Puma concolor (puma): 112866613 Help Entry 112866613         CDS       T08890                                  Symbol PCLO Name (RefSeq) protein piccolo   KO K16882   protein piccolo Organism pcoo  Puma concolor (puma) Pathway pcoo04911   Insulin secretion Brite KEGG Orthology (KO) [BR:pcoo00001]  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     112866613 (PCLO)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:pcoo04131]     112866613 (PCLO) Membrane trafficking [BR:pcoo04131]  Exocytosis   Calcium ion-dependent exocytosis    Others     112866613 (PCLO) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  zf-piccolo C2 PDZ FYVE_2 Motif Other DBs NCBI-GeneID:  112866613 NCBI-ProteinID:  XP_025785337 UniProt:  A0A6P6IAX6 LinkDB All DBs Position Unknown AA seq 5124 aa AA seqDB search MGNEASLEGEGLPEGLAAAAAAAAGGGAGGAGSSLHTVIPAGMEADLSQLSEEERRQIAA VMSRAQGLPKGSVPPAAAEPSSMHRKQELDSSHPPKQSGKPPDPGRSAPPGLSKSRTTDT LRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNPLSAVSSVVNKFNPFDL ISDTDSSQEETAKKQKMAQKEQGKPEGITKPPPQQSPKPVPKQQGPARVPLKQDGSPRSV SSQQPEKIKLQPSGTGKPIEGLTQAPQTDQAQLPLQRDATRPQTKQSDTLRGESVKPSLQ SPSKPPIQQGGPGKPPAQQPGPEKLATAQPGPAKPLAQQTGPAKALAQQPGTAKPPAQPP GTTKPTAQQPGPKSPAQPVGPAKPQTQQAGSDKLPSQQPGPAKPPAQQPGTPKSPAHQPG SQSPAQPSGPAKTPSQQPGTGKTPAQQPGLAKPPPQQPGPAKPPPQQPGPAKPPPQQPGP PGPAKPPPQQPGPAKPPPQQPGPVKPPSQQPGPAKPPPQQPGPAKPPSQQPSPAKPPPQQ PVPAKPSAQLSTKPVSQTEAGKSPQPSTAPSAAQTPGQGLPKTICPLCNTTELLLHVPEK ANFNTCTECQTTVCSLCGFNPNPHLTEIKEWLCLNCQMKRALGGDLAPVPSSPQPKPKIA PVGPASAVSKPSPQPQHTSPKKDTVPKQEILKAPESKRPPPLVKQPTIHGSPPLAARQPP AAAESSPKPAPPKEPSVPSEQAEVPVADDKPKQPKTGKPATDVESSSSVAAQPDIPSPKV QLEDQEIITPPLKTDAAKPSQSFPPTGEKVTPFDSKVIPRPASDSKIISHPGPSPEGKGQ KQADPVQKREEPKKAQTKMSPKPDAKPMPKGSPPPAGPRPPTGPTAPTAQQPPKPQEQSR RFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGSQSQSALGAP TKQGPPPSQPPPSQGPPKSTGQVPPAPAKVVPVKKEAKAPVVEKLEPKSEPVPTVKRTET EKKPLPVKDSKPLTAEPQKAVLPPKLEKTPKPESACPLCKTELNIGSKDPPNFNTCTECK NQVCNLCGFNPMPHLTEVQEWLCLNCQTQRAISGQLGDMGKMPPTPSAPKASPMPVPPEQ PSQKTAMPTQVKVKKKEQEVKTEAEQIIPEKVKEIPSVEKIVPKGTTDHKQESKLEKTSA PEDKKPLPEEKKPPLEEKKPPTEDKKLPPGTKTALEEEQKQDLAKTQVPTAEEKPEGRVT PQVVQEKLPQTKMEDKPSGPPPSLSKDDEVPQKIKDQPQAARPATPDQVEPGKEKTEKED DKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPSDEKDLLKGLKKDSFSQESSP SSPSDLAKLESTVLSILEAQASTLVEEKSEKKTQPHEVSSEQPKDPQKTQSLSETVETTI SEEELKKSPEEKDTLKKDSQQDIPSTKDHEEKSEFVDDTATRRQLYDSVEDSSESENSPV PQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASASEDDEFIRSQLKE ISSSIESQKKEDMKGKGKATAGKHRRLTRKSSASFDDDAGRRHSWHDEDDETFDESPELK YRETKSQESEELVVAGGGGLRRFKTIELNSTIADKYSADSSQKKTALYFDEEPELEMESL TDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRSHG PLLPTIEDSSEEEELREEEELLKEQEKQRELEQQQRKASSKKSKKDKDELRAQRRRERPK TPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVY KLPTAVSLYSPTDEQSIMQKEGGQKALKSAEEMYEEMMHKTHKYKPFPAVPERDEMFEKE PLYGGMLIEDYIYESLVEDTYNGSVDGSLLTRQEDENGFMQQRGKEQKIRLPEQIYEDPM QQITDLQKEFYELESLHSIVPQEDIVSSSFIIPESHEIVDLGSMVTSTSEEKKLLDADAA YEELMKRQQMQLTPGSSPTQPPITDDMIESTVDFDRVPDASLTSSVLSGASLTDSTSSAT LSIPDVKITQHFSTEEIEDEYVTDYTREIQEIIAHESLILTYSEPSESATSVPPSDTPSL TSSVSSVCTTDSSSPVTTLDSITTVYMEPVDVVTKFEDSEGISSSTYFPGSIIDYPEEIS VSLDRATTPDGRTGADHIVISLSDVEPPILESIGTKPERLIADTVSTDLPVSAKDAVKKA KKDTGNGIILEVLEAYKDKREKTEVELTKMSFSETVFDQPPSSAVALPVGEQVSATCFIS GQVFDQTKPASPLPSGSPSVTSLPTKTRPFFRSSSLDTSAQPPPPPPPPPPPPPPPPPPP PPPLPPPTSPKPIIHPTKKLTITAPETVTTTAKPLVDAVTTVEATAIPRSNGLPVTKICT TAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPAVPQLPVTTQKSTDTHPKPTGLSLAS NMTLNLVTSADYKLPSPTSPASPHSNKSSPRFSKSLMETYVVITLPSEPGTPTDSSISQA VTSWPLGSPPKDLISIEPVFSVVPPMTTAGMPSSSEQSLYMSGALETFSAVPATTLSSFQ AAPTSVTQFFTTEVSKAEASAARSALTSVGLSSVSISIPPEPLALDNLHLEKRQHKENGK LPLVGDAIDLRTVPKVEVKVTEKCMDLSASTMDMKRQTTTHEVYGRQISAVQPSIINLSA TSSAVTPMPLVTETVTVVTCAASSGYTMGPESLVGIEHATPAPLQLTTSKHAEPPPYRIP SGQAFPAVREDAPINLSLGTSAHPVTLAVTKPVTAPPVGVTNGWTDSVTRQGMADGEVVD LSTTKSHRTVVTMDESASGVVTKIVEDDEKPVDLTAGRRAVCCDMVYKLPFGRSCTAQQP TTTLPEDRFGYRDDHYQYDRSGPSGYRGIGGMKPSMSDTNLAEAGHFFYKSKNAFDYSGG TDTAVDLTSGRITAGEVMDYSSKTTGPYPETRQVISEVGISTPQYSTARMTPPPGSQYGV GSVLRSSNGVVYSSVATPIPSTFAITTQPGSIFSTTVRDLSGVHTADAVTSLSALHQSQP MPRSYFLTTGASETDIAATGIDINASLQTITVETLTAETIDSVPTLTTASDVFSEVVGDE SAILIVPEEGKQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQKKLE ELQSMKQHLLYQQEEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKIRQIYQY NYDPSGTASPQTTTEQAILEGQYAAPEGGQFWATEDATTTASAVVAIEIPQSQGWYTVQS DGVTQYIAPPGILSTVSEIPLTDVVVKDEKPPKKRSAAAKVRGQYDELGEHMADDPRCFK KIVDSGVQTDDEDAADRTYVSRRRRTKKSVDTSVQTDDEDQDEWDVPARARRKARVGKYG DSTAEADKTKPLSKVSSIAVQTVAEISVQTEPVGTIRTPSVRARVDAKVEIIKHISAPEK TYKGGSLGCQTEADSDTQSPQYLSATSPPKDKKRPTPLEIGYSSHLRADSTLQLAPSPPK SPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQKVLHPDMAKVPPASPKTAKMMQRS MSDPKPLSPTADESSRAPFQYTEGYTTKGSQTMTPSGSQKKVKRTLPNPPPEETSTGTQS TYSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLRKKQAELDEEEKEIDAKL RYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTRPTRIESQHGIERPRT APQTEFSQFIPPQTQTESQLVPPTSPYTQYQYSSPALPTQAPTPYTQQSHFQQQTLYHQQ VSPYQTQPTFQAVATMSFTPQAQPTPTPQPSYQLPSQMMVIQQKPRQTTLYLEPKITSNY EVIRNQPLMIAPVSTDNTYAVSHLGSKYNSLDLRIGLEERSSMASSPISSISADSFYADI DHHTPRNYVLIDDIGEITKGTAALSTAFSLHEKDLSKTDRLLRSTETRRSQEVTDFLAPL QTSSRLHSYVKAEEDPMEDPYELKLLKHQIKQEFRRGAESLDHLAGLSHYYHADTGYRHF PKSEKYSISRLTLEKQAAKQLPAAILYQKQSKHKKSLIDPKMSKFSPIQESRDLEPDYTS YMTSSTSSIGGISSRARLLQDDITFGLRKNITDQQKFMGSSLGTGLGTLGSTLRSALQDE ADKPYSSGSRSRPSSRPSSVYGLDLSIKRDSSSSSLRLKAQEAEALDVSFSHASPSGRTK PTSLPISQSRGRIPIVAQNSEEESPLSPVGQPMGMARAAAGPLPPISADTRDQFGSSHSL PEVQQHMREESRTRGYDRDIAFIMDDFQHAMSDSEAYHLRREETDWFDKPRESRLENGHG