KEGG   Propithecus coquereli (Coquerel's sifaka): 105806167
Entry
105806167         CDS       T08746                                 
Symbol
PLCB1
Name
(RefSeq) LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pcoq  Propithecus coquereli (Coquerel's sifaka)
Pathway
pcoq00562  Inositol phosphate metabolism
pcoq01100  Metabolic pathways
pcoq04015  Rap1 signaling pathway
pcoq04020  Calcium signaling pathway
pcoq04022  cGMP-PKG signaling pathway
pcoq04062  Chemokine signaling pathway
pcoq04070  Phosphatidylinositol signaling system
pcoq04071  Sphingolipid signaling pathway
pcoq04072  Phospholipase D signaling pathway
pcoq04081  Hormone signaling
pcoq04082  Neuroactive ligand signaling
pcoq04261  Adrenergic signaling in cardiomyocytes
pcoq04270  Vascular smooth muscle contraction
pcoq04310  Wnt signaling pathway
pcoq04371  Apelin signaling pathway
pcoq04540  Gap junction
pcoq04611  Platelet activation
pcoq04613  Neutrophil extracellular trap formation
pcoq04621  NOD-like receptor signaling pathway
pcoq04713  Circadian entrainment
pcoq04720  Long-term potentiation
pcoq04723  Retrograde endocannabinoid signaling
pcoq04724  Glutamatergic synapse
pcoq04725  Cholinergic synapse
pcoq04726  Serotonergic synapse
pcoq04728  Dopaminergic synapse
pcoq04730  Long-term depression
pcoq04742  Taste transduction
pcoq04750  Inflammatory mediator regulation of TRP channels
pcoq04911  Insulin secretion
pcoq04912  GnRH signaling pathway
pcoq04915  Estrogen signaling pathway
pcoq04916  Melanogenesis
pcoq04918  Thyroid hormone synthesis
pcoq04919  Thyroid hormone signaling pathway
pcoq04921  Oxytocin signaling pathway
pcoq04922  Glucagon signaling pathway
pcoq04924  Renin secretion
pcoq04925  Aldosterone synthesis and secretion
pcoq04926  Relaxin signaling pathway
pcoq04927  Cortisol synthesis and secretion
pcoq04928  Parathyroid hormone synthesis, secretion and action
pcoq04929  GnRH secretion
pcoq04933  AGE-RAGE signaling pathway in diabetic complications
pcoq04934  Cushing syndrome
pcoq04935  Growth hormone synthesis, secretion and action
pcoq04961  Endocrine and other factor-regulated calcium reabsorption
pcoq04970  Salivary secretion
pcoq04971  Gastric acid secretion
pcoq04972  Pancreatic secretion
pcoq04973  Carbohydrate digestion and absorption
pcoq05010  Alzheimer disease
pcoq05016  Huntington disease
pcoq05017  Spinocerebellar ataxia
pcoq05022  Pathways of neurodegeneration - multiple diseases
pcoq05142  Chagas disease
pcoq05143  African trypanosomiasis
pcoq05146  Amoebiasis
pcoq05163  Human cytomegalovirus infection
pcoq05200  Pathways in cancer
pcoq05415  Diabetic cardiomyopathy
pcoq05417  Lipid and atherosclerosis
Module
pcoq_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pcoq00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105806167 (PLCB1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    105806167 (PLCB1)
   04310 Wnt signaling pathway
    105806167 (PLCB1)
   04070 Phosphatidylinositol signaling system
    105806167 (PLCB1)
   04072 Phospholipase D signaling pathway
    105806167 (PLCB1)
   04071 Sphingolipid signaling pathway
    105806167 (PLCB1)
   04022 cGMP-PKG signaling pathway
    105806167 (PLCB1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    105806167 (PLCB1)
   04081 Hormone signaling
    105806167 (PLCB1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105806167 (PLCB1)
   04613 Neutrophil extracellular trap formation
    105806167 (PLCB1)
   04062 Chemokine signaling pathway
    105806167 (PLCB1)
  09152 Endocrine system
   04911 Insulin secretion
    105806167 (PLCB1)
   04922 Glucagon signaling pathway
    105806167 (PLCB1)
   04929 GnRH secretion
    105806167 (PLCB1)
   04915 Estrogen signaling pathway
