Physeter macrocephalus (sperm whale): 102995725 Help Entry 102995725         CDS       T06011                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X6   KO K04963   ryanodine receptor 3 Organism pcad  Physeter macrocephalus (sperm whale) Pathway pcad04020   Calcium signaling pathway pcad04371   Apelin signaling pathway pcad04713   Circadian entrainment pcad04921   Oxytocin signaling pathway pcad04970   Salivary secretion pcad05010   Alzheimer disease pcad05012   Parkinson disease pcad05020   Prion disease pcad05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:pcad00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102995725 (RYR3)    04020 Calcium signaling pathway     102995725 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     102995725 (RYR3)   09154 Digestive system    04970 Salivary secretion     102995725 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     102995725 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     102995725 (RYR3)    05012 Parkinson disease     102995725 (RYR3)    05020 Prion disease     102995725 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     102995725 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pcad04040]     102995725 (RYR3) Ion channels [BR:pcad04040]  Voltage-gated cation channels   Ryanodine receptor    102995725 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  102995725 NCBI-ProteinID:  XP_028351367 Ensembl:  ENSPCTG00005021878 UniProt:  A0A455BRL6 LinkDB All DBs Position 11:104394260..104964701 Genome browser AA seq 4865 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIYYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTALFSQ FVSGNSRTAAPVTLPIEEVLQTLHDLIAYFQPPEEGLQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSIAHFTGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIRQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGANDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIDDGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPQLEVVRID GTLDSPPCLKVIHKTFGTQNSSATMIYCRLSVPVECHSSFSHSPCLDSDAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDVVATSQRASRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPIPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSDRHGWVVQCLEPLQMMALYIPEENRCVDILELCEQEDLMWFHYH TLRLYSALCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGFLRSGFYDLLISIHLASAKE RKLMMKNEYIIPITSSTRKIRLYPDKSKRHGLPGVGPRTCLKPGFRFSPACFVMTSEEHQ KQSPEIPLELLKTKALSMLTEAVRCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHGGDTQGGAEKEEVTQVEEKAVEAGEKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPKEIREELYDFHEDLLIHCGVPLEEEEEEEED ASWTGKFRALVYKIKGFSKPEKKQPTEEEERCPTTLKELISQTMICWAQEDQIQDAELVR MMFSLLQRQYDSIGELLQALRKTYTISQASVSDTISLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSHGYKRDVTEDHEDEEEIVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT VSLSTTEAVLALNRYICSAVLPLLTRCAPLFAGTEHYSSLIDSTLQTIYRLSKGRSLTKA