LDRKLPERLVHSRPLSQHQEQIIQMNGKTVHYIFPHARIKITRDSKDHTVSGNGLGIRIV GGKEIPGHNGEIGAYIAKILPGGSAEQTGKLMEGMQVLEWNGIPLTSKTYEEVQSIIGQQ SGEAEICVRLDLNMLSDSENPQHLELHEPPKAVEKAKSPGVDPKQLAAELQKVSLQQSPL VLSSVVEKGSHVHSGPTSAGSSSVPSPGQPGSPSVSKKKHGSSKPTDAAKVVSHPITGEI QLQINYDLGNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEYKRRTK YVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLIDLSSTSHLDN TPRWYSLKEQTESLDHGKSHSSQGSQQPPKPSVIKSRSHGIFPDPSKDMQVPTIEKSHSS PGSSKSSSEGHLRSHGPSRSQSKTSVTQTHLEDAGAAIAAAEAAVQQLRLQPTKPTNHRP AESSVSTGSSGSSFGSGYSVDSEGSSGTAGETNLFPIPRIGKMGQNGQEPVKQPGVGVGL TDAEVKTQVMGEIKIALKKEMKTDGEQLIVEILQCRNITYKFKSPDHLPDLYVKIYVMNI STQKKVIKKKTRVCRHDREPSFNETFRFSLSPAGHSLQILLFSNGGKFMKKTLIGEACIW LDKVDLRKRIVNWHKLLVSPTQTH NT seq 15375 nt NT seq  +upstreamnt  +downstreamnt atgggcaacgaggcgagcttggaaggggaagggctcccggaagggctggcggcggcggcg gcggcggcagccggaggaggggctggcggggcggggagctccttgcacaccgtgatcccg gccggcatggaggcggatctgagccagctgagcgaagaggagaggagacagatcgccgct gtcatgtcaagggcgcaggggctgcccaagggaagcgttcccccggccgctgcggagccg tcttccatgcacaggaaacaagagttggatagtagtcatcctccaaaacaatcagggaaa ccgccggacccagggcgttcagctccgcctggtctcagtaagagtagaactacagacact ttgaggtcagagcagaagttgcctggaaggagtccttccactattagcttgaaagaatca aagtccagaactgatctgaaggaagagcacaagtctagtatgatgcctggcttcctctca gaggttaaccctttaagtgctgtctcctcggttgtaaataaatttaatccttttgatttg atatcagacactgattcatcccaggaagaaactgccaagaaacagaaaatggctcagaaa gaacagggaaaacccgaaggaatcacaaaacctccaccacaacagtcacctaagccagtt cctaagcagcaaggacctgcgagggtcccactgaagcaggatggctctcccagatcagta tcttctcagcaaccagagaagattaaattacaaccttcagggacaggaaagccaattgag gggcttacccaggctcctcagacagaccaggcacaattgccccttcaaagagatgcaacc aggcctcagacaaagcagtcagacacactaaggggagaatcagttaaaccctctttgcaa agcccatccaaaccacctattcagcagggaggtcctggaaaacctccagcccagcagcct ggacctgaaaaacttgctacagcacagcctgggcctgcaaagcccttagctcagcaaaca gggccagcgaaggccctagctcaacagccggggacagcaaagcccccagcccagccacca gggacaacaaagcctactgctcagcagcctgggccaaagtctccagctcagcctgttggg cctgcgaagcctcaaactcaacaggctgggtcagacaaacttccatctcagcagccaggg ccagcaaagcccccagcccagcagccagggacaccaaaatctccagctcaccagcctggg tcacagtctccagctcagccatctgggcctgcaaagactccatctcagcaaccagggaca ggaaaaactcctgctcaacagcccggcctggcaaagcccccacctcaacagcccggcccg gcaaagccccctcctcagcagcccggcccggcaaagccccctcctcagcagcccggcccg cccggcccggcaaagccccctcctcagcagcccggcccggcaaagccccctcctcagcag cccggcccggtaaagcccccttctcagcagcccggcccggcaaagcccccacctcaacag ccaggcccggcaaagcccccttctcagcagcccagcccggcaaagcccccacctcaacag ccagtcccggcaaagccttcagctcagctgtctacaaaaccagtaagccaaacagaagct gggaaatctcctcagccatccactgctccgtctgcagcccagactccaggacaaggcctc cctaaaaccatctgtcctctttgcaataccactgaacttctgttgcatgttccagaaaag gccaattttaacacatgcactgagtgtcaaaccactgtgtgtagcctgtgtggttttaat cccaatcctcatttaaccgagataaaagagtggctctgtttaaactgtcagatgaagaga gctctcggaggtgatctggctccagttccctcatcacctcagcctaaaccgaagattgct