Puma concolor (puma): 112857938 Help Entry 112857938         CDS       T08890                                  Symbol HMCN1 Name (RefSeq) hemicentin-1   KO K17341   hemicentin Organism pcoo  Puma concolor (puma) Brite KEGG Orthology (KO) [BR:pcoo00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04990 Domain-containing proteins not elsewhere classified [BR:pcoo04990]     112857938 (HMCN1) Domain-containing proteins not elsewhere classified [BR:pcoo04990]  EGF-like domain-containing proteins   hEGF / cEGF domain-containing proteins    112857938 (HMCN1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  I-set Ig_3 Ig_2 ig V-set C2-set_2 TSP_1 EGF_CA G2F V-set_CD47 C2-set_3 cEGF TSP1_spondin VWA_4 Receptor_2B4 GBD_Hemicentin TSP1_CFP_C FXa_inhibition EGF_3 TSP1_ADAMTS EGF TSP1_CCN Fibulin_C DRL_cat hEGF Motif Other DBs NCBI-GeneID:  112857938 NCBI-ProteinID:  XP_025777066 UniProt:  A0A6P6HNU1 LinkDB All DBs Position Unknown AA seq 5547 aa AA seqDB search MEIGPVTITTDPKKFQYELRELYVQGGGDCPEMSIGAIKIALEISLPGSFIYVFTDARSK DYRLTHEVLQLIQQKQSQVVFVLTGDCDDRGHIGYKVYEEIASTSSGQVFHLDKKQVNEV LKWVEEAVQSSKVHLLSTDHLEQAVNTWKIPFDPSLKEVTVSLSGPSPGIEIRNPLGKLI KKGFGLNELLNIHNSAKVVNVKEPEAGMWTVKTSSSGRHSVRITGLSTIDFRAGFSRKPT LDFKKTVSRPVQGIPTYVLLNTSGISIPAKVDRLELLSISGSSLKTIPVKYYPDRKPYGL WNISDFIPPNEAFFLRVTGYDKDDYLFQRVSSVSFSSIIPDAPKVTMPMKTPGYYLQPGH ISCSVESLLPFTLSFVRNGVTLGVDQYLRESASVNWEIEKVTLSDEGAYECIAVSSAGTG RAQTFFDVSEPPPVIQVPDNVTVTPGERAVLTCLVISAVDYNVTWQRNDRDVRLADPARM RILANLSLELRSVKFSDAGEYHCVVSNEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSE VSIMCSATGFPKPKITWTINDMFIMGSHRYRMTSEGTLFIKNAVPKDAGIYGCLASNAAG TDKQTSTLRYIEAPKLIVVQSELLVALGDTTVMECKTSGIPPPRVKWFKGDLELRPSTFL IIDPLLGLLKIQETQDLDAGDYMCVAVNDAGRAAGKITLDVGSPPVFIQEPADVSMEIGS NVTLPCYVQGYPEPKIKWRRSDNMPIFSRPFSVSSISQLRTGALFISNLWANDKGTYICE AENQFGKIQSQTTVTVTGLVAPLIGISPSVTSVIEGQQLTLPCALLAGNPIPERRWIKNS AMLVQNPYITVRSDGSLHIERVRLQDGGRYTCVASNVAGTINKTTTVDVHVLPTIQHGRQ VLSTIEGIPVTLPCKASGNPKPSIIWSKKGELISTSSAKFSSGADGSLYVVSPGGEESGE YICTATNAAGYAKRKVQLTVYVRPRVIGDQRGLSQDEPAEISALAGEDVTLPCEVKSLPP PIITWAKETQLISPFSPRHTFLPSGSMKIIETRVSDSGMYLCVATNIAGNVTQSVKLNVH VPPKIQRGPKLIKVQVGQRVDIPCNAQGTPLPVITWFKGGSAMLVDGGQHISSSDGTLSI NQAMLSDAGIYTCVATNIAGSDESEITLHVQEPPTLEDLEPPYNTPFQERVANQRIAFPC PAKGTPKPTIKWIWNGRELTGREPGISILEDGALLVIASVTPFDSGEYICVAVNEAGTTE KKYNLKVHVPPVIKDKEQVTNVSVLVNHLANLFCEVEGTPSPVIMWYKDDVQVTESSSIQ ITNNGKILKLFRATPEDAGRYSCKAVNIAGTSQKYFNIDVLVPPTIIGASSPNEVSVVLN HDTTLECQVKGTPFPVIHWFKDGKPLYLGDPNIELLDRGQVLHLKNARRSDKGRYQCAVS NAAGKQAKDIKLTVYIPPSIKGGNVTTEIAALINSIIKLECETRGLPMPAITWYKDGQPV ISGSQALYIDKGRFLHIPRAQVSDSATYTCHVTNVAGTAEKSFHVDVYVPPMIEGDLAVP LSKQVIIAHSLTLECKATGNPPPVLTWLKDGVPVKTSDNVRTEDGGKKLEILSTLEADRG QYVCVATSVAGEKEIKYEVDVLVPPAIDGGDETSYFIVMVNNLLELDCQVTGSPTPTIMW LKDGQLIDEKDGFRILLNGRKLVIAQAQVSDTGLYRCVATNIAGDHKKEFEVTVHVPPTI KSPDLSERAIVKYKPITLQCIANGIPNPSITWLKDGQPVNTAQGNLKIQSSGRVLQIARA LMEDAGRYTCVATNAAGEAQQHLQLHVHEPPSLEDAGKMLNETVVLNNPIQLECKAAGNP LPAITWYKDNRPLSGSTSVTFLNRGQIIDIESAQIADAGIYKCVAINSAGATELFYSLQV