Puma concolor (puma): 112852708
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Entry
112852708 CDS
T08890
Symbol
TYK2
Name
(RefSeq) non-receptor tyrosine-protein kinase TYK2
KO
K11219
non-receptor tyrosine-protein kinase TYK2 [EC:
2.7.10.2
]
Organism
pcoo
Puma concolor (puma)
Pathway
pcoo04217
Necroptosis
pcoo04380
Osteoclast differentiation
pcoo04620
Toll-like receptor signaling pathway
pcoo04621
NOD-like receptor signaling pathway
pcoo04630
JAK-STAT signaling pathway
pcoo04658
Th1 and Th2 cell differentiation
pcoo04659
Th17 cell differentiation
pcoo05145
Toxoplasmosis
pcoo05160
Hepatitis C
pcoo05161
Hepatitis B
pcoo05162
Measles
pcoo05164
Influenza A
pcoo05165
Human papillomavirus infection
pcoo05167
Kaposi sarcoma-associated herpesvirus infection
pcoo05168
Herpes simplex virus 1 infection
pcoo05169
Epstein-Barr virus infection
pcoo05171
Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:
pcoo00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
112852708 (TYK2)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
112852708 (TYK2)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
112852708 (TYK2)
04621 NOD-like receptor signaling pathway
112852708 (TYK2)
04658 Th1 and Th2 cell differentiation
112852708 (TYK2)
04659 Th17 cell differentiation
112852708 (TYK2)
09158 Development and regeneration
04380 Osteoclast differentiation
112852708 (TYK2)
09160 Human Diseases
09172 Infectious disease: viral
05161 Hepatitis B
112852708 (TYK2)
05160 Hepatitis C
112852708 (TYK2)
05171 Coronavirus disease - COVID-19
112852708 (TYK2)
05164 Influenza A
112852708 (TYK2)
05162 Measles
112852708 (TYK2)
05168 Herpes simplex virus 1 infection
112852708 (TYK2)
05167 Kaposi sarcoma-associated herpesvirus infection
112852708 (TYK2)
05169 Epstein-Barr virus infection
112852708 (TYK2)
05165 Human papillomavirus infection
112852708 (TYK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
112852708 (TYK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pcoo01001
]
112852708 (TYK2)
Enzymes [BR:
pcoo01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
112852708 (TYK2)
Protein kinases [BR:
pcoo01001
]
Non-receptor tyrosine kinases
JAK family [OT]
112852708 (TYK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Jak1_Phl
FERM_F2
FERM_F1
SH2_1
Kinase-like
Kdo
FERM_C_FAK1
ABC1
RIO1
RA_2
Motif
Other DBs
NCBI-GeneID:
112852708
NCBI-ProteinID:
XP_025772023
UniProt:
A0A6P6H909
LinkDB
All DBs
Position
Unknown
AA seq
1184 aa
AA seq
DB search
MPLCRWGATTRDSRPDGDEAQPMVSRGGLKVLLHWAGPDGGDPWVTFSEATLTAEEVCIH
IAHKVGITPSCLNLFALFDAQAQVWLPPNHILEVSRDMNLTLYFRMRFYFRNWHSMNPQE
PAVYRCGPTRAKSSSEQAEQGVQLLDPASFEYLFEQGKHEFVNDVAPLWELSSEEEIHHF
KNESLGMAFLHLCHLALCHGIPLEKVAKKISFKDCIPRSFRLQLRRHNALTRLRLRRLFR
RFVRAFQPGHVSQPVIMVKYLATLEQLAPRFGTERVLVCRLEEQAQAVGDPCYVRDGSQS
PPEPGPELAPGPPTHEVLVTGTGGIRWRPVQAEVSRGPSGDGCSRNPRAGPSGKKSKAQE
VGNQPVDRPQEAPWAYFCDFQDITHVVLKERHVSIHRQDKCLELTLPSRAVALSLVSLVD
GYFRLTADSSHYLCQEVAPPRLVMSIRDGIHGPLLEPFVLAKLRPEDGLYLIHWSTSHLN
RLILTVAQRDQAPGGQQLHLRKFPIELRAGSFELEGWDRSFPSVRELRTALQGCSLRAGD
DCFSLRRCCLPRPGELSNLIIMRGSRASPGPLNLSQLSFHRVCQDDITQLSHLGQGTRTN
VYEGILRVGERGPKEGTADGGDPPTPSGDRGQELRVVLKVLDPSHHDIALAFYETASLMS
QVSHVHLAFVHGVCVHGSENIMVTEYVEHGPLDVWLRRERGHVPVAWKVAVAQQLASALS
YLEDKSLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWTAPEC
LSGGASTLTTAADKWGFGVTLLEICFDGEAPLQGRGPSEKECFYQKQHQLPQPSCPELAT
LTSQCLTYEPAQRPSFRTILRDLTQLQPQNLADVLAVNPDSPASDPTVFHKRYLKKIRDL
GEGHFGKVSLYCYDPTNDGTGEMVAVKALKAGGGPQLRTGWRREIDILRTLYHKHIVKYK
GCCEDQGEKSVQLVMEYVPLGSLRDYLPRHNVGLAQLLLFAQQICEGMAYLHAQHYVHRD
LAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASD
VWSFGVTMYELLTYCDSSQSPPSKFIELIGLTQGQMTVLRLTELLERGERLPRPEKCPCE
IYLLMKNCWEAEASFRPTFQNLIPILKTVQEKYQGQAASVFNVC
NT seq
3555 nt
