Puma concolor (puma): 112850045
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Entry
112850045 CDS
T08890
Symbol
TOP2B
Name
(RefSeq) DNA topoisomerase 2-beta
KO
K03164
DNA topoisomerase II [EC:
5.6.2.2
]
Organism
pcoo
Puma concolor (puma)
Pathway
pcoo01524
Platinum drug resistance
Brite
KEGG Orthology (KO) [BR:
pcoo00001
]
09160 Human Diseases
09176 Drug resistance: antineoplastic
01524 Platinum drug resistance
112850045 (TOP2B)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03032 DNA replication proteins [BR:
pcoo03032
]
112850045 (TOP2B)
03036 Chromosome and associated proteins [BR:
pcoo03036
]
112850045 (TOP2B)
Enzymes [BR:
pcoo01000
]
5. Isomerases
5.6 Isomerases altering macromolecular conformation
5.6.2 Enzymes altering nucleic acid conformation
5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
112850045 (TOP2B)
DNA replication proteins [BR:
pcoo03032
]
Eukaryotic type
DNA Topoisomerases
112850045 (TOP2B)
Chromosome and associated proteins [BR:
pcoo03036
]
Eukaryotic type
Chromosome condensation proteins
Other regulators of chromosome condensation
112850045 (TOP2B)
Centrosome formation proteins
Centriole proteins
112850045 (TOP2B)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
DNA_topoisoIV
TOPRIM_C
DNA_gyraseB
DTHCT
Toprim
HATPase_c
DUF7180
Motif
Other DBs
NCBI-GeneID:
112850045
NCBI-ProteinID:
XP_025769431
UniProt:
A0A6P6H240
LinkDB
All DBs
Position
Unknown
AA seq
1627 aa
AA seq
DB search
MVRIKITNLCLFGIGIETRIMGCLSNETLFDQNNAAKKEESETANKNDSSKKLSVERVYQ
KKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADN
KQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDE
KKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYT
CITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYV
KDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVG
KLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLS
EKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLEC
TLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVG
LQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFIT
PIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHR
ILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTY
NDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMS
AYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLSR
LLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNN
VRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVY
KEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTL
TCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFI
LEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEETQNQHDDSSSDSG
TPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEEL
DKVEAQEREDILAGMAGKAIKGKVGKPKVKKLQLEETMPSPYGRRIVPEITAMKADASKK
LLKRKKGDLDTTAVKVEFDEEFSGTPVEGTGEEALIPSAPVNKGPKPKREKKEPGTRVRK
TPTSSGKSTAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSE
EEEDDADDDEDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSSH
DKKGQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKG
KPSSDTTAKPKRTPKQKKVETINSDSDSEFGIPKKSTPPKGKGRGAKKRKASGSENEGDY
NPGRKTSKTPSKKMKKTSFDQDSDVDIFPSDFTSEAPSLPRSGRARKEVKYFAESDDEED
VDFAMFN
NT seq
4884 nt
NT seq
+upstream
nt +downstream
nt
atggttaggattaagatcaccaacctctgtctctttggaattggcatagaaactagaatc
atgggatgcctcagtaatgagactctttttgatcagaacaatgctgcaaaaaaagaagag
tcagaaactgcaaacaaaaatgattcttcaaagaagttgtctgttgagagagtgtatcag
aaaaagacacaacttgaacatattctccttcgtcctgatacgtatattgggtcagtggag
ccgttgacacagctaatgtgggtatatgatgaagatgtaggaatgaattgcagagaggtt
acctttgtgccaggtttatacaagatctttgatgaaattttggttaatgcagctgacaat
aaacagagggataagaatatgacctgtattaaagtttctattgatcctgaatctaacatt
ataagcatttggaataatgggaaaggcattccagtagtagaacacaaagtagagaaagtt
tatgttcctgcattaatttttggacagcttttaacatccagtaactatgatgatgatgag
aaaaaagtaacaggtggtcgcaatggttatggtgcaaaactttgtaatattttcagtaca
aagtttacagtagagactgcttgcaaagaatacaagcatagttttaagcagacatggatg
aataacatgatgaaaacttctgaagccaaaattaaacattttgatggtgaagattataca
tgcataacattccaaccagatctgtctaaatttaagatggaaaaacttgacaaggatatt
gtggccctcatgaccagaagagcttatgatttggctggttcatgcaaaggggtcaaggtc
atgtttaatggaaagaaattgcctgtaaatgggtttcgcagttatgtagatctttatgtg