HVAPSISGSSNMVAVVVNNLVRLECEARGIPAPSLTWLKDGSPVSSFTNGIQVLSGGRIL ALTSAQISDTGRYTCVAVNAAGEKHRDIDLRVYVPPNIMGEEQNISVLISQAVELLCQSD AIPPPTLTWLKDGRPLLKKPGLSISENGSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYN VNIWVPPNIYGSDELAQLTVIEGHLISLLCESSGIPPPNLIWKKKGSPVLADSAGRVRTL SGGRQLQISIAEKSDAGLYSCVASNVAGTAKKDYSLQVYIRPTISNSGSHPTEIIVTRGK SISLECEVQGIPQPKVTWMKDGRPLTKGRGMEILDEGRILQLKNIHISDTGRYMCVAVNV AGMADRKYDLSVHTPPSIIGNHGKPENISVVEKNSVSLTCEASGIPLPSITWLKDGWPVS LSSSVRILSGGRTLRLMQTRIEDAGQYTCVVRNAAGEERRIFGLSVLVPPRIVGENTLED MKVKEKQSVTLTCEVTGNPVPEITWHKDGQLLQEDDTYHVMSGGRFLKITKAQVSHTGRY ACLASNTAGDKSKSFSLNVLVSPTIAGIDSDGGPEDVTVILNSPTSLVCEAYSYPPATIT WFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCIATNEAGEMIKHYEVKVYIPPI INKGDLLGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVTIAANGH TLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDAGRSGEAKD VIINNPISLYCETNAAPPPTLTWYKDGRPLTSNDRVLILPGGRVLQIPRAKVEDAGRYTC VAVNEAGEDSLQYDVRVLLPPIIKGASSDLPEEVTVLVNKKTLMECLSSGSPTPKNSWQK DGQPLLENGHHKFLSNGRILQILNTQITDIGRYVCIAENRAGSAKQYFNLNVHVPPSVIG PNPENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNALIVPGGRTLQIIRAKVS DGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHGSESLSVVNVREGTSVSLECESNAVPP PVITWYKNGQMITESTRLEILADGQMLQIKEAEVSDTGQYVCRAINVAGRDDKNFHLNVY VPPSIEGPENEVVVETISNPVTLTCDATGIPPPTIAWLKNHKPIENSDSLEVHILSGGSK LQIARSQHSDSGNYTCIASNMEGKAQKNYILSIQVPPSIAGAEIASEVSVLLGENVELTC MASGIPTPLIQWLRDGKPINSSETERIRVTADGSTLNIYGALPSNVGKYTCVATNPAGEE DRIFNLNVYVPPAIRGNKEEAEKLMALVDTSINIECRATGTPLPQINWLKNGLPLPLSSH IRLLSGGQVIRIVRAQVSDVAEYTCVASNRAGVDNKHYSLQVFVPPNLDNAMGTEEITVV KGSSASMTCFTDGTPTPRMSWLRDGQPLGLNTRLTVSTQGMVLQLIKAETEDSGRYICIA SNEAGEVSKHFNLKVLEPPHINGSEEPVEISVIVNNPLELNCFASGIPTPKITWMKDGRP LPQTEQIQTLGGGEVLQISSAQVEDTGRYTCLASSTAGDDDKEYLVRVHVPPNIAGTDES QDFTVLRNRQVTLECKSDAVPPPIITWLKNGDRLQASPRVRILSGGRYLQINNADLSDTA NYTCVASNVAGKTTREFILTVNVPPNIKSGPQSLVVHVNRSTVLECLAGGVPTPRVTWRK DGAVLSAGHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAL GPTNITVTVNVQITLACEATGRPKPSIRWKKNGHLLNVDQNQNSYRLLSSGSLVIISPSV DDTATYECTVTNDAGEDKRTVDLTVQVPPSIADEPTDFLVTKHAPTVITCTASGVPFPSI HWTKNGIRLLPRGDGYRILSSGAIEMSATQFTHAGRYTCVARNAAGSAHRHVTLRVQEPP VIQPQPSELDVIVNNPILLPCEATGTPSPFITWQKEGINVIASGKSHAVLPSGGLQISRA VREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHPKEYTTAVDKPISLPCEADGLPPP DITWHKDGHAVMESVRQRILSSGALQIAFAQPDDAGQYTCMAANVAGSSSTSAKLTVHVP PRIRSTEVHYMVNENSQAILPCVADGIPTPAINWKKDDVLLTNLLGKYTLEPYGELILEN VVPEDSGTYTCVANNAAGEDTHMVSVTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPL PKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEP PVFKGDYPSNWIEPLGGNAVLNCEVKGDPAPTIQWSRKGVDIEINHRIRQLLNGSLAIYG TVNEDAGDYTCVATNDAGAVERSMSLTLQSPPIITLEPVETVIHAGGKVILNCQATGEPH PTITWSRQGHSIPWDDRVNMLSNNSLHIAAAQKEDTSEYECVARNLMGSVLVRVPVTVQV HGGYSQWSTWRSCSVTCGKGIQKRSRLCNNPFPANGGKPCQGSDSEIRNCQRKLCPVDGS WSEWSPWEECTRSCGRGNRTRTRTCSNPSAQYGGRPCEGNAVEIIMCNIRPCPVHGAWGT WQPWSACSESCGKGAQIRTRLCNNPPPSFDGSYCDGAETQMQICNERPCPVDGKWTTWAS WSACTVSCGGGARQRTRECSDPVPQHGGSRCEGSDVQSDFCNNDPCPTHGNWSPWSGWGI CSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHSWGQCSA SCGGGEKTRKRLCNNPVPSKSGRPCPGDTTQVSRCNMQTCPGGPQRARGSVIGNINDVEF GIAFLNATVTDNPTSDTRVIRAKITNVPRSLGPAMRKIVSILNPIYWTTAKEIGEAVNGF TLTNAVFKRETQVEFATGEILRMTHIARGLDSDGALLLDIFVSGYVLQLQSPAEVTVKDY TEDYIQTGPGQLYAYSTRLFTIDGISVPYTWNHTVFYDEAQGRMPFLVETLHASSVESDY NQLEETLGFKIHASISKGDRSNQCPSGFALDSVGPFCADEDECAAGNPCSHICHNTVGTY HCSCSKGLTIAADGRTCQDIDECALGGHACHAGQDCDNTIGSYRCVVHCGIGFRRTSDGL SCQDINECQESSPCHHRCFNAIGSFHCGCEPGYQLKGRKCIDVNECRQNVCRPDQHCKNT RGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGFRSQG VGRPCMDINECEQVPKPCAYQCSNTPGSFKCICPTGQHLLGDGKSCAGLERLPNYGTQYN SYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASRD TCVDIDECENRDTCQHECKNTFGSYQCICPPGYQLTLNGKTCQDVDECLEQSVRCGPNRM CFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALDYKLVSLPFGIAAN QDLIRLVAYTQDGVMHPRTTFLMVDVEQTVPFALRDENLKGVVYTTRPLREPETYRMRVR ASSYSANGTIEYQTTFIVYIAVSAYPY NT seq 16644 nt NT seq  +upstreamnt  +downstreamnt atggaaattggcccagtgacaattaccacagatcccaagaaatttcaatatgaactcaga gaattgtatgttcagggtggtggtgattgtccagaaatgagtattggagctataaaaatt gccttggaaatttctcttccggggtctttcatctatgttttcactgatgcacggtccaag gattatcggctcactcatgaggtgctacagcttatccaacagaaacagtcacaagttgta tttgtgctcactggagactgtgatgacaggggccatattggatataaagtctatgaagaa attgcctctacaagttctggtcaagtgttccatctggacaaaaaacaagttaatgaggtg ttaaaatgggtagaggaagcagtgcagtcctctaaagttcacctgttatcaacagatcat ttggaacaagctgtaaacacttggaaaattccttttgatcccagcctaaaagaggttact gtgtctctgagtggcccttctccagggattgaaattcgcaatcctttagggaagctgata aaaaaaggatttggcctgaatgagctattaaatatccataactctgccaaggtggtgaat gttaaagagccagaggctggaatgtggacagtgaagacttctagcagtggaaggcactct gttcgcatcaccggccttagtacgattgatttcagagctggtttttcccgaaagcccacc ctggatttcaaaaaaacagtcagcagaccagtgcaaggaattcctacttatgtgctgctg aatacttctggaatttccatcccagccaaagtagatcgtcttgaacttctgagtatctca ggcagttctctgaagactatccctgttaaatattaccctgaccgaaaaccttatggcttg tggaatatttctgactttataccaccaaatgaagccttctttctcagagtcacaggctat gataaggatgattatctctttcagagggtttcaagtgtttccttctctagtatcatccca gatgctcccaaagttacaatgcccatgaaaaccccgggatactacttgcagccaggccac atttcctgctctgttgagagtcttttaccctttaccttgagctttgtcagaaatggagtt acacttggagtagaccagtatttaagggaatctgccagtgtgaactgggagattgaaaag gtcactttgtctgatgaaggtgcctatgagtgcatcgctgtcagcagtgcggggactgga cgggcacagacattttttgatgtgtcagagccccctccagtcatccaagtgcctgataat gtcacagtcactcctggagaaagagcagttttgacatgtctcgtcatcagcgcggtggat tacaatgtaacctggcagaggaatgacagagatgtcagactggcagacccagcaaggatg aggatcctggccaacctctcattggagctaaggagtgtgaaattcagtgatgctggggag tatcattgtgtagtctccaatgaaggaggatcatcagctgcttcggttttcctcacggtg caagaaccacccaaagtcactgtgatgcccaagaatcaatcattcacaggaggatctgag gtctctatcatgtgttctgcaacaggttttcccaaaccaaagatcacctggaccattaat gatatgtttatcatgggttcacacaggtataggatgacctcagaaggtaccttatttatc aaaaatgcagttcccaaagatgcagggatttatggttgcctggcaagtaatgcagctgga acagacaaacagacttctacccttagatatattgaagccccgaagttgatcgtagttcag agcgagctcttggttgctcttggggatacaacagttatggaatgtaaaacttctggtatt cctccacctcgagttaagtggttcaaaggggatcttgagctgaggccctcaacattcctc attattgaccctctcttgggacttttgaagattcaagaaactcaagacctggatgctggt