Puma concolor (puma): 112864130 Help Entry 112864130         CDS       T08890                                  Symbol SOS1 Name (RefSeq) son of sevenless homolog 1   KO K03099   son of sevenless Organism pcoo  Puma concolor (puma) Pathway pcoo01521   EGFR tyrosine kinase inhibitor resistance pcoo01522   Endocrine resistance pcoo04010   MAPK signaling pathway pcoo04012   ErbB signaling pathway pcoo04014   Ras signaling pathway pcoo04062   Chemokine signaling pathway pcoo04068   FoxO signaling pathway pcoo04072   Phospholipase D signaling pathway pcoo04150   mTOR signaling pathway pcoo04151   PI3K-Akt signaling pathway pcoo04510   Focal adhesion pcoo04540   Gap junction pcoo04630   JAK-STAT signaling pathway pcoo04650   Natural killer cell mediated cytotoxicity pcoo04660   T cell receptor signaling pathway pcoo04662   B cell receptor signaling pathway pcoo04664   Fc epsilon RI signaling pathway pcoo04714   Thermogenesis pcoo04722   Neurotrophin signaling pathway pcoo04810   Regulation of actin cytoskeleton pcoo04910   Insulin signaling pathway pcoo04912   GnRH signaling pathway pcoo04915   Estrogen signaling pathway pcoo04917   Prolactin signaling pathway pcoo04926   Relaxin signaling pathway pcoo04935   Growth hormone synthesis, secretion and action pcoo05034   Alcoholism pcoo05160   Hepatitis C pcoo05161   Hepatitis B pcoo05163   Human cytomegalovirus infection pcoo05165   Human papillomavirus infection pcoo05200   Pathways in cancer pcoo05205   Proteoglycans in cancer pcoo05206   MicroRNAs in cancer pcoo05207   Chemical carcinogenesis - receptor activation pcoo05208   Chemical carcinogenesis - reactive oxygen species pcoo05210   Colorectal cancer pcoo05211   Renal cell carcinoma pcoo05213   Endometrial cancer pcoo05214   Glioma pcoo05215   Prostate cancer pcoo05220   Chronic myeloid leukemia pcoo05221   Acute myeloid leukemia pcoo05223   Non-small cell lung cancer pcoo05224   Breast cancer pcoo05225   Hepatocellular carcinoma pcoo05226   Gastric cancer pcoo05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:pcoo00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     112864130 (SOS1)    04012 ErbB signaling pathway     112864130 (SOS1)    04014 Ras signaling pathway     112864130 (SOS1)    04630 JAK-STAT signaling pathway     112864130 (SOS1)    04068 FoxO signaling pathway     112864130 (SOS1)    04072 Phospholipase D signaling pathway     112864130 (SOS1)    04151 PI3K-Akt signaling pathway     112864130 (SOS1)    04150 mTOR signaling pathway     112864130 (SOS1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     112864130 (SOS1)    04540 Gap junction     112864130 (SOS1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     112864130 (SOS1)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     112864130 (SOS1)    04660 T cell receptor signaling pathway     112864130 (SOS1)    04662 B cell receptor signaling pathway     112864130 (SOS1)    04664 Fc epsilon RI signaling pathway     112864130 (SOS1)    04062 Chemokine signaling pathway     112864130 (SOS1)   09152 Endocrine system    04910 Insulin