Puma concolor (puma): 112853203 Help Entry 112853203         CDS       T08890                                  Symbol TSC2 Name (RefSeq) tuberin   KO K07207   tuberous sclerosis 2 Organism pcoo  Puma concolor (puma) Pathway pcoo04072   Phospholipase D signaling pathway pcoo04115   p53 signaling pathway pcoo04140   Autophagy - animal pcoo04150   mTOR signaling pathway pcoo04151   PI3K-Akt signaling pathway pcoo04152   AMPK signaling pathway pcoo04211   Longevity regulating pathway pcoo04218   Cellular senescence pcoo04714   Thermogenesis pcoo04910   Insulin signaling pathway pcoo04919   Thyroid hormone signaling pathway pcoo05163   Human cytomegalovirus infection pcoo05165   Human papillomavirus infection pcoo05168   Herpes simplex virus 1 infection pcoo05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:pcoo00001]  09130 Environmental Information Processing   09132 Signal transduction    04072 Phospholipase D signaling pathway     112853203 (TSC2)    04151 PI3K-Akt signaling pathway     112853203 (TSC2)    04152 AMPK signaling pathway     112853203 (TSC2)    04150 mTOR signaling pathway     112853203 (TSC2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     112853203 (TSC2)   09143 Cell growth and death    04115 p53 signaling pathway     112853203 (TSC2)    04218 Cellular senescence     112853203 (TSC2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     112853203 (TSC2)    04919 Thyroid hormone signaling pathway     112853203 (TSC2)   09149 Aging    04211 Longevity regulating pathway     112853203 (TSC2)   09159 Environmental adaptation    04714 Thermogenesis     112853203 (TSC2)  09160 Human Diseases   09161 Cancer: overview    05231 Choline metabolism in cancer     112853203 (TSC2)   09172 Infectious disease: viral    05168 Herpes simplex virus 1 infection     112853203 (TSC2)    05163 Human cytomegalovirus infection     112853203 (TSC2)    05165 Human papillomavirus infection     112853203 (TSC2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:pcoo01009]     112853203 (TSC2) Protein phosphatases and associated proteins [BR:pcoo01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      112853203 (TSC2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Tuberin DUF3384 Rap_GAP HEAT Cnd1 Motif Other DBs NCBI-GeneID:  112853203 NCBI-ProteinID:  XP_025772513 UniProt:  A0A6P6HAJ4 LinkDB All DBs Position Unknown AA seq 1705 aa AA seqDB search MAKPTSKDSGLKEKFRILFGLGTPRPNPRSAEGKQTEFIITAEILRELSVECGLNNRIRV IGQICEVAKTKKFEEHAVEALWKAVEDMLQPERPPEARHAVLALLKAIVQGQGDRLGVLR ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELAGFVLQWMDIGLSSEFLLVL VNLVKFNSCYLDEYIASMVHMICLLCVQTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFI VTLCRTVNVKELCEPCWKLMRNLLGTHLGHSAIYNMCRIMEDRAYMEDAPLLRGAVFFVG MALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSVTRLIKKYRRELQAVTWDI LLDIIERLLQQLQSLDSPELRAIVHDLLTTVEELCDQNEFHGSHERYFELVERCADQRPE ELISSVVISQLSHIPEDKDPQVRKLATQLLVDLAEGCHTHHFNSLLDIVEKVMARSLSAP PELEERDVVAYSASLEDVKTAVLGLLVILQTKLYALPASHAVRVYETLVSHLQLHYKHGY TLPIASSIRLQAFDFLLLLRADSLHRLGLPSKDGAVRFSPYCVCDSTEPERGSEKKAGGP LSPPTGPSGPAPAGPAVRLGSLPYSLLFRVLLQCLKQETDWKVLKLVLGKLPESLRFKVL IFTSPCSVDQLSSALCSMLSGPRTLERLRGTPEGFSRTDLHLAVVPVLTALISYHNYLDK