gattatatgtgtgtagctgtcaatgatgctggaagagcagctggcaagataactctggat gttggctcacctccagttttcatacaagaacctgctgatgtgtctatggaaattggctca aatgtgacactaccttgctatgtccagggttatccagaaccaaagattaaatggcgtagg tcagacaacatgccaatcttctcaagacccttttcagtgagttccatcagccaactaaga acaggagctctctttatttcaaacttatgggcaaatgataaaggaacctatatttgtgag gcagaaaaccagtttggaaagatccagtcccagacaacagtaacagtgacaggacttgtt gctccactcattggaatcagcccttcggtgaccagcgtcattgaaggacagcagcttact ttgccttgtgctctgttggctggaaatcccattccagaacgtcggtggattaagaattca gccatgttggtccaaaatccttacatcactgtacgcagtgacgggagtctccacattgag agagttcgccttcaggatggaggcagatatacttgtgtggccagtaatgttgctggaacc attaataaaactaccaccgtggatgtgcatgttctgccaaccattcagcatgggcggcag gtactcagcacaattgaaggcattccagtaactttgccgtgcaaagcaagtggaaatccc aagccatctatcatttggtccaagaaaggagagttgatttccaccagcagcgctaagttt tcctcaggggctgatggaagtttgtatgtggtgtcccccgggggtgaagagagcggggag tatatctgcaccgctaccaatgcagctggctatgccaagaggaaagtgcagctgaccgtc tatgtaaggcccagagtgattggagaccaacgaggactgtcccaggatgagcctgctgag atttccgccctcgcaggagaagacgtgacacttccatgtgaagtgaagagcttaccccca cccatcatcacctgggccaaagagacgcagctcatctccccattctctccaaggcacaca ttccttccttctggttcaatgaagatcattgagacccgtgtttcagatagtgggatgtat ctttgcgttgccacaaatattgctgggaatgtgactcagtctgttaaattaaatgtccat gttcctccaaagatacagcgtggccctaaactaatcaaagtccaagttggtcaaagagtg gacattccgtgcaatgctcaagggacacctcttcctgtaatcacctggtttaaaggtgga agtgccatgctggttgatggagggcagcatattagcagttcagatggaactttaagcatc aaccaagccatgctctctgacgccggcatatatacatgtgttgctactaacatagcaggc agtgatgaatcggaaataaccctacatgtccaagaaccacctacactggaagatctagaa cctccatataacactccattccaagaaagagtggccaaccaacgcattgcatttccatgt cctgcaaaaggtacccccaaaccaaccatcaaatggatatggaatggtagagagctgaca ggcagagagcctgggatttctatcttggaagatggtgcattgttggtcattgcttctgtt acaccctttgacagtggggagtacatctgtgtggcagtcaatgaagctggaaccacagaa aaaaaatataacctcaaagtccatgttcctccagtaattaaagataaagaacaagtaaca aatgtatctgtgttggtcaatcacctggccaatctcttttgtgaagttgaaggtactcct tctcctgtcattatgtggtacaaagatgacgtccaggtgactgaaagcagcagtattcag atcacgaacaatggaaagatattaaagctctttagagccactccagaggatgcaggaaga tattcctgcaaagcagttaatattgcaggcacttctcagaagtattttaacatcgatgtg ctagttcctcccaccataataggtgccagctccccaaatgaagtctctgttgtcctcaac catgacaccactctcgaatgccaagtcaaaggcactcccttccccgttattcactggttc aaagatggcaagcctttatatttgggagatcctaatattgaacttctagacagaggacaa gttttacatttaaagaatgcacgaagaagtgacaagggtcgctaccagtgtgctgtatct aatgcagctggcaaacaagccaaggacataaaactcacggtctatataccacctagtatt aaaggagggaatgtcaccacagaaatagcagcactgatcaacagcataattaaactggaa tgtgaaactcggggacttccaatgcctgctattacttggtataaggacggccagccagtc atatccggctcacaagccctttatattgataaaggacgatttcttcatatccctcgagca caggtttctgattcagcaacatacacatgtcatgtcaccaatgttgctggaactgctgaa aaatcattccatgtggatgtctatgttcctccaatgattgaaggtgacttggctgtgcct ctgagtaagcaagtgattattgctcattcactgacactagagtgtaaagctactggcaac cctcctccagttctcacctggttaaaagatggcgtacctgtgaaaaccagtgacaacgtc cgtacagaagatggtgggaagaaactagaaatcttgagtaccctagaagccgaccgggga cagtatgtatgtgtggctaccagtgtggcaggagaaaaggaaatcaaatacgaagttgat gtcttagtgccaccagctatagacggaggagatgagacatcttacttcattgtgatggtt