Puma concolor (puma): 112849369
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Entry
112849369 CDS
T08890
Symbol
GART
Name
(RefSeq) LOW QUALITY PROTEIN: trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
pcoo
Puma concolor (puma)
Pathway
pcoo00230
Purine metabolism
pcoo00670
One carbon pool by folate
pcoo01100
Metabolic pathways
pcoo01523
Antifolate resistance
Module
pcoo_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
pcoo00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
112849369 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
112849369 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
112849369 (GART)
Enzymes [BR:
pcoo01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
112849369 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
112849369 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
112849369 (GART)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
ATP-grasp_2
CPSase_L_D2
ATP-grasp_4
Dala_Dala_lig_C
CbiJ
ATP-grasp_3
RimK
ATP-grasp_5
Motif
Other DBs
NCBI-GeneID:
112849369
NCBI-ProteinID:
XP_025768780
UniProt:
A0A6P6GZC4
LinkDB
All DBs
Position
Unknown
AA seq
1008 aa
AA seq
DB search
MAARILVIGGGGREHTLAWKLAQSNRVKHVLVAPGNAGTACLEKISNTAISISDHTALAQ
FCKDENIEFVVVGPEAPLAAGIVGNLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TARWRAFTRPEEACSFIMSADFPALVVKASGLAAGKGVIVAKSTEEACRAVQEIMQEKAY
GAAGETIVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDHGPNTGGMGAYCPAP
QVSKDLLLKIKNTVLQRTVDGMQQEGMPYTGSAGISVNKMSRENXSFSQLPCXFMFSQVI
LPLLKSDLYEVIQSTFDGLLHTSLPVWLENRTALTVVMASKGYPGDYTKGVEITGFPEAQ
ALGLEVFHAGTALKDGKVVTSGGRVLSVTAIQENLISALEEAKKGLAAIKFEGAIYRKDI
GSRAIAYLQQPRGLTYKESGVDIAAGNTLVKKIKPLAKATSRPGCDVDLGGFAGLFDLKA
AGFKDPLLACGTDGVGTKVKIAQQCNRHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSCG
KLDLDTTEAVVAGIARACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLPH
LEKITEGDVVIGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTRI
YSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKSGVDLDAQTWRIPRIFSWLQQEGH
LSEEEMARTFNCGVGAVLVVSKDRTEQILRDIKQHSEEAWVIGKVVACPEGSPRVKVKHL
IETMQANGSVLENGTLKNHFSVQPKKTRVAVLISGTGSNLQALIDNTREPSSCAHIVVVI
SNKAAVAGLDKAERAGIPTRVINHKLYKSRVEFDTAIDQVLEEFSTDIVCLAGFMRILSG
PFVRKWNGKMLNIHPSLLPSFKGSNAHEQVLEAGVTVTGCTVHFVAEDVDAGQIILQEAV
PVKRGDTVTTLSERVKLAEHRLFPAALQLVASGTVQLGENGKIRWVTE
NT seq
3027 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgcatacttgtaattggcggtggcggaagggaacatacactggcctggaaa
ctcgcacagtctaatcgtgtcaaacatgtgttggttgccccgggcaatgcaggcactgcc
tgcttggaaaagatttcaaatactgccatctcgataagtgatcacactgcccttgctcag
ttctgcaaagatgagaacattgaattcgtagttgttggaccagaggcacctctggctgct
ggaattgttgggaacctgacctctgcaggagtgcgatgctttggtcccacagcagaagca
gctcagttagagtccagcaagagatttgccaaagagtttatggaccgacacggaatcccg