cctgttggtcctgcatctgccgtgagcaaaccatccccacagccacagcacacttctcca aagaaggatactgtacccaagcaggagatcttgaaggcacctgagtctaagaggccccca cctctagtgaaacaaccgaccattcacggctctcccccacttgccgccaggcaacctcca gcggcggcggagtcttcgcccaagccagcccctcccaaagagccctcggttccctctgag caggccgaggtccccgtggctgatgataaaccaaagcagcccaagacaggaaagccagcc acagacgtcgagtcttcatcgtcagtagcagcacaacctgatattccaagccccaaagta cagttggaagatcaagagataataacccctcctctaaaaacagacgctgccaaaccctcc cagagttttccaccaacgggagaaaaagtcaccccgtttgattctaaagtcataccccga cctgcatcagattcgaaaattatttcacatcctgggcccagcccagagggcaaaggtcaa aaacaagctgatccggttcagaagagagaagagcccaagaaagcacaaaccaaaatgagt cctaagccagatgccaagccgatgccaaaagggtcacctccacccgcaggcccacgacct cccactggcccaactgcccccacagctcagcagcccccaaagcctcaggagcagtcgcga cgtttcagtctgaatctgggaagtattaccgatgcccctaaatcacagcccacgactcct caagaaactgtgactggaaaactctttgggtttggagcatcaatcttcagccaggcatca aatttaatctccacagcaggccagcctgggtctcaatctcagagtgctcttggagcccca acaaaacagggccctcctccttcacagccacctccttctcaggggccacccaaatccaca ggtcaggtaccaccggcacctgcaaaggttgtacctgtgaaaaaggaagcaaaagctcca gtagttgaaaaattagaacccaaatctgaaccagttccaacagtaaaaagaacagaaaca gaaaagaagcctctgcctgttaaggatagcaaacctctaacagctgagcctcaaaaggct gtccttccccccaaattggagaaaactcccaaaccagaatcagcctgtcctctctgcaag actgaactcaacataggttctaaggatcctcctaacttcaatacttgcacggaatgcaag aatcaagtgtgtaatctctgtggatttaaccctatgccacacttgactgaggttcaagaa tggctttgtttaaattgccaaacccagagagcaatatcaggacagcttggagatatgggc aaaatgccacctacaccttcagcgccaaaagcctcccctatgcctgtccctccagaacaa ccatctcagaaaacagcaatgcctactcaagtaaaagtgaaaaagaaggaacaagaagta aaaacagaagctgaacaaatcattccagaaaaagtgaaagagataccatcagtggaaaag attgtcccaaaggggaccacagaccacaaacaagagagtaaactagagaaaacttcagcc cctgaagacaaaaagccactcccagaagaaaaaaagccccctcttgaagagaaaaagcca cccactgaagacaaaaagttacctccaggaacaaaaacagctctggaggaggaacagaaa caagacttagctaaaactcaagtaccaactgctgaggaaaagcctgaaggcagagtgact ccacaggttgtacaagagaagctaccacagaccaagatggaagacaaaccctctggccca cctccaagtttgtcaaaagatgatgaggtgcctcaaaaaattaaagaccagccacaggca gcacgcccagcaacgcctgatcaggtggaacctgggaaagaaaaaacagaaaaggaagat gacaaatcagacacttcaagttctcagcaaccaaaaagcccacaaggtctgagtgacaca ggatattcttctgatgggatatcaagttcacttggtgaaattccaagtcttattccaagc gatgaaaaagatttgctcaagggactcaaaaaggactctttttcccaagaaagcagtcct tccagcccctcagatttggctaagttagaaagtacggtcctctccattttggaagctcag gcaagtacacttgttgaagaaaagtcagaaaagaaaactcaacctcatgaggtttcttct gagcagccaaaggacccacagaaaactcagagtttatctgaaacagtggaaactacaatt tcagaagaggagctcaaaaagagtccagaagaaaaagacactttaaaaaaagatagccaa caagacattccttccacaaaggaccacgaagaaaagtccgagtttgttgatgacacagct acaagaagacagctttatgattcagttgaagacagtagtgaaagtgaaaattcacctgtt ccacaaagaaaacggagaaccagtgttggttcatcgagcagtgatgagtataaacaggaa gatagtcaagggtctggtgaagaggaggactttattcgaaaacagattatagaaatgagt gctgacgaagatgcttcagcttctgaagatgatgagttcattaggagccagctcaaagag