KEGG   Phasianus colchicus (Ring-necked pheasant): 116228472
Entry
116228472         CDS       T07365                                 
Symbol
RYR2
Name
(RefSeq) ryanodine receptor 2
  KO
K04962  ryanodine receptor 2
Organism
pcoc  Phasianus colchicus (Ring-necked pheasant)
Pathway
pcoc04020  Calcium signaling pathway
pcoc04260  Cardiac muscle contraction
pcoc04261  Adrenergic signaling in cardiomyocytes
pcoc04371  Apelin signaling pathway
Brite
KEGG Orthology (KO) [BR:pcoc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    116228472 (RYR2)
   04020 Calcium signaling pathway
    116228472 (RYR2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    116228472 (RYR2)
   04261 Adrenergic signaling in cardiomyocytes
    116228472 (RYR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:pcoc04040]
    116228472 (RYR2)
   04990 Domain-containing proteins not elsewhere classified [BR:pcoc04990]
    116228472 (RYR2)
Ion channels [BR:pcoc04040]
 Voltage-gated cation channels
  Ryanodine receptor
   116228472 (RYR2)
Domain-containing proteins not elsewhere classified [BR:pcoc04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   116228472 (RYR2)
SSDB
Motif
Pfam: RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6
Other DBs
NCBI-GeneID: 116228472
NCBI-ProteinID: XP_031448184
Ensembl: ENSPCLG00000000627
LinkDB
Position
Unknown
AA seq 4970 aa
MAEGGEGEDEIQFLRTDDEVVLQCTATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP
DLSICTFVLEQSLSVRALQEMLANTEEKAEGSAQGGGHRTLLYGHAILLRHSYSGMYLCC
LSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL
HLSYGNGSLHVDAAFQQTLWSVAPISSGSEFAQGYLIGGDVLRLLHGHMDECLTVPSGEH
GEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHITTGKYLSLLDDK
SLLLTDKEKADVKSTAFCFRSSKEKLDVGVRKEVDGMGAPEIKYGDSICFIQHVDTGLWL
SYQSADAKSVRMGSVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNRFIRG
LDALSKKVKSSTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEE
GMINLVLECIDRLNVYSSAAHFADVAGKEAGEAWKSILNSLYELLAALIRGNRKNCAQFS
GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIICLLDKHGRNHKVLD
VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISEGSAQYRK
WYYELMVDHLEPFVTAESTHLRVGWASTEGYSPYPGGGAEWGGNGVGDDLYSYGFDGLHL
WSGCVARTVNSPNQHLLRTEDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVV
SFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPKEKLKVEHSREYKQDRSYTRDLLG
PTLNLSQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNK
RQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADERAEEKVKKMKLPKNYQL
LSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRL
VPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHATRLDVSNGIMEKFRIFRTEK
TYAVKSGKWYFEFEAVTAGDMRVGWTRPGCLPDQELGSDEEAFVFDGFKAQRWHQGNEHF
GRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFEVGDGFLPVCSLGSSQV
GRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITIWLSKRLPQFLPVPQNHEHIEVMR
IDGTIDTCPCLKVTQKSFGSQNSKTDVMFFRLSMPIECAEVFSRTTAGGLPGTGLFGPKN
DLEDYDADSDFEVLMKTAHGHLAADRTEREKDATKPELNNHKDFVQEKPSRLKQRFMLRR
TKPDYSTSHSARLTEDVLADDRDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQ
YDTSFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCLVD
AASGLLTFTANGKELGTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFK
SEHKNPVSQCPPRLHVQFLTHVLWSRVPNHFLKVDVSRISERQGWMIQCLNPLQFMALHI
PEENRTIDILELTEQEELLKFHYHTLRLYSAVCALGNNRVAHAMCSHVDESQLLYAIENK
YMPGLLRAGYYDLLIDIHLNTYATARLMMNNEFIVPMTDETKSITLFPDENKKHGLPGIG
LSTSLRPRMQFSSPSFVSINSECFQFSPEFPLEILKAKTIEMLTEAVQEGSLHVRDPVGG
STEFLFVPLIKLFYTLLIMGIFHNGDLKHILQLIEPRVFKEAANLEDERDLSEKELSSDE
LKSEGEEETRGEQVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAIVAFSDDFVA
KLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKTDCPCPEEIRD
QLLDFHEDLMTHCGIELDEDGTLDGNNDLTIRGRLLYLMEKVTYLKKKQAEKPVDDDAKT
SSTLQQLISDTMVRWAQESVIEDPDLVRAMFVLLHRQYDGIGGLVRALPKTYTINSVSVE
DTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEV
MVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSM
RGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCPLLISKGYPDIGWNPVE
GERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIQIS
EDPTRDGPSPINGSSRILEMEEQEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKG
EAIRIRSILRSLIPLEDLVGVISIPFHMPTIAKDGTVVEPDMSAGFCPDHKAAMVLFLDR
VYGIEDQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPL
FAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEECLLSICGQLRPSMMQHLLRRLVF
DVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQ
KKYEQELFKLALPCLSAVAGALPPDYMESNYVNMMEKQSSMDSDGNFNPQPVDTSNITIP
EKLEYFINKYAEHSHDKWSMEKFANGWTYGETYSESAKVQPLMKQYKLLSEKEKEIYRWP
IKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQISVDAAHGYSPRAIDMSNVTLS
RDVHAMAEMMAENYHNIWAKKKKMELEAKVGGGNHPLLVPYDTLTAKEKAKDREKAQDIL
KFLQINGYVVSRGLKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRGKGEH
FPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLSSGGHASNKEKEMVTSLFCKLGV
LVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKMALRAFLDNAAEDLEKTME
NLKQGQFTHSRNQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILEDVQVSCYRI
LSSLYALGTSKSIYVERQRSALGECLAAFSGAFPVAFLETHLNKHNIYSIYNTKNARDRA
VLNLPTSVEEVCPNIPSLVKLMEEIVELAESGIRYTQMPHIMEVILPMLCSYMSHWWEHG
PENNPDKAEVCCTALTSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAKPQ
LLKTHFLPLMDKLKKKAAVVVSDEEHLRAEGRGDMSEAELLILDEFTTLARDLYAFYPLL
IRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLIS
DTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQDLIALAK
NRFSMKDTEDEVRDIIRSNLHLQGKLEDPAIRWQMALYKDLPNRTEDSSDPEKTVERVLD
IANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYD
KSWIETEEHYFEDKLIEDLAKPGDEPPEEDESLKRVDPLHQLILLFSRTALTEKCKLEED
FLYMAYADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKHDNIKDLRNKFASLGENSLEKE
MEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGGNSTVQQKML
DYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCD
LFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVI
DEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKL
SQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFD
MFLKLKDLTSSDAFKEYDPDGKGIISKRDFHKAMESHKHYTQSETEFLLSCAETDENETL
DYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELSESVLNYFQPFLGRIEI
MGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIF
EMQLAAQISESDLNERSANKEDNEKDKPEEQDPGMGFFSLVTMKSALVALKYNLMTLMKM
LSMKSLKKQMKKVKKMTMKDMVMALFSSYWSILMGLLHFACSVFRGFFRIICSLLLGGSL
VEGAKKIKVAELLANMPDPTQDEVRGEGEEGERKPAETALPTEDLTDLRTLSEESDLLSD
IFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSIAPMPEAQEKVQEQVKEDEKEEKEETKS
EPEKAEGEDGEKEEKAKEDKSKQKLRQLHTHRYGEPEIQESAFWKKIIAYQQKLLNYFAR
NFYNMRMLALFVAFAINFILLFYKVSTSAVTEEKEIPVVSTGENMKLDSLESDSQRVIAV
HYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYI
TEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAAL
DFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNF
FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSE
DGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVI
LLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLAN
YLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN
NT seq 14913 nt   +upstreamnt  +downstreamnt
atggccgaggggggcgagggcgaggacgagatccagttcttgagaactgatgatgaagtg
gttctgcagtgcactgcaactgttcacaaggagcaacagaaattgtgtcttgctgcagaa
ggatttggcaacaggctttgctttttggaatccacatcaaattctaagaatgtgccacct
gacttgtccatctgcacctttgtgcttgagcagtctctgtcagtacgagccctgcaggaa
atgctggctaacacagaggagaaggcagaagggtctgcacaaggtggtggtcatcgaaca
cttctctatggacatgcaatcctgttgcgccattcctacagtggtatgtatctgtgctgc
ctctcaacatctcgatcttcaatggataagctggcatttgatgtaggattgcaagaggac
actacaggtgaggcatgctggtggactatccatcctgcttctaagcagcgatcagaagga
gaaaaagtacgtgttggagatgaccttattttagtcagtgtctcttctgaaagatacttg
catctctcctatggcaatggtagcttacatgttgatgcagctttccagcaaactctttgg
agtgtagcaccaatcagttcaggaagtgaatttgcacaaggatatctgataggtggggat
gttctgagattgttgcatggtcatatggatgaatgcttgacagtcccttcgggtgaacat
ggagaagaacaaaggagaactgtccattatgaaggtggtgcagtgtcaattcatgctcgt
tccctttggcgattagaaactctgagagttgcgtggagtggcagccacataagatgggga
cagccattcagactaagacatataacaacaggaaaatatttaagtctcctggatgacaag
agtcttctccttactgacaaagagaaagcagatgtaaaatctacagcattctgttttcgg
tcttccaaggaaaaactggatgtaggtgtgagaaaagaggtagatgggatgggagcacct
gaaataaaatatggagattcgatatgcttcatacaacatgtagacacaggcttatggctc
tcataccagtctgcagatgcgaagtctgtaagaatgggttctgtgcaacgcaaggcaata
atgcaccatgaaggtcacatggatgatggtttaacattgtccagatctcagcatgaggaa
tcccgtacagcacgtgtcatccgtagtacagtcttccttttcaacaggtttataaggggc
cttgatgctctcagcaaaaaagtgaagtcttccacagtagatttacctattgagtcagtc
agtctgagccttcaagacctgattggctactttcaccctcctgatgaacatttagaacac
