KEGG   Puma concolor (puma): 112855545
Entry
112855545         CDS       T08890                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
pcoo  Puma concolor (puma)
Pathway
pcoo01521  EGFR tyrosine kinase inhibitor resistance
pcoo01522  Endocrine resistance
pcoo04010  MAPK signaling pathway
pcoo04012  ErbB signaling pathway
pcoo04014  Ras signaling pathway
pcoo04015  Rap1 signaling pathway
pcoo04022  cGMP-PKG signaling pathway
pcoo04024  cAMP signaling pathway
pcoo04062  Chemokine signaling pathway
pcoo04066  HIF-1 signaling pathway
pcoo04068  FoxO signaling pathway
pcoo04071  Sphingolipid signaling pathway
pcoo04072  Phospholipase D signaling pathway
pcoo04114  Oocyte meiosis
pcoo04140  Autophagy - animal
pcoo04148  Efferocytosis
pcoo04150  mTOR signaling pathway
pcoo04151  PI3K-Akt signaling pathway
pcoo04210  Apoptosis
pcoo04218  Cellular senescence
pcoo04270  Vascular smooth muscle contraction
pcoo04370  VEGF signaling pathway
pcoo04371  Apelin signaling pathway
pcoo04380  Osteoclast differentiation
pcoo04510  Focal adhesion
pcoo04540  Gap junction
pcoo04550  Signaling pathways regulating pluripotency of stem cells
pcoo04613  Neutrophil extracellular trap formation
pcoo04620  Toll-like receptor signaling pathway
pcoo04650  Natural killer cell mediated cytotoxicity
pcoo04660  T cell receptor signaling pathway
pcoo04662  B cell receptor signaling pathway
pcoo04664  Fc epsilon RI signaling pathway
pcoo04666  Fc gamma R-mediated phagocytosis
pcoo04668  TNF signaling pathway
pcoo04720  Long-term potentiation
pcoo04722  Neurotrophin signaling pathway
pcoo04725  Cholinergic synapse
pcoo04726  Serotonergic synapse
pcoo04730  Long-term depression
pcoo04810  Regulation of actin cytoskeleton
pcoo04910  Insulin signaling pathway
pcoo04912  GnRH signaling pathway
pcoo04914  Progesterone-mediated oocyte maturation
pcoo04915  Estrogen signaling pathway
pcoo04916  Melanogenesis
pcoo04917  Prolactin signaling pathway
pcoo04919  Thyroid hormone signaling pathway
pcoo04921  Oxytocin signaling pathway
pcoo04926  Relaxin signaling pathway
pcoo04928  Parathyroid hormone synthesis, secretion and action
pcoo04929  GnRH secretion
pcoo04934  Cushing syndrome
pcoo04935  Growth hormone synthesis, secretion and action
pcoo05010  Alzheimer disease
pcoo05022  Pathways of neurodegeneration - multiple diseases
pcoo05034  Alcoholism
pcoo05132  Salmonella infection
pcoo05135  Yersinia infection
pcoo05160  Hepatitis C
pcoo05161  Hepatitis B
pcoo05163  Human cytomegalovirus infection
pcoo05164  Influenza A
pcoo05165  Human papillomavirus infection
pcoo05166  Human T-cell leukemia virus 1 infection
pcoo05167  Kaposi sarcoma-associated herpesvirus infection
pcoo05170  Human immunodeficiency virus 1 infection
pcoo05200  Pathways in cancer
pcoo05205  Proteoglycans in cancer
pcoo05206  MicroRNAs in cancer
pcoo05207  Chemical carcinogenesis - receptor activation
pcoo05208  Chemical carcinogenesis - reactive oxygen species
pcoo05210  Colorectal cancer
pcoo05211  Renal cell carcinoma
pcoo05212  Pancreatic cancer
pcoo05213  Endometrial cancer
pcoo05214  Glioma
pcoo05215  Prostate cancer
pcoo05216  Thyroid cancer
pcoo05218  Melanoma
pcoo05219  Bladder cancer
pcoo05220  Chronic myeloid leukemia
pcoo05221  Acute myeloid leukemia
pcoo05223  Non-small cell lung cancer
pcoo05224  Breast cancer
pcoo05225  Hepatocellular carcinoma
pcoo05226  Gastric cancer
pcoo05230  Central carbon metabolism in cancer
pcoo05231  Choline metabolism in cancer
pcoo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pcoo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112855545 (MAP2K1)
   04012 ErbB signaling pathway
    112855545 (MAP2K1)
   04014 Ras signaling pathway
    112855545 (MAP2K1)
   04015 Rap1 signaling pathway
    112855545 (MAP2K1)
   04370 VEGF signaling pathway
    112855545 (MAP2K1)
   04371 Apelin signaling pathway
    112855545 (MAP2K1)
   04668 TNF signaling pathway
    112855545 (MAP2K1)
   04066 HIF-1 signaling pathway
    112855545 (MAP2K1)
   04068 FoxO signaling pathway
    112855545 (MAP2K1)
   04072 Phospholipase D signaling pathway
    112855545 (MAP2K1)
   04071 Sphingolipid signaling pathway
    112855545 (MAP2K1)
   04024 cAMP signaling pathway
    112855545 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    112855545 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    112855545 (MAP2K1)
   04150 mTOR signaling pathway
    112855545 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112855545 (MAP2K1)
   04148 Efferocytosis
    112855545 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    112855545 (MAP2K1)
   04210 Apoptosis
    112855545 (MAP2K1)
   04218 Cellular senescence
    112855545 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112855545 (MAP2K1)
   04540 Gap junction
    112855545 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    112855545 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112855545 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    112855545 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    112855545 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    112855545 (MAP2K1)
   04660 T cell receptor signaling pathway
    112855545 (MAP2K1)
   04662 B cell receptor signaling pathway