acagcacggtggagagctttcaccagacctgaggaggcctgcagctttattatgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcagctgggaaaggggtgattgtt
gcaaagagcacagaagaagcctgcagggccgtacaggagatcatgcaggagaaagcttat
ggagcagctggagaaacaattgtcattgaagaacttcttgaaggagaagaggtttcttgt
ctgtgcttcactgatggcaggaccgtggcccccatgcccccagcacaagaccataaacga
ttgctggagggcgatcacggccccaacacagggggaatgggagcctattgtcctgcacct
caggtttccaaggatttgctgctgaaaataaaaaatacagtccttcagaggacagtggat
ggcatgcagcaggagggtatgccatacacaggttctgctggtatctcagtgaataaaatg
tctagagagaactaaagtttctctcagttgccatgttgatttatgttttcccaggtgatc
ctcccgctgcttaaaagtgatctttatgaagtgattcagtctacctttgatggcctgctc
cacacatctctgcctgtctggctggaaaaccgcaccgccctaactgtcgtgatggcaagt
aagggctacccaggagattacaccaagggtgtggagataacaggctttcctgaggctcaa
gctttaggactggaggtgttccacgcaggcactgccctgaaagatggcaaagtggtgact
agtgggggtagagtcctttcggtaacagccatccaggaaaatctcatttcagcccttgaa
gaagccaagaaaggactagctgctataaaatttgagggagccatttacaggaaggacatt
ggctctcgtgccatagcttacctccaacagcccaggggcctgacttacaaggaatctggg
gtagacattgcagctggaaatacgctggtcaagaaaattaaacctttagcaaaagctacc
tccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttgaaagca
gctggtttcaaagatcctcttctggcctgtggaacagatggtgtggggactaaagtgaag
attgcccagcagtgtaatagacatgataccattggccaagatttggttgcaatgtgtgta
aatgatattctggcccaaggggcagagcccctcttcttccttgattacttttcctgtgga
aaacttgacctcgatacaactgaagctgttgttgctggaattgccagagcctgtgggaaa
gctggatgtgctctccttggaggtgaaactgcagaaatgcctgacatgtatcctcctgga
gagtatgacctggccggttttgccgtcggtgccatggagcgggatcagaaactcccccac
ctggaaaaaatcaccgaaggggatgttgttattggaatagcttcatctggtcttcacagc
aatggatttagccttgtgaggaaaattgtagcaaaatcttccctccagtactcctctcca
gcacctgatggctgtggtgaccagaccttaggggacttacttctgactccaacgagaatc
tacagccattcgctattacctgtcctgcgttcaggacatgtcaaggcctttgcccatatt
actggtggaggattgctagaaaacatccccagagtccttcctgagaaatctggagtggat
ttagatgcccagacctggaggatccccaggatcttctcgtggttacagcaagaaggacac
ctctctgaggaagagatggccagaacatttaactgtggggttggggccgtcctcgtggtg
tcaaaggataggacagagcagattctgagggatatcaagcagcacagcgaagaagcctgg
gtgattggcaaggtggttgcgtgtcctgaaggttctcctcgtgtgaaagtcaagcatctg
attgaaaccatgcaagcaaatggatcagtattggagaatggcactctgaaaaatcatttc
tctgtccaaccaaaaaagacaagagtggctgtcttaatatctggaacaggatcaaacctc
caagccctcatagacaatactagggagccaagtagctgtgcacacatcgttgttgttatc
tccaacaaagctgcagtggctggcttagataaagcagaaagagccggaattcccaccaga
gtaatcaatcataaattatataaaagtcgtgtagaatttgacactgcaattgaccaagtc
cttgaagagttctccacagacatagtctgtcttgcaggattcatgagaattttatctggc
ccctttgtcagaaaatggaatgggaaaatgctcaacatccatccatccttgctcccgtct
tttaagggttcaaatgcacatgagcaagtcctagaagccggggtcacagtcactgggtgt
actgtgcactttgtagctgaagatgtagatgctggacagattatcttacaagaagctgtt
ccagtgaagaggggcgacaccgttacaactctgtctgaaagagtgaaattagcagagcac
agactatttcccgcagccctccagctggtagccagtggaactgtacagcttggagaaaat
ggcaagattcgttgggtcacagagtag
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