Puma concolor (puma): 112871908 Help Entry 112871908         CDS       T08890                                  Symbol SETX Name (RefSeq) probable helicase senataxin   KO K10706   ATP-dependent RNA/DNA helicase, senataxin [EC:5.6.2.5 5.6.2.3] Organism pcoo  Puma concolor (puma) Pathway pcoo05014   Amyotrophic lateral sclerosis Brite KEGG Orthology (KO) [BR:pcoo00001]  09160 Human Diseases   09164 Neurodegenerative disease    05014 Amyotrophic lateral sclerosis     112871908 (SETX)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03021 Transcription machinery [BR:pcoo03021]     112871908 (SETX) Enzymes [BR:pcoo01000]  5. Isomerases   5.6  Isomerases altering macromolecular conformation    5.6.2  Enzymes altering nucleic acid conformation     5.6.2.3  DNA 5'-3' helicase      112871908 (SETX)     5.6.2.5  RNA 5'-3' helicase      112871908 (SETX) Transcription machinery [BR:pcoo03021]  Eukaryotic type   RNA polymerase II system    Other transcription-related factors     Transcription termination factor      112871908 (SETX) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  AAA_11 AAA_12 AAA_19 UvrD-helicase AAA_30 AAA_22 ResIII nSTAND3 SLFN-g3_helicase Helicase_RecD AAA_16 UvrD_C_2 Motif Other DBs NCBI-GeneID:  112871908 NCBI-ProteinID:  XP_025790789 UniProt:  A0A6P6ISL3 LinkDB All DBs Position Unknown AA seq 2663 aa AA seqDB search MSTCCWCTPGGISTADFLKRYASRTHTGEFQTADEDLCYCLECVAEYHKARDDLPFLHEV LWELETLRLINHFEKSMKAEIGDDDELYIVDNNGEAQLFDFTGQDFENKLRVPLLEILKY PYLLLHERVNELCVEALCRMEQANCSFQVFDKHPGIYLFLVHPNEMVRRWAILTARNLGK VDRDDYYDLQEVLTCLFKVIELGLLEDPDIYTSSVLEKGKLILLPSHMYDTTNYKNYWLG ICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMERQADDDSVDPFWPALHCFMVILDRL GSKVWGQRIDPIEAFQTIINNMSYNREIQNIRNSSVRTKSEPESYLDDMVTCSQIVYNYN PEKTKKDSGWRSAICPDYCPNMYEEMETLASVLQSDIGQDMRVHNSTFLWFIPFVQSLMD LKDLGVAYIVEVIHHLHSEVKDVLNQTDAVCDKVTEFFLLILVSVIELHRNKKCLHLLWV SSQQWVEAVVKCAKLPTTAFARSSEKSSGNCSKGAAVISSLSLHSMPSNSVQLACVQLIR SLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTTQETHELQTCLKQIIRNIKFKVP RCSTFVDLTPVCKTPPASYNKEESEQTGKKSKKGLHCLENSSPTFSKGPMKAEAFQMPEN RLVKASNASEEDSEHNYIKDLKLEGRLSAESCIKQGSNRLVPERAQDAVKTSKGKQKSVK ENPTDSRNGPERGCDRGVIIAARSLTDSGTDSLEKASTSTEDFSFKDDVLGKTSKGRTKG QKAEICAKLSHVIKKQHRKSTLIDDGNLEEKLTVSTIDSFFSRKDSGGQKGDGFINHLSL DPDDVPDDKNGERKSQNSLLLKKKQFKSKELDIFSSHENSCQIQECQADGKDLVSFTEMT DICVKKTSPFKDPVTLLESRDKEVGKSTTSQVSSHLREQVPSLSPQSSTLTDSQIDRDLH NLSLIAQASVIKFPSESTQKSSSQLQRKVKDKRCFTANPNNAGEACRGQVIIISDSDDDD GDEGILGFEKHIKRDKIGIKKEYPEEHTSVASTNVEQKLMKEEEAKSLLEFEESDSQFFE