Puma concolor (puma): 112867739
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Entry
112867739 CDS
T08890
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
pcoo
Puma concolor (puma)
Pathway
pcoo05012
Parkinson disease
pcoo05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
pcoo00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
112867739 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
112867739 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
pcoo01001
]
112867739 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
pcoo04131
]
112867739 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
pcoo04147
]
112867739 (LRRK2)
Enzymes [BR:
pcoo01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
112867739 (LRRK2)
Protein kinases [BR:
pcoo01001
]
Serine/threonine kinases: TKL group
LRRK family
112867739 (LRRK2)
Membrane trafficking [BR:
pcoo04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
112867739 (LRRK2)
Exosome [BR:
pcoo04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
112867739 (LRRK2)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
LRR_4
COR-B
Ras
COR-A
ARMC6
LRR_9
Beta-prop_RSE1_2nd
Arf
WD40_CDC20-Fz
Beta-prop_EML_2
LRR_NXF1-5
Beta-prop_IFT122_1st
LRR_13
Beta-prop_WDR36-Utp21_1st
AAA_22
T2SSE
Beta-prop_THOC3
nSTAND3
Ank_2
Beta-prop_NOL10_N
ABC_tran
Kdo
PduV-EutP
GTP_EFTU
SRPRB
G-alpha
TsaE
MMR_HSR1
AAA_7
ASA1
TniB
AAA_16
NB-ARC
ARM_CUL7_CUL9
WD40_Prp19
MobB
WD40_WDHD1_1st
AAA_29
Septin
nSTAND_NTPase5
NACHT
FtsK_SpoIIIE
SRP54
LRR_6
Beta-prop_HPS5
Motif
Other DBs
NCBI-GeneID:
112867739
NCBI-ProteinID:
XP_025786523
UniProt:
A0A6P6IHW3
LinkDB
All DBs
Position
Unknown
AA seq
2527 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYADHASKLFQGKN
VHVPVLIVLDLYMRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGRDWEILGIHQLIL
KMLTVHNASVNLLTVGLKALDLLLTSGKITLLILDEETDIFLLIFDAMRTFSANDEVQKL
GCKALRVLFERVSEEQLTEFVENKDYMILLNALKNFKDEEEIVLHVVHCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKAFPDNEKIQEVSCCLLHRLTLGNFFNILVLNDVHEFVVKAV
RRYSENATLQIAALSCLALLTETIFLNQDLEEKNENQENDDEEEEKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNASMDTM
VVVAPKIITVMRYHEASLSVQLEALRAILHFIVPGMPEESKEDTEYQHKLHMVKKQCFRN
DIHKLVLAALNRFIGNPGIQKCGLKVISSIAHFPDALQVLSLEGAIDSVLHTLQMYPDDQ
EIQCLGLGLIGCLITKKNLCIGTGHLLAKILVSSLQRFKDMAEVQIKGFQTILTILELSV
SFSNLLVHHSFDSVIFHQMSSSIMEQKDQQFLNLCCKCFAKLAMDDELKSVMLEKACDQN
NSIMVECLLLLGADANRTKEATSLICQVCEKASSPKLVELLLNGGSREQDVRKALTISIG
KGDSQIISLLLRRLALDLANNSICLGGFCIGKIEPSWLGPLFPDRTSNLRKETNIGSTLA
RMVLRYQMKSVVEEGAASGSDGNFPEEVLDKFDEWTFIPDSCVDSVFGQSDDLDSEGSEG
SFLVKRKSNSISVGEFYRDRALQRCSPNLQRHSNSLGPIFDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELHQ
NGLTNFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDISRNDINPSVLLDPAV
KCPTLKQFNLSYNQLSSFPENLGDVVEKLEQLILEGNKISGICSHLSLKELKILNLSKNH
ITSLSEDFLEACPKVESFSARMNYLAAVPFLPSSLTSLKLSQNRFTCVPEAILNLPHLRS
LDMSSNDIQYLPSPAHWKSLNLRELLFSFNQISVLDLSEKAHVWSRVEKLHLAHNKLKEI
PPEIGCLENLTSFDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLTKSKKSDPGVQSATVGIDVKDWPIQI
RGKGKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILLERKNVPIEFPVIDRKRLLQLVKEN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPK
HPKGIISRRDVEKFLSKKKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDHHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPEQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDILNSAELICLMRHISIPKNFIVECMVATNH
NSKSASIWLGCGHTDKGQLSFLDLNMEKHTSEEVTDSRILCLALVHLPAEKESWIVCGTQ
SGMLLVISTEDGKKRHTLKKMTDSVTCLYCNSVPKQSKQKNFLLVGTADGNLAIFEDKTV
KCKGAAPLKILNIGNVSTPLMCLSESMNSTEKNIMWGGCGTKLFSFSDDFTIQKLIETKT
NQLFSYAAFSDSNIIAVVVDTALYVAKKNSPFVEVWDKKTEKLCELIDCVHFLKEEMVKV
NAESKHKISYSGRVKTLCLQKNTALWIGTGGGHVLLLDLSTRRIIRIVHNFCDSVRVMMT
AQLGSLKNVMLVLGYIRKSTEGTQHQKEIQSCLSVWDINLPHEVQNLEKHIEVRNELAEK
MRRISVE
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggtagctgtcaggggtgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtccaaattctg
gaggatttgctggtgttcacgtacgcggaccacgcctccaagttatttcaaggcaaaaat
gtccacgtgcctgtgttgatcgtcttggacttgtatatgagagtcgctagtgtgcagcag
gtgggttggtcacttctatgcaaattgatagaaatctgtccaaatacaatgcaaagctta
atgggaccgcaggatattggacgtgattgggaaatacttgggatccaccaactgattctt
aaaatgctaacagttcataatgccagtgtaaacctgttaacagttggactaaaggcctta
gatctcctcctaacttcaggtaaaataactttgctgatattggatgaagagactgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgacgaagtccaaaaactt
ggatgcaaagctttacgtgtgctgtttgaaagagtttcagaggagcagctgactgaattt
gttgagaataaagattatatgatcttgctaaatgcattaaaaaattttaaagatgaagag
gaaattgtgcttcatgtagtgcactgtttacactccctagcaattccttgtaataatgtt
gaagtcctcatgagtggcaacgtgaggtgttacaatattgtggtagaagccatgaaagca
ttccctgacaatgaaaaaattcaagaagtgagttgctgcttgctccataggcttacctta
ggtaatttttttaatattcttgtattaaacgatgtacatgagtttgtggtgaaagctgtg
cggcggtattcagagaacgccacgttacaaattgcagcactcagctgtttagcactcctc
actgagaccattttcctaaatcaagatttggaggaaaagaatgaaaatcaggagaatgat
gatgaggaagaagaaaaattgttttggttggaagcctgttacaaagcgttgacgtggcat
agaaagaacaagcacgtgcaggaagctgcatgctgggccctaaacaatctcctcatgtac
caaaacagtctccatgagaagatcggagatgaagatggccagttcccagctcatagggaa
gtgatgctctccatgctgatgcattcttcatcaaaagaagtcttccaggcctctgcaaat
gcgttgtccactctgttagaacaaaatgttaatttcagaaaaatcctcttgtcaaaagga
atatacctgaatgtattggagttaatgcagaagcatatacattctcctgaggttgcagaa
agcggctgtaaaatgctaaatcatctttttgaaggaagtaatgcttccatggatacaatg
gtagtagtggcccccaaaataataacagttatgagatatcatgaggcatcattatcagtg
cagctggaggcacttcgagctattttacattttatagttccaggcatgccagaagagtcc
aaggaagatacagaatatcaacataagctacatatggttaaaaaacagtgtttcaggaat
gatattcacaaactggtcctagcagcgttgaacaggttcattggaaatcctgggattcag
aaatgtggattgaaagtaatttcttctatagcacattttcctgatgcattacaagtatta
tccctggaaggtgctattgattcagtacttcacacacttcagatgtatccagatgaccaa
gaaattcaatgtctgggtttaggtcttataggatgcttgattacaaagaagaatttatgc
ataggaactgggcatctgctggcaaaaattctggtttccagtttacaacgatttaaggat
atggctgaagtacagattaaaggatttcagacaatcttaacaatactggaattgtcagtg