gaagacaaacaaaacaggcttcgtgcactgaagaatcgccagaacctcttccaggaagag
ggcatgatcaacctcgttcttgaatgtattgatcgcttgaatgtatacagcagtgcagct
cattttgcagatgtagctgggaaggaagctggagaagcatggaaatcaattctgaattcc
ttgtatgaattactagcggctcttattcgagggaatcgtaaaaactgtgctcaattttct
ggatctcttgattggctgatcagcagattagaaagactagaagcctcttctggaatacta
gaagtattacactgtgtattggtggaaagccctgaagctctaaacattattaaggaagga
catattaaatcaatcatctgtcttttggacaaacatggaagaaaccataaggttttggat
gtcttatgttctctctgtgtatgtcatggagtagctgtgcggtctaatcaacatctcatc
tgtgataatctcctgccaggaagagatctactcttacagacccgccttgtcaaccatgtg
agcagcatgcgacctaatattttcttgggaattagtgaaggctctgcccagtacagaaaa
tggtactatgaacttatggtggaccatctagagccttttgtgactgcagaatcaactcac
ctacgagtaggctgggcttcaacagagggctattcaccgtatccggggggaggagcagaa
tggggaggaaatggtgttggtgatgacttgtattcttacggcttcgatggtctgcatctg
tggtcaggctgtgtagctcgaacagtaaattctccaaaccaacatctgttaagaactgaa
gatgttattagttgttgtttggatctgagcgcccccagcatctcttttcggataaatgga
cagccagttcaaggaatgtttgagaatttcaacatagatggccttttcttcccagttgtc
agcttctctgcaggaataaaggtacgtttcttgcttggaggtcgtcatggagaattcaag
ttccttcctccacctggatatgccccttgctttgaagctgttctaccaaaagagaaattg
aaagtggaacatagccgcgagtacaagcaggatcgaagctatacaagagatcttctgggt
cccactctcaatctgtcacaagcagctttcaccccagttcctgtagatactagccagatt
gttttgcctccccacttggaaagaattagagagaagttagcagaaaacatccatgaactt
tgggttatgaataagattgaactgggctggcagtatggaccagttagagatgacaacaaa
agacagcacccatgcttagtggagttctcaaaattgccggagcaggaaagaaattataac
ttgcagatgtctcttgaaacactcaaaaccctgctggcattaggctgccatgttggaatt
gctgatgaacgtgctgaagaaaaagtgaaaaaaatgaaacttcctaagaactaccagttg
ttgagtggatataagcctgcacccatggatctgagcttcatcaaactgaccccttctcaa
gaagctatggtcgataaactagcggagaatgctcacaacgtgtgggcaagggaccgaatc
aggcaaggctggacctatggtatccagcaggatgtgaaaaatcgacgaaatcctcgcctt
gtaccttatgcccttttggatgatcgaacaaagaagtcaaacaaagacagtcttcgggaa
gcagtccgcacccttctaggctatggatacaacctggaagctcctgatcaagatcatgca
acaagactggatgtgagcaatgggataatggaaaaattccggatcttccgcacagagaaa
acatatgcagtgaaatctggaaagtggtacttcgagtttgaggcagttacagcaggagac
atgagagttggctggacaaggcctggttgtctgccggatcaggaacttggctcagatgaa
gaagcttttgtttttgatggctttaaggcacagcggtggcatcaaggtaatgagcatttt
ggccgctcctggttggcaggagatgttgttggatgcatggttgacatgaatgaacacact
atgatgttcaccttaaatggtgaaatcctgcttgatgactcaggttcagaacttgcattt
aaggattttgaggttggtgatggatttctgcctgtgtgcagcctgggttcatctcaagtg
ggaagaatgaactttggaaaagatgtcagcactctaaaatatttcactatctgtggctta
caggaagggtatgaaccctttgctgttaatacaaacagagacattaccatttggctgagt
aaaaggctccctcagtttcttccagtgccacaaaatcatgaacatattgaggtgatgaga
attgatggaaccatagacacttgtccttgcctgaaggttacacagaagtcctttggttcg
caaaacagtaaaacagacgtcatgttttttcgattaagtatgcccattgaatgtgctgag
gtgttctccagaacaactgcaggagggctaccaggcactggtctttttggcccaaagaat
gatttggaggattacgatgctgactctgattttgaagttctaatgaaaactgctcatggt
catctagcagctgaccggacagagagagagaaggatgccacaaaaccagagttgaataac