QRDTIEECLLSICNHLRPSMLQQLLRRLVFDVPQLSEYCKMPLKLLTNHYEQCWKYYCLP SGWGSYGLAVEDELHLTEKLFWGILDSLSHKRYDPDLFRMALPCLSAIAGALPPDYLDTR ISATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQNGWKYG ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVDRTKEGEALFQQREN EKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVIAENYHNIWAKKKKLELESKGDG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGVVVSRGIKDMELDASSMEKRFAYKFL KKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGNDSATMVSCLHILAQTLDTRTV MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSVFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAA IPVAFLEPTLDCYNPLSVFNAKTPRERSILGMPDTVEEMCPDIPQLEGLMKEINDLAESG ARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIIN SNLAIDEASWMKRIAVYAQPIISKARADLLRSHFIPTLEKLKKKAVQTVQEEEQLKADSK GDTQEAELLILDEFAILCRDLYAFYPMLIRYVDNNRSNWLKSPDAHSDQLFRMVAEVFIL WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLYSIQTSL IVAALKKMLPIGLNMCTPGDQELISLAKSRYSYKDTDEEVKEHLWNNLHLQEKSDDPAVK WQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRA VVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEET EKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYASMMAKSCQSGEDEEEEEDKEKTFEE KEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQK MLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVL QNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYW YYSGKDVIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHV FANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNV EMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCA EADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLTYFE PYLGRIEIMGEAKKIERVYFEISESSRTQWEKPQVKESKQQFIFDVVNEGGEQEKMELFV NFCEDTIFEMQLASQISESDSADRPEEEEEENEDSSHTLEVEGEEEDDKSFECASAFAVA CASVKRNVANFLKRATLKNLKKQCRKVKKMTLKELVKVFFSFFWTLFVGLFHLLFAILGG IFQILWSTVFGGGLIEGAKNIRVIKILGDMPDPTQFGIHDDAMEAERAEVPEPGIATELV HFGKGERGDADIMSDLFGLQSKKEGGLKHGPEVGLGDLSEIIGEDEPPTLESTVREKRKA QAAETKAAHETEGKVESEKADMEDGEKEDTAKEEEQAEAGWADVTKRKKRWCGQKIEKPE AFMASFFKGLEIYQTKLLHYLARNFYNLRLLALFLAFAINFILLFYKVTEEPLEEETEDI ANLWNSFNDEEEEEAVVFFVLQESTGYMAPTLRTLAIIHTIISLVCVVGYYCLKVPLVVF KREKEIARKLEFAGLYITEQPSEDDVKEQWDRLVINTPSFPNNYWDKFVKRKVINKYGDL YGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYL AWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYT VVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMY RIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTP HGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQY EDQLG NT seq 14598 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagttcctgcggactgaagatgaa gtggtcctccagtgcatcgccaacgttcacaaggagcagaggaagttctgcctggcagct gagggacttgggaatcgcctgtgcttcttggaacccacttcagaagcgaagtatgttcct ccagatctctgcgtctgcaattttgtactggaacagtccctctctgtcagagccctacag gaaatgcttgccaacacaggtgaaaatggcggcgaaggggctgcacaagggggtggccac aggaccctgctgtatggccacgcgattctcctgcggcactccttcagcggaatgtatcta acatgtttgactacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggaccatacatcccgcttccaagcagaggtct gagggagaaaaggttcgaattggtgatgacctcatccttgtcagcgtatcctctgaaaga taccttcatctctcaatatcaaatggtaacatacaagtggatgcctcctttatgcaaaca ctctggaatgtacatcctacgtgctcaggaagtagcatcgaagaaggatacctacttggt gggcatgtagtacgtcttttccatggtcacgatgagtgtttgacaataccatctacagac cagaatgattcccagcacaggaggatatactacgaagctgggggagctggcacgagagcc agatctctgtggagagtggaaccccttcggataagttggagtggcagtaacatcagatgg ggccaggctttccgacttcggcatctcaccacaggccactatctggccttgacagaggac caaggccttatactgcaagaccggggaaaatcagacaccaagtccacagccttctctttc cgagcatcaaaggaaatcaaggagaaactggattccagtcacaagcgagatatagagggc atgggagtcccagaaatcaagtacggagactctgtctgctttgtccaacatatagccagt ggtctctgggtgacctacaaagcacaagatgccaagacatcccgcctgggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgacgggttaacactgcagagatgc cagcatgaggagtcccaggctgcccggatcatccggaacacgaccgctttattcagccag tttgtaagtggaaacagccgcacagcagcccctgtcaccctgccgatagaagaggtcctg cagaccttacacgacttgattgcctacttccagcccccggaggaggggttgcagcatgag gacaagcagaacaagctccgctcactcaaaaacagacagaatcttttcaaggaagaggga atgttggcccttgtgttaaactgcattgatcgcttaaatatctacaatagcatagcacac ttcacagggattgccagggaggagagtgggatggcctggaaagaaattctgaacctcctc tacaaattgctggctgctctcattcgtggaaacagaaacaactgcgctcaattctccaat aaccttgattggctaatcagcaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcctgattgaaagcccagaagccttaaacctgatagcagaaggccac atcaagtcaatcatttcccttttggataagcacgggcgaaatcacaaggttctggatgtg ctgtgttccctctgtctctgcaatggggtcgcagtgagagccaaccagaatctgatctgt gacaacttgctgccccggagaaacctgctcctgcagacgcggctgattaacgatgtgaca agtattcggccaaacatcttcctgggagtcgccgagggctcagcgcagtacaagaagtgg tacttcgagctaatcatcgaccaggtggaccccttcctcacagcagagcccacacacctg cgggtgggctgggcgtcttcctcaggctatgccccataccctggaggcggagaaggatgg gggggcaatggtgttggcgatgacctatactcctatggctttgatggacttcacctttgg tcaggccgcatacccagagccgtggcctccatcaaccagcacctcctgaagtcagacgac gtggtgagctgttgcctggacctcggagcacccagcatctctttccgcatcaatgggcag cctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttttcagcaggtgtcaaagtacgtttcctgatggggggacgtcacggagaatttaagttc ctgcctccctctggctatgccccttgctacgaagccttacttccaaaagaaaagatgaga ttggagcctgtcaaagagtataaacgggatgctgaaggtgttcgagatctgttgggtacc acccagttcctctcccaagcttctttcattccgtgccccatagataccagtcaggttgtt ttaccacctcacctagagaagatccgagacaggctggctgaaaacatccacgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatacgggacgacaataaaaga caacacccctgccttgtcgagttttcaaagctgcctgaaactgagaagaattataaccta caaatgtcaaccgaaaccttaaaaaccctcctggccctggggtgccacatcgctcatgtt aacccggctgctgaggaggatctcaagaaggtcaagttgcccaaaaactacatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctgttacctcctcaagaa attttagtggataagcttgcagaaaatgcacacaatgtttgggcaaaagacagaataaga caaggatggacctatggcattcaacaggatttaaagaacaaaagaaacccccgtctggtg ccatatgcgttattggatgagcgtaccaagaagtcaaatagggacagccttcgtgaagct gttcggacttttgttggttacggctataacattgagccatcagaccaagaactagctgac ccagctgtggagaaagtcagcatagacaagatccgctttttccgggtagagcgctcttat gcggtgagatctggaaagtggtattttgagtttgaggtggtgaccggaggagacatgcgt