Puma concolor (puma): 112851518 Help Entry 112851518         CDS       T08890                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism pcoo  Puma concolor (puma) Pathway pcoo04020   Calcium signaling pathway pcoo04024   cAMP signaling pathway pcoo04260   Cardiac muscle contraction pcoo04261   Adrenergic signaling in cardiomyocytes pcoo04371   Apelin signaling pathway pcoo04713   Circadian entrainment pcoo04911   Insulin secretion pcoo04921   Oxytocin signaling pathway pcoo04972   Pancreatic secretion pcoo05020   Prion disease pcoo05022   Pathways of neurodegeneration - multiple diseases pcoo05410   Hypertrophic cardiomyopathy pcoo05412   Arrhythmogenic right ventricular cardiomyopathy pcoo05414   Dilated cardiomyopathy pcoo05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:pcoo00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     112851518 (RYR2)    04020 Calcium signaling pathway     112851518 (RYR2)    04024 cAMP signaling pathway     112851518 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     112851518 (RYR2)    04921 Oxytocin signaling pathway     112851518 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     112851518 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     112851518 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     112851518 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     112851518 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     112851518 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     112851518 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     112851518 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     112851518 (RYR2)    05414 Dilated cardiomyopathy     112851518 (RYR2)    05415 Diabetic cardiomyopathy     112851518 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:pcoo04040]     112851518 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:pcoo04990]     112851518 (RYR2) Ion channels [BR:pcoo04040]  Voltage-gated cation channels   Ryanodine receptor    112851518 (RYR2) Domain-containing proteins not elsewhere classified [BR:pcoo04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    112851518 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 PI3_PI4_kinase Motif Other DBs NCBI-GeneID:  112851518 NCBI-ProteinID:  XP_025770809 UniProt:  A0A6P6H575 LinkDB All DBs Position Unknown AA seq 4982 aa AA seqDB search MANSQACVSCSPHVAYTESSHLPSSPLYNLSFLQDDEVVLQCTATIHKEQQKLCLAAEGF GNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEEWKFMM KTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTI HPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSE AAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRV AWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDAGV RKEVDGMGTSEIKYGDSVCYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDG LNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKASTVDLPIESVSLSLQDLIGY FHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREG GEAWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVES PEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDL LLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEG YSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLS APSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPC YEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIR EKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKT LLALGCHVGIADEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAEN AHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGY HLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGC QPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEIL LDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVN TNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGAQNSTADIMFY RLSMPIECAEVFSKTVAGGLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKD KEATKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQ TSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKR SNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPA AFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQ FLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYS AVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMN SEFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRIQFSSPSFVSINNECYQYSPEF PLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHI LQLIEPSVFKEAATPEEDTEALEKEPSMEDSKPEGAGEEEAKGGKRPKEGLLQMKLPEPV KLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKT KEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSD LTIRGRLLSLVEKVTYLKKKQAEKPVESGSKKSSTLQQLISETMVRWAQESVIEDPELVR AMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLM IRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCY FCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDL EKVVRYLAGCGLQSCPMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVR LLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLETEEEEDDTI HMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQM PTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASL DTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLT KAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYC LPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYME SNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWI YGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRVERTREGDSMALYN RSRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELES KGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFA YSFLQQLIRYVDEAHQYILEFDGGSRSKAEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYF LSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDA RTVMKTGLESVKSALRTFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALL PMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAF AGAFPVAFLETHLDKHNIYSIYNTKSSRERAALNLPTNVEDVCPNIPSLEKLMEEIVELA ESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILK IIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKA EARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEDLFRMVAEV FIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSTQ TSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDIIRSNIHLQGKLEDP AIRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQKSTSMHRRYYSLGSTVEHP QRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDK LIEDLAKPGADPPEEEEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSC HDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGQK MLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSASHFESHRLQT GEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESI SDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVV GFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVE SSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEF LLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESV LNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEK MELFVNFCEDTIFEMQLAAQISESDLNERSANKEESEKEKPEEQGPRMGFFSIVTVKSAL FALRYNILTLMRMLSLKSLKKQMKKVKKMTMKDMVTAAFSSYWSIFMSLLHFVASVSRGF FRIICSLLLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDGEEGDRRPMEAALPSEDLTD LKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPIPDVQEKFQEQKVK EEEKEEKEESKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKII AYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKEPPTRSSSGNAKVS SLDSGSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKE VARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDR ISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWY MTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVA FNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRII FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGF ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQ LN NT seq 14949 nt NT seq  +upstreamnt  +downstreamnt atggctaattctcaggcctgtgtttcttgcagtcctcatgttgcctacacggagtcgtcc catttaccgtcttcccccttatataacttgtcctttttgcaggatgatgaagtggtccta cagtgcaccgcgaccatccacaaagaacaacagaaactgtgcttggcagcagaagggttt ggcaacagactttgcttcctggagtctacttcgaattccaagaatgttcccccagacctc tccatctgcacttttgtgctggaacagtctctctctgtccgggccctacaggagatgctg gctaacacagtggagaaatcagaagggcaagttgatgtggaagaatggaaattcatgatg aagactgctcaaggtggtggtcatcgaacactcctgtatggacatgccatattgctacgc cattcctatagtggcatgtacctgtgctgtctgtccacctcccggtcttcaactgataaa ctggcctttgatgttggcttgcaagaggacacaacaggtgaggcttgttggtggactatt catcctgcgtccaagcagaggtcggaaggagaaaaggtgcgcgttggagatgacctcatc ttagtcagtgtgtcctctgagaggtacctgcatttgtcttacggcaatggcagcttacac gtggatgctgctttccagcagactctctggagcgtggccccaatcagctcaggaagtgaa gccgcccaagggtatctaattggtggtgacgtcctcaggttgctgcacggacacatggat gaatgcctcactgtcccttcgggagaacacggtgaagagcagcggagaactgttcactat gaaggcggtgctgtatctgtccatgcacgttccctgtggagactagagacactaagagtt gcgtggagtggaagccacataagatggggccagcccttccgactacgccatgtcacaaca ggaaagtacttgagtctcatggaagacaaaaaccttctactcatggacaaagaaaaggct gatgtaaagtcaacagcatttaccttccggtcttccaaggaaaaattggatgcaggggtg agaaaagaagtcgatggcatgggaacatcagaaataaaatatggagactcagtatgctat attcaacatataaatacaggcctgtggcttacttaccagtctgtggatgtgaaatcagtg agaatgggatccatacaacgtaaggctattatgcatcatgaaggtcacatggatgacggc ttaaatctctctagatctcagcatgaagaatcacggaccgcacgagtcatccggagcact gtcttccttttcaatagatttataaggggccttgatgcgctcagcaaaaaagtgaaggct tccacagtagacctccctatagaatctgtgagtctgagtctgcaggacctgattggttac ttccatccccccgacgagcacttagagcatgaagacaaacagaacagattacgggctcta aagaaccgtcagaatctcttccaggaagagggcatgatcaaccttgtgctcgagtgcatc gacaggctgcatgtctatagcagcgcggcgcatttcgcggacgtggcggggagagaagga ggcgaggcttggaagtcgattctgaattctctctatgagttgctagcggctctaattaga ggaaatcgtaaaaactgtgcccaattttctggctccctggactggttgatcagccgattg gaaagactggaagcttcttctggtattcttgaagttttgcactgtgtgttagtagaaagt ccagaagccctaaatattatcaaagaaggacacattaaatccataatctcccttttagac aagcatggaagaaaccacaaggttctggacgtcttgtgctctctctgcgtctgccatgga gtagcggtccgttccaaccagcatctcatctgtgacaatctgctgccgggaagagatcta cttctgcagacacgtcttgtaaaccacgttagcagcatgagacccaatatttttctgggc gtcagtgaagggtccgcccagtataagaagtggtattatgagctgatggtggaccacacg gagccgttcgtgactgccgaagccactcacctgagggtgggctgggcgtccaccgaaggg