Puma concolor (puma): 112860068 Help Entry 112860068         CDS       T08890                                  Symbol EGFR Name (RefSeq) epidermal growth factor receptor   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism pcoo  Puma concolor (puma) Pathway pcoo01521   EGFR tyrosine kinase inhibitor resistance pcoo01522   Endocrine resistance pcoo03272   Virion - Hepatitis viruses pcoo04010   MAPK signaling pathway pcoo04012   ErbB signaling pathway pcoo04014   Ras signaling pathway pcoo04015   Rap1 signaling pathway pcoo04020   Calcium signaling pathway pcoo04066   HIF-1 signaling pathway pcoo04068   FoxO signaling pathway pcoo04072   Phospholipase D signaling pathway pcoo04144   Endocytosis pcoo04151   PI3K-Akt signaling pathway pcoo04510   Focal adhesion pcoo04520   Adherens junction pcoo04540   Gap junction pcoo04630   JAK-STAT signaling pathway pcoo04810   Regulation of actin cytoskeleton pcoo04912   GnRH signaling pathway pcoo04915   Estrogen signaling pathway pcoo04921   Oxytocin signaling pathway pcoo04926   Relaxin signaling pathway pcoo04928   Parathyroid hormone synthesis, secretion and action pcoo04934   Cushing syndrome pcoo05160   Hepatitis C pcoo05163   Human cytomegalovirus infection pcoo05165   Human papillomavirus infection pcoo05171   Coronavirus disease - COVID-19 pcoo05200   Pathways in cancer pcoo05205   Proteoglycans in cancer pcoo05206   MicroRNAs in cancer pcoo05207   Chemical carcinogenesis - receptor activation pcoo05208   Chemical carcinogenesis - reactive oxygen species pcoo05210   Colorectal cancer pcoo05212   Pancreatic cancer pcoo05213   Endometrial cancer pcoo05214   Glioma pcoo05215   Prostate cancer pcoo05218   Melanoma pcoo05219   Bladder cancer pcoo05223   Non-small cell lung cancer pcoo05224   Breast cancer pcoo05225   Hepatocellular carcinoma pcoo05226   Gastric cancer pcoo05230   Central carbon metabolism in cancer pcoo05231   Choline metabolism in cancer pcoo05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:pcoo00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03272 Virion - Hepatitis viruses     112860068 (EGFR)  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     112860068 (EGFR)    04012 ErbB signaling pathway     112860068 (EGFR)    04014 Ras signaling pathway     112860068 (EGFR)    04015 Rap1 signaling pathway     112860068 (EGFR)    04630 JAK-STAT signaling pathway     112860068 (EGFR)    04066 HIF-1 signaling pathway     112860068 (EGFR)    04068 FoxO signaling pathway     112860068 (EGFR)    04020 Calcium signaling pathway     112860068 (EGFR)    04072 Phospholipase D signaling pathway     112860068 (EGFR)    04151 PI3K-Akt signaling pathway     112860068 (EGFR)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     112860068 (EGFR)   09144 Cellular community - eukaryotes    04510 Focal adhesion     112860068 (EGFR)    04520 Adherens junction     112860068 (EGFR)    04540 Gap junction     112860068 (EGFR)   09142 Cell motility    04810 Regulation of actin cytoskeleton     112860068 (EGFR)  09150 Organismal Systems   09152 Endocrine system    04912 GnRH signaling pathway     112860068 (EGFR)    04915 Estrogen signaling pathway     112860068 (EGFR)    04921 Oxytocin signaling pathway     112860068 (EGFR)    04926 Relaxin signaling pathway     112860068 (EGFR)    04928 Parathyroid hormone synthesis, secretion and action     112860068 (EGFR)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112860068 (EGFR)    05206 MicroRNAs in cancer     112860068 (EGFR)    05205 Proteoglycans in