Puma concolor (puma): 112854192 Help Entry 112854192         CDS       T08890                                  Symbol TOP2A Name (RefSeq) DNA topoisomerase 2-alpha   KO K03164   DNA topoisomerase II [EC:5.6.2.2] Organism pcoo  Puma concolor (puma) Pathway pcoo01524   Platinum drug resistance Brite KEGG Orthology (KO) [BR:pcoo00001]  09160 Human Diseases   09176 Drug resistance: antineoplastic    01524 Platinum drug resistance     112854192 (TOP2A)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03032 DNA replication proteins [BR:pcoo03032]     112854192 (TOP2A)    03036 Chromosome and associated proteins [BR:pcoo03036]     112854192 (TOP2A) Enzymes [BR:pcoo01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.2  DNA topoisomerase (ATP-hydrolysing)      112854192 (TOP2A) DNA replication proteins [BR:pcoo03032]  Eukaryotic type   DNA Topoisomerases    112854192 (TOP2A) Chromosome and associated proteins [BR:pcoo03036]  Eukaryotic type   Chromosome condensation proteins    Other regulators of chromosome condensation     112854192 (TOP2A)   Centrosome formation proteins    Centriole proteins     112854192 (TOP2A) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  DNA_topoisoIV TOPRIM_C DNA_gyraseB DTHCT HATPase_c Toprim Microp_apicomplexa_20 Motif Other DBs NCBI-GeneID:  112854192 NCBI-ProteinID:  XP_025773442 UniProt:  A0A6P6HCI9 LinkDB All DBs Position Unknown AA seq 1534 aa AA seqDB search MEVSPLQPVNENMLINKTKKNEDAKKRLSIERIYQKKTQLEHILLRPDTYIGSVELVTQQ MWVYDEDIGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKVDETGNPLKIIHEQVNPRWEVC LTMSEKGFQQISFVNSIATSKGGRHVDYIADQIVTKLVEVVKKKNKGGVAVKAHQVKNHM WIFVNALIENPTFDSQTKENMTLQVKSFGSTCHLSEKFIKAAIGCGIVESILNWVKFKAQ VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSNECTLILTEGDSAKTLAVSGLGVVGRDK YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD RKEWLTHFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSPLARLLFPPKDDHTLKFLYDDNQRVEPEW YIPIIPMVLINGAEGIGTGWSCKIPNFDIREVVNNIRRLMDGEEPLPMLPSYKNFRGTIE ELAPNQYVISGEVAILNSTTIEISELPIRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR GYDSDPVKAWKEAQQKVPDEEENEESDNENEAEKGDSVKDSGPTFNYLLDMPLWYLTKEK KDELCKLRNEKEQELETLKRKSPSDLWKEDLAAFIEELEAVETKEKQEEQIGLPGKGGKA KGKKIQMAEVLPSPCGKRVIPRVTIEMKAEAEKKIKKKIKSENTEGSPQEDGMELEGLKQ RLEKKQKREPGTKTKKQTTLPFKPVKKGKKRNPWSDSESDMSSNESDFDVPPREIEPRRA ATKTKFTVDLDSDDDFSDFDEKTQDEDFVPSDVSPVKTKTSPPVPTNKELKPQKSATSVM DLDSGGAKDSVPPSLDSPAADFSAETEVINPVSKKKVAVKKTAAKSQSSTSTAGAKKRAA PKGTKKEPGLNSDVSQKPDPPKTKNRRKRKPSTSDDSDSNFEKMISKTVTSKKSKGESED FHLDLDSAVAPRAKSGRAKKPIKYLEESDEDDLF NT seq 4605 nt NT seq  +upstreamnt  +downstreamnt atggaggtgtcaccactgcagcctgtaaatgaaaatatgctaatcaacaaaacaaagaaa aatgaagatgccaagaaaagactgtctattgaaaggatctatcaaaagaaaacccaactg gaacatattttgctccgcccagacacctatattggctccgtggaattagtgacccagcaa atgtgggtttacgatgaagatattggcattaactatagggaagtcacctttgtccctggg ttgtacaaaatctttgatgagattctagtcaatgctgcagacaacaaacaaagggaccca aaaatgtcttgtattagagtcacaattgacccggaaaacaatttaattagtatatggaat aatgggaaaggtattcctgttgttgaacacaaagttgagaagatgtatgtcccagctctc atctttggacagctcctaacttctagtaactatgatgatgatgaaaagaaagtaacaggt ggtcgaaatggctatggggccaaattgtgtaacatattcagtaccaaatttactgtggaa acagccagtagagaatacaagaaaatgttcaaacagacatggatggataacatgggaagg gctggtgagatggaactcaagcccttcaatggggaagattatacatgtattaccttccaa cctgatttgtccaagtttaaaatgcaaagcctagacaaagatattgttgcactaatggtc agaagagcatatgatattgccggatccactaaagatgtcaaagtgtttctcaatggaaat aagctgccagtaaaaggattccgtagctatgtagatatgtatttgaaggataaggtagat gaaactggcaatccgttgaaaattatccatgaacaagtaaaccccaggtgggaagtatgc ttaacaatgagtgaaaaaggctttcagcaaattagctttgtcaacagcattgctacttcc aagggtggcagacatgttgattatatagctgatcagattgtgactaaacttgttgaggtt gttaaaaagaagaacaagggtggtgttgcagtaaaagcacatcaggtgaaaaatcacatg