ARQREMVYCLEQGLIYRCASQCVVALAVCSVEMPDIIIKALPVLVVKLTHISATASMAIP LLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCRL PFRKDFVPYITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARPPKQGLNNSPP VREFQESSAADAFRCRSISVSEHVVRSRIQTSLTSASLGSADENSMAQADDNLKNLHLEL TETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLG LDSGELQGSPELSSDPGAHVRQTEEAPAKLESQAGQQVCRGARDRVRSMSGGHGLRVGAL DAPATHCPGSQTTPASTSERASAAAQLPAQEKTSLAAYVPLLTQGWAEILVRRPTGNTSW LMSLENPLSPFSSDINNMPLQELSNALMAAERFKERRDTALYKSLSVPAAGSAKPPPPPR SNTVASFSSLYQTSCQGELHRSISWADSAVVLEEGSPSETDLPGEPTELEDFEATLGPER RCRRPEAYSRSSSSSSQEEKSFAAEEVAAGGLPIGRAVSAEGARPSAGLSFQPAQPLSKS SSSPELQTLQDTLGDPGDKADVGRLSPEAKARSQSGTLDGAGATWSTPGEESQGRGPARP EGPLPSGCPRSPGGLRPRGYTISDSAPSRRGKRVERDAFKSRAGASNTEKVPGINPSFVF LQLYHSPFFGDESNKPILLPNEVCSFERSVQLLDQIPSYDTHKIAVLYVGEGQSSSELAI LSNEHGSYRYTEFLTGLGKLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQGMRLP PGQFNFVHVIITPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMA SQVHHSRSNPTDIYPSKWIARLRHIKRLRHRIREEAHYSNPSLPLTQTHPPGHAKAPAPA EPMPTYETGQRKRLISSVDDFTEFV NT seq 5118 nt NT seq  +upstreamnt  +downstreamnt atggccaagccgacaagcaaggattcaggcttgaaggagaagttcaggattctgtttgga ctgggaactccgcggccaaaccccaggtctgcagagggcaagcagacggagtttatcatc acggcggaaatcctgagagagctgagcgttgaatgtggcctcaacaatcgcatccgggtg atagggcagatctgtgaagttgcaaaaacgaagaagtttgaagagcatgcagtggaagcg ctctggaaggccgtcgaggacatgctgcagccagagcggccaccggaggcccggcatgcg gtgctggctctgctgaaggccatcgtgcaggggcagggggaccgcttgggcgttctcagg gccctcttctttaaggtcatcaaggattacccctctaatgaagatctccatgaaagactg gaagttttcaaggccctcacagacaatgggagacacatcacatatttggaagaagaactg gctgggtttgtgctgcagtggatggacatcggcctgtcctcagagttccttctggtgctt gtgaacttggtcaaattcaacagctgttacctggatgaatacatcgcatcaatggtccac atgatctgcctgctgtgcgtccagactgtgtcctccgtggacatagaggtctctctgcag gtgctggacgccgtcgtctgctacaactgcctgccggctgagagcctgcccctgttcatc gtcactctctgtcgtaccgtcaacgtcaaggagctctgtgagccttgttggaagctgatg cgtaatcttctgggcacccacctgggtcacagtgccatctacaacatgtgccgcatcatg gaggacagagcctacatggaagatgccccgctgctgagaggggccgtgttctttgtgggc atggctctctggggggcgcaccgactctactcgctcaagaactccccaacatctgtgctg ccgtcgttttacgaggccatgacctgtccgaacgaggtggtgtcctacgaaatcgtcctg tctgtcaccagactcatcaagaagtaccggagggagctccaggctgtgacgtgggatatc ctgctggacatcatcgaacgtctgctgcagcagctccagagcctggacagcccggagctc agagccatcgtccatgacctgctgaccacagtggaggagctgtgtgaccagaatgagttc cacggctcgcacgagagatacttcgagctcgtcgagagatgtgcagaccagaggccggag gagctgatcagctcggtggtcatctctcagctctcccacatcccggaggacaaagacccc caagtccggaaactggccacccagttgctggtggacctggccgaaggctgtcacacccac cacttcaacagcctgctggacattgtggagaaggtgatggcccgctccctttccgcaccc cctgagctggaggaaagagatgtggtggcatattcagcctccttagaggatgtgaagact gccgtcttggggctcctggtgatccttcagaccaagctgtacgccttgcctgccagccac gcggtgcgtgtgtacgagaccctcgtcagccacctgcagctccactacaagcacggctat accctgcccatcgccagtagcatccggctgcaggcctttgacttcctgctgctgctgagg gcggactccctgcaccgcctcggcctgcccagcaaggacggggctgtgaggttcagcccc tactgcgtctgcgactccacggagccagagagaggctctgagaagaaggccggcggcccc ctgtcgcctcccaccgggccgtccggcccagcacctgccggtcccgctgtgcggcttggc tccctgccctattccctgctcttccgggtcctgctgcagtgcttgaagcaggagacggac tggaaggtgctgaagcttgttctcggcaagctgcccgagtccctgcgcttcaaggtcctc atcttcacgtccccgtgcagcgtcgaccagctgtcttccgccctctgctccatgctttca