cancer     112860068 (EGFR)    05207 Chemical carcinogenesis - receptor activation     112860068 (EGFR)    05208 Chemical carcinogenesis - reactive oxygen species     112860068 (EGFR)    05230 Central carbon metabolism in cancer     112860068 (EGFR)    05231 Choline metabolism in cancer     112860068 (EGFR)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     112860068 (EGFR)   09162 Cancer: specific types    05210 Colorectal cancer     112860068 (EGFR)    05212 Pancreatic cancer     112860068 (EGFR)    05225 Hepatocellular carcinoma     112860068 (EGFR)    05226 Gastric cancer     112860068 (EGFR)    05214 Glioma     112860068 (EGFR)    05218 Melanoma     112860068 (EGFR)    05219 Bladder cancer     112860068 (EGFR)    05215 Prostate cancer     112860068 (EGFR)    05213 Endometrial cancer     112860068 (EGFR)    05224 Breast cancer     112860068 (EGFR)    05223 Non-small cell lung cancer     112860068 (EGFR)   09172 Infectious disease: viral    05160 Hepatitis C     112860068 (EGFR)    05171 Coronavirus disease - COVID-19     112860068 (EGFR)    05163 Human cytomegalovirus infection     112860068 (EGFR)    05165 Human papillomavirus infection     112860068 (EGFR)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     112860068 (EGFR)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     112860068 (EGFR)    01522 Endocrine resistance     112860068 (EGFR)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pcoo01001]     112860068 (EGFR)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:pcoo04147]     112860068 (EGFR) Enzymes [BR:pcoo01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      112860068 (EGFR) Protein kinases [BR:pcoo01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    112860068 (EGFR) Exosome [BR:pcoo04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    112860068 (EGFR)   Exosomal proteins of pancreatic cancer cells    112860068 (EGFR)   Exosomal proteins of bladder cancer cells    112860068 (EGFR) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Kinase-like ABC1 Borrelia_P83 Motif Other DBs NCBI-GeneID:  112860068 NCBI-ProteinID:  XP_025779072 UniProt:  A0A6P6HTC1 LinkDB All DBs Position Unknown AA seq 1207 aa AA seqDB search MRPSGTAGAALLLLLAAHFQASPALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYMQRNYDLSFLKTIQEVAGYVLIALNTVEKIPLENLQIIRGNVLYENTHALS VLSNYGTNKTGLRELPMRNLHEILQGAVRFSNNPVLCNVETIQWRDIVDNDFISNMSMDF QNHVGNCQKCDPGCPNGSCWGPGKENCQKLTKIICAQQCSGRCRGRSPSDCCHNQCAAGC TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV VTDHGSCVRACSSDSYEVEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFK NCTSISGDLHILPVAFRGDSFTHTPPLDPKELDILKTVKEITGFLLIQAWPENRTDLHAF ENLEIIRGRTKQHGQFSLAVVGLDITSLGLRSLKEISDGDVIVSGNQKLCYANTINWKKL FGTSSQKTKIINNKDEKGCKAIGHVCHPLCSSEGCWGPEPKDCVSCQNVTRGKECVEKCN VLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDSCVQCAHYIDGPHCVKTCPAGIM GENNTLVWKFADANRMCHLCHSNCTYGCSGPGLEGCATDGPKIPSIATGIVGGLLLVVVV ALGVGLFLRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY GVTVWELMTFGSKPYDGIPASEISTILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQ QGFFHSPSTSRTPLLSSLSATSNNSTVTCIDRNGSCPLKEDSFLQRYSSDPTGTLTEDNM DDTFLPAPEYINQAVPKRPAGSVQNPVYHNQPLNPAPGRDPHYQNPHSNAVDNPEYLNTH PTCVNSVLDGPTLWAQKGNHQISLDNPDYQQDFFPKEAKSNGIFKGPAAENADYLRVAPP SSEFIGA NT seq 3624 nt NT seq  +upstreamnt  +downstreamnt atgcgaccctccgggaccgcgggagccgcgctcctgctgctgctggctgcgcacttccag gcgagtccggcgctggaggagaagaaagtttgccaaggcacaagtaaccggctcacccag ttgggcacttttgaggaccactttctcagcctgcagaggatgtttaataactgtgaggtg gtccttgggaatttggaaatcacctacatgcaaaggaattatgacctttccttcttaaaa