cataaagattttgttcaagaaaagccttcacgtcttaaacaaagatttatgcttaggagg
acaaagccagattatagcacaagccattctgcaaggcttactgaggatgtgctagcagat
gatagggacgactatgattatttgatgcaaacttccacgtactattattcagtgagaata
tttcctggtcaagaacctgctaatgtttgggtaggctggattacatctgactttcatcag
tatgacacaagctttgacttggacagagtgcgtactgttacagtaacactaggagatgaa
aaaggaaaggtccatgagagtataaaacgcagcaactgctatatggtatgcgcaggagag
agcatgagccctgggcaaggacgtaataataatggtctggagattggttgcttagttgat
gctgccagtggcctgctgaccttcacagctaatggcaaagaactgggcacgtactatcag
gttgaaccaagtacaaagttatttcctgctgtatttgctcaggctacaagccccaatgtt
ttccagtttgagttgggtagaataaagaatgtaatgccattatctgctggcttattcaaa
agtgaacacaaaaacccagtctcccagtgtcctccacgtctccatgtccagtttctgact
cacgtgctttggagtagagtgccaaaccacttcttgaaagttgatgtctctaggatcagt
gaacgtcaaggctggatgatacaatgcttgaatcctttgcagttcatggcccttcacatt
cctgaagaaaacagaacaattgatattttagagctgacagaacaagaagaactgctgaaa
tttcactaccatactctccgattatattcagctgtgtgtgctttagggaacaaccgagtg
gcccatgctatgtgtagccatgtggatgaatctcagcttctgtatgctattgagaataaa
tatatgccaggattattgcgtgcaggatattatgacttactcatagacatccatctcaat
acctatgcaactgccaggttaatgatgaataatgaatttattgttccaatgactgatgag
accaagagtattaccttgtttcctgatgagaacaagaaacatggcctccctggtatagga
ctcagtacttccttgaggccaagaatgcagttctcctcaccgagttttgtaagcattaac
agtgagtgctttcagtttagtcctgaattcccgctagaaatcttaaaggccaaaacaata
gagatgctgactgaagctgttcaggagggcagcctccacgtcagagacccagttggaggt
tccactgaatttctgtttgtccccctcatcaagctcttttacaccctcctaattatggga
atcttccacaacggggatcttaaacacatcttacagttgattgagccacgggtttttaaa
gaagctgcgaatctggaggatgaaagggatctctcagagaaggagctgagttcagatgag
ctcaagtcagaaggagaggaagaaaccagaggagagcaagtgccaaaggaaggactcctt
cagatgaaacttcctgaacctgttaaactacagatgtgtcatctactccagtacctgtgt
gattgccaggtacgacaccgaatagaagccattgtagcattttcagatgattttgtggcc
aagcttcaagagaatcagcgcttccggtacaatgaagtgatgcaggccttaaacatgtct
gctgccttgacagctagaaaaacaaaggaatttcgatccccacctcaggagcagattaac
atgctgctgaacttcaaagatgataaaactgattgtccttgccctgaagaaattagggat
caactcctggatttccatgaagacctaatgacacattgtggaattgaactggatgaagat
ggaactttggatggaaataatgatttaaccattaggggtcgcctcctatacctaatggaa
aaagttacatatctgaagaagaagcaagctgagaagccagttgatgatgatgctaagaca
tcctctactcttcagcaattgatttcagatacaatggtgcgctgggcccaggaatcagta
atagaagacccagatttagtcagggccatgtttgtactgctccatcgccaatatgatggt
attggtggcttggttcgagccctaccaaagacttacaccataaatagtgtgtccgtggaa
gatacaatcaatctcctggcatcccttggccaaatccgttccttgctcagtgtcaggatg
gggaaggaggaagagaaacttatgattcgtggattaggagacatcatgaataataaagta
ttttatcaacatcccaatctcatgagagctttaggcatgcatgagaccgtcatggaagtg
atggtaaatgtacttggtggaggagaatccaaggaaatcactttcccaaaaatggtggca
aactgctgtcgtttcctatgttatttttgccgcattagtaggcagaatcaaaaagctatg
tttgatcatcttagctatttattggaaaatagcagtgttggccttgcctctccttctatg
cgaggatcaactcctttagatgttgcagcagcatctgtgatggataacaatgaacttgca
ctagctttaagggagcctgatctggagaaggtggttcgatacttggctggatgtggattg
cagagttgtcctttgttgatttctaaaggctatccagacattggatggaatccagttgaa