FESPHEVFSVWQDQEPDNKNSVQEDENNSRLTHINDVTNDWGYDTDYVSEEVIKKVAEGI EKHTEPQSGSSVGEFCETEVKKRKRKRYEKPVAEDPLRPSPSERNEDQSDNERGLTENDL KSIELRSSSRSNLQRGTTDSLKKSSPKLRTYSKPVRRVPHSKTKKTHSDTKKGQNKSSNY ISCRTTPAIVPPKVLRQCPEPTSTVEKLGLKKAPRRAFDLSQRSLGYLVQLRDHGKTVGV VDTRKKTKLISPQTLSVRNNKKLLTSQDLQSRRQAKHKSKQKRQGSLGSESRAPTRAGLR SAQNPDTLAPESDSSDCRAKGGVEVGANNTGKPSIKRASSEPEPVKMKRVSQVADDPCLS NQCASVVLNGRKATHEAIVSTSAGPLGGGDLTERRLELTALKEGEPRSNSDSEDENIFLT QHDPADMDLCSQMENGNEKLIEMVHGKDTALMEEESWSSTKSKHKDCVEAAQNQGEYCSK HCGAKAVDEDVFRKPGLPPSASKRPSTAKVFSSSSTSRIANLSKSLESTSAPPPALKQKS DGVPSVLKVPQPASVLSPKPVGEVKSFSDVLRPQTLNNSNRQGYKLTFGESRSFSASSAV NVLLSSQSISDTFVKEVLKWKYEMFVNFDQCGPPTSLCQSISRPVPVRFQDCGDYFNVFF PLMILNTFETVAQEWISSPNKEKFYQLHVRKFPAEYKKYWEFVVHLEECELTKQLHPKEN DLVFLVLEKQNGEKKNTERNRMPDLHEYHCGYVHKFRRTSVMRNGKSECSLSIQTQDNLP LSLNELVKCTVISSLVTTQRKLKAMSLLSGRNQLARAVLNPNPMDFCTKDLLTTTSERII AYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKG RSDENSNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGP EKSINNEVLRFSLDSQVNHRMKKDLPSHVQEMHRRKEFLDHQLDELSRQRALCRGGKETQ RQELDEKIAKVSKERQELASKIKEVQGRPQKTQSIIILESHVICCTLSTSGGLLLESAFR GQGGVPFSCVIVDEAGQSCEVETLTPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQS MMARFCKLLEDSVEHNVIGRLPVLQLTVQYRMHPDICLFPSNYVYNRSLKTNRLTETNRC SSDWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKDKRRDVTFRNIGIITHY KAQKTMIQKDLDKEFDRKGPAEVDTVDAFQGRQKDCVIVTCVRANAMQGSIGFLASLQRL NVTITRAKYSLFILGHLRTLMENQHWNHLIQDAQKRGAIVKTCDKNYRHDAAKILKLKPI LQRSLTHPPTVAPEVARPQGGLPSSKPDGEFAKTSFPSSLYHVPSGCKESTGAVTTKDPE RPPIQDRLRDPRLLRRLGIDPEAKGTCPRDPQPLSPQHPGATPPSGEPGFPLSHQDPGGA QLSTARGTTLSNREPPAAGTDVSVSKRACDWEGGLSRRRETRAFSEGDRETQSPESRHPK RRSGWDNRRLEEEDSGSKRRKFL NT seq 7992 nt NT seq  +upstreamnt  +downstreamnt atgagcacatgttgttggtgtacgcccggtggtatttccaccgctgacttcctcaagcgc tatgcgtccaggacccacaccggggaatttcagacagccgacgaagacctctgctactgc ctggagtgtgtggccgagtaccacaaagcacgcgacgacctgcccttcctgcatgaggtt ttgtgggaattagaaaccttacgtctcataaatcattttgaaaaatccatgaaggcagaa attggagacgatgatgaattgtacatagtagacaacaatggagaggcacagctgtttgac ttcactggccaagactttgaaaataagcttcgagttcctcttcttgaaatcctgaagtat ccgtatctgcttttacacgagcgtgttaacgaattatgtgttgaagcactttgtcggatg gaacaagctaattgctcctttcaggtttttgacaaacatccaggcatttatttgtttctg gtccatcccaatgaaatggttcggcgttgggctatcctgaccgcaaggaacttgggaaaa gtggacagagatgattattatgatctgcaggaggttttgacttgtctttttaaagtcatt gagttggggcttctggaagatccagacatctacacttcttctgtcctcgagaagggtaaa ctgattcttctgccttcgcacatgtacgataccaccaactacaagaactattggctaggt