KEGG   Puma concolor (puma): 112866443
Entry
112866443         CDS       T08890                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pcoo  Puma concolor (puma)
Pathway
pcoo01521  EGFR tyrosine kinase inhibitor resistance
pcoo01522  Endocrine resistance
pcoo04010  MAPK signaling pathway
pcoo04012  ErbB signaling pathway
pcoo04015  Rap1 signaling pathway
pcoo04024  cAMP signaling pathway
pcoo04062  Chemokine signaling pathway
pcoo04068  FoxO signaling pathway
pcoo04150  mTOR signaling pathway
pcoo04270  Vascular smooth muscle contraction
pcoo04510  Focal adhesion
pcoo04650  Natural killer cell mediated cytotoxicity
pcoo04720  Long-term potentiation
pcoo04722  Neurotrophin signaling pathway
pcoo04726  Serotonergic synapse
pcoo04730  Long-term depression
pcoo04810  Regulation of actin cytoskeleton
pcoo04910  Insulin signaling pathway
pcoo04914  Progesterone-mediated oocyte maturation
pcoo04928  Parathyroid hormone synthesis, secretion and action
pcoo04934  Cushing syndrome
pcoo05010  Alzheimer disease
pcoo05022  Pathways of neurodegeneration - multiple diseases
pcoo05034  Alcoholism
pcoo05160  Hepatitis C
pcoo05161  Hepatitis B
pcoo05200  Pathways in cancer
pcoo05205  Proteoglycans in cancer
pcoo05208  Chemical carcinogenesis - reactive oxygen species
pcoo05210  Colorectal cancer
pcoo05211  Renal cell carcinoma
pcoo05212  Pancreatic cancer
pcoo05213  Endometrial cancer
pcoo05214  Glioma
pcoo05215  Prostate cancer
pcoo05216  Thyroid cancer
pcoo05218  Melanoma
pcoo05219  Bladder cancer
pcoo05220  Chronic myeloid leukemia
pcoo05221  Acute myeloid leukemia
pcoo05223  Non-small cell lung cancer
pcoo05224  Breast cancer
pcoo05225  Hepatocellular carcinoma
pcoo05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pcoo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    112866443 (BRAF)
   04012 ErbB signaling pathway
    112866443 (BRAF)
   04015 Rap1 signaling pathway
    112866443 (BRAF)
   04068 FoxO signaling pathway
    112866443 (BRAF)
   04024 cAMP signaling pathway
    112866443 (BRAF)
   04150 mTOR signaling pathway
    112866443 (BRAF)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    112866443 (BRAF)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    112866443 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    112866443 (BRAF)
   04062 Chemokine signaling pathway
    112866443 (BRAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    112866443 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    112866443 (BRAF)
   04928 Parathyroid hormone synthesis, secretion and action
    112866443 (BRAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    112866443 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    112866443 (BRAF)
   04720 Long-term potentiation
    112866443 (BRAF)
   04730 Long-term depression
    112866443 (BRAF)
   04722 Neurotrophin signaling pathway
    112866443 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    112866443 (BRAF)
   05205 Proteoglycans in cancer
    112866443 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    112866443 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    112866443 (BRAF)
   05212 Pancreatic cancer
    112866443 (BRAF)
   05225 Hepatocellular carcinoma
    112866443 (BRAF)
   05226 Gastric cancer
    112866443 (BRAF)
   05214 Glioma
    112866443 (BRAF)
   05216 Thyroid cancer
    112866443 (BRAF)
   05221 Acute myeloid leukemia
    112866443 (BRAF)
   05220 Chronic myeloid leukemia
    112866443 (BRAF)
   05218 Melanoma
    112866443 (BRAF)
   05211 Renal cell carcinoma
    112866443 (BRAF)
   05219 Bladder cancer
    112866443 (BRAF)
   05215 Prostate cancer
    112866443 (BRAF)
   05213 Endometrial cancer
    112866443 (BRAF)
   05224 Breast cancer
    112866443 (BRAF)
   05223 Non-small cell lung cancer
    112866443 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    112866443 (BRAF)
   05160 Hepatitis C
    112866443 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    112866443 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    112866443 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    112866443 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    112866443 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    112866443 (BRAF)