gtcggctgggccaggccaggctgtcggcctgacattgagctgggggccaatgaccaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaagggagtgggtattttggacgg acctggcagccaggagatgtggttggatgtatgattaacctggatgatgcctcaatgatc ttcacgttgaatggggagttgctgatcaccaacaaaggctctgagcttgccttcgctgac tacgagattgacgacggctttgtgcccatatgctctctgggcctgtctcagatcggccgc atgaatctcgggatggacgccagcaccttcaagttttataccatgtgcggcctccaagag ggctttgagccttttgctgtcaacatgaaccgcgacgtggccatgtggttcagcaagcgc ctcccaacctttgtcaatgtgcccaaggatcatccacagctagaggtcgtgaggatcgat ggcaccctggacagccctccgtgcctcaaggtgatccacaagacgttcggcacacagaac agcagtgccaccatgatctactgccgcctgagcgtgccggtggagtgccactcctccttc agtcacagcccgtgtctggacagtgacgctttccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactacgcaattcgcatctttgctggacaggacccc tcctgcgtctgggtcggatgggtgactcccgactatcatttgtacagtgaaaagtttgac ttgaataaaaactgtaccgtgactgttactctgggggacgaaagaggccgggtccacgaa agtgtgaagcgcagcaactgctacatggtctggggtggggacgtcgtggccacgtcccaa agagcaagtcgcagcaacgtggacctagagatcggctgcctcgtggatctggcaatgggc atgttgtccttctcggccaacgggagggaactcggcacctgctaccaggtggagcccaat accaaagtgtttccagcggtcttcctgcagcccacaagcacctctttgtttcagtttgaa cttgggaagctgaagaacgccatgcccctgtcggcagccatattcaagagtgaagagaaa aaccccatccctcagtgcccaccacggctggacgtccaaaccatccagcccgtcctctgg agccgcatgcccagcagcttcctgaaggtggagacggagcgggtgagcgaccgccatggc tgggtggtgcagtgcctggagcccctacagatgatggcgctctacatccccgaggagaac aggtgtgtggacatcctggagctctgcgagcaggaggacctcatgtggttccattaccac acgctgagactctacagcgccttgtgcgccctgggaaacagccgggtggcttacgccctg tgcagccacgtggacctctcccagctcttctacgccattgacaacaagtacctccctggc ttccttcgctccggcttctatgacctgctcatcagcatccacctggccagcgctaaggag aggaagctgatgatgaagaatgagtacatcatccccatcaccagcagcaccaggaaaatc cgcctgtacccggacaagtccaagaggcatgggctccctggggtgggcccgaggacgtgc ctcaagccagggttcaggttctcccccgcctgcttcgtcatgaccagcgaggaacaccag aagcagagccccgagatccccttggagcttctcaagacgaaggcgctgagcatgctgacg gaggcagtgcggtgcagtggggctcacatccgggaccccgtcggggggtccgtggagttc cagtttgtgcctgtgctgaaactcatcggaaccctgctggtcatgggggtgtttgacgat gacgatgttcggcagatcctccttctcatcgacccctccgtgtttggggagcacggtggg gacacacagggcggagcagagaaggaggaggtgacccaggtggaggagaaggctgtggag gctggggaaaaggccagcaaggaggctcccgtcaaaggcttgttgcagacccgattaccg gagtccgtcaagctgcagatgtgtgagctcctcagctatctctgtgactgtgaactgcag caccgggtggaggccatcgtggcctttggtgacatttatgtctccaagctccaggcaaat cagaagttccgttacaacgaactcatgcaggccctgaacatgtctgcggccctgactgct cggaagaccagggagttccgctcacccccgcaggagcagatcaacatgcttcttaacttt caactgggggagaactgcccgtgccccaaagagatccgggaggagctgtatgacttccac gaggaccttctcattcactgcggggttcccctggaggaagaggaagaggaggaggaggac gcctcctggactggaaaattccgtgccttggtgtataaaatcaaaggcttttccaagcca gagaagaaacagccgacagaggaggaggagagatgccctacgacgctgaaggagctcatc tcacagaccatgatctgctgggcccaggaggaccagatccaggatgcagagctggttcgg atgatgttcagcctcctgcagaggcagtatgacagcatcggggagctgctgcaggcgctg cggaagacctacaccatcagccaggcctccgtgagcgacaccatcagcctgctggctgcc ctcggccagattcgctgcctgctcagtgtccggatgggcaaggaggaggagctgctcatg