    105806167 (PLCB1)
   04921 Oxytocin signaling pathway
    105806167 (PLCB1)
   04926 Relaxin signaling pathway
    105806167 (PLCB1)
   04935 Growth hormone synthesis, secretion and action
    105806167 (PLCB1)
   04918 Thyroid hormone synthesis
    105806167 (PLCB1)
   04919 Thyroid hormone signaling pathway
    105806167 (PLCB1)
   04928 Parathyroid hormone synthesis, secretion and action
    105806167 (PLCB1)
   04924 Renin secretion
    105806167 (PLCB1)
   04925 Aldosterone synthesis and secretion
    105806167 (PLCB1)
   04927 Cortisol synthesis and secretion
    105806167 (PLCB1)
  09154 Digestive system
   04970 Salivary secretion
    105806167 (PLCB1)
   04971 Gastric acid secretion
    105806167 (PLCB1)
   04972 Pancreatic secretion
    105806167 (PLCB1)
   04973 Carbohydrate digestion and absorption
    105806167 (PLCB1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    105806167 (PLCB1)
  09156 Nervous system
   04724 Glutamatergic synapse
    105806167 (PLCB1)
   04725 Cholinergic synapse
    105806167 (PLCB1)
   04728 Dopaminergic synapse
    105806167 (PLCB1)
   04726 Serotonergic synapse
    105806167 (PLCB1)
   04720 Long-term potentiation
    105806167 (PLCB1)
   04730 Long-term depression
    105806167 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    105806167 (PLCB1)
  09157 Sensory system
   04742 Taste transduction
    105806167 (PLCB1)
   04750 Inflammatory mediator regulation of TRP channels
    105806167 (PLCB1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    105806167 (PLCB1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105806167 (PLCB1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    105806167 (PLCB1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105806167 (PLCB1)
   05142 Chagas disease
    105806167 (PLCB1)
   05143 African trypanosomiasis
    105806167 (PLCB1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105806167 (PLCB1)
   05016 Huntington disease
    105806167 (PLCB1)
   05017 Spinocerebellar ataxia
    105806167 (PLCB1)
   05022 Pathways of neurodegeneration - multiple diseases
    105806167 (PLCB1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105806167 (PLCB1)
   05415 Diabetic cardiomyopathy
    105806167 (PLCB1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    105806167 (PLCB1)
   04934 Cushing syndrome
    105806167 (PLCB1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcoq04131]
    105806167 (PLCB1)
Enzymes [BR:pcoq01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     105806167 (PLCB1)
Membrane trafficking [BR:pcoq04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    105806167 (PLCB1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    105806167 (PLCB1)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y PH_14 PLCB1-4-like_EFh
Other DBs
NCBI-GeneID: 105806167
NCBI-ProteinID: XP_012494692
Ensembl: ENSPCOG00000013737
LinkDB
Position
Unknown
AA seq 1075 aa
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLEMAVSMDIKSERHCLAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKKQQRPLQI
LVMTMNFEAVINAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTT
EISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKY
PLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGA
GEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKS
FEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVAL
NFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIIS
GQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPIWEEEPIVFKKVVLPSLAC
LRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYA
DVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEVDPGETPSEAPSEARTTPAENGV
NHTTSLAPKPPSQALHSQPAPGKRSEQRAPVKGEDNLQSVITXVEAQTIEELKQQKSFVK
LQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSEPS
SPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQK
LTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRS
YIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDENPKLQVELEQEYQDKFKRLPLEI
LEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKPPSSEELGGDIPGKEFDTPL
NT seq 3228 nt   +upstreamnt  +downstreamnt
atggccggggctcaacccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactcaactattgttactcct
attattttgaggactgaccctcagggatttttcttttactggacagatcaaaataaggag
actgaattgttagagatggcagtctctatggacattaaaagtgagaggcattgcttggcc
cccaaagaccccaaattacgtgaacttttggatgtggggaacatcgggcgactagagcac
cgcatgatcaccgtggtatacgggcctgacctcgttaacatctcccatctgaatctcgtg
gctttccaagaagaagtggccaaggaatggacaaatgaagttttcagtctggcaacaaac
ctgttggcccaaaacatgtccagggatgcatttctggaaaaagcctatactaaacttaag
ctgcaagtcactccagaagggcgtattcctctcaaaaagcagcaaagacctttgcaaatc
ttagtcatgacaatgaactttgaggcagttataaatgctggccagctggctggaaactcc
tccgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtggagctagactgc
tggaaaggacggactgcagaagaagaacctgttatcacccatggattcaccatgacaact
gaaatatccttcaaggaagtgatagaagcaatcgcggagtgtgcatttaagacttcacct
tttccaattctcctttcatttgagaaccatgtggattccccaaagcagcaggccaagatg
gcggagtactgccgactgatctttggggatgctcttctcatggagccgctggaaaaatac
ccactggaatctggagttccccttccaagccctatggatttaatgtataaaattttggtg
aaaaataagaagaaatcacacaagtcttcagaaggaagtggcaaaaagaagctctcggaa
caagcttccaacacgtacagtgactcttccagcgtgttcgagccttcatccccaggagct
ggagaagctgatacagagagtgatgatgatgacgatgatgatgactgtaaaaaatcttca
atggatgaggggactgctgggagtgaggccatggccacagaagagatgtccaacctggtg
aactacattcagccggtcaagttcgagtcatttgaaatttcaaaaaaaagaaataaaagt
tttgaaatgtcttccttcgtggaaaccaaaggacttgaacaacttacgaagtctccggtg
gaatttgtagaatataacaaaatgcagctcagcaggatctatccaaaaggaacacgtgtg
gattcatccaactacatgcctcagctcttctggaacgcaggctgtcagatggtggcactt
aatttccagacgatggacctggctatgcaaataaatatgggaatgtatgaatacaacggg
aaaagtggctacagattaaagccagagtttatgcggaggcctgacaagcattttgatcca
tttactgaaggcatcgtagacgggatagtggccaacactttatctgttaagattatttca
ggtcagtttctttctgataagaaagtggggacttatgtggaagtggatatgtttggtttg
cccgtggacacaaggaggaaggcatttaagaccaaaacatcccaaggaaatgctgtaaat
ccgatctgggaagaagaacctattgtgttcaagaaggtggttcttccttctctggcctgc
ttgaggatagcagtttatgaagaaggaggtaaatttatcggccaccggatcttgccagtg
caagccattcggccaggctatcactatatctgtctgaggaatgaaagaaaccagcctctg
acgctgccagctgtgtttgtctacatagaagtcaaagactacgtgccagatacatatgca
gatgtgatcgaagctttgtcaaacccaatccgatacgtgaatctgatggagcagagagct
aagcaactggctgctttgaccctggaagatgaagaagaagtaaagaaagaggttgatcct
ggggaaacaccatcagaggctccaagtgaagccaggacgactccagcagaaaacggggtg
aatcacactacatccctggcacccaaaccaccctcccaggctctccacagccagccagct
ccaggtaaacgatctgaacagagagctccagtgaagggtgaagacaatctgcagtctgta
attacataggtggaggcgcagaccatcgaagagctaaagcaacagaaatcgtttgtgaaa
cttcaaaagaagcactacaaagaaatgaaagacttggttaagaggcaccacaagaaaacc
actgaccttatcaaagaacacactacaaaatataatgaaattcagaatgactacttgaga
aggagagcagctttggaaaagactgccaaaaaagacagtaagaaaaaatcagaacccagt
agccctgaccatggttcatcaacgattgaacaagaccttgctgccctggatgcagaaatg
acccaaaagttaatagacttgaaggacaaacaacaacagcagctgcttaatcttcgtcaa
gaacagtattacagtgaaaaataccagaagcgggaacatattaaactgcttattcaaaag
ttgacagatgttgctgaagagtgtcagaacaatcagctaaagaagctcaaagaaatctgt
gagaaagagaagaaggaattaaagaagaaaatggataaaaagaggcaggagaagataaca
gaagctaaatccaaagacaaaagtcagatggaagaggagaagacagaaatgatccggtca
tacatccaggaggtggtgcagtacatcaagaggttagaagaggcacaaagtaaacggcaa
gaaaaactcgtagagaaacacaaggagatacgtcagcagatcctggatgaaaatcccaag
ctgcaggtagagctggagcaagaataccaagacaagttcaaaagactgcccctagagatt
ttggagttcgtgcaggaagccatgaaagggaagatcagtgaagacagcaatcacggttct
gcccctctctccctgtcctcagaccctggaaaagtgaaccacaagcctccttccagtgag
gagctgggaggagacatcccaggaaaagagtttgatactcctctgtga

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