ggagagagatatttggattttcttcgttttgctgtattttgcaatggagagagtgtggag
gaaaatgctaatgttgtagtcagactgcttattcgtcgaccggaatgttttggtccagct
ctaagaggagaaggaggcaacggtctacttgctgccatggaggaagcaatacaaatatca
gaagatccaacaagagatggaccttccccaattaatggatctagtagaatccttgaaatg
gaagaacaagaagatgacaccattcatatggggaatgcaatcatgaccttttacgctgct
ttgattgatctcttaggacgctgtgcccctgaaatgcatctaatacatgctggtaaaggg
gaggccataagaatccggtcaattctaaggtctttgattccactggaagatttggtgggc
gtaattagcattccattccacatgccaaccatagctaaagatggtactgtggtggaacct
gacatgtctgcggggttttgcccagatcacaaggcagccatggttttgttccttgacagg
gtctatggaattgaggatcaggattttcttctacatcttcttgaagttggctttctgcca
gatctccgtgctgctgcttctttagatacagctgctttaagtgctacagatatggcttta
gctctgaatcgatacctttgcacagcagtcttgcctctgttgaccagatgcgcccctctt
tttgctggcacagagcaccatgcttcccttattgattccttactgcatactgtgtacaga
ctttcaaagggctgctctcttaccaaagctcagcgagattccattgaggagtgtttactt
tctatctgtgggcagttgagaccttctatgatgcagcatttgctgagaagattagtattt
gatgttcccctattaaatgaacatgcaaagatgcctctcaagttgctgacaaatcattat
gaaagatgctggaagtattattgtttaccaggtggatggggtaactttggtgctgcctca
gaagaagaacttcatttatccagaaagttattttggggtatttttgatgctttgtctcaa
aagaagtatgaacaagaactgttcaaactggctttgccttgtttgagtgcagttgcaggg
gcattacctccagattatatggaatcaaattatgtcaatatgatggaaaaacaatcttca
atggattcagatggaaacttcaatccccaacctgttgatacttcaaacattacaatccct
gaaaaactagaatatttcattaacaaatatgcggaacactctcatgataaatggtcgatg
gaaaagtttgccaatggatggacatatggtgaaacatattctgaatctgcaaaagtgcaa
cccttaatgaaacagtataaattactctctgaaaaggagaaagaaatttatcgatggcca
atcaaagaatcgctaaaaaccatgctggcgtggggatggcggattgaaaggacacgggag
ggagattccatggcattgtataatcggacgcgtcgcatatctcaaaccagtcaaatctct
gtagatgcagcccatggttacagtcctcgagcaattgacatgagcaatgttaccctctcc
agagatgtgcacgctatggcagagatgatggctgaaaactaccataacatatgggcaaag
aaaaagaaaatggagcttgaagcaaaagtaggaggaggaaaccatccccttcttgttcct
tatgatacactcacagccaaagaaaaagctaaggacagagaaaaagcacaggatattctg
aaatttctacagattaatggatatgtagtctccagaggacttaaggacctggaattggac
acaccttccattgagaaacgctttgcctacagtttcctccagcagcttataagatatgta
gatgaagctcatcagtacattttggaatttgatggtggcagcagaggcaaaggagagcat
ttcccatatgaacaagaaatcaagttttttgccaaagttgtgctccctttgattgatcag
tatttcaaaaatcatcgcttgtatttcttatctgcagcaagtaggcctctcagcagtgga
ggccatgcctctaataaggagaaagaaatggtgacaagcctgttctgcaaacttggagtt
cttgtcaggcataggatttcactgtttggaaatgatgcaacatcaatagtcaactgtctt
cacatattgggccagaccttggatgccagaactgtgatgaaaactggtctggagtctgtt
aagatggcattgagagcatttttggacaatgctgctgaggatctggagaaaacaatggaa
aatcttaagcaaggccagtttacacacagcagaaaccagcccaagggagttacacaaatc
attaattataccacagtggctctccttccagtgctatcttcattatttgaacatattgga
cagcaccagtttggggaagatttgatattggaagatgttcaagtgtcttgttacagaata
ttgtccagtttgtatgctctgggaaccagcaaaagtatatacgtagagcggcaacgatca
gcactaggagaatgcttggctgctttctcaggtgcctttccagtggcttttttggaaact
cacttgaacaaacataacatctactcaatttacaataccaagaatgcaagagacagagca