atcaacgggctgggagacataatgaacaacaaggtgttttaccagcaccccaacctcatg cgagtccttggcatgcacgagacagtcatggaggtgatggtgaacgtgctgggtgcagag aaatctcagattgcctttccaaagatggttgctagctgttgccgcttcctgtgctatttc tgtcgaattagccgacaaaatcagaaggccatgtttgagcatctcagttacctgctggag aatagcagtgttggcctagcctccccgtccatgagaggatccaccccgctggatgtggct gcttcctctgtgatggacaacaacgagttagcgctgggcttagaggaaccggacctcgag aaggtggtgacctacttggcaggctgtggcctacagagctgccccatgcttctggccaaa ggataccctgatgtcggctggaaccccattgaaggggagcgctatctgtccttcctgagg tttgccgtcttcgtgaacagtgaaagtgtggaagaaaacgctagcgtcgtggtcaagctg ctcatcagacgccccgagtgcttcggcccagccctgcggggtgaaggaggaaatggtcta ttggcggccatgcaaggcgccattaagatctctgagaacccagccctcgacctcccctct catgggtacaagagagacgtcacggaggaccatgaagatgaagaagagattgtgcacatg ggcaatgccattatgtcattttattcggctcttatagatctgctgggccgctgtgctcct gaaatgcaccttatccagacaggaaagggggaagccatccggatcaggtccatcctgcgc tccctggtccccactgaggacttggttggaatcatcagcatccccttgaaactgccctcc ctgaacaaagatggatcagtcagcgaaccagatatggcggccaacttttgccctgaccac aaggcacccatggtgctgttcttggaccgtgtttatggtataaaggatcaaactttcctg ctccacttgctggaggttggatttttacctgacttaagagcctctgcctctttagataca gtttccctaagcaccaccgaggccgtgctggcactgaacaggtacatatgttctgccgtg ctcccactcctcacaagatgcgcccctctctttgctggaacagagcactactcctctttg atcgactctacgctgcagacaatatacaggctttccaagggccgttccctcaccaaagct cagagggacaccatagaggagtgtttgctgtccatttgcaatcacttgaggccttccatg ttacagcaactcctgcgacgtctagtttttgatgtgccgcaactcagtgaatactgcaaa atgcctcttaagcttctgacaaatcactacgaacagtgctggaagtattactgtctgcct tcaggctgggggagctacggtctggctgtggaggatgagctgcatctgacagagaagctc ttctgggggattcttgactccctttcccataagaggtatgacccagatcttttccgaatg gccctgccctgtctcagtgctatagctggggccttgccaccagactatttagataccaga atctcagccacattggagaaacagatctcagtggacgcagatggcaacttcgaccccaag cctatcaacaccatgaatttctccttgcctgaaaaattggaatacatcgtcaccaagtat gctgagcactcgcatgataaatgggcctgtgataagagtcagaatggatggaaatacgga atttccctggatgaaaatgtgaagacccatccattgatcaggcctttcaagacattaaca gagaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaaccatgctggct gtgggctggacggtagacaggaccaaagagggagaagccctatttcaacagcgggaaaat gagaagcttcgaagcgtgtcccaggccagccagggcaacagctacagccctgctcccctg gatctctccaacgttgtgctctccagagagctccaggggatggtggaggtgatagctgag aactatcacaatatctgggccaagaagaagaagctggagctggagagcaaaggtgatggc agtcaccctcttttggtaccatatgacaccttgactgccaaggaaaagttcagggaccgg gagaaggcacaggacctgtttaagttcctccaagtgaacggcgttgtggtttctagaggt atcaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataagtttttg aagaagatcctgaaatatgttgattctgctcaagagtttattgcccatttggaagccatt gtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaa gttctcctcccactggttgaccagtactttaccaatcaccgcctctacttcctctcgtcc cctctgaagccccttagcagcagcgggtatgcctctcataaagagaaagaaatggtggcc agcctgttctgcaaactcgctgctcttgttcgacataggatttccctcttcgggaacgat tctgctacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggacagtc atgaagtcgggctcagagctggtgaaggccgggttgcgagcattctttgaaaatgcagcc gaagacttagagaagacttcagaaaacctgaagctcggcaagtttacccattccagaacg