atttgcatgttgctgaccattctcgaggagcaggctatggactccctgttgctgggctca gacaaacagaatgatttcatgcaatcaatacttcacaccatggagaggcaagcagatgat gatagcgtggatcctttctggccagcattacactgtttcatggtgattctggatcgcctc ggatcaaaggtctggggtcaacgcatcgatcctattgaggcgtttcagaccattatcaat aacatgagctacaatagagagatccaaaatatacggaacagctctgtaaggaccaagtcg gaaccggagtcgtatttggatgatatggtgacttgtagccagatcgtgtacaattacaac cctgaaaagaccaaaaaggattctgggtggagatcagccatttgcccagattactgtcct aacatgtacgaagagatggaaacgttagccagtgtgcttcagtcagatattggtcaagac atgcgtgttcacaatagcacgtttctgtggttcatcccctttgttcagtccctcatggat cttaaggatttgggtgtggcttacatagtagaggtgattcaccatctgcactctgaagtc aaagatgtcctcaaccaaacagatgctgtgtgtgacaaagttactgagtttttccttctg attttggtgtccgtgattgaactgcacagaaataaaaaatgtttgcacttgctgtgggtt agttcccagcagtgggtggaggctgttgtaaaatgcgccaagcttcccaccaccgcgttt gcacggagttctgagaagtcatctggaaattgctccaaaggagcagcagtgatatcgtct ctgtcactgcattcgatgccatctaattctgtccagctggcttgtgtgcagctgatcaga agtctccttaaagaagggtatcagcttgggcagcagactctgtgcaagcgattctgggac aagctcaacttatttctgcgtgggaatttatctctaggttggcagttgactactcaggaa acccatgagttacaaacttgtttaaagcaaattattagaaacataaaattcaaagtacct cggtgtagcacttttgtggatctgactcccgtatgtaaaacccctcctgcgtcttacaat aaagaagaaagtgaacagacagggaagaaatctaaaaaaggcctgcactgtctggaaaac tccagcccaacattttctaaaggaccaatgaaagctgaggcatttcagatgccagagaat agattggtcaaagcaagtaacgctagcgaagaggatagtgagcacaattacataaaagat ttgaaactagaaggccgtctctcagcagagtcatgcataaagcagggtagcaacaggctt gtcccggaaagagctcaagatgcagtcaaaacaagtaaagggaagcagaagtctgtgaag gagaatcctacggattccagaaatggtccggaaaggggatgtgacagaggggtgataata gccgcacgttcgttgactgattctggcaccgactctctggagaaggcgtccacatcaact gaggatttctctttcaaggatgatgttcttggcaaaacctcaaaaggaagaactaaggga cagaaagctgaaatctgtgctaagttatcacatgtaataaagaagcaacacaggaaaagt actttgatcgatgacggcaatttagaggaaaaactgactgtgtctaccattgacagtttc ttttcaaggaaagattcaggaggtcagaaaggggatggcttcataaaccatctctcgtta gaccctgatgacgttcctgatgataaaaacggggagcgaaaatctcaaaacagtttattg ctgaagaagaaacaattcaagagcaaagagttagatattttctcttcccatgaaaatagc tgtcaaatacaggaatgccaagcagatggtaaagatttggtctcgtttacggaaatgacc gatatttgtgtgaagaaaacgtctcccttcaaagaccccgtgactcttcttgaatcgaga gataaggaagttggcaagagtaccaccagtcaggtgtcttctcacttgagggaacaggtt cctagcctcagtccacagtccagcaccttgacagattcccagatagaccgagacctccac aacttatctttgatagcccaagccagtgttattaagtttccatcagagtcaactcaaaaa agctcatcccagctacaaagaaaagtaaaagataaaagatgtttcacagctaacccgaat aatgctggagaagcctgccggggccaggtgattattatttcagattctgatgatgatgat ggtgatgaagggattctgggttttgagaaacacattaaacgagataaaataggcatcaag aaagaatatccagaggagcatacttcagtagctagtacaaatgtggaacagaagctaatg