attagtagtagtattgagagccagaagaaggaagacatgaaaggaaaagggaaagcaaca gcggggaaacacaggcgactaactcggaaaagcagtgccagctttgatgatgatgcaggg agacgccattcgtggcatgatgaagatgatgagacatttgatgagagtcctgagcttaag tacagagaaactaaaagtcaagagagtgaagaacttgtagttgctggaggaggggggcta cgtcgcttcaaaaccattgaactcaacagcacaatagcagataaatactctgcagactca tcacagaaaaaaacggctttgtattttgatgaggagccagaattggaaatggaaagcttg acagactccccagaagataggtcaagaggggaagggtcttctagtcttcatgcttccagc ttcactcctggcacatcccctacctcagtgtcgtctcttgatgaggacagtgacagtagc ccaagtcacaaaaaaggagagagcaaacaacaacgtaaggctcgccacaggtcacatggt cctcttttacctactattgaagattcttcagaggaagaagaattgagagaggaggaagaa ttattaaaggagcaagaaaagcagcgggaattggaacagcagcaaagaaaggcttctagt aagaaatcaaagaaagacaaagatgaacttcgagctcagagaaggagggaaagaccaaag acaccacccagtaatctctctcccattgaagatgcatctccaacagaagaattacgccag gctgcggaaatggaggagctgcatcgatcttcttgttctgaatactcacctagcatagag tcagacccagaaggctttgaaataagcccagaaaagataatagaagtgcaaaaagtttat aaattgcccacagctgtgtctttatattcaccaacagatgagcagtctattatgcagaaa gaaggtggccaaaaggcattaaaaagtgccgaggagatgtatgaagaaatgatgcacaaa acccacaaatataaaccttttccagctgtaccagaacgagatgaaatgtttgaaaaagag cctttgtatggcgggatgttaatagaggattatatttatgaatctttagtagaggacaca tacaatggttcggtagatggcagtctgctaacaaggcaagaagacgaaaatggatttatg cagcagagagggaaagagcagaaaataagactcccagaacagatttatgaagatcctatg caacaaataacagacctccagaaagagttttatgagttagaaagcttacattctattgtg cctcaagaagacattgtttcaagctcttttatcatcccagaaagccatgaaatagtggat ctgggtagtatggtgacttccaccagtgaagaaaaaaaattattagacgctgatgctgcc tatgaagaactcatgaagaggcagcaaatgcagttaacacctggatccagtccaacccag ccccccatcacagatgacatgatagagtctaccgtggactttgacagggtgcccgatgca tctttgacatcaagtgttctctcaggagcatctcttacagattcgaccagcagtgcaaca ctctctatcccagatgtcaaaataacccaacatttttcaacagaagaaattgaggatgaa tatgtaacagattatacaagggaaatccaagagataattgcccatgaatcactgattttg acctactctgagccttcagaaagtgctacatctgtcccaccctctgacacaccctctctc acgtcttctgtttcttcagtttgtaccacagatagctcctcacccgtcactaccttggat agcataaccacagtttatatggaaccagtggatgtagtaactaaatttgaagattctgag ggaatttcttcatcaacatattttccgggcagcattatagactatccggaagaaataagt gtatctttagatcgagccaccacaccagatggaagaactggtgctgatcatatcgtgatt tccttatctgatgtggagcctcctattctagaatctataggaactaaaccggagaggctg attgctgacactgtttccactgacttacctgtatctgcaaaagacgcagtgaagaaagcc aagaaggacactgggaatggaattattctcgaggttctggaagcttacaaagataaaagg gagaagactgaggttgaactaacaaagatgagcttttctgaaactgtgtttgatcaacct ccttcttctgcagtggcccttccagtaggggagcaggtttcagcaacgtgctttatatca ggacaggtctttgaccaaacaaaacccgcatctccgttgccatccggcagtccttctgtt acctctcttccaactaaaacgcgtccattctttagaagttcttctttggacacatcagca cagcctcctcctccccctccccctccccctccccctcctcctccaccccctcctcccccc cctccacctctccctccaccaacctcacccaagccaatcattcatcctacaaaaaagtta acaattacagctccagagactgtaaccactacagctaaacctctagttgatgctgttact