cagattaaaggcgtttctcagaatattaattacaccacggtggctctgcttcccatcctg acgtccgtctttgagcatgtagctcagcatcagttcggggtggatctactcttgggtgac gtgcagatttcatgctaccatatactgtgcagcctctactcccttgggacaggaaagaac atctatgttgaaaggcaacgtcctgcccttggagaatgcctggcctcactggcagctgcc ataccagtggcattcctggagcccacccttgactgctacaacccactctcagtcttcaac gccaaaacccccagggagaggtctattctggggatgccagacacggtggaggagatgtgc cctgacatcccccagctggaaggcctgatgaaggaaatcaacgacctggccgagtcaggg gcccggtacacggagatgccccacgtcatcgaggtgatcttacccatgctctgcaactac ctgtcctactggtgggagcgggggcctgagcacctgccccccagcacagggccctggtgc accaaggtcacctctgaacacctcagtgtcatcctgggcaacattctgaaaatcatcaac agcaacctggccatcgacgaggcctcctggatgaagcgcattgcagtgtatgcccagcca atcatcagcaaagccagggcggacctgctaagaagccacttcatcccaactctggagaag ctgaagaagaaggctgtccagactgtgcaggaggaggagcagctgaaagccgacagcaaa ggggacacccaggaggcagagctcctcatcctggatgagtttgccatcctctgcagagac ctctatgccttctaccccatgctgatccgctacgtggacaacaacagatctaactggctc aaaagccccgatgctcactctgaccagctcttccgcatggtggcagaggtcttcatcctg tggtgtaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaacgaaatt aataatttggcatttttaactggagacagcaaaagcaagatgtcaaaatctggaggacag gaccaggagcggaagaagacgaagcggaggggagacttgtattccatccagacctccctc atcgtggctgcactcaagaaaatgctgcccattggtttgaatatgtgcaccccaggcgat caggagctgatctccctcgcaaaatcacggtacagctataaggacacagacgaagaggtg aaggaacatctgtggaataacttgcacttgcaggaaaagtccgatgacccagctgtaaag tggcaactgaacctatacaaggatgttttgaagagtgaagaaccttccaacccagaaaag acagtggagcgtgtgcagagaatttcagcagctgtcttccacctagagcaggtggaacag cctttgaggtccaagaaggcggtctggcacaaactgctatcaaagcagcggaaacgggca gtggtggcctgtttcaggatggcccctctctacaacctgcccaggcaccgctctattaac ctcttcctccatggctatcagagattttggatagaaacagaggagtattcctttgaagag aaactagtacaggatttggctaaatctcccaaggtggaagaggaggaggaggaggagaca gaaaagcagccagacccacttcatcagatcatcctccactttagccgcaatgctctcaca gagaggagcaaactggaagacgaccctttgtacacctcctatgccagcatgatggccaag agttgtcagagtggggaagacgaagaagaggaggaagacaaggaaaaaacatttgaagag aaagaaatggaaaagcagaaaaccctctatcagcaagctcggctgcatgagcgtggagcc gcagagatggtcctccagatgataagcgccagcaaaggtgagatgagccccatggtggtg gagactctgaagctggggatcgccattctgaatgggggcaacgctggcgtgcagcagaaa atgctagattacctaaaggagaaaaaggatgctgggttctttcaaagcctttctggtctt atgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaataaagctgaaggc ctggggatggttactgaggaaggaacactcattgttcgtgagcgtggtgaaaaagtactc cagaatgatgagtttacacgagatctctttagattcctacagttactttgtgaaggacat aacagtgatttccagaacttcctgcggactcagatgggcaacaccaccaccgtgaatgtc atcatcagtaccgtggactaccttctgcgtctgcaggaatcaatcagtgacttctactgg tattattcagggaaggacgtcattgatgaatctggacagcacaatttttccaaagccctg gcggttaccaagcagattttcaattctcttacggaatacatccagggcccctgcattggg aaccagcagagcctcgctcacagtaggctatgggatgcagtggtcggcttcctccatgta tttgctaacatgcagatgaaactctctcaggattccagtcagatcgagctgctgaaggaa ctcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtg gtaaatggaacgattggcaagcagatggttgacacactggtagagtcctctaccaatgta gaaatgatcttgaaattctttgacatgttcttgaaacttaaagacttaaccagctcagac accttcaaagaatatgaccccgatgggaaggggatcatctccaaaaaggaattccagaag