tactctccctaccctggaggcggtgaggagtggggtggcaatggagttggagatgacctc ttttcctacggatttgatggccttcacctctggtcaggttgtattgcacgtactgtaagc tcaccgaatcaacatctcttgagaaccgatgatgtcatcagttgctgtttagatctgagc gccccaagcatctcattccgaattaacgggcaacctgttcaaggaatgtttgagaatttc aacatcgatggcctcttctttccagttgttagtttctctgcaggaataaaggtacgcttt ctacttggggggagacatggagaatttaaattccttcctccacctgggtatgctccttgt tatgaagctgttctcccaaaagagaagttgaaagtggaacacagcagagaatacaagcaa gaaagaacttacacccgagacctgctgggccccacggtttccctgacgcaggccgccttc acaccaatccctgtggacaccagccagattgtgttacctcctcacctggagagaataaga gaaaaactggcagagaatatccatgaactctgggttatgaataaaattgaacttggctgg cagtatggtccggttagagatgacaataagagacagcatccgtgtctggtggagttctcc aagctaccggagcaggaacgcaattacaatttgcagatgtcgcttgagaccctgaagact ttgttggcattaggatgtcatgtgggaatagcagatgaacatgctgaagaaaaggtgaaa aaaatgaagctgcccaagaattaccagctgacaagtgggtataagcctgccccgatggac ctgagcttcattaaactcacgccgtctcaggaagcgatggtggacaagttggcggagaac gctcacaacgtgtgggcccgggatcgaatccggcagggctggacttacggcatccagcag gatgtaaagaacagaagaaaccctcgcctggttccctacacccttctagatgaccgcacc aagaagtccaacaaggacagcctccgtgaggccgtgcgcacgctgctgggatatggctac catctggaggcgccagatcaagatcatgctgcccgagccgaagtgtgtagcggcaccggg gagaggttccgaatcttccgcgcggagaaaacctatgccgtcaaggcaggaaggtggtat tttgaatttgaggctgtcactgctggagacatgagagtcggatggagcaggccaggttgt caacctgaccaagagctgggctcagacgaacgtgcctttgcttttgatggcttcaaggcc cagcggtggcaccagggcaacgaacactatgggcgctcttggcaagcgggcgatgttgtg ggatgcatggtggacatgacggagcacaccatgatgttcacactgaatggcgaaatcctt ctggatgactcgggctcagaactggcgttcaaggacttcgatgttggtgacggattcatt cctgtctgtagccttggagtggctcaggtgggcaggatgaactttggaaaggatgtcagc accttgaaatatttcaccatctgtggcttacaagagggttacgaaccgtttgctgtgaac acaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctccaggtccct tcaaaccatgagcatatcgaggtgaccagaatagacggcaccatcgacagttctccgtgt ttaaaagtcacccagaagtcctttggcgctcagaacagcactgccgacatcatgttctat cgcctgagcatgccaatcgagtgtgccgaggttttctccaagacggtggcaggcgggctc ccaggcgccggcctctttgggcccaagaatgatctggaggattacgatgcagattctgac tttgaggttctaatgaagacagctcatggccatctggtgccagaccgtgttgacaaagac aaggaagccacaaaaccagagtttaataaccacaaagactatgctcaggaaaagccctct cgtctgaaacaaagatttttgcttagaagaacaaagccagattatagcacgagccattct gcaaggctcacggaagatgtccttgcagatgatcgggatgattatgactacttgatgcaa acgtccacgtactattactcagtgagaatctttcccggccaagaacctgctaacgtctgg gtgggctggattacatcagatttccatcagtatgatacaggctttgacttggacagagtt cgtacagtaaccgttactctaggagatgaaaagggaaaagtacatgaaagcatcaaacgc agcaactgctatatggtgtgcgcgggcgagagcatgagcccagggcaaggacgcaacaat aatggcctggagatcgggtgcgtggtggatgctgccagtgggcttctcacgttcaccgcc aacggcaaggagctgagcacctactaccaggtggagccaagtacaaagttatttcctgca gcttttgcccaagctacaagtcccaatgttttccagtttgagctgggaagaatcaagaat gtgatgcctctctccgcgggattattcaagagtgagcacaaaaaccctgtgccacagtgt cccccgcgtctccacgtgcagtttctgtcccacgtcctgtggagcagaatgcccaaccag ttcctgaaggtagatgtgtctcgaataagtgagcgccaaggctggctggtgcagtgtttg gatcctctgcagttcatgtctctccatatcccggaggagaacagatctgttgacatactg gagctgacagagcaggaagagctgctgaaattccactaccacacgctccggctttactcc gccgtctgcgccctcgggaaccaccgggtggcgcatgcgttgtgcagccacgtggacgaa ccccagctgctctacgccatcgagaacaagtacatgcccggtttgctgcgggccggctac tatgacctgcttattgacatccacctgagctcctacgccactgccaggctcatgatgaac agtgagttcatcgtgcccatgacggaggagaccaagagcatcaccctcttccctgatgag aacaaaaagcatggcctcccggggattggcctcagcacctccctcaggccacggatacag