   01522 Endocrine resistance
    112866443 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcoo01001]
    112866443 (BRAF)
Enzymes [BR:pcoo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     112866443 (BRAF)
Protein kinases [BR:pcoo01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   112866443 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD Ribosomal_S13_N C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal
Other DBs
NCBI-GeneID: 112866443
NCBI-ProteinID: XP_025785139
UniProt: A0A6P6IBS2
LinkDB
Position
Unknown
AA seq 840 aa
MGRMHAPGKGQSQSALPYCRSVPTWLKLMSDDVKEQIYKLAKKGLSPSQIGVILRHSHGV
AQVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLG
NGTDFSVSSSASTDTVTSSSSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNK
QRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHV
EVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYD
QLDLLFVSKFFEHHPIPQEEASIAETALTSGSSPSAPPSDSTGPQILTSPSPSKSIPIPQ
PFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRSDGAPLNQLMRGLRK
YQSRTPSPLLHSVPSEIVFDFEPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQR
ERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKM
LNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHII
ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRW
SGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQ
IIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQERSRRKYRLFNSGYP
WKILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq 2523 nt   +upstreamnt  +downstreamnt
atgggtcgcatgcacgctcccgggaagggccagtcccagtcggctctgccttactgccgc
agcgtgcccacctggctgaagttgatgtccgacgacgtgaaggagcagatctacaaactg
gccaagaagggcctgtctccctcacaaatcggtgtgatcctgagacactcccatggtgtt
gcacaagtgtggaatatcaaacaaatgattaagttgacacaggaacatatagaggcccta
ttggacaaatttggtggggagcataatccaccatcaatatatctagaggcctatgaagaa
tacaccagcaagctagatgccctccaacagagagaacaacagttattggaatccctgggg
aatggaactgatttttctgtttctagctctgcatcaacggacaccgttacatcttcctct
tcttctagcctttcagtgctaccttcatctctttcagtttttcaaaaccccacagatgtg
tcacggagcaatcccaagtcaccacagaaacctatcgttagagtcttcctgcctaataaa
cagaggacagtggtacctgcaagatgtggagttacagtccgggacagtctaaagaaagct
ctgatgatgagaggtctaatccctgagtgctgtgctgtttacagaattcaggatggagag
aagaaaccaattggctgggacactgatatctcctggctcaccggagaggaattgcatgta
gaagtgttggaaaatgttccacttacaactcacaactttgtacggaaaacgtttttcacc
ttagcattttgtgacttttgtcgaaagctgcttttccaaggttttcgctgtcaaacgtgt
ggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaattatgac
caacttgatttgctgtttgtctccaagttctttgaacaccacccaataccacaggaggag
gcctccatagcagagactgccctaacgtctggatcgtccccttctgcccccccctccgat
tctactgggccccaaattctcaccagtccgtctccttcaaaatccattccaattccacag
cctttccgaccagcagatgaagatcatcgaaatcaatttggacagcgagaccggtcctca
tcagctccaaatgtgcatataaatacaatagaacctgtcaatattgatgacttgattaga
gaccaggggtttcgtagtgatggagcccctttgaaccagctgatgcgtggtcttcggaaa
taccaatcccggactcccagtcccctcctacattctgtccccagtgaaatagtgtttgat
tttgagcctggcccagtgttcagaggatcaaccacaggcttgtctgccaccccccctgcc
tcattgccgggctctctcactaatgtaaaagcattacagaaatctccagggcctcagcgg
gaaaggaaatcttcttcatcctcagaagataggaatcgaatgaaaacacttggtagaagg
gattcaagtgatgattgggagattcctgatgggcagatcacagtgggacagagaattgga
tccgggtcatttgggacagtctacaagggaaagtggcatggtgatgtggcagtgaaaatg
ttgaatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagtaggagta
ctcaggaaaactcggcatgtgaacatcctgctcttcatgggctattcaacaaagccccag
ctggctattgtcacccagtggtgtgagggctccagcttataccaccatctccacatcatc
gagaccaaattcgagatgatcaagctgatagatattgctcggcagactgcgcagggcatg
gattacttacacgccaagtcaatcatccacagagacctcaagagtaataatatttttctt
catgaagacctcacagtaaaaataggtgattttggtctagccacagtgaaatctcgatgg
agtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcaccagaagta
attcgaatgcaagataaaaacccatatagctttcagtcagatgtatatgcatttgggatt
gttctatatgaattgatgactggacagttaccttattcaaacatcaacaacagggaccag
ataatttttatggtgggacgaggatatctttctccagatctcagtaaggtacgaagtaac
tgtccgaaagccatgaagagattgatggcagagtgcctaaaaaagaaaagagatgagagg
ccactgtttccccaagaaaggtccagaagaaagtatagactctttaacagtggttacccc
tggaagattcttgcctctattgagctgctggcccgctcattgccaaaaattcaccgcagt
gcatcagaaccctccttgaatcgggctggcttccagacagaggattttagtctctatgct
tgtgcttctccaaaaacacccatccaggcagggggatatggagaatttgcagccttcaag
tag

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