcctgggaggactcgccttcctctgtcaacccagccacgtccctcagcgctatc
attagaactcccaaatgctaccacatctcctcgctgaatgaaaatgccgccaaacgtctg
tgtcgcaggtattctcagaaactgatccagcacactgcctgccagctgctgaggacgtat
ccggctgccacccgcatcgactcatccaaccccagccccctcctcttctggctccatggg
atacagctcgtggcgctcaactaccagacagatgatctccctttacatttaaatgctgcc
atgtttgaggccaacggtggctgtggttatgttctgaaacccccagttctgtgggacaag
aactgtcccatgtatcagaagttttctcccttggaaagagacctggacaacatggagcct
gccgtctattctttaactattgtctctgggcagaacgtgtgcccgagtaacagcacggga
agcccgtgtatagaggtcgacgtcctgggcatggccctggatagctgccacttccgcacg
aagcccatccaccgcaatactctgaaccccatgtggaatgaacagttcctcttccgggtt
cactttgaagatctcctatttcttcgatttgccgttgtggagaacaacagctcggtggta
actgctcagagaatcatccccctcaaggctctaaagcgaggatatcgacatcttcagctg
cgaaacctccacaatgaagtcttggaaatctctagtttattcataaacagcaggaggatg
gaagaaaattcctctggcaatactatgccggcctctttgatgtttaatacagaagaaaga
aaatgtttgcagattcacagagtcacagtacatggggtcccaggtccagagccctttgct
gttttctccataaatggaggcaccaaggcaaagcagcttctccaacaaagtctgaccatt
gatcaagacaccaaacctattgccacagactattttttaatggaagaaaaatattttata
tctaaagaaaagaatgaatgtaggaaacaaccattccagagagccattggtccagaagaa
gagatcatgcagattttaagcagctggtttccagaagagggatatgttggcaggattgtc
ttaaaaacccagcaggaaaacctggaagagaagagcatcgttcaagatgacaaggagatg
atcttgagctcagaggaggagagtttctttgtccaagtgcatgacgtttctccagagcaa
ccgcgaacggtcatcaaggcgccccgcgtcagcaccgcgcaggacgtcattcagcagacc
ttatgcaaagccaaatattcctatagcatcttgagcaacccgaacccgggtgattatgtg
cttttggaagaggtggtgaaagacactgccaacaggaagtcttctaccccaaagtcctcc
cagcgtgtccttttggatcaggagtgtgttttccaagctcaaagcaggtggaaaggtgca
ggaaaatttatccttaagctaaaggaacaagtgcaggcatcccgagaagacaaaagaaaa
ggcatctcttttgcaagcgaactcaagaagctcaccaagtcgactaaacagccccgagga
ctcacatcaccttctcaggtcttggcctcagaaaatgtccaaaacaaggaggagaaacct
gtgggcggcttgtcctccagtgacacgatagactatcgacagtga
DBGET
integrated database retrieval system
