KEGG   Physeter macrocephalus (sperm whale): 102989171
Entry
102989171         CDS       T06011                                 
Name
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase
  KO
K00512  steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32]
Organism
pcad  Physeter macrocephalus (sperm whale)
Pathway
pcad00140  Steroid hormone biosynthesis
pcad01100  Metabolic pathways
pcad04913  Ovarian steroidogenesis
pcad04917  Prolactin signaling pathway
pcad04927  Cortisol synthesis and secretion
pcad04934  Cushing syndrome
Module
pcad_M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
pcad_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
pcad_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
pcad_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:pcad00001]
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    102989171
   04917 Prolactin signaling pathway
    102989171
   04927 Cortisol synthesis and secretion
    102989171
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102989171
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:pcad00199]
    102989171
Enzymes [BR:pcad01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.19  steroid 17alpha-monooxygenase
     102989171
    1.14.14.32  17alpha-hydroxyprogesterone deacetylase
     102989171
Cytochrome P450 [BR:pcad00199]
 Cytochrome P450, animal type
  CYP17 family
   102989171
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 102989171
NCBI-ProteinID: XP_007126965
Ensembl: ENSPCTG00005020262
UniProt: A0A2Y9FMJ7
LinkDB
Position
20:complement(58366818..58375090)
AA seq 509 aa
MWVLLVLLLLTLAYLFWPKTTGSGAKYPKSLPSLPLVGSLPFLPKHGHQHVNFFKLQEKY
GPIYSFRLGSKTTVMIGHYQLAREVLLKKGKEFSGRSKVLTLDILSDNQKGIAFADHGAV
WQLHRKLAQNAFALFKDGNLKLEKIINREASLLCDSLATRHGESINLSEHLSLAVTNIIS
FICFNFSFKNEDPALKAIYKFNDGILEAQGKEILSDIFPGFKIFPSKALEKIKSCVRMRN
ELLSEILEKSKEKFTSDSITNLLDILIQAKVNADNNNAGPDHDSKLLSDRHMLTTIGDIF
GAGVETTTSVIKWIVAFLLHYPPLKKRIQDDVDQNIGFNRAPTISDRNRLVLLEATIREV
LRIRPVSPTLIPHKAIVDSSIGDLTIDKGTDVVVNLWALHHSEKEWHRPDLFMPERFLDP
TGTKLISPSLSYLPFGAGPRSCIGEMLARQELFLFMAWLLQRFDLEIPDDGKLPSLEGNP
GLVLQIDPFKVKIKVRQAWKDAQAEGSTS
NT seq 1530 nt   +upstreamnt  +downstreamnt
atgtgggtgctcctggttctcctgctgctcacccttgcctatttattttggcccaagacc
acgggctctggtgccaagtaccccaagagcctcccatccctgcccctggtgggcagcctg
ccgttcctccccaaacatggccaccagcacgtgaacttcttcaagctgcaggaaaaatac
ggccccatctattcctttcgtctgggttccaagactactgtgatgattggccactaccag
ctggccagggaggtgctcctcaagaagggcaaggaattctccgggcggtccaaagtgttg
actctagacatcctgtcagacaaccaaaagggcatcgccttcgccgaccacggtgcagtc
tggcagctgcatcggaagctggcacagaacgcctttgccctgttcaaggatggcaacctg
aagctagagaagatcattaatcgggaagccagtttactgtgcgactccctggccacccgg
catggagagtccataaatttgtcggagcatctctctctggcggtgaccaacataatcagc
tttatctgcttcaacttctccttcaagaatgaggatcctgccctgaaggccatatacaag
ttcaatgatggcatcctggaggctcagggcaaggagattttgtcagacatattccctggg
tttaagattttccccagcaaagccctggaaaagataaagagttgtgttcgaatgcgaaac
gaattgctgagtgaaatccttgaaaaaagtaaggagaaattcaccagtgactccatcact
aacttgctggacatactgatccaagccaaggtgaacgcagacaataacaatgctggacca
gaccacgattcaaagctgctttcagatagacacatgctcaccaccataggggacatcttt
ggggccggcgtggaaaccaccacctcagtgataaagtggattgtggccttcctgctacat
tatcctccattgaagaagaggatccaggatgatgtcgaccagaatataggtttcaatcgc
gcaccaactatcagtgaccggaaccgccttgtcctgctggaggccaccatccgagaggtg
cttcgaatccggcctgtgtcgcccacgctcatcccccacaaggctatcgttgactccagc
attggtgaccttaccattgacaagggcacagatgttgtggtcaatctgtgggcactgcat
cacagtgagaaggagtggcaccggcccgacctgttcatgcccgagcgcttcttggacccc
acggggaccaagctcatctcgccatcgttaagctacttgcccttcggagcaggaccccgc
tcctgcataggtgagatgctagcccgccaggagctcttcctcttcatggcctggttgctg
cagaggttcgacctggagatcccggatgatgggaagctaccctctctggagggcaacccc
ggtttagtcttacagatcgatcctttcaaagtgaagatcaaggtgcgccaggcctggaag
gacgcccaggccgagggcagcacctcgtga

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