Physeter macrocephalus (sperm whale): 102996362
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Entry
102996362 CDS
T06011
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X8
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
pcad
Physeter macrocephalus (sperm whale)
Pathway
pcad00310
Lysine degradation
pcad01100
Metabolic pathways
pcad05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
pcad00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
102996362 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
102996362 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
pcad03036
]
102996362 (DOT1L)
Enzymes [BR:
pcad01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
102996362 (DOT1L)
Chromosome and associated proteins [BR:
pcad03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
102996362 (DOT1L)
HMT complexes
Dot1-containing complex
102996362 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
102996362
NCBI-ProteinID:
XP_023990174
Ensembl:
ENSPCTG00005020060
UniProt:
A0A2Y9TL50
LinkDB
All DBs
Position
2:complement(22474083..22532072)
Genome browser
AA seq
1731 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAVPADTPMDSGAEEEKAGATAVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTA
NPERKPKKTQSALDLLHAQTVSRAASPSPQGAPYQLPPSTQRRPPEQLLLAPAPPALHRL
LESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNARLLGAVQQLFGHCQAQKEEIKRLF
QQKLDELGVKALTYNDLMQARKAISAHNQQLREQTEQLEKGNRELRSQSLRLLKARCEEL
KLDWSTLSLEGLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDD
ALSLHLRGKGGLGREPEAEPGRLHLELDCTRFSLPHLSNMSPELSMNGHAAGYELCGALS
RPSPKQNTPQYLASPLDQEVVPCTPNHSGRPRLEKLSGLALPDYTRLSPAKLVLRRHLSQ
DHTANSRATASELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPAALQMTGEKGSE
KREQAGPVVCLQGLKERPYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEK
VRSTPSPVPQARESSSTLEKQMGAGAHGSGGSAAGSRSLALAPAGFAYAGSVAISGALAG
SPAPLVSGAEPPAPDESSSSGSLFATVGSRSSTPQHPPLLAQPRNCGSASPAPQLCASPR
LGAQGPLPDASKGDLPSEAGFSDPESEAKRRIVFTISAGSSSAKQSPSSKHSPLSSGARG
DGGQSHGQDSRKRGRRKRAAAGTPGLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSN
INQPLEITAISSPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSED
EPGSARIERKIATISLESKSPPKTLENGGGLAGRKVPASEPVNSSKWKSTFSPISDLGLA
KAADSPLQAASALSHNSLFAFRPGLEEPGAADAKLAAHPRKSFPGALPGAGGLSPSSHPA
SGFALGGGLAADLSLHSFSDGASLSHKAPEAAGLGTPLSFPGPRGKEGGAAEPGPFVNKR
QLDGLAPKGEGGPPVCGPADKASATHGKAGKGRDREPDVKNGHNLFMAAAAAAAAAAATA
PPGGLLSSPGLAPAASSAGGTAPSAQTHRPFLGAFTPGPQFALGPMSLQANLGPSVLQSL
FSSVPAAGLVHVSTAATRLTNSHTMGSFSSGVAGGAVGGAFNHAVPPASAHPFGASFGSG
AACRSATLSLTPLQAVASTPASSFQAPSPAEPRPPPPPPHLGRPPPGQPALHAPPPPNAA
LPPPPALLPANSEPVLLQNLASLPANQAFLPASSAASVPPANASLSIKLASLPHKVSRPS
FTVHHPPLPGLALAQAAPVIPQANSTGPPAVWVSLGMPPPYAARLAGVKPR
NT seq
5196 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggctgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atccggtgggtctgtgaagaaatcccagatctcaagcttgctatggagaattatgtttta
atcgactacgacaccaaaagcttcgaaagcatgcagaggctctgtgacaagtacaaccgt
gccatcgacagcatccaccagctgtggaagggcaccacacagcccatgaagctgaacacg
cggccgtccacggggctcctgcgccacatcctgcagcaggtctacaaccactcggtgacc
gaccccgagaaactcaacaactacgagcccttctccccggaggtatacggggagacctcc
ttcgacctggtcgcccagatgatcgacgagatcaagatgaccgaggacgacctgtttgtg
gacctgggtagcggagtgggccaggttgtgctgcaggtcgccgcggctaccaactgcaaa
catcactatggtgtcgagaaagctgacatcccggccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagaga
ggagatttcctctcggaggagtggagagagcggatcgccaacacgagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggttcgcaaacatg
aaggaaggtggcagaattgtgtcctcgaagccctttgcacctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgccgctaaaa
ggctcggtgtcgtggacggggaagccggtgtcttactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggaacaggaggca
gctcggcgccggcagcagcgggagaacaagagcaacacgaccacccccaccaaggtgccc
gagagcaaggcggccgtgcccgccgacacccccatggactctggtgctgaggaagagaaa
gccggggcgaccgctgtcaagaagccgtctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggccggccggaagcgcggacgtcccaagaagatgagcaccgcc
aaccccgagcgcaagcccaagaagacccagagtgcactggacctgctgcacgcccagacc