acagtagaggctacagctattccaagaagtaatgggttacctgtaacaaaaatatgtacc actgcacctcctcctgttcctcctaagccatcttccatcccatctggacttgtctttaca catagacctgagccaagtaaacctccgattgcccctaaaccagcagtccctcagcttcca gtaactacacaaaaatcaacagatacacaccccaagccaacaggtctatctttagcttca aacatgacattaaatttagtgacttcagcagattataaattaccttcccctacctcccca gcatcccctcactctaacaagtcctcaccaagattttccaaatccctcatggaaacctac gtggttatcacattgccatctgaacctgggactccaaccgattcttcaattagtcaagca gttaccagttggcccctgggatcaccccccaaagacctgatttccatcgaaccagtgttt tctgtagttcctcctatgacaactgcaggaatgccaagttcttcagaacagagcttgtac atgtcaggagctttggagacattttctgctgtccctgccacaacgttatcttcatttcaa gcagccccaacctcagttacacagtttttcacaactgaagtttccaaggctgaggcttca gcagccagaagtgcactcactagtgttggtctcagcagcgtctctatatcgattcctcca gagcctcttgctctagataacctacatttagagaagcgtcagcataaggaaaatggaaag ttgccgcttgttggtgatgccattgatttgcgtacagtaccaaaagtagaagttaaagta actgaaaagtgtatggatctttctgcctccacaatggatatgaaaaggcagaccaccaca catgaagtctatgggagacaaatcagcgccgtccaaccatctattataaatctcagtgca acttcatcagcagtaacgccgatgcccctggtcactgagacggtgactgttgtcacgtgc gcagctagttcaggttacaccatgggcccagaaagcctagtgggtatagaacatgcaaca ccagcacccctccagcttactacatcaaagcatgctgagcctcccccgtacaggataccg agtggccaggcctttcctgcagttagggaggatgcaccaataaacttatctttaggtaca tcagcacacccagtgacattggctgttacaaaacctgttaccgcacctcctgtcggagtc acaaatggatggacggatagcgtcacacgccagggaatggctgatggggaagtagtagat ctcagtacaaccaagtctcacagaactgttgtaacgatggatgaatctgcttccggtgtg gtgaccaaaatagtagaagatgatgaaaagcctgtcgatctgactgcaggaagaagagct gtatgctgcgatatggtttacaagttaccttttggaaggagctgcacagcacagcagccc acaactactcttcctgaggatcgttttggttatagggatgaccactatcaatatgaccgg tcaggcccttctggttatagagggattgggggaatgaaaccttccatgtctgacacgaat ttagcagaagctggacattttttctataaaagtaagaatgcttttgattactctggagga actgatacagcagtagatctaacttcagggagaattactgcaggtgaggtaatggattat tcaagcaagactacaggtccatatccagaaacacgacaagtcatttcagaagttgggatt agtaccccacagtattccacagcgagaatgactccacctccgggatcccagtatggtgtg gggagtgttttgaggtcatccaatggtgttgtctattcttcagtagcaactccgattccc tccacatttgctatcaccacacagcctggctccattttcagcaccacggtgagggatttg tctggcgtgcacacagctgacgcggtgacttcgctatccgccctgcaccagagccagcca atgcctagatcatatttcctaacaacaggtgcgtctgaaacagacattgcagcaaccggt atcgatatcaatgccagtttgcaaactattacagtggaaacccttaccgctgagacaata gactccgttcccactctaaccacagcctctgatgtgttttccgaagtggtgggagacgaa agtgccattttaattgtccccgaagaaggcaaacaacagcagcagctcgacttggagcgt gagctcttggaactggagaaaatcaagcagcaacgttttgctgaggaattagagtgggaa cgtcaggagattcaaaggttccgagaacaggaaaagatcatggttcaaaaaaagctggag gagctgcagtctatgaagcagcaccttctgtatcagcaggaagaagagcggcaagcccag ttcatgatgaggcaggagacattagctcagcagcagttacagctggagcagatccaacag ctgcagcaacagcttcaccagcagctagaagagcagaagattcgccagatctaccagtat aactatgacccctctggaactgcttctccgcaaaccacgacagagcaggcaattttggaa ggtcagtacgctgccccagaaggcggccagttttgggcaactgaggatgcaaccaccacg