KEGG   Physeter macrocephalus (sperm whale): 102995357
Entry
102995357         CDS       T06011                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pcad  Physeter macrocephalus (sperm whale)
Pathway
pcad00562  Inositol phosphate metabolism
pcad01100  Metabolic pathways
pcad04015  Rap1 signaling pathway
pcad04020  Calcium signaling pathway
pcad04022  cGMP-PKG signaling pathway
pcad04062  Chemokine signaling pathway
pcad04070  Phosphatidylinositol signaling system
pcad04071  Sphingolipid signaling pathway
pcad04072  Phospholipase D signaling pathway
pcad04081  Hormone signaling
pcad04082  Neuroactive ligand signaling
pcad04261  Adrenergic signaling in cardiomyocytes
pcad04270  Vascular smooth muscle contraction
pcad04310  Wnt signaling pathway
pcad04371  Apelin signaling pathway
pcad04540  Gap junction
pcad04611  Platelet activation
pcad04613  Neutrophil extracellular trap formation
pcad04621  NOD-like receptor signaling pathway
pcad04713  Circadian entrainment
pcad04720  Long-term potentiation
pcad04723  Retrograde endocannabinoid signaling
pcad04724  Glutamatergic synapse
pcad04725  Cholinergic synapse
pcad04726  Serotonergic synapse
pcad04728  Dopaminergic synapse
pcad04730  Long-term depression
pcad04742  Taste transduction
pcad04750  Inflammatory mediator regulation of TRP channels
pcad04911  Insulin secretion
pcad04912  GnRH signaling pathway
pcad04915  Estrogen signaling pathway
pcad04916  Melanogenesis
pcad04918  Thyroid hormone synthesis
pcad04919  Thyroid hormone signaling pathway
pcad04921  Oxytocin signaling pathway
pcad04922  Glucagon signaling pathway
pcad04924  Renin secretion
pcad04925  Aldosterone synthesis and secretion
pcad04926  Relaxin signaling pathway
pcad04927  Cortisol synthesis and secretion
pcad04928  Parathyroid hormone synthesis, secretion and action
pcad04929  GnRH secretion
pcad04933  AGE-RAGE signaling pathway in diabetic complications
pcad04934  Cushing syndrome
pcad04935  Growth hormone synthesis, secretion and action
pcad04961  Endocrine and other factor-regulated calcium reabsorption
pcad04970  Salivary secretion
pcad04971  Gastric acid secretion
pcad04972  Pancreatic secretion
pcad04973  Carbohydrate digestion and absorption
pcad05010  Alzheimer disease
pcad05016  Huntington disease
pcad05017  Spinocerebellar ataxia
pcad05022  Pathways of neurodegeneration - multiple diseases
pcad05142  Chagas disease
pcad05143  African trypanosomiasis
pcad05146  Amoebiasis
pcad05163  Human cytomegalovirus infection
pcad05200  Pathways in cancer
pcad05415  Diabetic cardiomyopathy
pcad05417  Lipid and atherosclerosis
Module
pcad_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pcad00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102995357 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    102995357 (PLCB4)
   04310 Wnt signaling pathway
    102995357 (PLCB4)
   04371 Apelin signaling pathway
    102995357 (PLCB4)
   04020 Calcium signaling pathway
    102995357 (PLCB4)
   04070 Phosphatidylinositol signaling system
    102995357 (PLCB4)
   04072 Phospholipase D signaling pathway
    102995357 (PLCB4)
   04071 Sphingolipid signaling pathway
    102995357 (PLCB4)
   04022 cGMP-PKG signaling pathway
    102995357 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    102995357 (PLCB4)
   04081 Hormone signaling
    102995357 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102995357 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102995357 (PLCB4)
   04613 Neutrophil extracellular trap formation
    102995357 (PLCB4)
   04621 NOD-like receptor signaling pathway
    102995357 (PLCB4)
   04062 Chemokine signaling pathway
    102995357 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    102995357 (PLCB4)
   04922 Glucagon signaling pathway
    102995357 (PLCB4)
   04929 GnRH secretion
    102995357 (PLCB4)
   04912 GnRH signaling pathway
    102995357 (PLCB4)
   04915 Estrogen signaling pathway
    102995357 (PLCB4)
   04921 Oxytocin signaling pathway
    102995357 (PLCB4)
   04926 Relaxin signaling pathway
    102995357 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    102995357 (PLCB4)
   04918 Thyroid hormone synthesis
    102995357 (PLCB4)
   04919 Thyroid hormone signaling pathway
    102995357 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    102995357 (PLCB4)
   04916 Melanogenesis
    102995357 (PLCB4)
   04924 Renin secretion
    102995357 (PLCB4)
   04925 Aldosterone synthesis and secretion
    102995357 (PLCB4)
   04927 Cortisol synthesis and secretion
    102995357 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102995357 (PLCB4)
   04270 Vascular smooth muscle contraction
    102995357 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    102995357 (PLCB4)
   04971 Gastric acid secretion
    102995357 (PLCB4)
   04972 Pancreatic secretion
    102995357 (PLCB4)
   04973 Carbohydrate digestion and absorption
    102995357 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    102995357 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    102995357 (PLCB4)
   04725 Cholinergic synapse
    102995357 (PLCB4)
   04728 Dopaminergic synapse
    102995357 (PLCB4)
   04726 Serotonergic synapse
    102995357 (PLCB4)
   04720 Long-term potentiation
    102995357 (PLCB4)
   04730 Long-term depression