gtgtcgcgggcggcgtcaccctcgccgcagggcgccccctaccagctacctcccagcacg
cagcggcgcccccctgagcagctgctgctggcgcccgccccgcccgccctgcacaggctg
ctagaatccttcaagattcagtacctacagttcctggcatacacaaagacccctcagtac
aaggccaacctgcagcagctgctggaccaagagaaggagaagaacgcccggttgctgggt
gccgtgcagcagctgttcggccactgccaagctcagaaggaggagatcaagaggcttttc
cagcagaaactggatgagctgggagtgaaggcgctgacctacaatgacctgatgcaagcg
cggaaggcgatctcggctcacaaccagcagttgagggagcagacagagcagctggagaag
ggcaaccgggagctgaggagccagagcctgcggctgctcaaggcacggtgcgaggagctg
aagctggactggtccacgctgtccctggagggcctgctgaaggagaagcaggccctgaag
agccagatctcggagaagcagaggcactgcctggagctgcagatcagcatcgtggagctg
gaaaagagccagcggcagcaggagctcctgcagctcaagtcctgcgtgccgcccgacgac
gccctgtccctgcacctgcgcgggaagggtggcctgggccgagagccggaggccgagccc
ggccggctacacctggagctggactgcaccaggttctccctgccccacttgagcaacatg
agcccggagctgtccatgaacggccacgcggccggctacgagctctgcggtgcgctgagc
cggccctcgcccaagcagaacaccccccagtacctggcctcccccctggaccaggaggtc
gtgccctgcaccccgaaccacagtggccggccgaggctcgagaagttgtccggcctggcc
ctgcccgactacaccaggctctcccccgccaagctggtgctgcggcgccacctgagccag
gaccacacagccaacagcagggcgaccgccagcgagctgcacccacgagctgagcatgcc
aaggagaacggcctcccataccagagccccggcatcgccaacggcatcaaactgagcccg
caggaccctcggccctcatcccctgcggccttgcagatgacgggagagaagggcagtgag
aagcgggagcaggccggcccggtggtgtgtctgcagggcttgaaggagcgcccctacgcc
agcagtggggaggccatcaccagcctgcccgtgagcatcccgctcagcaccgtgcagccg
agcaagctgccagtcagcatccctctggccagcgtggtgctgcccagccgcgccgagaag
gtgagaagcacccccagccccgtgccgcaggcccgagagtcctcttccacgctggagaag
cagatgggtgctggcgcccacggctccgggggcagcgctgccgggagcagaagcctcgcc
ctggcccccgcaggcttcgcctacgccggctcggtggccatcagcggggccctggcaggc
agcccggcaccgctcgtctccggagccgagccccccgccccggacgagtcctccagctcc
ggaagcctcttcgccactgtggggtcccgcagctccacccctcagcacccccccctgctg
gcgcagccccgcaactgcggttcggcttcgcccgccccccagctctgtgccagtccccgg
ctcggcgcccagggcccgctccctgacgccagcaaaggagacctgccctctgaggccggc
ttctcggatcccgagagtgaagccaagagaaggatcgtcttcaccatctcagccggctct
agcagcgccaagcagtcgccttccagcaagcacagccctctgtcctcgggcgcccgtggc
gacggcggccagagccacgggcaggacagccgcaagaggggcagaaggaagcgggcggcg
gccgggacccccggcctcagctcgggcgtgtcccccaagcgccgggccctgccgtcggtc
gccggcctcttcacgcagtcttcagggtccccgctgaacctcaactccatggtcagcaac
atcaaccagcccttggaaatcacggccatctcgtcccccgagagctccctgaagagctca
cctgtcccttaccaggacaacgaccagccgcccgtgctcaagaaggagaagcccctgagc
cagaccaatggggcccactattccccgctgacctcggatgaggagcagggctctgaggat
gagcccggcagtgccagaattgagagaaaaattgcaacaatctccttagaaagcaaatct
cctccgaaaaccttggaaaatggtggcggcctggcgggaaggaaggtgccagccagcgag
ccggtcaacagcagcaagtggaagtccaccttctcgcccatctccgacctcggcctggcc
aaggcagccgacagcccgctgcaggccgcctccgctctgagccacaactccctgttcgct
ttccggcctggcctggaggaacctggtgcggctgatgccaagctggctgcccaccccagg
aagagcttcccaggcgcgctgccgggggcgggcgggctgagccccagcagccatcccgcc
agcggcttcgccctgggcgggggccttgcggccgacctcagtttacacagcttcagcgat
ggtgcttctctctcccacaaggcccccgaggcggccggcctgggcacccccctgagcttt
cccggcccccggggcaaggagggcggcgccgcagagcccggccccttcgtgaacaagagg
cagctggacggactggccccgaagggcgaggggggcccacctgtgtgcggacccgcggac
aaggcctcagcgacacacggcaaggcaggcaagggccgtgaccgcgagcccgacgtcaag
aacggccacaacctcttcatggccgccgctgccgccgccgccgccgccgccgccaccgcg
ccccccgggggcctcctcagcagcccgggccttgccccggcggcgtcctcggcagggggc
acggccccatccgcccagacccaccgccccttcttgggcgccttcacccccggccctcag
ttcgcgctgggccccatgtccctgcaggccaacctgggcccgtccgtgctgcagtccctg
ttcagctccgtgcccgccgccggcctggtgcacgtctcaaccgccgccaccagactgacc
aactcgcacaccatgggcagcttctcctccggggtggccggcggtgcagtcggaggtgcc
tttaaccacgcggtgcctcccgcctccgctcatccgtttggagccagtttcggcagtggg
gctgcatgtcgcagcgccacgctgagcctaaccccgctgcaggcggtggccagcaccccg
gcctcttcctttcaggccccgtcccctgcggagccgaggccgcccccgccccctccgcac
ctgggccggccccctccggggcagcccgccctccacgccccgccccctcctaacgccgcc
ttgcctccgccccctgcgctgctcccggctaactctgagcccgtgctcctgcagaacctc
gcgtccctcccagctaaccaagctttcttacctgcctcctctgctgcctctgtgccgcct
gctaacgcctctctgtccatcaagctcgcctcacttccgcacaaggtgtcccgcccctcc
ttcacggtgcaccacccgcccctgcccgggctggccctggcccaggccgcgcccgtgatc
ccgcaggccaactccacggggccgcccgccgtgtgggtttcccttggcatgccacctccg
tatgccgcgcgccttgcgggggttaagccgcgataa
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