gccatggaagggcaaaaacagtacacgcagtcggagattgactttctcctttcgtgcgcg gaagcggatgagaatgacatgtttaattacgttgactttgtagaccggttccacgagccg gccaaggacatagggtttaacgtggcggtgttattgacaaacctctccgaacatatgcca aatgattctcgccttaagtgtctgttggacccagccgaaagcgtactcacttactttgaa ccgtacctaggacgcattgagatcatgggtgaggccaagaaaattgagcgtgtttatttt gagatcagtgagtccagtcgaactcagtgggagaagccccaggtgaaggagtctaagcag cagttcatctttgatgtcgtcaatgaaggcggagagcaagaaaagatggagctgttcgtg aacttctgtgaagacaccatctttgagatgcagttagcgtcacagatctcagaatcggac tcagctgacaggccagaagaggaggaggaagaaaatgaagactcttcccatacgttagaa gttgagggtgaagaggaggacgacaagtcttttgagtgtgcctctgcgtttgccgtggcc tgtgcctcagtgaagagaaatgtggccaactttctgaagagggccaccctgaagaacctc aagaagcagtgtaggaaggtaaagaagatgactctgaaggagctggtgaaggtgttcttc tctttcttctggacgttgttcgtggggcttttccacttgctcttcgccatattgggagga atctttcagattctctggagcacagtgtttggagggggcctcatagaaggcgcaaagaac atcagagtcataaagatcctgggtgacatgcctgacccaacccaatttggtatccacgat gatgcgatggaggctgagagggcagaagtgcccgagccaggtatcgccacggaactcgtg cactttggaaagggggagaggggagatgcggatattatgtcagatctctttggactccag tcaaagaaagaaggtggcttaaagcatgggcctgaagtgggtttgggtgacctctctgag attattggcgaggatgaaccccccacgttagagagtactgtacgggagaaaaggaaagca caggcagcagagacgaaagcagctcatgaaacagaaggaaaagtggagtctgagaaggca gacatggaagatggggagaaagaggacacagccaaagaagaagagcaggccgaggccggg tgggcagatgtgaccaaaaggaagaagcgatggtgtggccagaaaattgagaagcctgaa gccttcatggccagtttctttaaagggctggaaatctatcagaccaagttgctgcactac ctggccaggaatttctacaacctgaggctccttgctctgtttttagccttcgctatcaac ttcatcctgctcttttacaaggtcaccgaggaacctttagaagaagagacagaagacatt gcaaacctgtggaattcctttaatgatgaggaagaggaagaagcagtggtgttctttgtc ctgcaggagagcactggatatatggcgccaacattgcgaaccctggccattatccacacc atcatttctttagtctgcgtggtgggctattactgcctgaaggttcctttggtggtattc aaaagagaaaaagaaattgccaggaagttggagtttgctggcctgtatatcaccgaacag ccttctgaagatgacgtcaaggagcaatgggaccgcttagtaatcaacacaccatctttt cctaataactactgggacaagtttgtaaagagaaaggtgatcaacaagtatggagatctc tacggagcagaacgcattgctgaactcctggggttggacaaaaatgcccttgactttagc ccagtagaagagaccaaagcagaggcagcctccctggtgtcatggctaagttccatcgac atgaagtaccatatctggaagctgggagttgtttttactgacaattcctttctctacctc gcctggtacacaaccatgtcagtcctgggccactacaacaacttcttcttcgctgctcat ctgctggatatcgcgatgggcttcaagacgctgaggactattctgtcatctgtcactcac aatggcaaacagttggtcctgactgtcggtctcctggccgtggtggtttacctctatacc gtggtggccttcaacttcttccgcaagttctacaacaaaagtgaagacgacgacgagccc gacatgaagtgtgatgacatgatgacgtgttacctgttccacatgtacgtgggagtgaga gctggaggtggcattggcgatgaaattgaagaccccgctggggacccgtacgaaatgtac cgcatcgtctttgacattacattcttcttcttcgtcattgtcatcctgctggctatcatc caaggtcttatcattgatgcttttggggagctgagagaccagcaggaacaagtacgagag gatatggagactaaatgtttcatctgtgggatcggcaatgactactttgacacgacccct catggttttgaaacacacaccttacaagagcacaacttagccaactacttgttcttcctg atgtatttgattaataaagatgaaacagagcacacaggtcaggaatcttacgtctggaag atgtaccaagaaaggtgttgggatttcttccccgctggtgactgcttccggaaacagtat gaagatcagcttggataa

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