aataacttactggagctagattgtcaagtgacaggctctcccacaccaactatcatgtgg ctaaaggatggccagctaattgatgaaaaggatggattcaggattttgctaaatggacgc aaattggttattgcccaggctcaggtgtcagatacaggcctttatcgctgcgtggcaaca aacattgctggcgaccacaagaaggaatttgaagttactgttcatgtacctccaacaatc aaatccccagatctttctgagagagctatagtgaaatacaagcctatcactttgcagtgc attgccaatggcattccaaatccatctattacgtggttaaaagatggccaacctgtgaac actgcccagggaaatctcaaaatacagtcttccggtcgagttttacaaattgccagagcc ctgatggaagatgctggcagatacacatgtgtggccaccaatgcagccggagaagcacaa cagcaccttcagctacatgtgcatgaaccacctagcctggaggatgcagggaagatgctg aatgagacggtggtgctgaacaaccccattcagttggagtgtaaggcagctggcaacccc ttgcccgctattacatggtacaaagataatcgtccactctcggggtccaccagtgtgact ttcttgaacagaggacagatcattgatattgaaagtgcccagattgctgatgctggtata tataaatgtgtggccatcaactcagctggagctacagagttattttacagtctacaggtc catgtggccccatcgatttctggcagcagtaacatggtggcagtggtggttaataacctg gtgaggttagaatgtgaagccagaggtatccctgccccaagtctgacctggttgaaagat ggtagccctgtctctagtttcactaatgggatacaggttctgtctggaggccgcatccta gcactgaccagtgcacaaatcagtgataccgggagatatacctgcgtggcagtgaatgct gctggggagaaacacagggacattgaccttagagtatatgttccaccaaatattatggga gaagaacagaacatctctgtcctcattagtcaagccgtggagctgctatgtcaaagtgat gctatccccccacctactttgacttggttaaaggatggccgccccttgctgaagaaacca ggcctcagtatctctgaaaatggaagtgtgttaaagattgaagatgctcaagttcaagac actggtcgttacacttgtgaggcaacaaatgttgctggaaaaactgagaaaaactataat gtaaacatttgggtaccaccaaatatttatggttctgatgaacttgctcaacttacagtc attgaagggcatctcattagtttactgtgtgaatcaagtggtattccacccccaaatctc atttggaagaaaaaaggctccccagtgctggctgattctgcagggcgagtcagaacttta tccggaggcagacagttacagatctcaattgctgaaaaatctgatgcagggctatattca tgtgtggcatcgaatgttgctggaactgcaaagaaagactacagtctgcaagtttacatt cgaccaacaatatctaatagtggcagccaccctaccgaaattattgtgactcgagggaag agtatttccttggagtgtgaggtgcagggtattcctcaaccaaaagtgacctggatgaaa gatggccgccccttgaccaagggaaggggaatggaaatattggatgaaggtcgtatcctt cagctgaagaacattcatatatctgatacaggccgttatatgtgtgttgctgtgaatgta gcaggaatggctgacagaaaatacgacttaagtgtacatacccctccaagcatcatagga aaccatgggaaacctgaaaatatcagtgtcgtggaaaagaactcagtgtccctgacttgt gaagcttccggaattcccctgccttcgattacctggcttaaagatgggtggcctgtcagc cttagcagttctgtgagaattctctcaggaggcaggactctgcggttgatgcagaccaga atagaagatgcgggacagtatacttgtgttgtaagaaatgcagctggtgaagaaagaaga atctttgggctttcagtattagtgccacctcgcattgtgggcgaaaatacattggaagac atgaaggtcaaagagaaacagagtgttacactgacttgtgaagtgacagggaacccagtg ccagaaattacatggcacaaagatggacagctcctccaggaagatgacacctatcacgtt atgtctggtggccgctttcttaaaattactaaggctcaagtatcacacactggaagatat gcatgtttggcttctaacacggctggcgacaagagcaaaagtttcagtcttaatgtgttg gtatcccctacaattgctggtattgacagtgatggtggccctgaagatgtcaccgttatc cttaacagccccacatctttggtctgtgaagcttattcatatcctccagccaccatcacc tggtttaaggatggaacacctttagaatccaaccgaaatattcgtattcttccaggaggt aggactctgcagatcctaaatgcacaggaggacaatgctggaagatactcttgtatagcc actaatgaagcaggagaaatgataaagcactatgaagtgaaggtctacattccacccatc atcaataaaggggaccttctggggccaggtctttcccctaaagaagtgaagatcaaagta aacaatacgctgactttggaatgtgaagcttacgcgattccgtctgcctctctcagctgg tacaaggatggacagcctcttaaatcagatgatcatgttactattgctgcaaatggacac