ttttcctcccccagttttgtgagcatcaataacgaatgctaccaatacagtccagagttc ccgctggacatcctgaaggccaaaaccattcagatgctgacagaagctgttaaagagggc agcctgcatgcccgggaccccgtggggggcaccactgaatttctctttgtacctctcatc aagcttttctatactctgctcatcatggggatcttccacaatgaggacttaaaacacatc ttgcagctgatagagcccagtgtgttcaaggaagccgccactccggaagaagacactgag gctctggagaaagagccctccatggaagactccaagccagaaggagctggagaagaagaa gccaaagggggtaagaggcccaaggaaggactgctccaaatgaaactgcctgagccagtt aaattgcagatgtgtctgctgctccagtacctctgtgactgccaggtccgacaccggata gaagccatcgtggccttttcagatgactttgtagccaagctccaagacaatcagcgcttc cgttacaatgaagttatgcaagctttaaacatgtcggccgcgctcactgccaggaagaca aaggaatttcgatccccacctcaggaacagatcaatatgcttctcaattttaaggatgat aaaagtgaatgtccatgtcctgaagaaatccgagaccagctcttagattttcatgaagat ttgatgacacattgtggaattgagctggatgaagatgggtctcttgatggaaacagtgac ttaacaattagaggacgcctgctgtccttggtagaaaaggtgacatacctgaagaagaaa caggccgaaaaaccagttgagagtggctccaagaagtcctccactcttcagcagttgatt tctgaaaccatggtccgatgggcgcaagagtctgtcattgaagaccctgaactggtgagg gccatgtttgtgttgctccatcgacagtacgatggcattgggggtctggtccgggctctg ccaaagacctacactataaatggtgtctccgtggaggataccatcaacctgctggcatct ctcggtcagattcgttctctgctgagtgtaagaatgggcaaagaagaagagaagcttatg attcgtggattaggggatatcatgaataataaagtattttaccagcaccctaatctcatg agggcacttgggatgcacgagacggtgatggaggtcatggtgaatgtccttggaggtgga gagtccaaggaaatcacttttcccaagatggtggccaactgttgccgttttctttgttac ttctgtcgtataagtcggcagaatcaaaaagctatgtttgaccatctcagctatttattg gagaacagcagtgttggtcttgcctcaccagcaatgagaggttcaacaccactggatgtg gcagccgcatcagtgatggataataatgaactggccttagctctgcgtgagccagatttg gaaaaggtagttcgatatttggctggttgtggactgcagagttgcccaatgctggtatct aagggttacccagatattgggtggaatccagttgaaggagagagataccttgactttctc cgatttgctgtcttctgtaatggggagagtgtggaagagaatgctaatgttgtggtgagg ttgctcatccggaggcccgagtgtttcggtcctgctttgagaggggaaggtgggaacggt cttcttgcagcaatggaagaagccataaaaatagccgaggatccctctcgagatggtccc tcaccaactagcggatccagtaaaacacttgagacagaagaggaggaggatgacactatc cacatggggaatgccatcatgacgttttatgcagctttgattgacctcttaggacggtgt gctcctgaaatgcatttgattcatgctggtaagggggaagccatcagaatccggtcaatt ctgagatccctaattccactgggagatttggtgggagtaatcagcattgcttttcagatg ccaacaatagccaaagatgggaatgtggtggagcctgacatgtctgcggggttttgccca gatcacaaggcagccatggttttgttccttgacagggtctatggcattgaggttcaagat ttcctcctccatcttctcgaggttggctttctgcctgatctccgggctgctgcttcttta gatacggctgctttgagtgccacagacatggccctggccctcaatcggtacctttgcaca gccgtgttgcctttattaacaagatgtgcccctcttttcgcgggcacagaacaccacgct tctctcattgactcgttactgcacactgtgtacagactttcgaagggctgctcacttacc aaagctcagcgggattccatagaagtttgtttgctctctatttgtggccaattgagacct tctatgatgcagcacttgctccgaagattagtgtttgatgtcccattattaaatgaacat gcgaagatgcctcttaagttgctgacaaatcattatgaaagatgctggaaatattactgc ctgcctggagggtgggggaacttcggagctgcctcagaagaagaacttcatttatcaaga aagttgttttggggcatttttgacgccctgtctcaaaagaaatacgaacaagaacttttc aaactggcactgccttgcctgagtgccgttgcgggagctttgcctccagactacatggag tcaaattatgtcagtatgatggaaaaacagtcatcaatggattctgaagggaactttaac ccacaacctgttgatacctcaaacattacaattcctgagaagttggaatacttcattaac aaatatgctgaacattctcatgacaaatggtcaatggacaagttggcaaatggatggatt tatggagagatatattcagactcgtctaaagttcagccgttaatgaagccatataaacta ttatctgaaaaggaaaaagaaatttatcgctggccaatcaaagaatctttaaaaaccatg ctggcgtggggttggagggttgagagaacacgggagggagacagcatggccctctacaac cgttctcgtcgtatttctcagacaagccaggtttctgttgatgctgcgcatggttatagc ccccgagccattgatatgagcaatgtcacactgtccagagacctgcacgctatggcagaa