tggatttttgtgaatgccttaattgaaaacccaacctttgattctcagacaaaagagaac atgactttacaagtcaagagctttggatcaacctgccatttaagtgaaaaattcatcaaa gctgcaattggttgtggtattgtagaaagcatactaaactgggtgaagtttaaggcccaa gtccagttaaacaagaagtgttcagctgtaaaacataacaggatcaagggaattcccaaa ctcgatgatgccaatgatgcagggggtcgaaactccaatgagtgtacacttatcctgact gagggagactcagctaaaactttggctgtttcgggccttggtgtggttgggagagacaaa tatggggttttcccgcttagaggaaaaatactcaatgttcgagaagcttctcataaacag atcatggaaaatgctgaaattaacaatatcatcaagattgtgggtcttcagtacaagaaa aactatgaagatgaagattcattgaagactcttcgttatgggaagataatgattatgaca gatcaggaccaagatggttcccatatcaaaggcttgctgattaattttatccatcacaac tggccctctcttctgcgacaccgttttctggaagaatttatcactcctattgtaaaggtg tctaaaaacaagcaagaaatggcattctatagccttcctgaatttgaagaatggaagagt tctacaccaaatcataaaaaatggaaagtcaagtactacaaaggtttgggcacgagcaca tcaaaagaggctaaggaatactttgcagatatgaaaagacatcgtattcaattcaaatat tccggtcctgaagatgatgccgccatcagcctggcctttagcaagaaacagatagatgat cgaaaggaatggttaactcatttcatggaggacagaaggcaacggaagttacttggcctt cctgaggattacttgtatgggcaaactaccacatatctgacatacaatgacttcataaac aaggaacttatcctgttctcaaattctgataacgagagatctattccatctatggtggat ggtttgaaaccaggtcaaagaaaggttttgtttacctgtttcaaacggaatgacaagcga gaggtgaaggttgctcagttagctgggtcagtggctgagatgtcctcttatcatcatggt gagatgtcactaatgatgaccattatcaatttggctcagaattttgtgggtagcaataat ctgaacctcttgcaacccattggtcagtttggtaccaggctgcatggtggtaaggattct gctagtcctcgatacatcttcacaatgctcagccctttggctcggttgttatttccacca aaagatgatcatacattaaagtttttatatgatgacaatcaacgtgttgaacctgaatgg tacattcctattatacccatggtgctgataaatggtgctgaaggaatcggtactgggtgg tcctgcaaaatcccgaactttgatattcgtgaagttgtaaataatatcaggcgtctgatg gatggagaagaacctttgccaatgcttccgagttacaagaacttcaggggtacgattgaa gagctggctccaaatcaatatgtgattagtggtgaagtggctattcttaattccacaacc attgaaatctcagaacttcccatcagaacatggacccagacatataaagaacaggttcta gaacccatgttgaatggcactgagaagacaccacctctcataaccgattatagggaatac catacagacaccactgtgaagtttgttgtgaagatgactgaagagaaattggcagaggca gagagagtgggactgcacaaagtcttcaaactccaaactagtctcacatgcaactctatg gtgctttttgaccatgtaggatgtttaaagaaatatgacacagtgttggatattctaaga gacttctttgaactcaggcttaaatattatggattaagaaaagaatggctactaggaatg cttggtgctgaatctgctaaactgaacaatcaggctcgctttatcttagagaaaatagat ggcaaaataatcattgaaaataagccaaagaaggaattaattaaagttctgattcagagg ggttatgattctgatcctgtgaaggcttggaaagaagcccagcaaaaggtaccagatgaa gaagaaaatgaagagagtgacaatgaaaatgaagctgaaaagggtgactctgtaaaagat tctggaccaaccttcaactaccttcttgatatgcctctttggtatctcaccaaggaaaag aaggatgaactgtgcaagctgagaaatgaaaaagaacaagagctagaaacattaaagaga aagagtccatcagatttgtggaaagaagacctagctgcttttattgaagagctggaggct gttgaaacaaaggaaaaacaagaagaacaaataggactccctgggaaaggggggaaagca aaggggaaaaaaatacagatggctgaagttttgccttctccatgtgggaaaagagtcatc ccccgagtgaccatagagatgaaagcagaggcagaaaagaaaattaaaaagaaaattaag agtgaaaacactgaagggagccctcaagaggatggtatggaactagaaggtctgaaacaa aggttggagaagaaacagaaaagagaaccaggtaccaagacaaagaagcaaactacgttg ccatttaaaccagtcaaaaaaggaaagaagagaaacccctggtctgattcagaatcagat atgagcagtaatgaaagtgactttgatgttcccccacgagagatagagccacggagagca gcaacaaaaaccaaatttacagtggatttggattcagatgatgatttctcagattttgat gaaaaaactcaagatgaggattttgtcccatcagatgttagcccagttaagaccaaaact tccccaccagtacctactaacaaagaactgaagccacagaagagtgccacatcagtaatg gaccttgattctggtggtgccaaggacagtgtaccaccttctctagattctccggctgct gatttctcagctgaaactgaagtcataaaccctgtttctaaaaagaaggtagcggtgaag aagacagcagcaaaaagtcagtcttccacctccactgcaggtgccaaaaaaagggctgca ccaaaaggaaccaaaaaggagccaggcttgaattctgatgtctctcaaaagcctgatcct cccaaaaccaaaaatcgccgcaaaaggaaaccatccacttctgatgattctgactctaat tttgagaaaatgatttctaagacagtcacaagcaagaaatccaagggggagagtgaggat ttccatctggacttagactcagctgtggctcctcgggccaaatctggacgggcaaagaaa cctataaagtacctcgaagaatcagatgaagatgatctgttctaa

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