KEGG   Puma concolor (puma): 112866046
Entry
112866046         CDS       T08890                                 
Symbol
DDB2
Name
(RefSeq) DNA damage-binding protein 2 isoform X1
  KO
K10140  DNA damage-binding protein 2
Organism
pcoo  Puma concolor (puma)
Pathway
pcoo03420  Nucleotide excision repair
pcoo04115  p53 signaling pathway
pcoo04120  Ubiquitin mediated proteolysis
pcoo05161  Hepatitis B
pcoo05169  Epstein-Barr virus infection
pcoo05200  Pathways in cancer
pcoo05202  Transcriptional misregulation in cancer
pcoo05210  Colorectal cancer
pcoo05212  Pancreatic cancer
pcoo05213  Endometrial cancer
pcoo05214  Glioma
pcoo05216  Thyroid cancer
pcoo05217  Basal cell carcinoma
pcoo05218  Melanoma
pcoo05220  Chronic myeloid leukemia
pcoo05222  Small cell lung cancer
pcoo05223  Non-small cell lung cancer
pcoo05224  Breast cancer
pcoo05225  Hepatocellular carcinoma
pcoo05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pcoo00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    112866046 (DDB2)
  09124 Replication and repair
   03420 Nucleotide excision repair
    112866046 (DDB2)
 09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    112866046 (DDB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112866046 (DDB2)
   05202 Transcriptional misregulation in cancer
    112866046 (DDB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112866046 (DDB2)
   05212 Pancreatic cancer
    112866046 (DDB2)
   05225 Hepatocellular carcinoma
    112866046 (DDB2)
   05226 Gastric cancer
    112866046 (DDB2)
   05214 Glioma
    112866046 (DDB2)
   05216 Thyroid cancer
    112866046 (DDB2)
   05220 Chronic myeloid leukemia
    112866046 (DDB2)
   05217 Basal cell carcinoma
    112866046 (DDB2)
   05218 Melanoma
    112866046 (DDB2)
   05213 Endometrial cancer
    112866046 (DDB2)
   05224 Breast cancer
    112866046 (DDB2)
   05222 Small cell lung cancer
    112866046 (DDB2)
   05223 Non-small cell lung cancer
    112866046 (DDB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    112866046 (DDB2)
   05169 Epstein-Barr virus infection
    112866046 (DDB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:pcoo04121]
    112866046 (DDB2)
   03400 DNA repair and recombination proteins [BR:pcoo03400]
    112866046 (DDB2)
Ubiquitin system [BR:pcoo04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   Cul4 complex
    Target recognizing subunit (DCAF)
     112866046 (DDB2)
DNA repair and recombination proteins [BR:pcoo03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      112866046 (DDB2)
SSDB
Motif
Pfam: WD40 WD40_Prp19 WD40_WDHD1_1st WD40_CDC20-Fz Beta-prop_EML_2 Beta-prop_WDR75_1st WDR55 Beta-prop_RIG_2nd Beta-prop_WDR90_POC16_2nd Beta-prop_EIPR1 Beta-prop_IFT140_1st EIF3I Beta-prop_WDR19_1st Beta-prop_TEP1_2nd WD40_RFWD3 Beta-prop_TEP1_C Beta-prop_CAF1B_HIR1 NBCH_WD40 WD40_MABP1-WDR62_2nd Beta-prop_HPS5 Beta-prop_Vps41 Beta-prop_WDR35_TULP_N WD_LRWD1 EF-hand_1
Other DBs
NCBI-GeneID: 112866046
NCBI-ProteinID: XP_025784866
UniProt: A0A6P6I9I4
LinkDB
Position
Unknown
AA seq 426 aa
MAPRKRPETQKTPEVVVRPKTRRSRSPRELEPEAKKLCVKGPGSSRRFDSGCLWAGLASL
QVPPSYTSIVRALHHHKLGKAAWPSLQQGLQQSFVHSLTSYRIFQKAAPFDRRATSLAWH
PTHPSTLAVGSKGGDIMLWNFGIKDKPTFIKGIGAGGSVTGLKFNPLDTNQFFTSSMEGT
TRLQDFKGNTLRVFTSSDTCNIWFCSLDVSARSRMVVTGDNVGHVILLNMDGRELWNLRM
HKKKVTHVALNPCCDWLLATASVDQTVKIWDLRQVKGKSSCLHSLLHSHPVNAACFSPDG
AQLLTTDQKSELRVYSASQWDCPPSLIPHPHRHFQHLTPIKATWHPRYNLIVVGRYPDPN
FKSCTPHELRTIDVFDGSSGKMMYQLYDPESSGIISLNEFNPMGDTLASLMGYHILIWSQ
EAGMRK
NT seq 1281 nt   +upstreamnt  +downstreamnt
atggctcccaggaaacgcccagaaacccagaagacccccgaggtggttgtgcgccccaag
accaggaggagcagaagcccccgggagctggagcccgaggccaagaagctctgtgtgaag
ggccccggttctagcagaagatttgactcaggctgcctttgggcggggttggctagcctt
caggtcccgccatcatacaccagcatcgtcagggcccttcaccaccataagctgggcaaa
gctgcctggccatcactacagcagggtctccagcagtcctttgtgcactctctgacttct
taccggatattccaaaaggctgccccttttgacaggagggccacatccttggcatggcac
ccaactcaccccagcaccctggctgtgggttccaaagggggagatatcatgctctggaac
tttggcataaaggacaaacccaccttcattaaagggattggagctggagggagcgtcact
gggctgaagtttaaccctcttgataccaaccagtttttcacctcctcaatggagggaaca
actaggctgcaagactttaaaggcaacacgctccgagtgtttaccagctcagacacctgc
aacatctggttttgcagcctggatgtgtctgccagaagccgaatggtggtcacaggcgac
aatgtgggacatgtgatcctgctgaacatggacggcagggagctttggaatctgagaatg
cacaaaaagaaagtgacccatgtggctctgaacccatgctgtgattggctcctggccaca
gcctctgtggaccaaacagtgaaaatctgggacctgcgccaggttaaagggaaatccagc
tgcctccactcgctgctgcatagccatcctgtcaacgcagcttgtttcagtcctgacgga
gcccagctcctgaccactgaccagaagagtgagctccgggtttactcggcctcccagtgg
gactgccccccgagcctgatcccacaccctcaccgccacttccagcacctgacgcccatc
aaggcaacctggcatcctcggtacaacctcattgttgtgggccgatacccagatcctaat
ttcaaaagttgtaccccccatgaattaaggaccattgatgtgtttgatggaagctcaggg
aagatgatgtatcagctctatgacccagaatcttctggtatcatttcgctcaatgagttc
aatcccatgggggacacgctggcctctctgatgggttatcacattctcatttggagccag
gaagctgggatgcggaaatga

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