ggtcccagaactctggagcggctccgaggcaccccggaaggtttctccaggaccgacctg cacctggctgtggttcctgtgctgacggcgttaatctcttaccataactatttggacaaa gccagacagcgggagatggtgtactgcctggagcaaggcctgatctaccgctgtgccagc cagtgcgtggtggccctggccgtgtgcagcgtcgaaatgcccgacatcatcatcaaggcg ctgcctgtcttggtcgtgaagctcacacacatttcggccacagccagcatggccattcca ctcctcgaattcctgtcaactctggccaggctgcctcacctctacaggaactttgccgct gagcagtacgcgagtgtgtttgccatctccctgccgtacaccaacccctccaagtttaat cagtacatcgtgtgcctggcccatcacgtcatagccatgtggttcattagatgccgtctg ccttttcggaaggattttgttccttatatcactaagggcctacgctccaatgtcctcctg tcttttgacgacaccccggagaaggacagcttcagagcgcggagcaccagtctcaacgag aggcccaagagtttgaggatagccagaccccccaaacaaggcttgaataactccccaccc gtgagagaattccaggagagctctgcagccgacgccttccggtgccgcagcatcagtgtg tctgaacatgtggtccgcagcaggatccagacgtccctcacgagtgccagcttggggtct gcggatgagaactcaatggcccaggctgacgacaacttgaaaaatctccacctggagctc acggagacttgtctggacatgatggccagatacgtgttctccaacttcacggcggtcccc aagaggtcccccgtaggggagttcctcttggctggcggcaggaccaagacctggctggtt ggaaacaagctcgtcaccgtgacgacgagcgtggggaccggaacccggtcactgctgggc ttggactcaggagagctgcagggcagcccagagctgagctctgaccccggtgcgcacgtg aggcagacagaggaggcgcctgccaagttggagtcccaggctgggcagcaggtgtgccgt ggggcccgggaccgcgtccgctccatgtctgggggccacggccttcgtgttggtgccttg gacgctccagccacccactgcccaggctcacagaccacaccagccagcacgtccgagagg gcctcggctgccgcccagctcccggcgcaggagaagacgagcctggcggcctacgtaccc ctgctgacccagggctgggcggagatcttggtccggaggcccacggggaacaccagctgg ctgatgagcctggagaaccccctcagccccttctcctcggacatcaacaacatgcccctg caggagctgtccaacgccctcatggccgctgagcgcttcaaggagcgtcgtgacacggcc ctgtacaagtcactttcggtgccggcggccggctccgccaagccccctccgcccccacgt tctaacacagtggcctctttctcctccctgtaccagaccagttgccaaggagagctgcac aggagcatttcctgggcagactccgcggtggttctggaggagggaagtcccagcgagact gatttaccaggcgagcccactgagctggaggactttgaggccaccctgggcccagagagg cgctgtcggcgccctgaagcctacagtagatcgtcttccagctccagccaagaggagaag tctttcgccgcagaggaggtggctgccggagggctccccatcgggcgggccgtgtctgcc gagggagcccggccctctgcggggctctccttccagcccgcccagcccctcagcaagtct agctcctcgccggagctgcagaccctgcaggatacacttggggaccctggggacaaggcc gacgttggccggctaagccccgaggccaaggcccgctcacagtccgggactctggatggg gcaggtgccacctggtcaaccccaggtgaagagagtcagggccggggccctgcaaggccc gagggtcccttgccttctggctgtccccgttcccccggtggcctgcgtcccagaggctac accatttcggattcagccccgtcacgcagaggcaagagggtagagcgggacgccttcaag agcagagctggggcctccaatactgagaaggtgccgggcatcaaccccagcttcgtgttc ctgcagctctaccactctcctttctttggcgacgagtccaacaagccgatccttctgcct aacgaggtatgttccttcgagcggtcggtgcagctcctcgaccagatcccatcctacgac acgcacaagatcgcggtcctgtacgtgggagaaggccagagcagcagcgagctcgccatc ctgtccaacgagcacggctcgtaccggtacacagagttcctgacgggcctgggcaagctc atcgagctcaaggactgccagccggataaggtgtacctgggcggtctggacgtgtgcggg gaggacggccagttcacctactgctggcacgatgacatcatgcagggtatgcgccttccg ccgggccagttcaacttcgtccacgtgatcatcacccccctggactacgagtgcaacctg gtgtcgctgcagtgcaggaaggacatggagggcctcgtggacaccagcgtggccaagatc gtgtctgatcgcaacctgcccttcgtggcccgtcagatggctctgcacgccaacatggcc tcccaggtgcaccatagccgctccaaccccacggatatctacccgtccaagtggatcgcc aggctccgtcacatcaagcggctgcgccaccggatccgtgaggaagcccactactccaac cccagcctgccgctgacgcagacgcaccctccgggccacgccaaggccccggccccggcc gagcccatgcccacgtacgagacgggccagcggaagcgcctcatctcctctgtggatgac ttcaccgagttcgtgtga

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