gcctcggccgtcgtggcgattgaaataccacagagccaaggatggtacacagtgcagtct gatggcgtcactcagtacatcgccccacctggcatcctgagtacggtttcagaaatacct ctaacagatgtggttgtgaaagatgagaaaccacccaaaaagagaagcgctgcggctaaa gtccgtggacagtatgatgagctcggggaacatatggccgatgatccgcgctgctttaaa aagatagtggacagtggcgttcaaaccgacgacgaggacgcggcagatcggacttatgtg agtaggaggaggagaaccaaaaagagtgttgatacaagtgtccaaactgatgacgaagat caggatgaatgggatgtgcctgctagagcaaggaggaaagctcgagtagggaaatatggt gacagcactgcagaggctgacaagaccaaacccctttccaaagtctccagcatagcagtt caaacagtagcagagatatctgtgcagactgaaccagtcggaaccataagaacgccttca gtacgggcacgcgtggatgccaaggtagaaataattaaacacatttcagcacctgaaaag acttacaaagggggcagtttaggatgtcaaacagaagcagattcagacacacagagtcct caatatctgagtgccacatctccacccaaagacaagaaacgcccaacacctttagagatt ggttactcatctcaccttcgggcagattccacattacagctggctccttccccacccaaa tctccaaaagtcctttattcacccatctcaccactttcaccaggcaaagccttagaatca gcctttgtaccttatgaaaaacccctccctgatgatataagtccgcagaaagtactgcat ccagatatggctaaagtgcccccggcaagtcctaaaacagccaagatgatgcagcggtcc atgtctgaccccaagcctctgagtccaacagcagatgaaagttccagggctccttttcag tataccgagggctacacgacaaaaggttctcaaaccatgacaccttctggctcccagaaa aaagttaagagaactctgccaaacccacctcccgaggagacctccacaggcactcagtca acatacagcacaatgggcacagtttccaggagaaggatctgcagaaccaacacaatggca cgggccaagattctccaggatatagacagagagcttgatcttgtagagagggaatctgca aagcttagaaagaaacaagcagaacttgatgaggaagaaaaggagatcgatgccaagtta cggtacctggaaatgggaattaacaggaggaaagaggcattattaaaggagagggaaaag agagagcgtgcctacctccagggagtagctgaggatagggattatatgtctgacagtgag gtgagcagcacccgacccaccagaatagaaagtcagcatggcatagagcgaccaagaact gctccccaaactgaatttagtcagtttataccaccgcaaacccaaacagaatctcaactg gttcctcctacgagtccttatacacaataccagtattcttcccctgctcttcctacccaa gcacccaccccatatacccaacagtcccattttcagcaacagactttgtaccatcagcaa gtttcaccttatcagactcaaccaacatttcaagctgtggcaacaatgtccttcacacct caagctcaacctacaccaaccccacaaccttcttaccagttgccatcacaaatgatggtg atacaacagaagccaaggcaaactacattatatttggagcccaagataacttcaaactat gaggtaattcgcaaccaacccctgatgatagcacctgtttctactgataatacgtatgct gtttcccaccttgggagtaagtacaatagcttagacttgagaataggattggaggaaaga agtagtatggcaagcagtccaatatcaagcatatctgcagattctttctatgcagatatt gaccatcatactccacgaaattatgtcctaattgatgacattggagaaattaccaaagga acagcagcattaagcactgcatttagccttcatgaaaaggatctgtcaaaaacagaccgt ctccttcgatccactgaaacacgtaggtctcaagaagtgacggatttcctggcaccatta cagacttcctccagattgcatagttatgtgaaagcagaggaagatcccatggaggatcct tatgagttaaagcttctgaaacaccagattaaacaagaattccgtagaggagcagagagc ttagatcaccttgctggtctttcccattactaccatgctgatactggctatagacatttt ccaaaatccgaaaagtacagcatcagtagactcacacttgaaaaacaagcagcaaaacaa ctaccagcagccatactttatcaaaagcagtcaaagcataagaaatcactaattgatcct aaaatgtcaaaattttctcccattcaagaaagtagagaccttgaacctgactatacaagc tatatgacttctagcacctcatctattggcggcatttcttccagagcaaggcttcttcaa gatgatatcacttttggactcagaaaaaatattacagaccaacagaagtttatgggctca