aaggaagaagaggcaaagtccctattggagtttgaggaatcagattctcagttttttgag tttgaaagtccacatgaggtgttttcagtttggcaagatcaggaaccagacaacaagaat tcagttcaagaggatgaaaacaattcacgtctgactcacataaacgatgtcacgaatgat tggggttacgatacagattatgtatctgaagaggttattaagaaagtagcagagggcatt gaaaaacacacagaaccacagagtggtagttctgtcggggaattttgtgaaactgaagtg aaaaaacgtaagagaaaacgatatgaaaaacctgtagctgaagatcctctgaggccttca ccttctgagagaaatgaggaccagtctgataatgagagaggtctgactgaaaatgatctt aaaagtatagagctgaggtcaagttccaggtcgaatcttcaaagaggcaccacagattca ctaaagaagtcttctccaaagcttcgtacttactccaaacccgttaggagagtcccgcat tctaaaactaagaaaacacattcagataccaaaaaagggcagaataaaagttcgaattac ataagttgtaggacgactcctgctatcgtcccaccaaaggtacttcgccagtgccctgaa ccaacttcaactgttgaaaaacttggtctgaaaaaggctcctcgtagggcattcgattta tctcagcgatctctagggtatttagttcagttacgggaccatggcaaaaccgtgggagtg gttgataccagaaaaaagactaaattaatttctcctcagactctctctgtcagaaataat aagaaactgttgacaagtcaagatcttcagtcgcgaaggcaggcgaaacacaaatcaaag cagaagaggcaaggctctctgggttctgaaagcagagctcctacaagagcagggctgcgt tcagcacagaatcctgacactctcgccccagaatccgatagctcagattgtcgtgctaaa ggaggcgtcgaggtgggtgctaacaatactgggaagccatcaataaaacgcgcgtcttct gaaccagaacccgtgaaaatgaaacgtgtttctcaggtggctgatgatccttgcctttcg aaccagtgcgcttctgttgtgttaaatggaagaaaagcaacacatgaagccattgtctct acgtcagctggccctttaggtggaggcgacctaacagaacgtcgtttagagttgaccgct ctgaaagagggagagcccagatccaacagtgactcggaagatgagaatatatttctaacc cagcacgatcccgcagatatggatttatgttcacagatggaaaatggtaacgagaaactc attgaaatggttcatggaaaagatacagctctgatggaggaagaatcttggagcagcaca aaatctaagcacaaggattgtgtcgaagccgcgcaaaaccagggtgaatactgctccaaa cactgcggagctaaagcagtggatgaagatgtgtttcgtaaaccgggcttgcccccctct gcgtccaagagaccctccactgccaaggtctttagctcaagtagtacttcacgaattgct aatctttcgaagtctttggaaagtacctccgcaccgccaccggctctcaaacagaagtca gacggggtaccatctgttttgaaagtcccacagccagcctctgtgttgtctccaaagcca gtgggtgaggtgaagagtttttctgatgttctccgtcctcagactctgaataattccaac aggcaaggttacaagcttacctttggcgaaagcagatctttttcagcttcctctgcggta aacgttctcttgtcctcacagtctatctcagacacctttgttaaagaggtcttaaagtgg aagtacgaaatgtttgtgaactttgatcagtgtgggccccccaccagcctttgtcagtcc atctcaagaccggtgcctgtcagattccaagattgtggagattatttcaatgtttttttc cctttgatgatactgaatacttttgaaacggtggcacaggagtggatcagctctccaaac aaagagaagttctatcagttgcatgtacggaaatttcctgctgagtataaaaagtactgg gagtttgtggttcatcttgaggaatgtgaactaactaaacagctgcatccaaaggaaaat gatttggtgtttttggttcttgaaaaacaaaatggagagaagaagaacacagagagaaat cgcatgccggatctccacgaatatcactgcggttatgttcataaatttcgccgcacttca gtcatgcgtaatgggaaatctgagtgttccctttccatccagactcaagataatttgcca ctcagtttaaatgaactcgtgaaatgcactgtaatcagttctctggtaactacacaaagg