gttcttaatttacctactagtgtagaagaagtttgcccaaatattccttccttggtgaag
ctaatggaagaaattgtggaactggcagaatctggtattcgctacacacaaatgccacat
ataatggaagtgatattgcctatgctttgtagttacatgtcacactggtgggagcatggg
ccagaaaacaatcctgacaaagctgaagtgtgttgtacagccttgacatcagagcacatg
aacactctgttgggtaacatattgaaaatcatctataacaaccttggtattgatgaagga
gcctggatgaagaggttagcagtgttttcccagcccatcataagcaaagcgaagccacag
ctcttaaagacacacttcctgccactgatggataagctaaagaaaaaagcagcagtggtt
gtatcggatgaagagcatctaagagcagaaggcagaggtgacatgtcggaggctgaactg
ctcatcctagatgagttcaccactttggcacgggacctctatgccttctaccctttgttg
attagatttgtggactataacagggcaaaatggctgaaagagcccaaccctgaagctgaa
gaattgttccgcatggtggctgaagtctttatttactggtcaaagtctcataatttcaaa
agggaagagcagaactttgtggtacaaaatgaaatcaacaatatgtccttccttatcagt
gacaccaaatctaagatgtccaaggcagcagtttctgaccaagagaggaagaagatgaag
cggaaaggtgaccggtactctatgcagacctctctcattgtggcagcactgaagagatta
cttcctattggcctaaatatttgtgctcctggagaccaagatctaattgcactggccaaa
aaccgattcagcatgaaagatactgaggatgaggtacgagatatcattcgcagtaatctt
catctccagggcaagcttgaggatcccgccattagatggcagatggcactttacaaagat
ttacctaacaggactgaagattcatcagatccagagaagaccgtggaaagagttcttgat
atagctaatgtactgtttcatctggaacaggttgaacatcctcagcggtccaaaaaagca
gtttggcataagctgctgtctaaacagaggaaaagagcagtagttgcttgctttagaatg
gcaccattatataacctgccaaggcaccgagctgtcaatctctttcttcaaggatatgat
aaatcttggattgaaacagaggaacactattttgaagacaaactgatagaagatttagca
aaacctggagacgaaccaccagaagaagatgaaagccttaaaagagtggatccattgcat
caacttattctgctattcagtcgaacagccttaactgaaaaatgcaaattggaggaagat
tttctctatatggcttacgctgacattatggcaaagagttgccatgatgaagaagatgat
gatggtgaagaagaagtgaagagctttgaagtcacaggatcccaacgcagcaagcacgat
aatatcaaagatttaagaaacaaatttgccagcctcggcgagaactctctggaaaaagaa
atggaaaagcaaaaacttctgtatcagcaagccagactgcatgaccggggtgctgctgag
atggttcttcagacaatcagtgctagtaaaggtgagatggggccaatggttgcagctacc
ctgaagctaggaattgccatcttaaatggaggaaattctactgttcaacagaaaatgctt
gattacctcaaggataagaaagatgtgggtttctttcagagtcttgctggtcttatgcag
tcctgtagtgttcttgatttaaatgcatttgaacgtcaaaacaaagcagaaggccttggc
atggtgactgaagagggctcaggagaaaaggtgatgcaggatgatgagttcacctgtgac
ctctttcgctttcttcaattgctttgtgaaggacacaattcagattttcagaattacctg
agaactcagactggtaacaacacaactgttaatattatcatttccactgtggattactta
ctgagagttcaggagtcaattagtgatttctattggtattattctgggaaggatgttatt
gatgaacaaggccaacgaaatttctccaaagccatccaggttgcaaaacaagttttcaat
actctcacagagtatatccaggggccatgtactgggaatcagcaaagtctagcacacagc
agactatgggatgctgttgttggttttcttcatgtatttgctcacatgcagatgaagctg
tctcaggattccagtcaaattgaattactgaaagaattaatggatcttcagaaggacatg
gttgtcatgttgctgtctatgctggaaggtaatgttgtgaatggaactattggcaagcaa
atggttgacatgcttgtggaatcgtccaacaatgtggagatgattctgaagttttttgat
atgttcttaaaactgaaggatttgacttcttctgatgcattcaaagagtatgatcctgat
ggcaaaggcataatttcaaaaagagattttcacaaggcaatggaaagtcataagcattac
actcagtctgaaactgaatttctattatcatgtgctgaaacagatgagaatgagactctg