accatccaagaggttgccggctatgtactcattgccctcaacacagtggagaagattcct ttggaaaacctgcagatcatccgaggaaatgtgctctatgaaaacacccatgccttatcc gtcttatccaactatggcacaaataaaaccggactgcgggagctgcccatgagaaactta catgaaatcctgcaaggcgctgtgcggttcagcaacaaccctgtcctctgcaacgtggaa accatccagtggcgggatatcgttgacaacgatttcataagcaacatgtcgatggacttc cagaaccacgtgggcaactgccaaaagtgtgatccaggatgtcccaatggaagctgctgg ggtccgggaaaggagaattgccagaaattgaccaaaatcatctgcgcccagcagtgttcc gggcgctgccgcggcaggtcccccagcgactgctgccataaccagtgtgctgccggctgc acggggccccgagagagcgactgcctggtctgccgcaagttccgggatgaagccacgtgc aaggacacctgcccgccactcatgctctacaaccccaccacctaccagatggacgtcaac ccagagggaaaatacagctttggtgccacctgtgtgaagaaatgcccccgtaactatgtg gtgacagaccacggttcgtgtgtccgtgcctgcagttctgatagctacgaagtggaggaa gatggcgtccgcaagtgtaaaaagtgtgaagggccttgccgtaaagtttgtaatggaata ggaattggtgaatttaaagacacactttccatcaatgctacaaatattaaacacttcaaa aattgcacctcgatcagtggagatcttcatatcctgccagtagcatttagaggtgactcc ttcacgcatactccacctctagatccaaaggaactggatattctaaaaactgtaaaggaa attacagggtttttgctgattcaggcctggcctgaaaacaggactgacctccatgctttc gagaacctagaaatcatacgtggaagaacaaagcaacatggtcagttttctcttgcggtt gtcggcctggacataacgtccttgggattacgctccctcaaggagataagtgatggagat gtgatcgtttcaggaaaccaaaaattgtgctatgcaaatacaataaactggaaaaaactg tttgggacttcaagtcagaaaaccaaaattataaacaacaaagatgaaaaaggctgcaag gccataggccatgtctgtcatccgttatgctcatcagagggatgctggggcccagagccg aaagactgcgtgtcctgccaaaacgtcacccgtggcaaggaatgtgtggagaagtgcaat gttctggagggggagccaagggagtttgtggagaattctgagtgcatacagtgccatcca gaatgcctgccccaggccatgaatatcacctgcacaggacgaggaccagacagctgcgtg cagtgtgcacactacattgacggccctcactgcgtcaagacctgcccagctggcatcatg ggagaaaacaacaccctggtctggaagtttgcagacgccaatcgcatgtgtcacctgtgc cattcaaactgtacctacggctgttctgggccaggtcttgaaggctgtgcaacagatggg cccaagatcccatccatcgccactgggattgttgggggcctcctcttggtggtggtggtg gcccttggggtgggcctctttctgcgccgacgccacatcgtccgcaagcgcacacttcgc agactgctgcaggaaagagagcttgttgagcctcttacgcccagcggagaagctcccaac caagctctcttgaggatcttaaaggaaacagaattcaaaaagatcaaggtgctgggctct ggagcatttggcacagtgtacaagggactctggatcccagaaggtgagaaggttaaaatt cccgtggccatcaaggagttacgagaagccacatctccaaaagccaacaaggaaatcctt gatgaagcttacgtgatggccagtgtggacaatccccacgtgtgccgcctcctgggcatc tgcctgacgtccacggtccagctcatcacacagctcatgcccttcggctgcctcctggac tatgtccgagagcacaaggacaacattggctcccagtacctgctcaactggtgtgtgcag attgcgaagggcatgaactacctggaagaccggcgcttggtgcaccgtgacctggcagcc aggaatgtcctggtgaagacgccacagcatgtcaagatcacagattttgggctggccaaa ctgcttggcgccgaggagaaagaataccatgcggaaggaggcaaagtgcctatcaagtgg atggctttggaatcaattttacaccgaatttacacccaccaaagtgacgtctggagctat ggagtcaccgtttgggagttgatgacctttgggtctaaaccttacgacggaatccccgca agtgagatctcgaccatcctggagaaaggagagcgcctcccacagccacccatatgcacc atcgatgtctacatgatcatggtcaagtgctggatgatagatgcagacagtcgcccgaaa ttccgtgagttgatcattgaattctccaaaatggcccgagacccccagcgctaccttgtc atccagggagatgagagaatgcatctgccaagccctacagactccaatttttaccgcgcc ctgatggacgaagaagacatggaagacgtcgtagatgccgatgagtacctcatcccccag caaggcttcttccacagcccctccacatcccggacccccctcctgagttctctgagtgcc accagcaacaattccaccgtgacttgcatcgatagaaatgggagctgccccctcaaggaa gacagcttcttgcagcggtacagctcagaccccactggcaccttgactgaggacaacatg gatgacactttcctcccggcacctgaatacataaaccaggctgttcccaaaaggcctgcg ggttccgtccagaaccccgtctatcacaatcagcctctaaatccagctcctggcagagac cctcactaccaaaatccccacagcaatgcagtggacaaccctgagtatctcaacacccac cccacttgcgtcaacagtgtgctcgatggccccaccctctgggcccagaaaggcaaccac cagattagcctggacaaccctgactaccagcaggacttctttcccaaggaagccaagtca aatggcatctttaagggtcctgcagctgaaaatgcagactacctaagggtagcaccgccc agcagtgaatttattggagcatga

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