NT seq
+upstream
nt +downstream
nt
atgcctctgtgccgttggggtgccaccaccagggacagcaggcctgatggggatgaggct
cagcccatggtctccaggggaggcctaaaggtcctcctgcactgggctggccctgatggc
ggggacccctgggtcaccttcagcgaggccacactgaccgcagaggaggtctgcatccac
atcgcacacaaagtcggcatcactccatcctgcctcaatctcttcgccctctttgatgcc
caggcccaggtgtggctgcccccaaaccacatcttggaggtctccagagacatgaacctg
acattgtacttccgcatgaggttttatttccggaactggcacagcatgaatcctcaggag
ccggccgtgtaccgctgtgggcccaccagggccaagtcttcctcggaacaggcagagcag
ggggtgcaactcctggacccagcctcctttgagtacctctttgagcagggcaagcacgag
tttgtgaatgatgtggcaccactgtgggagctgtcgagcgaggaggagatccaccatttt
aagaacgagagcctgggcatggcctttctgcacctctgccacctcgccctttgccatggt
atccccctggagaaggtggccaagaagatcagcttcaaggactgcatcccgcgctccttc
cggctgcagctccggcggcacaacgcgttaacacggctgcgcctacggaggctcttccgc
aggtttgtgcgggccttccagccgggccacgtctcccagccggtcatcatggtcaagtac
ctggccacgctggagcagctggcaccccgcttcggcacggagcgcgtgctcgtgtgccgg
ctggaggagcaggcccaggccgtgggggacccctgctacgtccgggacgggagccagtcc
cccccggagcctgggcctgaattggcccccggaccccctactcatgaggtgctggtgaca
ggcactggtggcatccggtggcgaccagtccaggcagaggtgagcagaggtcccagtggc
gatggttgcagcaggaacccccgtgctggcccatcagggaagaaaagcaaggcccaggag
gtgggcaaccagccagtggacaggcctcaggaagcgccatgggcctacttctgtgacttc
caggacatcacccacgtggtgctgaaagagcgccacgtcagcatccaccgtcaggacaag
tgcctggagctcaccctgccttcccgggctgtggccctgtccttggtgtcgctggtggac
ggctatttccgcctgacggccgactcgagccactacctgtgccaggaggtggcccctcca
cggctggtgatgagcatccgggatggcatccacgggcccttgctggagccattcgtgctg
gccaagctgcggcccgaagatggcctctacctcatccactggagcaccagccacctcaac
cgtctcatcctcacggtggcccagcgtgaccaggcacctggcgggcagcagctgcacctc
cgtaaattccccattgagctgcgggccgggagcttcgagctggagggctgggaccgctcc
ttcccgagcgtgcgggagctgcgcaccgccctgcagggctgctcgctgcgggccggggac
gactgtttctccctgcgccgctgctgcctgccacgccccggagagctctccaacctcatc
atcatgcgtgggtctcgggccagccctgggccactcaacctcagccagctcagcttccac
cgcgtctgccaggatgacattacccagctgtctcacttgggccaaggcacgaggaccaat
gtgtatgagggcatcttacgggtgggggaaagaggtcccaaggagggcacggcagatggt
ggggacccccccacgcccagtggggaccgtgggcaggagctacgagtggtactcaaggtg
ctggatcccagtcaccacgacatcgccctggccttctacgagacagccagcctcatgagc
caggtctcccacgtgcacctggcctttgtgcacggcgtctgcgtgcacggctctgagaac
atcatggtgacagagtacgtggagcacggacccctggatgtgtggctgcggcgggagagg
ggccacgtgcctgtggcctggaaggtggcagtggcccagcagctggccagcgctctcagc
tacctggaagacaagagcctggttcatggtaatgtgtgtggccggaacatcctgctggca
cggctgggactggcggagggcaccagccccttcatcaagctgagcgatcccggtgtgggc
ctgggcgccctttccagggaggagcgggtagagaggatcccctggacagcccccgagtgc
ctgtcaggtggggccagcaccctaaccactgcagctgacaaatggggctttggtgtcacc
ctcctggagatctgcttcgacggggaggcccctctgcagggccgcggcccttctgagaaa
gagtgcttctaccagaagcagcaccagcttcctcagccctcatgcccggagctggccaca
ctcaccagccagtgcctgacctatgaaccagctcagcggccctccttccgcaccatcctg
cgtgacctcactcagctgcagccccagaatcttgctgacgtcttggctgtgaaccccgac
tcgcctgcatcagaccccaccgttttccacaagcgctatttgaaaaagatccgggatctg
ggcgagggtcatttcggcaaggtcagtctgtattgctacgacccgactaacgacggcacc
ggcgagatggtggctgtgaaggccctcaaggcaggcgggggcccccagctccgcactggc
tggcggcgggagatcgacatcctgcgcacgctctaccacaagcacatcgtcaaatacaag
ggatgctgtgaggaccaaggagagaagtcggtgcagctcgttatggagtacgtgcctctg
ggcagcctccgggactaccttccccggcacaacgtcggactggcccaactgctactcttc
gcccagcagatctgtgagggcatggcctaccttcatgcacagcactacgtccaccgagac
ctggctgcccgcaacgtgctgctggacaacgacaggctggtcaaaatcggggactttggc
ctagccaaggctgtgcctgaaggccatgagtactaccgcgtgcgcgaagatggggacagc
cccgtattctggtatgctccagagtgcctgaaggagtgtaagttctactatgcatccgac
gtctggtccttcggggtcaccatgtatgagctgctgacctactgtgactccagccagagc
cccccttcgaaattcatcgagctcataggcctcacccaagggcagatgacggtgctgagg
ctcactgagctgctggaacgaggggagaggctgccgcggccagagaaatgcccttgcgag
atctacctcctcatgaagaactgctgggaggcagaggcctcattccgccccactttccag
aacctcatccccattctcaagacggtccaggagaaataccaaggccaggccgcctcagtg
ttcaatgtgtgctga
DBGET
integrated database retrieval system