signaling pathway     112864130 (SOS1)    04912 GnRH signaling pathway     112864130 (SOS1)    04915 Estrogen signaling pathway     112864130 (SOS1)    04917 Prolactin signaling pathway     112864130 (SOS1)    04926 Relaxin signaling pathway     112864130 (SOS1)    04935 Growth hormone synthesis, secretion and action     112864130 (SOS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     112864130 (SOS1)   09159 Environmental adaptation    04714 Thermogenesis     112864130 (SOS1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112864130 (SOS1)    05206 MicroRNAs in cancer     112864130 (SOS1)    05205 Proteoglycans in cancer     112864130 (SOS1)    05207 Chemical carcinogenesis - receptor activation     112864130 (SOS1)    05208 Chemical carcinogenesis - reactive oxygen species     112864130 (SOS1)    05231 Choline metabolism in cancer     112864130 (SOS1)   09162 Cancer: specific types    05210 Colorectal cancer     112864130 (SOS1)    05225 Hepatocellular carcinoma     112864130 (SOS1)    05226 Gastric cancer     112864130 (SOS1)    05214 Glioma     112864130 (SOS1)    05221 Acute myeloid leukemia     112864130 (SOS1)    05220 Chronic myeloid leukemia     112864130 (SOS1)    05211 Renal cell carcinoma     112864130 (SOS1)    05215 Prostate cancer     112864130 (SOS1)    05213 Endometrial cancer     112864130 (SOS1)    05224 Breast cancer     112864130 (SOS1)    05223 Non-small cell lung cancer     112864130 (SOS1)   09172 Infectious disease: viral    05161 Hepatitis B     112864130 (SOS1)    05160 Hepatitis C     112864130 (SOS1)    05163 Human cytomegalovirus infection     112864130 (SOS1)    05165 Human papillomavirus infection     112864130 (SOS1)   09165 Substance dependence    05034 Alcoholism     112864130 (SOS1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     112864130 (SOS1)    01522 Endocrine resistance     112864130 (SOS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH PH_10 PH_19 IQ_SEC7_PH RHG20_PH Takusan Motif Other DBs NCBI-GeneID:  112864130 NCBI-ProteinID:  XP_025782978 UniProt:  A0A6P6I799 LinkDB All DBs Position Unknown AA seq 1708 aa AA seqDB search MTGCNPCFLGLVYLCSQIRGSQVVRDLGGQQVQPVNPDVPRTKYTHTRPFPKLKAQRRQK RGGIPRGPTTQWGPLPRSSHPTRKARVRLLGALSLLPCSPPGRPSSLALPSSFAGEQENP ERTGPARQRMLSSQQVQFASRKLERYTGVGGGRGGTSGQPDPPTTTSGLSPPPLPPGPAP PRAARVSGSPLRGAGSAAGASLRTPSPSRRLRRGKPGRVCPNKTASREVNVLSPIPRREL EEAQFSVEVTAGHFSAFSVLPWSCCQPPVLGVQYAGFSGLKNALAIMLALSNCRARLPAG TRPALLALCGLVKLAVVIGICHRKFGTSRGGDPPLPVDLLQELNQLSCKMFNILEFSVYF LGIQFAGILSVLMELLAHSSDSRFDSQGFSGKNYMAQTPGGPGSVQGQVHPTLESSDDAL QYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSL PVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVA MCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKV FREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFED LAEELAFDPYESYARDILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLA PVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESAC RFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFD GLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTSEYKHAFEIILKDENSVI FSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEEN IIFEENTQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLII ERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFE RDADLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHI SRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMI RHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYR LDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNP EVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEF TDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISY SRIPESETESTASAPNSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSSDTVFVQVS LPHGPRSASVSSISLTKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPR QPTSKAYSPRYSIADRTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHG NAFFPNSPSPFTPPPPQTPSPHGTRRHLPSPPLTQEVDLPSITGPPVPPRQSTSQHIPKL PPKTYKREHTHPSMHRDGPPLLENAHSS NT seq 5127 nt NT seq  +upstreamnt  +downstreamnt atgacgggctgtaatccctgtttcttagggcttgtttacctctgcagtcaaatcagaggc tcccaagttgtcagggatctcggaggtcaacaagtccagcctgttaaccccgacgtccca agaacaaagtacacacatacacgcccctttccgaaactaaaggcccagagacgccaaaag agaggtgggattcctcgcggcccaaccacacaatgggggccgcttccccgtagctcgcac cccacccggaaggcccgggttcgacttcttggggccctttcgctcctcccctgcagtcct ccggggcgcccttcctcgctcgcgcttccctcctccttcgctggggagcaggaaaacccg gagcgaaccggccctgctcggcagcgcatgctcagtagccagcaggttcagttcgctagt aggaagctcgagcgctacaccggcgtcggcggcggccgcggcggcacctccgggcagcca gatcctccaacgacgacctcgggcctttcccctcccccgctaccccccggccccgctccg cctcgggccgctcgcgtttcggggtcgccgctgcgcggagcgggctccgcggccggagcg tccctccgcacgccctcccccagccgccggctccgccgcggcaagccaggcagagtttgt ccgaataaaacagcctcccgagaggttaatgtcctgtctcctattccgagacgagagttg gaggaggctcagttttcagtggaggtcacagcaggccacttttccgccttctcggtctta ccctggagctgctgtcagcctccggttttaggtgtccagtatgctggttttagtgggctc aagaatgctctagccataatgcttgctctaagtaattgcagagctcgcttgccagcggga acacggcctgctttgctcgccctctgtggacttgtcaagctggcagttgtcattggtatc tgccaccgcaaatttggaacttccaggggtggagatcctcctcttccagtcgacttattg caggaactgaatcagttgtcctgcaagatgttcaacattttggagttctctgtttatttc cttgggatacagtttgcgggcattctctctgtgctgatggagctactagcacactcctca gactccagattcgacagtcaagggtttagtggaaagaactatatggcccagacaccagga ggcccaggttcagtccaggggcaagttcatcctactcttgagtctagtgatgatgctctt cagtatgttgaagaattaattttgcagttattaaatatgctgtgccaagctcagccccga agtgcttcagatgtagaggaacgtgttcaaaaaagtttccctcatccaattgataagtgg gcaatagctgatgcccaatcggctattgaaaagaggaagcgaagaaaccctttatctctc ccagtagaaaaaattcatcctttattaaaggaggtcctaggttataaaattgaccaccag gtttctgtttacatagtagcagtattagaatacatttctgcagacattttaaagctggtg gggaattatgtacgaaatatacggcattatgaaattacaaaacaagatattaaagtggca atgtgtgctgataaggtattgatggatatgtttcatcaagatgtagaagatataaatata ttatctttaaccgatgaagagccttccacctcaggagagcaaacttactatgatttggta aaagcatttatggcagaaattcgacagtacataagggaactaaatttaattataaaagtt tttagagagccctttgtctccaattcaaaattattttcagctaatgacgtagaaaatata tttagtcgtatagtagatatacatgaacttagtgtaaagttactgggccatatagaagat actgtggaaatgactgatgaaggtagtccccatcccttagtaggaagctgctttgaagac ttagcagaggaactggcatttgatccatatgaatcatatgctcgagatatcttacggcct ggttttcatgatcgtttccttagtcagttatcaaagccaggagcagcactctatttacag tcaataggcgaaggtttcaaagaagctgttcaatatgttttacccaggctacttctagcc