KEGG   Puma concolor (puma): 112859466
Entry
112859466         CDS       T08890                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pcoo  Puma concolor (puma)
Pathway
pcoo01521  EGFR tyrosine kinase inhibitor resistance
pcoo01522  Endocrine resistance
pcoo04010  MAPK signaling pathway
pcoo04012  ErbB signaling pathway
pcoo04014  Ras signaling pathway
pcoo04015  Rap1 signaling pathway
pcoo04022  cGMP-PKG signaling pathway
pcoo04024  cAMP signaling pathway
pcoo04062  Chemokine signaling pathway
pcoo04068  FoxO signaling pathway
pcoo04071  Sphingolipid signaling pathway
pcoo04072  Phospholipase D signaling pathway
pcoo04140  Autophagy - animal
pcoo04150  mTOR signaling pathway
pcoo04151  PI3K-Akt signaling pathway
pcoo04210  Apoptosis
pcoo04218  Cellular senescence
pcoo04270  Vascular smooth muscle contraction
pcoo04360  Axon guidance
pcoo04370  VEGF signaling pathway
pcoo04371  Apelin signaling pathway
pcoo04510  Focal adhesion
pcoo04519  Cadherin signaling
pcoo04540  Gap junction
pcoo04550  Signaling pathways regulating pluripotency of stem cells
pcoo04613  Neutrophil extracellular trap formation
pcoo04625  C-type lectin receptor signaling pathway
pcoo04630  JAK-STAT signaling pathway
pcoo04650  Natural killer cell mediated cytotoxicity
pcoo04660  T cell receptor signaling pathway
pcoo04662  B cell receptor signaling pathway
pcoo04664  Fc epsilon RI signaling pathway
pcoo04666  Fc gamma R-mediated phagosome formation
pcoo04720  Long-term potentiation
pcoo04722  Neurotrophin signaling pathway
pcoo04726  Serotonergic synapse
pcoo04730  Long-term depression
pcoo04810  Regulation of actin cytoskeleton
pcoo04910  Insulin signaling pathway
pcoo04912  GnRH signaling pathway
pcoo04914  Progesterone-mediated oocyte maturation
pcoo04915  Estrogen signaling pathway
pcoo04916  Melanogenesis
pcoo04917  Prolactin signaling pathway
pcoo04919  Thyroid hormone signaling pathway
pcoo04921  Oxytocin signaling pathway
pcoo04926  Relaxin signaling pathway
pcoo04928  Parathyroid hormone synthesis, secretion and action
pcoo04929  GnRH secretion
pcoo04935  Growth hormone synthesis, secretion and action
pcoo05010  Alzheimer disease
pcoo05022  Pathways of neurodegeneration - multiple diseases
pcoo05034  Alcoholism
pcoo05132  Salmonella infection
pcoo05152  Tuberculosis
pcoo05160  Hepatitis C
pcoo05161  Hepatitis B
pcoo05163  Human cytomegalovirus infection
pcoo05164  Influenza A
pcoo05165  Human papillomavirus infection
pcoo05167  Kaposi sarcoma-associated herpesvirus infection
pcoo05170  Human immunodeficiency virus 1 infection
pcoo05200  Pathways in cancer
pcoo05205  Proteoglycans in cancer
pcoo05206  MicroRNAs in cancer
pcoo05207  Chemical carcinogenesis - receptor activation
pcoo05208  Chemical carcinogenesis - reactive oxygen species
pcoo05210  Colorectal cancer
pcoo05211  Renal cell carcinoma
pcoo05212  Pancreatic cancer
pcoo05213  Endometrial cancer
pcoo05214  Glioma
pcoo05215  Prostate cancer
pcoo05218  Melanoma
pcoo05219  Bladder cancer
pcoo05220  Chronic myeloid leukemia
pcoo05221  Acute myeloid leukemia
pcoo05223  Non-small cell lung cancer
pcoo05224  Breast cancer
pcoo05225  Hepatocellular carcinoma
pcoo05226  Gastric cancer
pcoo05230  Central carbon metabolism in cancer
pcoo05231  Choline metabolism in cancer
pcoo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pcoo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112859466 (RAF1)
   04012 ErbB signaling pathway
    112859466 (RAF1)
   04014 Ras signaling pathway
    112859466 (RAF1)
   04015 Rap1 signaling pathway
    112859466 (RAF1)
   04370 VEGF signaling pathway
    112859466 (RAF1)
   04371 Apelin signaling pathway
    112859466 (RAF1)
   04630 JAK-STAT signaling pathway
    112859466 (RAF1)
   04068 FoxO signaling pathway
    112859466 (RAF1)
   04072 Phospholipase D signaling pathway
    112859466 (RAF1)
   04071 Sphingolipid signaling pathway
    112859466 (RAF1)
   04024 cAMP signaling pathway
    112859466 (RAF1)
   04022 cGMP-PKG signaling pathway
    112859466 (RAF1)
   04151 PI3K-Akt signaling pathway
    112859466 (RAF1)
   04150 mTOR signaling pathway
    112859466 (RAF1)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    112859466 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    112859466 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    112859466 (RAF1)
   04218 Cellular senescence
    112859466 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112859466 (RAF1)
   04540 Gap junction
    112859466 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    112859466 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112859466 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    112859466 (RAF1)
   04625 C-type lectin receptor signaling pathway
    112859466 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    112859466 (RAF1)
   04660 T cell receptor signaling pathway
    112859466 (RAF1)
   04662 B cell receptor signaling pathway
    112859466 (RAF1)
   04664 Fc epsilon RI signaling pathway
    112859466 (RAF1)
   04666 Fc gamma R-mediated phagosome formation
    112859466 (RAF1)
   04062 Chemokine signaling pathway
    112859466 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112859466 (RAF1)
   04929 GnRH secretion
    112859466 (RAF1)
   04912 GnRH signaling pathway
    112859466 (RAF1)
   04915 Estrogen signaling pathway
    112859466 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    112859466 (RAF1)
   04917 Prolactin signaling pathway
    112859466 (RAF1)