gactatgaggagtttgtgaaacgatttcatgagcctgccaaggacattggtttcaatgtc
gctgtcctcctgaccaacctctccgaacacatgccccatgatactcgcttgcaaactttt
cttgaactgtcagaaagtgtgctgaactactttcagcctttccttggacgtatagaaatc
atgggcagtgcaaagcgcattgaacgagtgtattttgaaataagtgaatcaagtcggact
cagtgggaaaaacctcaggtaaaagagtcaaagagacagtttatatttgatgttgtaaat
gaaggtggggagaaagaaaagatggagctttttgttaatttctgtgaagacaccatcttt
gaaatgcaactggctgcccaaatctctgaatcagatctgaatgaaaggtcagcaaataaa
gaggacaatgagaaagataagcctgaggaacaggatcctggaatgggtttcttctcactt
gtaactatgaagtcagcattagtagcgctcaagtataatttaatgactcttatgaaaatg
ctcagcatgaagagcttaaagaaacagatgaaaaaagtgaagaaaatgaccatgaaggac
atggttatggctttattttcttcctactggagcattttaatgggcttactgcattttgcc
tgtagtgtcttccggggtttctttcgcatcatttgcagtttgttgcttggaggaagccta
gtagaaggagcaaagaaaatcaaggtggctgagctattagccaatatgccagatcccact
caggatgaggtgcgtggggaaggagaagagggagagaggaagccagcagaaactgcattg
cctactgaagacttgactgatttgagaactttatcagaggagagtgatctactctcagat
atatttggtttggatttgaaacgagaaggtggacagtataaattgatccctcacaaccca
aatgctggtttgagtgatttactgagcactccttccatagcgccaatgcctgaggcacag
gaaaaagtccaggaacaggtgaaagaagacgaaaaagaagagaaggaagaaacaaaatct
gaacctgaaaaagcagaaggagaggatggagaaaaagaagagaaagcaaaggaagacaaa
tcaaaacagaaattaagacagcttcatactcacagatatggagaaccagaaattcaggaa
tcggctttctggaagaaaataattgcatatcaacagaagcttcttaactattttgctcga
aacttttataatatgaggatgttggcattgtttgttgcctttgccatcaacttcatcctg
cttttctataaggtttccacctctgctgtgacagaagaaaaggaaatccctgtagtgtct
actggagaaaatatgaagttggacagcttagagagtgacagccagagggtcattgcagta
cattatgtcctggaagaaagcagtggctacatggagcccacactgcggattttggccatc
ctacatacagtcatctccttcttctgcatcattgggtattactgtttgaaagtcccacta
gtaatttttaagagagagaaggaagtagcaaggaagttggaatttgatgggctgtatatc
actgaacagccctcagaagatgatattaaagggcaatgggatagacttgtaatcaacaca
cagtcttttccaaacaactactgggacaaatttgtgaaaagaaaggtcatggataaatat
ggtgagttctatggccgtgacagaatcagtgaattactaggaatggacaaagctgctctc
gattttagtgatgctcgagaaaagaagaaaccaaagaaggatagctccttatctgctgtg
ctaaactccattgatgttaagtatcagatgtggaaattaggagttgttttcactgataat
tctttcctttacctagcttggtacatgaccatgtcagtccttggccattacaacaatttt
ttctttgctgctcatctccttgacattgcaatgggattcaagacattacgaactatactc
tcatcagtgacccacaatggcaaacagcttgtcctaacagtgggattactggcagtagtg
gtatacttgtacacagtagtggcattcaattttttccgaaagttctacaacaaaagtgaa
gatggtgatatgccagatatgaaatgcgatgatatgctaacatgctacatgtttcacatg
tatgttggagtacgtgcaggtggaggcattggtgatgaaatagaggatccagcaggagat
gaatatgaaatctatcgaattatctttgacatcactttcttcttctttgtgattgtcatc
ctgcttgccattattcaagggttaattattgatgcttttggtgagttaagagatcagcaa
gaacaagttaaggaagacatggagacaaagtgctttatctgtggaataggaaatgactac
tttgatacagtgccccatggctttgaaactcatacactgcaggagcacaacttggccaat
tatttgttttttctgatgtatcttattaacaaagatgaaacggaacatacaggacaggaa
tcctatgtatggaaaatgtatcaagaacgatgctgggagttttttcctgctggtgattgt
ttccgaaaacagtatgaagaccagcttaattaa

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