aagttgaaagccatgtctttgttgagtggacggaaccaactagccagagctgttctgaac ccaaaccccatggacttctgtacgaaagatttactgactacgacgtctgagagaatcatc gcctacttgaaagatttcaacgaagaccaaaagaaagcgatagaaactgcatacgccatg gtcaaacactccccatcagttgccaagatctgtttgattcatggaccacctggaacagga aaatcaaaaactatcgttggcctcctgtaccgcctgctgacagagaaccagaggaagggg cgttcggatgaaaactccaatgccaaaatcaaacaaaaccgtgttcttgtgtgtgcgcct tccaacgcggctgttgatgaacttatgaaaaaaatcatcctcgaatttaaagagaagtgt aaagacaagaagaatcctttgggaaactgtggagatataaatttagtacgtctgggtcca gaaaagtctattaataatgaggtcctaagatttagtttggacagccaagttaaccacaga atgaaaaaagacttaccttctcatgttcaggagatgcatagaagaaaggaatttctggat catcagctagatgaactttcccgccagcgtgctttatgccgaggtggaaaggaaacacag aggcaagaattagatgaaaaaattgcaaaagtttcaaaagagaggcaggaactagcttct aaaattaaagaggttcaaggacgcccacaaaaaacacagagcatcatcatcttagagtcc cacgtcatctgctgcacactgagcacgagtggcggtttactgctcgagtctgcttttcgt gggcaagggggtgtccccttcagttgtgtcatcgtcgatgaggctgggcagtcttgtgaa gtggagactcttaccccgctcatccatcgttgtaacaagctgatcctcgtcggagaccca aaacagctccctcccacggtcatttccatgaaagcacaggagtatggctatgaccagtca atgatggctcgcttctgcaagctgctggaagacagcgtagagcacaatgtgatcggcagg ctgcctgttttacagcttactgttcagtacaggatgcacccagacatatgcctcttcccc tctaattacgtttataacagaagcttgaaaacaaatagactgactgaaaccaatcggtgt tcatcagactggccatttcaaccttacctcgtgtttgatgtcggagacggttcagaaaga cgggataatgactcatatataaatgttcaagaaataaaactggtaatggaaataattaaa cttattaaagacaaaagaagggatgttactttccggaacattggcataataacccattac aaggctcagaagacgatgattcagaaggatttggacaaagagtttgatagaaaagggccg gcagaagtagataccgtggacgcgttccagggccgccagaaagattgtgttatcgtcacg tgtgtcagagcaaatgccatgcaaggctccattggatttctggcaagtttgcaaagattg aatgtcaccattacacgagccaagtacagcctcttcatcctcggacatttaaggaccttg atggaaaatcagcactggaatcacctgattcaggacgcacagaagcggggtgccattgtc aagacgtgcgacaaaaactacaggcacgacgcagccaagattctgaaactcaagcccatc ctgcagagaagtctgactcacccgcccaccgtggccccagaggtggccagaccccagggt ggcttgcccagcagcaagccagacggtgaatttgccaagacgtctttcccttcctccctg tatcacgtgccttctggctgtaaggaatccactggtgctgttaccaccaaggaccctgaa agacctcctattcaggaccggcttcgggacccacgactgcttaggaggctgggcatagac cccgaagccaaagggacgtgcccgagggacccgcagcccctgagcccccagcatcctggg gccacgcctccctcgggggagccaggcttccctctgagtcaccaggacccgggtggtgcc cagctgtccaccgccagagggaccacgctgagcaaccgggagcctccagctgccggtacg gatgtctccgtgagtaaaagagcatgtgactgggaaggagggctcagccgcaggagagag accagggctttcagcgaaggggaccgggagacgcagagccctgagagccgtcacccgaag aggcgctccggctgggacaacaggagactggaggaggaagacagtggttccaagagaaga aagtttttatag

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