aaagacaaattggacgaaactggagtggccctgaaagttattcatgaacttgcaaatgaa
agatgggatgtttgtctcacactgagtgaaaagggattccagcaaatcagctttgtaaat
agtattgcgacaacaaaaggtggacgtcatgtggattacgtagtagatcaagttgttggt
aaactgattgaagtagttaagaaaaagaacaaagctggggtatcagtaaaaccatttcaa
gtaaaaaaccatatatgggtttttattaattgccttatcgaaaatccaacttttgattct
cagacgaaagaaaacatgactctgcagcccaaaagttttgggtccaaatgccaactgtca
gaaaaattttttaaagcagcctctaactgtggcattgtagaaagtattctgaactgggtg
aaatttaaggctcagactcagctgaacaagaagtgttcatcagtaaagtatagtaaaatc
aaaggtattcccaagctggatgatgctaatgatgctggtggcaaacattccctggagtgt
acattgatactaacagagggagactctgccaagtcgctggctgtgtctggattaggtgtg
atcgggcgagacagatacggagtctttccacttaggggaaaaattcttaacgtccgagaa
gcttcccataaacagatcatggaaaatgcagaaataaacaatattatcaaaatagttggt
ctacaatacaagaaaagttacgatgatgcagaatctctgaaaactttacgctatgggaag
attatgattatgactgatcaggatcaagatggttctcacataaaaggcctgcttattaat
ttcatccatcacaattggccatcacttttgaagcatggttttcttgaagagttcattact
cctattgtaaaggctagcaaaaataagcaggaactttccttctatagtattcctgaattt
gacgagtggaaaaaacatatagaaaaccagaaagcctggaaaataaagtactacaaaggt
ttgggtaccagtacagctaaagaagcaaaggaatattttgctgatatggaaaggcaccgc
atcttgtttagatatgctggccctgaagatgatgctgccattactttggcattcagtaag
aagaagattgatgacagaaaagaatggttaacaaattttatggaagatcggagacagcgt
aggttacatggcttaccagagcaatttttgtatggtacagcaacaaagcatttgacttac
aatgatttcatcaacaaagaattgattctcttctcaaactcagacaatgaaagatctata
ccatctcttgttgatggctttaaaccaggccaacgtaaagttttatttacctgtttcaag
aggaatgataaacgtgaagtaaaagttgcccagttggctggatctgttgctgagatgtct
gcttatcatcatggagagcaagcattgatgatgactattgtgaatttggctcagaacttt
gtgggaagtaacaacattaacttgcttcagccaattggtcagtttggaactcggcttcat
ggtggcaaagatgctgcaagccctcgttatattttcacaatgttaagctctttatcaaga
ctgctttttcctgctgtggatgacaacctgcttaaattcctttatgatgataatcaacgt
gtagagcctgagtggtatattcctataattcccatggttttaataaatggtgctgagggc
attggcactggatgggcttgtaaactacccaactatgatgctagggaaattgtgaacaac
gtcagacgaatgctagatggcttggatcctcatcctatgcttccaaactacaaaaacttt
aaaggaacgatccaagagcttggtcaaaaccaatatgcagtcagtggtgaaatatttgtg
gtggatagaaacacagtagagattacagagcttccagttagaacttggacacaggtatac
aaagaacaggttttggaacctatgctaaatggaacagataaaacaccagcattaatttct
gattataaagaatatcatactgatacaactgtgaaatttgtggtgaaaatgactgaagag
aagctagcacaagcagaagctgctggattacataaagtttttaaacttcaaactactctt
acttgtaattccatggtactctttgatcatatgggatgtctcaagaaatatgaaactgtg
caagacattttgaaagaattctttgatttacgattaagttattacggtttacgtaaggag
tggcttgtaggaatgttgggagcagaatctacaaagcttaacaatcaagcccgtttcatt
ttagagaagatacagggaaaaattaccatagagaataggtcaaagaaagatttgattcaa
atgttagtccagagaggttatgaatctgacccagtgaaagcctggaaagaagcacaagaa
aaggcagcagaagaggaagaaacacaaaaccagcatgatgatagttcctctgattcagga
actccttcaggccccgattttaattatattttaaatatgtctctgtggtctcttactaaa
gaaaaagttgaagaactgattaaacagagagatgcaaaagggcgagaggtcaatgatctt
aaaagaaaatctccttcagatctttggaaagaagatttagcagcatttgttgaggaactg
gataaagtggaggcgcaagaacgagaagatattctggctggaatggctgggaaagcaata
aaaggtaaagttggcaaacctaaggtgaagaaacttcagttggaagagacaatgccttcc
ccttatgggagaagaatagttcctgaaattactgctatgaaggcagatgccagcaaaaag
ttgttgaagaggaaaaagggtgatctcgataccacagcagtaaaagtagaatttgatgaa
gaattcagtggaacaccagtagagggtacaggagaagaggcattgatcccgtcagctcct
gtaaataaaggtcccaaacccaaaagggagaaaaaggagcctggtaccagggtgagaaaa
acacctacatcatctggtaaatccactgcaaagaaagtgaagaaacggaatccttggtca
gatgatgaatccaagtcagaaagtgacttggaagaaacagagcctgtggttattcccaga
gattctttgcttaggagagcagctgctgaaaggcctaagtacacgtttgacttctcagaa
gaggaggaggatgatgctgatgatgatgaggacaataatgatttagaggaattgaaagtg
aaagcatctcccataacaaatgatggggaagatgaatttgttccttcagatggcctagat
aaagatgaatatacattttcacctggcaaatcaaaagctactccagaaaaatcttcacat
gacaaaaaaggtcaagattttgggaatctcttctcatttccttcatactcgcagaagtca
gaagatgattcagctaaatttgacagtaatgaagaagattctgcctctgttttttcacca
tcgtttggtctgaaacaaacagataaagttccaagtaaaacagtagctgctaaaaaggga
aaaccatcttcagatacaactgctaagcccaagagaacccctaaacagaagaaagtagag
actataaactctgactcagattcagaattcggcattccaaagaagagtacacccccaaaa
ggtaaaggccgaggagcaaagaaaaggaaagcatctggctctgaaaatgaaggtgattat
aaccctggcaggaaaacatccaaaacaccaagcaagaaaatgaagaaaacctcttttgat
caggattcagatgtggacatcttcccatcagatttcacttctgaagcaccttctctgcca
cggagcggtcgggctaggaaagaagtaaaatattttgcagagtccgatgatgaagaagat
gttgattttgcaatgtttaattaa
DBGET
integrated database retrieval system