atgatggctgaaaactaccataatatatgggcaaagaaaaagaagatggagctggagtcc aaaggaggtggaaaccatcccctgctggtaccctatgatacactgacagccaaagagaaa gccaaggatagggaaaaagcacaggacatcctcaagttcttacagatcaatggatatgct gtatccaggggattcaaggacctggaattggacacaccttccattgagaaacgatttgcc tatagtttccttcagcaactcattcgctatgtggatgaagcccatcagtatatcctggag tttgatggtggcagcagaagcaaggcggaacattttccttacgagcaagaaatcaagttc tttgctaaagttgtgcttcctttaattgatcagtatttcaaaaaccatcgtttatacttc ttatctgcagcaagcagacccctctgttctggaggacatgcgtcaaacaaggagaaagaa atggtgacgagcctattctgcaaacttggagttcttgtcaggcataggatttcactattt ggaaatgatgccacatcaattgtcaactgtcttcatattttgggtcagactttggatgca aggactgtcatgaagactggcctggagagtgttaaaagtgcgctcagaacgtttctggac aatgcggcggaggatctggagaagacaatggagaatctcaagcagggccagttcacccac acccgaaaccaacccaaaggtgttactcagattatcaattataccacggtggctctgttg ccaatgctgtcatcattatttgagcatattggccagcatcagttcggagaagatctaata ttggaagatgtacaggtgtcatgttatagaattctgactagcttatatgctttgggaacc agcaaaagtatttatgtggaaaggcaacgctctgcattaggagaatgtcttgctgctttt gctggtgcctttcctgtcgcatttttggaaactcatctcgacaaacataacatctactct atctacaataccaagtcatcgcgagaaagagcagctctgaatttgccaactaacgtggag gatgtgtgcccaaatataccgtctttggagaaactcatggaagaaattgtggaattagct gagtccggcattcgctacacacagatgccacacgtcatggaagtcatactgcccatgctt tgcagctacatgtctcgttggtgggagcacggacctgaaaataatccagaaagggctgaa atgtgctgtaccgccctgaactccgagcacatgaacacgctcttggggaatatattgaaa atcatatataataacctgggaattgatgagggagcctggatgaagaggttagcagtattt tcacagcccattataaataaagtgaaacctcagctcctgaaaactcatttcttgccatta atggagaaactcaagaaaaaagcagcgatggtggtgtcagaggaggaccatctgaaagct gaggccaggggggatatgtctgaggcagagcttctcattctcgatgagttcaccactctg gccagagatctctatgccttctacccgctcttgattagatttgtggactataacagggca aagtggctaaaagaacctaacccagaagcagaggaccttttccgcatggtggccgaagtg tttatctactggtcaaaatcccacaatttcaaaagagaagagcagaactttgtggtacag aatgaaatcaacaatatgtctttccttattacggacaccaagtcaaagatgtcaaaggcc gctgtctctgatcaggaaaggaagaagatgaagcgcaaaggagatcggtactccacgcag acctctctcattgtggcagctctgaagcggttactgcccattgggttgaacatctgtgcc cctggggaccaggagctcatcgctctggccaaaaaccgatttagtatgaaagacactgag gatgaagtacgagatataatccgcagtaatattcatttacaaggcaagttggaggatcct gctatcagatggcaaatggctctttacaaagatttaccgaacaggactgaagatacatca gatccagagaagaccgtagagagagtattagatatagcaaatgtgctttttcatcttgag cagaaatctacatctatgcaccggagatattacagtctgggaagtacagtggagcaccca cagagatcgaagaaagctgtatggcacaaacttctgtccaagcagaggaagagggcagtg gtggcctgcttccgaatggctcctttatataacctgccaaggcaccgggccgttaacctc tttcttcagggatatgaaaagtcttggattgaaacagaagaacactactttgaagataag ctgatagaagatttagcaaaacctggagcagaccctccagaggaagaggaaggcacgaag agagtcgatcccctccatcagctcatccttctgtttagtcgaacagctttaacggagaaa tgcaaactggaggaagattttttatatatggcttatgcagatattatggcaaagagttgt catgatgaggaagatgatgatggtgaagaagaagtgaagagttttgaagtcacaggatcc caacgcagcaaggaaaaagaaatggagaagcagaagcttctgtaccagcaagccaggctc catgaccgcggggctgctgagatggtgctacagaccatcagtgccagcaaaggtcagaaa atgctcgactatctcaaggagaagaaggacgtgggtttctttcagagccttgccggcctg atgcagtcgtgcagcgtcctcgacctaaatgcatttgagcggcagaacaaagctgaagga cttggaatggtcaccgaagaaggatcagcctctcactttgaaagtcacagactgcagact ggagaaaaggttctccaagatgacgagttcacgtgtgacctcttccgtttcctccagctg ctttgtgagggacacaactcagattttcaaaattatctgagaactcagactggcaataac acaactgtcaacatcatcatctctaccgtagactacctactcagagtccaggaatccatt agtgatttctattggtattactctgggaaagatgttattgatgaacaaggacaacggaat ttctccaaagcaattcaagtagcaaaacaagtctttaacacgctcacagagtatattcag