acacttcaaataaaggaggctcaaatatcagatactggacgctatacttgtgtagcatct aacattgcaggtgaagatgaactggattttgatgtgaatatacaagttcctccaagtttt cagaaactctgggaaataggaaacatgctggatgctggcaggagtggtgaagccaaggat gtgatcatcaacaatcccatttccctttactgtgaaacaaatgctgctcctcccccaaca ctgacatggtacaaagatggccgccctctgacctccaacgatagagtattgattctacca ggtgggcgagtgttgcagattcctcgagctaaagtagaagatgcagggagatatacatgt gtggctgtgaatgaggccggagaagattcccttcagtatgacgttcgtgtactcttgcca ccgattattaagggagcaagtagtgaccttccggaagaggtcaccgtgctggtgaataag aagacattgatggagtgtttatccagtggcagccccacaccaaagaattcctggcaaaaa gatggacagcccttgctcgaaaatgggcatcataaatttctatctaatggaagaattctt cagattctgaacactcaaataacagatatcggcaggtatgtgtgtattgctgagaacaga gctgggagtgccaaacaatattttaacctcaatgttcacgttcctccaagtgtcatcggt cctaaccctgaaaatctcactgttgtggtgaacaatttcatctctttgacctgtgaggtc tctggttttccacctcctgatctcagctggctcaagaatgaacagcctatcaagctaaat acaaatgctctcattgtgcccggtggtcgaactctgcaaattattcgggccaaggtatct gatggtggtgaatacacttgtattgctatcaaccaagctggtgaaagcaagaaaaaattt tccctgactgtctatgtgcccccaagcattaaagatcatggcagtgaatctctttctgta gttaacgtaagagaggggacctcagtgtcactggagtgtgagtcgaacgccgtgccccct ccagtcatcacctggtataagaatgggcagatgataacagaatccactcgcttggagatt ttagccgatggacaaatgctgcagatcaaggaagctgaggtatctgacacaggccagtat gtatgtagagctataaatgtagcaggacgggatgataaaaatttccacctcaatgtatat gtgccacccagtatcgaagggcctgaaaatgaagtggttgttgagacgatcagcaatcct gtgaccttaacatgtgatgccactggaatcccgcctcccacgatagcctggttgaagaac cacaagcccatcgaaaattctgactcacttgaagtacatattttgtctggaggtagcaaa ctccaaatcgcccggtctcaacattcagatagtggaaactatacatgcattgcatcaaat atggagggaaaagcacagaaaaattacattctttcaattcaagttcctccaagtattgct ggtgctgaaattgcaagtgaagtcagtgttcttctaggggaaaatgttgagctgacctgc atggcaagtggcattcccaccccacttattcaatggcttagagatggaaagcccataaat agcagtgaaacagaaagaatccgggtgactgcagatggcagtacattaaacatttacgga gctctcccatccaatgtggggaaatacacatgcgtcgctactaatcctgctggagaagaa gaccgaatttttaacttgaatgtctacgttccacccgcaattaggggtaataaagaagaa gcagagaaactaatggctttggtggatacttcaataaatattgaatgtagagccacaggg acacctctaccacagatcaactggctaaagaatggacttcctctgcctctctcctcccat atccggttgctctcaggagggcaggttatcaggattgtgagagctcaggtgtctgatgtt gctgagtacacttgtgtggcctccaacagagctggggtggataataaacattatagtctt caagtttttgtgccaccaaatctggacaatgcgatgggaacagaggagatcacagttgtc aagggtagttctgcctccatgacgtgctttacagatggaactccaactcccaggatgtct tggcttagagatgggcagcctctgggtcttaatacccgtctgacagtaagcactcaagga atggttcttcagcttatcaaagcagagactgaagattcaggaaggtacatctgcattgcc tcaaatgaagctggagaagtcagcaaacactttaacctgaaggtcctggaaccacctcat atcaatggatctgaagaacctgtagagatatcagtgattgttaataatccacttgaactt aactgctttgcttctggaattccaactcctaaaattacctggatgaaggatggaaggccc ctcccacagacagaacagatacaaactcttggaggtggagaggtccttcaaatatctagt gcccaggtagaggatacaggaaggtacacatgtctggcatccagtactgcaggagatgat gataaagaatatttagtgagagtgcatgtaccccctaatattgctggaactgatgagtcc caggatttcactgtgttacggaacagacaagtgacattggaatgcaaatcagatgcagtg cccccacctataatcacttggcttaaaaatggagatcggttacaggcaagccctcgggta cgaatcctctctggagggagatacttgcaaattaataatgcagatctaagtgatacagcc aattatacttgtgtggccagcaacgttgcaggaaagactacaagagaatttattctcact