cctgtttaccactgtctgcattactttgagcttttgaagcagttagaagaaaagagtgaa gatcaagaagacaaggaatgtttgaaacaagcaataacagctttgcttaatgttcagagt ggtatggaaaaaatatgttctaaaagtcttgcaaaacgaagactgagtgaatctgcatgt cggttttatagtcagcaaatgaaggggaaacaactagcaatcaagaaaatgaacgagatt cagaagaatattgatggttgggagggaaaagacattggacagtgttgcaatgaatttata atggaaggaactcttacacgtgtaggagccaagcatgagagacacatatttctctttgat ggcttaatgatttgctgtaaatcaaatcatgggcagccaagacttcctggtgctagcaat gcagagtatcgtctgaaagaaaagtttttcatgagaaaggtacaaattaatgacaaagat gacaccagtgagtacaagcatgcttttgaaataattttaaaagatgaaaatagtgttata ttttctgccaagtcagctgaagagaaaaacaattggatggcagcactgatatctctccag taccggagcacactggaaaggatgcttgacgtgacgatgctacaggaagagaaggaggag cagatgaggctccctagtgctgatgtttatcgatttgcagagcctgactccgaagagaat ataatatttgaagagaacacacagcccaaggctggaattccaattatcaaagcaggaact gttattaaacttattgagaggctcacgtaccatatgtacgcagatcccaattttgttcgg acatttcttacaacatacagatccttttgtaaacctcaagaactactgagtcttataata gaaaggtttgaaattccagagcctgagccaacagaagctgatcgcatagctatagagaat ggagatcaacccttgagtgcagaactaaaaaggtttaggaaagaatacatacagcctgta caactgcgagtattaaatgtatgtcggcattgggtagagcaccatttctatgattttgaa agagacgcagatcttttgcagcgaatggaagagtttattggaacagtaagaggtaaagca atgaaaaaatgggttgaatccatcactaaaataatccaaaggaaaaaaattgcaagagac aatggaccaggtcataatattacatttcagagttcacctcccacagttgagtggcatata agcaggcctgggcacatagagacttttgacctgctcaccttacacccaatagaaattgct cgacaactcactttacttgaatcagatctatatcgagctgtacagccatcagaattagtt ggaagcgtgtggacaaaagaagacaaagaaattaattctcctaatctcctaaaaatgatc cggcacaccactaacctcactctgtggtttgagaaatgtattgtagaaactgaaaactta gaagaaagagtagctgtggtgagtcgaataattgagattctacaagtctttcaagagctg aacaatttcaatggtgtccttgaggttgtcagtgctatgaactcatctcctgtttacaga ctagaccacacatttgagcaaataccaagtcgccaaaagaaaattttagaagaagctcat gaattaagcgaagatcattataagaaatatttggcaaaactcaggtctattaatccaccg tgtgtgcctttctttggaatttatctaactaatatcttgaaaacagaagaaggcaaccct gaggtcctaaaaaggcatggaaaagagcttataaactttagcaaaaggaggaaagtagca gaaataacaggagagatccagcagtaccaaaatcagccttattgtttacgagtagaatca gatatcaaaaggttctttgaaaatttgaatccaatgggaaatagcatggaaaaagaattt acagattatcttttcaacaaatccttagaaatagaaccgcgaaaccctaagcctctccca agatttccaaaaaaatacagctatcccctaaaatctcctggtgttcgtccatcaaaccca agaccaggtaccatgagacatcccacacctctgcagcaggagccaaggaaaattagttac agtaggatccccgaaagtgagacagaaagtacagcatctgcaccaaactctccaagaaca ccgttaacacctcctcctgcttcgggtgcttctagtaccacagatgtttgcagcgtattt gactctgatcattcgagcccttttcactcaagcagcgataccgtctttgtccaagtttca ctgccccatggcccaagatctgcttcagtatcatctataagtttaaccaagggcactgac gaagtgcctgtcccccctcctgttcctccacgaagacggccagaatctgcccccgcggaa tcttcaccatctaagattatgtctaagcatttggacagccccccagcaattcctcctaga cagcccacatcaaaagcctattcaccgcggtattcaatagcagaccggacctctatatca gaccctcccgagagccctcccttattaccaccgcgagaacctgtgaggacacctgatgtt ttctccagctcaccactacatctccagcctccccctttgggcaaaaaaagcgatcatggc aatgccttcttcccaaacagcccttcaccatttacgccacctcctcctcaaacaccttct cctcatggcacgagaaggcatctgccatcaccaccactgacacaagaagtggaccttcct tccatcactgggccgccggttcctccacgacaaagcacttctcaacatatccctaaactc cctccaaaaacttacaaaagggagcacacacacccctccatgcacagagatggaccacca ctgttggagaacgcccattcttcctga

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