   04921 Oxytocin signaling pathway
    112859466 (RAF1)
   04926 Relaxin signaling pathway
    112859466 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    112859466 (RAF1)
   04919 Thyroid hormone signaling pathway
    112859466 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    112859466 (RAF1)
   04916 Melanogenesis
    112859466 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    112859466 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    112859466 (RAF1)
   04720 Long-term potentiation
    112859466 (RAF1)
   04730 Long-term depression
    112859466 (RAF1)
   04722 Neurotrophin signaling pathway
    112859466 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    112859466 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112859466 (RAF1)
   05206 MicroRNAs in cancer
    112859466 (RAF1)
   05205 Proteoglycans in cancer
    112859466 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    112859466 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    112859466 (RAF1)
   05230 Central carbon metabolism in cancer
    112859466 (RAF1)
   05231 Choline metabolism in cancer
    112859466 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    112859466 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112859466 (RAF1)
   05212 Pancreatic cancer
    112859466 (RAF1)
   05225 Hepatocellular carcinoma
    112859466 (RAF1)
   05226 Gastric cancer
    112859466 (RAF1)
   05214 Glioma
    112859466 (RAF1)
   05221 Acute myeloid leukemia
    112859466 (RAF1)
   05220 Chronic myeloid leukemia
    112859466 (RAF1)
   05218 Melanoma
    112859466 (RAF1)
   05211 Renal cell carcinoma
    112859466 (RAF1)
   05219 Bladder cancer
    112859466 (RAF1)
   05215 Prostate cancer
    112859466 (RAF1)
   05213 Endometrial cancer
    112859466 (RAF1)
   05224 Breast cancer
    112859466 (RAF1)
   05223 Non-small cell lung cancer
    112859466 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    112859466 (RAF1)
   05161 Hepatitis B
    112859466 (RAF1)
   05160 Hepatitis C
    112859466 (RAF1)
   05164 Influenza A
    112859466 (RAF1)
   05163 Human cytomegalovirus infection
    112859466 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    112859466 (RAF1)
   05165 Human papillomavirus infection
    112859466 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    112859466 (RAF1)
   05152 Tuberculosis
    112859466 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112859466 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    112859466 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    112859466 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112859466 (RAF1)
   01522 Endocrine resistance
    112859466 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcoo01001]
    112859466 (RAF1)
Enzymes [BR:pcoo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     112859466 (RAF1)
Protein kinases [BR:pcoo01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   112859466 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 112859466
NCBI-ProteinID: XP_025778501
UniProt: A0A6P6HSU6
LinkDB
Position
Unknown
AA seq 668 aa
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQPFGFQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDATS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSPIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NSSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAHRERAPGSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatacaaggggcctggaagacgatcagcaatggctttggattcaaagatgca
gtgtttgatggccccagctgcatctcccctacaatagttcagccatttggctttcagcgt
cgggcatcagatgatggcaaacttacggactcttctaagacaagcaacactatccgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtgagaaatggaatgagcttgcatgat
tgccttatgaaagcactcaaggtgaggggcctgcagccggagtgctgtgcagtgttcaga
cttctccatgaacataaaggtaaaaaagcgcgtttagattggaatactgatgccacctcg
ttgattggagaagaacttcaagtagatttcctggatcacgttcccctcacaacacacaac
tttgctcggaagaccttcctgaagcttgccttctgtgacatctgtcagaagttcctgcta
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttattgttcccaaattctcct
attggtgatagtggggtcccagcactgccttctttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacaccccacgccttcacgttc
aactcttccagcccttcctctgaaggttccctctcccagaggcagaggtcaacatccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataac
agcctgaatgcttctcccagggcgtggtccagacgattttgtttgaggggaagagatgca
attcgaagccacagtgaatcagcctcaccttcagccttgtccagcagccctaacaatctg
agcccaacgggctggtcacagcccaaaacccctgtgccagcacacagagagagggcacca
ggatccgggacccaggagaaaaacaaaatcaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagcgaagtgatgctttccactcggattggatcaggctcattt
ggaacggtgtataagggcaagtggcatggagatgttgcagtgaaaattctaaaagttgtt
gaccccacgccagagcagttccaggccttcaggaatgaggtggctgtcctacgcaaaaca
cggcacgtgaacatcctgctcttcatgggctacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagactaagttc
cagatgttccagttgattgacatcgcccgccagactgctcagggaatggactatttgcat
gcaaagaatatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctg
acggtgaaaattggagattttggtttggcaacagtaaagtcgcgctggagcggttctcag
caggtcgaacaacccactggctctgtcctgtggatggcccccgaggtgatccgaatgcag
gataataacccattcagcttccagtctgatgtctactcctacggcattgtgctctatgag
ctcatgacaggggagcttccttactcccacatcaataaccgcgaccagatcatcttcatg
gtgggccgaggatatgcctccccagacctcagtaagctatataagaactgccccaaagca
atgaagaggcttgtagctgactgtgtgaagaaggttaaggaagagaggcctctttttccc
cagatcctgtcttccatcgagcttctccaacactctctgccgaaaatcaaccggagtgct
tctgagccatccctgcaccgggcggcccacactgaggatatcaacgcctgcacgttgacc
acatcccctagactgcctgtcttctag

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