gtaaatgttcctccaaacataaagagcggcccccagagtcttgtcgttcacgtaaatagg tcgactgtattggagtgccttgctgggggtgtgccgaccccaagggtaacatggagaaag gatggagctgttctatctgcaggtcacgcaagatactccatcttggaaaatggattcctt catatccagtcagcacatgtcacagacactggacgatatttgtgtatggctaccaatgct gctggaacagaccgcaggcgaatagatttacaggtccatgttcctccatccattgctctg ggtcctaccaacataactgtaacagtaaatgttcaaattactctggcttgtgaggctact gggagaccaaaaccatcaatcaggtggaagaaaaatgggcatcttcttaatgtggatcaa aatcagaattcatacaggctcctttcttcaggttcactagtaattatttccccttctgtg gatgacactgcaacctatgagtgcaccgtgacaaatgatgccggagaggataaaagaact gtggatctcactgtccaagttccaccttccatagctgatgagcctacagacttcctggta accaaacacgccccaacggtgattacttgcactgcttcgggagttccatttccctcaatc cactggacaaaaaatgggataagactacttcccaggggagacggttatagaattctgtca tcaggagcaattgaaatgtctgccactcagttcacccatgctggaagatacacttgtgtt gccaggaatgcagctggttctgcacatcgacacgtgacccttcgtgtccaggagcctcca gtcattcagcctcagccaagtgaactagacgtcattgtaaacaatccaattttattacca tgtgaggcaacagggacacccagtcctttcattacttggcaaaaagaaggcatcaatgtc atcgcttcaggcaaaagtcatgcagttcttcctagtggcggcttgcagatctccagagcc gtcagagaagatgctggcacttacatgtgtgtggctcagaatccagctggtacagcctta ggcaaaatcaaattaaatgttcaagttcctccagtcattagcccccatccaaaggaatat accactgctgtggataaacccatctccctaccatgtgaggcagatggcctcccaccacct gatattacctggcataaagatgggcatgcagttatggaatcagtccgccaacgcatcctc agctctggggccctgcagatagcatttgctcagcctgatgatgctggccagtacacgtgc atggcagctaacgtggcaggatcaagcagcacgagcgccaagctcactgtccatgtacca cctagaatccgaagcacagaagtacactatatggtcaatgagaattcacaagccattctt ccatgcgtggctgatggaatccccacaccagcaatcaactggaaaaaagacgatgttctt ttaactaacttattaggaaagtatactcttgagccctatggagaacttattctggaaaat gttgtgccggaggattctggcacctatacctgtgttgctaacaatgctgcaggtgaagat acgcacatggtcagtgtgacggtgcacgttctccccacttttactgaacttcctggagat gtgtctttaaataaaggagaacagctacgattaagctgtaaagccactgggattccattg cccaagttaacgtggaccttcaataacaatattatcccagcccactttgacagtgttaat ggacacagtgaacttgttattgaaagagtgtcaaaagaggattcgggtacttacgtgtgc accgcagagaacagtgttggttttgtgaaggcaataggatttgtttatgtgaaagaacct ccagtcttcaaaggtgattacccttctaattggattgagccgcttggtggtaatgcagtc ttgaattgtgaagtgaaaggagatcctgcccctaccatccaatggagcagaaaaggagtg gatattgaaattaaccacagaatccgtcaacttctcaatggctccttggccatttatggc actgtaaatgaagatgccggtgattatacgtgcgtagctaccaatgatgctggggcagtg gagcgcagcatgagcctgaccctgcagagtcctcctattattactcttgaaccagtagaa actgttattcatgctggtggcaaagtcatattgaattgtcaggcaactggagagcctcat ccaaccattacatggtctcgtcaagggcactctattccctgggatgaccgagttaacatg ttgtccaacaactccttacatattgctgctgctcaaaaagaagatacatctgaatatgaa tgtgttgctcgaaacttgatgggttctgtccttgtcagggtgccagtcacagtccaggtt cacggtgggtattcccagtggtctacatggagatcctgcagtgtcacctgtggcaaaggc atccagaagaggagtcgtctatgcaacaacccctttccggccaatggtgggaagccttgc caagggtcagattcagaaatacgaaactgtcaacgtaagctgtgtccagtggatggtagc tggtcagaatggagcccttgggaagaatgcacacggagttgtggacgtggcaacagaacc aggaccagaacttgcagtaacccatcagctcaatatggtgggcggccatgtgaagggaat gcagtagaaataatcatgtgcaacattaggccctgcccagttcatggagcatggggcact tggcagccttggagtgcatgcagcgagagttgcggtaaaggtgcccagataagaacaaga