tctttttccaacctgctggtgcatcattcctttgattcggtgatattccatcagatgtct
tccagtatcatggaacaaaaggatcaacagtttctaaacctttgttgcaagtgctttgca
aaattagctatggacgatgagttaaaaagcgtgatgttagagaaagcatgtgatcagaat
aacagtatcatggttgaatgcttgcttctgttgggagcagacgccaatcgaacaaaggag
gcaacttctttaatttgtcaggtatgtgagaaagcaagcagtcccaaattggtggaactg
ttactgaatggtggttcccgtgaacaggatgtccggaaagctctgacaataagcattgga
aaaggtgacagccagatcattagcttactcttacggagactcgccctggatctggccaat
aatagcatttgccttggaggattttgtataggaaaaatcgaaccttcatggcttggtcct
ttgtttccagataggacatctaatttaagaaaagaaacaaatataggatccaccctagca
agaatggtgctcagatatcagatgaaaagtgttgtggaagaaggagcagcctcaggcagt
gatgggaattttcctgaagaagttcttgataaatttgatgaatggaccttcattccagac
tcttgtgtagacagtgtgtttggtcaaagtgacgacctggatagtgaaggaagtgaaggc
tcatttcttgtgaaaagaaaatccaattcaattagtgtgggagaattttaccgagatcgt
gccttacagcgttgctcaccaaatttgcagagacattccaactcattgggacccattttc
gatcatgaagatttactgaggcggaaaagaaaaatattgtcttcagatgactcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttccctggcttctgag
agagagtatattacatcattagacctttcagcaaatgaactaagagacattgatgcccta
agccagaaatgctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatggactcacgaactttccacaacaattgtgtgaaaccctgaagtgtttgacacatttg
gacttgcacagtaataaatttacatcatttccctcttacttgttgaaaatgaattgtatt
gccaaccttgatatctctcgaaacgacatcaacccctcagtacttttggatcctgcagtg
aagtgcccaaccttgaagcagtttaacttgtcatataatcagctgtcttcttttcctgag
aaccttggtgatgtggtagagaaattggaacagctcattttagaaggaaataaaatatca
ggaatatgttcccacttaagcctgaaggaactgaaaattttaaaccttagtaaaaaccac
attacatccctatcagaagatttccttgaggcgtgtcctaaagtggagagtttcagtgcc
agaatgaattatcttgctgctgtgccttttttgccttcttctctgacaagcctaaaattg
tcccaaaacagatttacatgtgttcctgaagcaattttaaatcttccacacttacggtcc
ttagatatgagcagcaatgatattcaatatctaccgagtcctgcacactggaaatctttg
aacttaagggaactcttgttcagttttaatcagatcagtgtcttggacttgagcgaaaaa
gcacatgtatggtcaagagtagagaaactgcatcttgctcataataaactgaaagagatt
cctcctgagattggctgtcttgaaaacctgacctcctttgatgtcagttacaatctggaa
ctgagatcctttcctaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactacgtcttaattttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcagcagcggttaaaaaaggctgtgccctataaccgaatgaagcttatgattgtg
ggaaatactgggagtggtaaaaccaccttattgcagcaactaacgaaaagcaagaaatca
gatcctggggtgcaaagcgccacagttggtatagatgtgaaggactggcctatccaaata
agaggcaaagggaagaaagacctcattctaaatgtgtgggattttgcaggtcgtgaggaa
ttctacagcactcatcctcacttcatgacccagcgggccctctacctggctgtctatgac
ctcagcaaagggcaggctgaagtcgatgccatgaagccttggctcttcaatataaaggcc
cgtgcttcttcttcccctgtgattcttgttggcacacatttggatgtttccgatgaaaag
cagcgcaaagcctgcataagtaaaatcaccaaggaactgctgaacaagcgagggtttcct
gcaataagagattaccactttgtgaatgccacagaggaatccgatgctttggcaaagctt
cggaaaaccatcataaatgagagtcttaatttcaagatccgagatcagcctgtcgttggg
cagctgattccagactgctatgtagaacttgagaaaatcattttattggaacgtaaaaat
gtgccaattgaatttcctgtaatcgaccggaaacgattattacaactcgtaaaagaaaat
cagctacagttggatgaaaatgagcttcctcatgcggttcacttcctaaatgaatcaggg