    102995357 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    102995357 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    102995357 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    102995357 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    102995357 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102995357 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    102995357 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102995357 (PLCB4)
   05142 Chagas disease
    102995357 (PLCB4)
   05143 African trypanosomiasis
    102995357 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102995357 (PLCB4)
   05016 Huntington disease
    102995357 (PLCB4)
   05017 Spinocerebellar ataxia
    102995357 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    102995357 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102995357 (PLCB4)
   05415 Diabetic cardiomyopathy
    102995357 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102995357 (PLCB4)
   04934 Cushing syndrome
    102995357 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcad04131]
    102995357 (PLCB4)
Enzymes [BR:pcad01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102995357 (PLCB4)
Membrane trafficking [BR:pcad04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102995357 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102995357 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 102995357
NCBI-ProteinID: XP_007109134
Ensembl: ENSPCTG00005005900
UniProt: A0A2Y9EU48
LinkDB
Position
14:34024777..34185727
AA seq 1187 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEDKEGQVL
ECSLINSVRLGATPKDPKILAALEAIGKSENDLEGRVVCVCSGTDLVNISFTYMVAENSE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGQISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGNELSADDLGHKEAIANSVKKASD
DLEHENNKKGLVTIEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRISVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANAAKASVTPQ
SSSELRPTTTATLGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSDMINTHSAEEQEIRDQHLSQQCELLRKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV
NT seq 3564 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcgtttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggagaagtgaagacaaggaaggacaagttcta
gaatgttctctcatcaacagtgttcgactgggagccacaccaaaggatcccaaaattttg
gctgctcttgaagctattggaaaatcagaaaatgacctggaagggcgggtagtttgtgtc
tgcagtggtacagatctggtgaacatcagtttcacatacatggtggctgaaaattcagaa
gtaactaagcaatgggtcgaaggcctgagatccatcatacacaacttcagggccaacaat
gtcagtcccatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatgggaaaattccagttaggagtattaccagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagctaggtcttcccagtggaaagaatgatgaaattgag
cctgcagcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcggttgaatgaaattttgttc
ccattttatgatgctaaaagggcaatgcagatcattgagatgtatgagcctgatgaagac
ttgaagaaaaaaggccaaatatcaagtgatgggttttgcagatacctgatgtcagatgaa
aatgccccagtcttcctagatcgcctagagctttaccaagaaatggaccaccctctggct
cactacttcatcagctcttcccacaacacctatctcactggcaggcagtttggtgggaag
tcttcagtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaggaccaagaaccaataataactcatggaaaagcaatgtgc
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcatttgtcacatct
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggagatctcctgttgaaacaagcacttgaatcacat
ccactggaaccaggcaggcccttgccatccccaaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaggttgagaaaaaacagcttgaagctttgaaaagtatg
atggaagcaggagaatccgctgccccagtgaacatcttagaggatgacaatgaagaggaa
atagaaagtgctgagcaagaggaggaagctcaccctgaatacaaatatggaaatgaactt
tctgcggacgacttgggtcacaaggaagctattgccaatagtgttaagaaggcttcagat
gaccttgaacatgaaaacaacaaaaagggcctggtaactatagaagatgagcaggcatgg
atggcatcttataaatatgtaggcgctaccactaatatccatccatatttgtccacaatg
atcaactatgcacagcccgtaaagtttcaaggtttccatgtggctgaagaacgcaatatt
cattataacatgtcttcttttaatgagtcagttggtctaggctacttgaagacacatgcg
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgcctcagattttctggaacgctggctgccagatggtttcg
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcgtgcgggtaccttctcaaaccagatttcatgagacggcctgatcgaacatttgat
cccttctctgaaacgcctgttgatggggttattgcagccacttgctcagtgcaggtcata
tcaggccagttcttatcagataaaaaaattggcacatacgtagaagtggatatgtatggg
ttgcccactgacactatccggaaggaattccgaacacgcatggtgatgaacaatggactc
aatccagtttacaatgaagaatcatttgtatttcggaaggtgatcctccctgacctggca
gtcttgagaatttcagtgtatgatgacaacaacaagctgattggccagaggattctgcca
ctggatggcctccaagcaggctatcgacacatttctcttcgaaatgagggaaataaacct
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaaccagtgacatcgccgacgtgcccagtgac
acgtcgaagaatgacaagaaagggaaagctaacgcagcgaaagcaagcgtgacccctcag
agcagctcagagctcaggcccaccaccacggccaccctgggagctggcctggaggccaag
aaaggtattgaattgatccctcaagtgaggatagaagatttaaaacagatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagctcaattctttaaagaagaaacatgcaaag
gagcacagtaccatgcagaagctacattgcacacaagttgacaaaattgtggcgcagtat
gacaaggagaagtcaactcatgagaaaatcctagagaaggcaatgaagaagaagggggga
agtaattgtctcgaaatgaagaaagaaacagaaattaaaattcagacgctgacatcagat
cacaaatctaaggtcaaggagatcgtggcgcagcacacaaaagagtggtcagacatgatc
aacacccacagtgcagaggagcaggagatccgggatcagcacctcagccagcagtgtgag
ctgctcagaaagctcctgatcaacgcccacgagcagcagacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctatcaagaataaagcagaacgggaaaggcgggtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaagcgactcgcaatgaag
cagtccaaagaaatggaccagttgaaaaaagtccagcttgagcacctcgaattcctagag
aaacagaacgagcaggcgaaggagatgcagcagatggtgaaattggaagccgagatggac
cgcagaccagcaacagttgtgtga

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