ggtccttgcactgggaatcagcagagcttggcccacagcaggctatgggacgcagttgtg ggcttccttcacgtattcgcccacatgcagatgaagctgtctcaggattccagtcaaatc gagctattaaaagaattaatggatcttcagaaggatatggtggtcatgttgctgtccatg ctagaaggtaatgttgtcaatggaaccattggcaaacagatggtcgatatgcttgtggag tcttccaacaacgtggagatgattctcaagttttttgacatgttcttaaaactaaaggat ttgacctcttctgacacatttaaagaatacgaccctgacggcaagggagtcatttccaag agggacttccataaagcgatggagagccataaacactacacgcaatcagaaaccgagttt cttctgtcctgtgcagagacagatgaaaacgaaaccctggactatgaagagtttgtcaaa aggtttcacgagcccgcaaaggacatcggcttcaatgtggccgttcttctgaccaacctt tcggagcacatgcccaatgatacgcgactgcagactttcctggagttggcagagagcgtg ctgaattacttccagccttttctgggccgcatcgagatcatgggaagtgccaagcgcatc gagagggtgtattttgaaatcagtgagtccagccgaacccagtgggagaagccccaggtc aaggagtccaaaaggcagttcatatttgatgtggtcaacgaagggggagaaaaggagaaa atggaactttttgtcaacttctgtgaggacaccatattcgaaatgcagctggcagcgcag atctcagagtcggatttgaatgagaggtcagcgaataaagaagagagtgagaaggagaag ccggaagagcaggggcccagaatgggtttcttttccatcgtgacggtcaagtcagccctg tttgctctcaggtataatatcttgaccctcatgagaatgctcagcctgaagagcctgaag aaacagatgaaaaaagtgaagaagatgacgatgaaggatatggtcacggccgccttttcg tcctactggagtattttcatgagcctcctgcactttgtggccagcgtttccagaggcttc ttccgcatcatttgcagcctgctgcttggcgggagcctagtagaaggagcaaaaaagatc cgagtggcagagctcttagccaacatgccagaccccactcaggatgaggtgagaggggat ggagaagagggggacaggaggcccatggaggccgccctgccctcggaagatctgacagac ctgaaggaactgacggaggaaagcgaccttctttcggacatatttggcttggatctgaag agagaaggaggacagtacaaacttattcctcataatccaaacgctggcctcagcgatcta atgagcaacccggtccctatccctgacgtgcaagaaaaatttcaggaacagaaggtgaaa gaggaagaaaaggaggagaaagaagaaagcaaatctgaacctgaaaaggccgagggagaa gatggagaaaaagaagaaaaagccaaagaagataagggtaaacagaagttgaggcagctc catacacacagatacggagagccagaagttcccgagtcggcattctggaagaaaatcatc gcatatcaacagaaacttctaaactattttgctcgcaacttttacaacatgagaatgtta gccttattcgtcgcgtttgcaatcaatttcatcttgctcttttataaggtctccacttct tctgtggttgaaggaaaggagccccccactcgcagttcaagtggaaatgccaaagttagc agcctggacagtggctcacctagaatcatcgcggttcactacgtcctggaggagagcagc ggctacatggagcccacgctgcggatcttagccattcttcacacggtcatttctttcttc tgcatcatcggctactactgcttgaaagtcccattggttatttttaagcgagaaaaggaa gtagctcgaaaattggaatttgatgggctttatattacagaacagccttcagaagatgat attaaaggccagtgggatcgactcgtaatcaacacacagtcatttcccaacaactactgg gacaaatttgttaaaagaaaggttatggataaatatggggagttctatggccgggacaga atcagtgagctccttggtatggacaaagccgccctagatttcagcgatgcccgggaaaag aagaagccaaagaaagacagctccctgtcagccgtactgaactctattgatgtgaagtat cagatgtggaaactaggagtcgtcttcacggacaactctttcctctacctggcctggtat atgactatgtccgttctgggacactataacaactttttttttgctgctcatcttcttgac attgctatgggattcaagacactgagaaccatcttgtcatcggtaactcacaatggcaag cagcttgtattaactgttggcttgttagctgttgttgtatacctatatactgttgtggca ttcaactttttccgaaaattctacaataaaagtgaagatggtgacacaccggatatgaaa tgtgatgatatgctaacgtgctacatgttccacatgtacgtcggggtacgtgccggaggg ggtatcggcgatgaaatcgaagacccagcaggcgacgaatatgagatctatcgaatcatc tttgacatcaccttcttcttcttcgtgattgtcattctcttggccataattcaaggttta attattgatgcttttggagagctaagagaccaacaggagcaagtcaaagaagacatggag accaaatgtttcatctgtgggataggcaacgattacttcgacacagtgccacatggcttt gaaacccacactttacaggaacacaacctggccaattacctgttttttctgatgtatctc atcaacaaagatgaaacagagcacacaggacaggaatcttatgtctggaagatgtatcaa gaaaggtgctgggaattcttcccagcaggggattgtttccggaaacagtatgaagaccag ctaaattaa

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