    112855545 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    112855545 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    112855545 (MAP2K1)
   04062 Chemokine signaling pathway
    112855545 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112855545 (MAP2K1)
   04929 GnRH secretion
    112855545 (MAP2K1)
   04912 GnRH signaling pathway
    112855545 (MAP2K1)
   04915 Estrogen signaling pathway
    112855545 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    112855545 (MAP2K1)
   04917 Prolactin signaling pathway
    112855545 (MAP2K1)
   04921 Oxytocin signaling pathway
    112855545 (MAP2K1)
   04926 Relaxin signaling pathway
    112855545 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    112855545 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    112855545 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    112855545 (MAP2K1)
   04916 Melanogenesis
    112855545 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    112855545 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    112855545 (MAP2K1)
   04726 Serotonergic synapse
    112855545 (MAP2K1)
   04720 Long-term potentiation
    112855545 (MAP2K1)
   04730 Long-term depression
    112855545 (MAP2K1)
   04722 Neurotrophin signaling pathway
    112855545 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    112855545 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112855545 (MAP2K1)
   05206 MicroRNAs in cancer
    112855545 (MAP2K1)
   05205 Proteoglycans in cancer
    112855545 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    112855545 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    112855545 (MAP2K1)
   05230 Central carbon metabolism in cancer
    112855545 (MAP2K1)
   05231 Choline metabolism in cancer
    112855545 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112855545 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112855545 (MAP2K1)
   05212 Pancreatic cancer
    112855545 (MAP2K1)
   05225 Hepatocellular carcinoma
    112855545 (MAP2K1)
   05226 Gastric cancer
    112855545 (MAP2K1)
   05214 Glioma
    112855545 (MAP2K1)
   05216 Thyroid cancer
    112855545 (MAP2K1)
   05221 Acute myeloid leukemia
    112855545 (MAP2K1)
   05220 Chronic myeloid leukemia
    112855545 (MAP2K1)
   05218 Melanoma
    112855545 (MAP2K1)
   05211 Renal cell carcinoma
    112855545 (MAP2K1)
   05219 Bladder cancer
    112855545 (MAP2K1)
   05215 Prostate cancer
    112855545 (MAP2K1)
   05213 Endometrial cancer
    112855545 (MAP2K1)
   05224 Breast cancer
    112855545 (MAP2K1)
   05223 Non-small cell lung cancer
    112855545 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    112855545 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    112855545 (MAP2K1)
   05161 Hepatitis B
    112855545 (MAP2K1)
   05160 Hepatitis C
    112855545 (MAP2K1)
   05164 Influenza A
    112855545 (MAP2K1)
   05163 Human cytomegalovirus infection
    112855545 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112855545 (MAP2K1)
   05165 Human papillomavirus infection
    112855545 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112855545 (MAP2K1)
   05135 Yersinia infection
    112855545 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112855545 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    112855545 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    112855545 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    112855545 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112855545 (MAP2K1)
   01522 Endocrine resistance
    112855545 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcoo01001]
    112855545 (MAP2K1)
Enzymes [BR:pcoo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     112855545 (MAP2K1)
Protein kinases [BR:pcoo01001]
 Serine/threonine kinases: STE group
  STE7 family
   112855545 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_fungal ABC1 Kinase-like Seadorna_VP7 Haspin_kinase
Other DBs
NCBI-GeneID: 112855545
NCBI-ProteinID: XP_025774975
UniProt: A0A6P6HGQ8
LinkDB
Position
Unknown
AA seq 292 aa
MPKKKPTPIQLNPAPDGSAVNGTSSADSLIFSKSSSFNSPTFCFWDGGSLDQVLKKAGRI
PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN
SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG
DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC
LIKNPAERADLKQLMVHAFIKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 879 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggactcactgatcttctcgaagtcgtcatccttcaattccccg
accttctgcttctgggatgggggttccttggatcaagtcctgaagaaagctggaagaatt
cctgaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctgagg
gagaagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactctcgt
ggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggccaac
tccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattactcc
gtgcagtcggacatctggagcatggggctatctctggttgagatggcagtcgggaggtat
cccatccctcctcccgatgccaaggagctggagctgatgtttgggtgccaagtggaggga
gatgcggctgagacgccacccaggccgaggacccctggaaggcccctcagctcgtatgga
atggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgagcct
cctcccaagctgcccagtggagtattcagtctggaatttcaagattttgtgaataaatgc
ctcataaaaaacccagcagagagagcagatctgaaacaactcatggttcatgcctttatc
aagagatctgatggtgaggaagtggattttgcaggttggctctgctccaccatcggcctt
aaccagcccagtacaccgacccacgcggccggcgtctaa

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