gtccttcttcattttcaagacccagcgctgcagttaagtgacttatattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggaaggctatccgaaa
catcctaagggaatcatttcacgcagagatgtggaaaaatttctttcaaagaaaaagagg
tttccaaagaactacatgtcacagtactttaaactcctagaaaaattccagattgccctg
ccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgata
gagctccctcattgtgagaactctgaaattatcattcgactatatgaaatgccttatttt
ccaatgggattttggtcaaggttaatcaatcgattacttgaaatttcaccttacatgctt
tcaggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttg
aattggtctcctgaagcttattgtctggtaggatctgaagttttagaccatcacccagag
agtttcttaaaaattacagttccttcgtgtagaaaaggctgtattcttttgggccaagtt
gtggaccacatcgattctcttatggaagaatggtttcctggattactggaaattgatatc
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gaacatcaaaaaatcttgcttgatgacttgatgaagaaagcagaagaaggagaccttcta
gtcaatccggagcaaccaaggctcaccattcctatatctcaaattgctcctgacttaatt
ttggctgacctgcctagaaatattatgttgaataatgatgaattggaatttgaacaagct
ccagaattcctcttaggtgatggcagttttggatctgtttatcgagcagcctatgaagga
gaagaagtggctgtgaagattttcaataaacatacatcacttagattgttaagacaagag
ctggtggtcctttgccacctccaccaccccagcttaatatctttgctggcggctgggatt
cgtcctcgcatgttggtgatggagttagcctccaagggttcactggaccgcttgcttcag
caggacaaagccagtctcaccagaaccctacagcacaggattgcactccatgtggctgat
ggcttgagatacctccactcagccatgatcatataccgtgacttgaagccccacaacgtg
ctgctctttaccctgtaccccaatgctgccatcatcgcaaagattgctgactatgggatt
gctcagtactgctgtagaatggggataaagacatcagagggcacaccagggtttcgtgca
cctgaagttgcaagaggaaatgttatttataaccagcaggctgatgtttattcatttggc
ttactactctatgacatcttgacaactggaggtagaatagcagagggtttgaagtttcca
aatgagtttgatgaactggcaatacaagggaaattacctgatccagttaaagaatatggt
tgtgccccatggcctatggtggagaagttaattaaaaagtgtttgaaagaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgagttaatctgtctg
atgagacatatatcgatacctaaaaactttatagttgaatgcatggttgctacaaatcat
aacagcaagagtgcaagcatctggctgggctgtgggcacactgacaaaggacagctctca
tttcttgacttaaatatggaaaaacacacttctgaggaagttactgacagcagaatactg
tgcctagctttggtgcatcttcctgctgaaaaggaaagctggattgtgtgtgggacacag
tctggcatgctcctggtcatcagtaccgaagatgggaaaaagagacatacccttaaaaag
atgactgattctgtaacttgcttatattgcaattccgttcccaagcaaagcaagcaaaaa
aactttcttctggtgggaactgctgatggcaatttagcaatttttgaagataaaactgtt
aagtgtaaaggagccgctcctttgaagatactaaatataggaaatgtcagtactccactg
atgtgtttgagtgaatccatgaattccactgaaaaaaacattatgtggggaggatgtggc
acaaaacttttctcattttctgatgatttcaccattcagaagctcattgagacaaagaca
aatcagctgttttcttatgcagctttcagtgattccaacatcatagcagtggtggtggac
acggctctctacgttgctaagaaaaatagcccatttgtggaagtatgggataagaagact
gaaaaactctgtgaacttatagactgtgtgcactttttaaaggaggaaatggtaaaagta
aacgcggaatcaaaacacaaaatatcttattctgggagagtgaaaactctctgcctccag
aagaacactgccctctggataggaactggaggaggccatgttttactccttgatctttca
actcgtcgaattatacgtatagttcacaatttttgtgattctgtcagagtcatgatgaca
gcacagttaggaagccttaaaaatgtcatgctggttttggggtatatccggaaaagtact
gaaggcacacaacaccaaaaagagatacagtcttgtttgtctgtttgggatatcaacctt
ccacatgaagtgcaaaatttagaaaaacatattgaagtaagaaacgaattagctgaaaaa
atgagaagaatatctgttgaataa
DBGET
integrated database retrieval system