ctgtgtaataacccaccaccatcatttgatgggtcctactgtgatggagcagaaacacag atgcagatttgcaatgaaagaccctgtccagtggatggcaagtggaccacttgggccagt tggagtgcctgtactgtgtcctgtggaggaggtgccagacagagaacaagggagtgctct gatcctgtcccacagcatggagggagcagatgtgaagggagtgatgtccagagcgatttt tgcaataatgacccttgtccaactcatggtaactggagtccttggagtggctggggaata tgcagccggacatgcaacggaggacagatgcggcggtaccgcacatgtgataaccctcct ccctccaacggaggaagagcttgtggggggccagactcccagatccagagatgcaacact gacatgtgtcctgtggatggaagctggggaagctggcacagttggggccagtgctctgcc tcttgtggaggaggtgaaaagactcgaaagcggctgtgcaacaatccagtgccgtctaaa agtggtcgcccctgtccaggagacactacacaggtatccagatgcaatatgcaaacgtgt ccaggtgggccccagcgagccagaggaagtgttattggaaatattaatgatgttgaattt ggaattgctttccttaacgccacagtaacagataatcctacctctgatactagagtaata cgtgccaaaattaccaatgtacctcgcagtcttggtccagcaatgagaaaaatagtttct attctaaatcccatttattggacaacagccaaggagataggagaagcagtcaatggcttc accctcaccaatgcagtcttcaagagagaaacccaggtggaatttgcaactggagaaatc ttgcggatgactcatattgcccggggtttggattctgatggtgctttgctcctagatatt tttgtgagcggttatgtcctgcagcttcagtcacctgctgaagtcactgtaaaggattac acagaggactacattcagacaggtcctgggcagctgtatgcctactcaacccggctgttc accattgatggcatcagcgtcccatacacatggaaccacactgttttctatgatgaggca cagggaagaatgcctttcttggtagaaacacttcatgcttcctctgtagaatctgactac aaccaattagaagagacactgggttttaaaatccatgcttcaatttccaaaggagatcgc agtaatcagtgcccatctgggtttgccttagactcagttggacccttttgtgctgatgaa gatgaatgtgcggccgggaatccctgctcccatatctgccacaacaccgtgggaacctat cattgctcctgctcaaaaggcctcaccatagctgccgacggaaggacttgtcaagatatc gatgagtgtgctttaggtggacatgcctgccatgctggtcaggactgtgacaatacaatt ggatcctatcgctgtgtggtccattgtggaattggctttcgaagaacttctgatgggctg agttgtcaagatattaatgaatgtcaagaatccagcccctgtcaccaccgctgtttcaat gccattggaagttttcactgtggatgtgaacctgggtatcagctcaaaggcagaaaatgt atagatgtgaatgaatgcagacaaaatgtatgcagaccagatcaacactgcaagaacacc cgtgggggctataagtgcattgatctttgtccaaacggaatgaccaaggcagaaaatgga acctgcattgatattgatgaatgtaaagatgggacccatcagtgcagatataaccagata tgtgagaatacaagaggcagctatcgctgtgtgtgtcccagaggtttccggtctcaagga gttgggagaccctgtatggacattaatgaatgtgaacaagtgcctaagccttgtgcatat cagtgctccaacacccccggcagcttcaagtgtatctgtccaacaggtcaacatttatta ggggacgggaaatcttgcgccggattggaaaggctgcctaactatggcacccaatacaat agctataaccttgcacggttctcccctgtgagaaacaactatcaacctcaacagcattac agacagtactcacatctctacagctcctactcggagtatagaaacagcagaacatctctc tccaggactagaaggactattaggaaaacttgtcctgaaggctctgaggcgagccgtgac acatgtgtagatattgatgaatgtgaaaaccgagacacttgccagcacgaatgtaaaaat acctttggaagctatcagtgtatctgtccacctggctatcagcttacgctcaatggaaag acctgtcaagatgtcgatgagtgtctggagcagagtgtgcgctgtgggccaaatcgcatg tgcttcaacatgagaggaagctaccagtgcatcgataccccctgtccacccaactaccaa cgggatcctgtttcagggttctgcctcaagaactgtccacccaatgatttggaatgtgcc ttgagcccatatgccttggattacaaacttgtctcactcccatttggaatagctgccaat caagatttaatccggctggttgcatacacgcaggatggagtgatgcatcccaggacaact ttcctcatggtagatgtggaacagactgttccttttgccttaagggacgaaaacctgaaa ggagtggtgtatacaacacgacctttgcgagaaccagagacctaccgcatgagggttcga gcctcatcctacagtgccaatgggaccattgaatatcagaccacattcatagtatatata gctgtgtctgcctatccatactaa

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