tcccttggaacaggactgggcacattgggaagtaccctacgttcagctttgcaggatgaa gcagataagccatacagtagtggcagcaggtccagaccttcttccagaccttcgtctgtc tatgggcttgatttatcaattaaaagagattcttccagctcctccctaagactgaaagct caagaggctgaagctctagatgtttcctttagtcatgcttcaccttctggccgaactaag cctaccagtttaccaattagccagagtagaggaagaataccaattgtggcccagaattct gaagaggaaagtccactcagtcctgttggccagccaatgggaatggccagggctgcagct gggcccctgccaccaatatctgcagacactagggatcagtttggatcaagtcattcattg cctgaagttcagcaacacatgagagaagaatcacgaactagaggctatgaccgtgacata gcgttcatcatggatgacttccaacatgccatgtcagacagtgaagcctatcatctgcgt cgtgaagaaacagattggtttgacaaacccagggagtctcgtttggaaaatggacatggt ctggatcgcaaactgccagaaagattggtccactctagaccacttagtcaacatcaagag caaattatacagatgaacgggaagactgtgcactacatctttcctcacgcaaggataaaa ataacaagagactctaaggatcacacggtttcaggtaatggattaggaattagaattgtg ggtggtaaagaaatccctggacataatggagaaattggagcctatattgccaaaattctt cccggaggaagtgcagaacagacaggaaaacttatggaagggatgcaagtgttggaatgg aatggaattcctttaacttctaaaacatatgaagaagtgcagagtatcattggtcagcaa agtggggaagcagaaatatgtgtaagactggacctcaatatgctatcagactctgaaaat ccccagcacctggagcttcatgagccgccgaaagctgtggagaaagcaaaatccccaggg gttgatcctaagcagttggcagcagagctccagaaggtctcattacagcagtcaccactg gttctgtcgtccgttgttgagaaaggatctcacgttcattcaggtccaacatcagcagga tccagttccgtccccagccctgggcaaccggggtcaccctcagtgagcaaaaagaaacac ggcagcagcaagcctactgatgcagccaaggttgtctctcatccaattacaggggaaatt cagcttcaaatcaactatgatcttggaaatctcataatccatattctccaagcaagaaac cttgtccctcgagacaacaacggttattcggacccctttgttaaagtgtaccttcttcct gggagaggtcaagtcatggttgtccagaatgcaagtgctgagtacaagaggaggactaaa tatgttcaaaaaagtcttaatcctgaatggaatcaaacagtaatttataaaagtatctcc atggaacagctcaagaagaaaacactggaggtgaccgtctgggattatgatagattttct tccaatgactttcttggtgaggtactgattgatttatctagcacatctcacctcgataac actcctagatggtattctctcaaagaacagactgaaagcctcgatcatggcaagtctcat tccagtcagggcagccagcagcctccaaagccatctgtcatcaaaagcagaagccatggt atcttccctgacccatccaaggacatgcaggttcccaccattgagaaatcccacagtagt cctggtagctcgaaatcctcctccgaaggtcacctccgctctcacggaccgtctcgcagc cagagcaaaaccagcgtcacccagacccacctggaagatgcaggggctgccatagccgct gccgaagccgcagtgcaacagctccgcctgcaaccaacaaagcctaccaatcaccgcccc gcagaaagctccgtgtctaccggctcctcgggcagcagctttggcagcgggtacagcgtg gacagtgaaggaagcagcggcactgcaggggagactaatctatttcctattccaaggata gggaagatggggcagaatgggcaagagcctgtaaaacagccaggggtaggagtgggacta acagacgccgaagtcaaaactcaggtaatgggagaaatcaagattgcactgaagaaggaa atgaagacagatggtgaacaactgatagttgagattctccaatgcagaaatatcacctac aaatttaagtctcctgatcacttaccagatttatatgtaaaaatatatgtgatgaacatc tctacccagaagaaagtgatcaagaaaaaaacgagagtttgcagacatgatagagagcct tcattcaatgaaacttttagattcagcctcagtcctgctgggcattctcttcagatttta cttttctctaatggagggaagtttatgaaaaagaccttgattggcgaagcctgtatctgg cttgacaaagtggatctgagaaaaagaatagtcaactggcacaaacttttggtcagtcct actcaaacccattga

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