KEGG   Propithecus coquereli (Coquerel's sifaka): 105806352
Entry
105806352         CDS       T08746                                 
Symbol
JAK1
Name
(RefSeq) tyrosine-protein kinase JAK1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
pcoq  Propithecus coquereli (Coquerel's sifaka)
Pathway
pcoq01521  EGFR tyrosine kinase inhibitor resistance
pcoq04151  PI3K-Akt signaling pathway
pcoq04217  Necroptosis
pcoq04380  Osteoclast differentiation
pcoq04550  Signaling pathways regulating pluripotency of stem cells
pcoq04620  Toll-like receptor signaling pathway
pcoq04621  NOD-like receptor signaling pathway
pcoq04630  JAK-STAT signaling pathway
pcoq04658  Th1 and Th2 cell differentiation
pcoq04659  Th17 cell differentiation
pcoq05140  Leishmaniasis
pcoq05145  Toxoplasmosis
pcoq05152  Tuberculosis
pcoq05160  Hepatitis C
pcoq05161  Hepatitis B
pcoq05162  Measles
pcoq05163  Human cytomegalovirus infection
pcoq05164  Influenza A
pcoq05165  Human papillomavirus infection
pcoq05166  Human T-cell leukemia virus 1 infection
pcoq05167  Kaposi sarcoma-associated herpesvirus infection
pcoq05168  Herpes simplex virus 1 infection
pcoq05169  Epstein-Barr virus infection
pcoq05171  Coronavirus disease - COVID-19
pcoq05200  Pathways in cancer
pcoq05203  Viral carcinogenesis
pcoq05212  Pancreatic cancer
pcoq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pcoq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    105806352 (JAK1)
   04151 PI3K-Akt signaling pathway
    105806352 (JAK1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    105806352 (JAK1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    105806352 (JAK1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    105806352 (JAK1)
   04621 NOD-like receptor signaling pathway
    105806352 (JAK1)
   04658 Th1 and Th2 cell differentiation
    105806352 (JAK1)
   04659 Th17 cell differentiation
    105806352 (JAK1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    105806352 (JAK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105806352 (JAK1)
   05203 Viral carcinogenesis
    105806352 (JAK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105806352 (JAK1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    105806352 (JAK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105806352 (JAK1)
   05161 Hepatitis B
    105806352 (JAK1)
   05160 Hepatitis C
    105806352 (JAK1)
   05171 Coronavirus disease - COVID-19
    105806352 (JAK1)
   05164 Influenza A
    105806352 (JAK1)
   05162 Measles
    105806352 (JAK1)
   05168 Herpes simplex virus 1 infection
    105806352 (JAK1)
   05163 Human cytomegalovirus infection
    105806352 (JAK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105806352 (JAK1)
   05169 Epstein-Barr virus infection
    105806352 (JAK1)
   05165 Human papillomavirus infection
    105806352 (JAK1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    105806352 (JAK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    105806352 (JAK1)
   05140 Leishmaniasis
    105806352 (JAK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105806352 (JAK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcoq01001]
    105806352 (JAK1)
Enzymes [BR:pcoq01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     105806352 (JAK1)
Protein kinases [BR:pcoq01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   105806352 (JAK1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 FERM_C_FAK1
Other DBs
NCBI-GeneID: 105806352
NCBI-ProteinID: XP_012494904
Ensembl: ENSPCOG00000018189
UniProt: A0A2K6FGU0
LinkDB
Position
Unknown
AA seq 1153 aa
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLSSGEYTAEEL
CIRAAQECRISPLCHNLFALYDEKTKLWYAPNHTITADDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLMISSENEMN
WFNSNDSGNVVYYEVMVTGNLGIQWRQKPNVVPFEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVNVNKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEGLGSQKQFKNFQIEVRKGRYSLHGSDRSFPSLEDLMSHLKKQILRTDNISFVLK
RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIMQGEHLGRGTRTHIYSGT
LMDYKDDEGASEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL
LAREGIDTECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT
TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI
MRDINKLEEQNPDIVSEKKPAAEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT
GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS
GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD
FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD
SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTT
FQNLIEGFEALLK
NT seq 3462 nt   +upstreamnt  +downstreamnt
atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg
agctccaagaagaccgaggtgaatctggaggcccctgagccaggggtggaagtgatcttc
tatctgtcggacagggagcccctgcggctgagcagcggagagtacactgcagaggagctg
tgcatcagggctgcgcaggagtgccgtatctctcctctgtgtcacaacctctttgccctg
tatgatgagaagaccaagctgtggtatgctccgaatcacaccatcaccgccgatgacaag
atgtcactccggctccactaccggatgaggttctatttcaccaattggcatgggaccaat
gacaatgagcagtcggtgtggcgacattctccaaagaaacagaaaaatggctatgagaag
aaaaaggttccagatgcaacccctctccttgacgccagctcgctggagtatctgttcgct
cagggacagtatgatttggtgaagtgcctggctcccattcgagaccccaagactgagcag
gatggccatgacattgagaatgagtgtctggggatggccgtcctggccatctcacactat
gccatgatgaagaagatgcagctgccggaattgcccaaggacatcagctacaagcgatat
attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata
aataacgttttcaaggatttcctaaaagaatttaacaacaagaccatttgtgacagcagc
gtgtccacgcatgacctgaaggtgaaatacctggctaccttggaaacgttgacaaaacat
tatggtgctgaaatatttgagacctccatgttgatgatttcatcagaaaacgagatgaat
tggtttaattcaaatgacagtggaaacgtcgtttactatgaagtgatggtgactggaaac
cttggaatccagtggaggcagaaaccaaatgttgttccttttgaaaaggaaaaaaataaa
ctcaagcggaaaaaactggaaaataaacacaagaaggatgaggagaaaaacaaaatccgg
gaagagtggaataatttttcttacttccctgaaatcactcacatcgtcataaaggaatct
gtggtcaatgttaacaagcaggacaacaaaaaaatggaattgaagctgtcttcccacgag
gaggccttgtcctttgtgtccctggtagacggctacttccggctcacagcggatgcccac
cattacctctgcaccgacgtggctcccccgctgatcgtccacaacattcagaatggctgt
cacggtccaatctgcacagaatatgccatcaataaattgcggcaagaaggaagcgaggag
gggatgtacgtgctgaggtggagctgcactgactttgacaacatcctcatgaccgtcacc
tgctttgagaagtccgaggggctgggcagccagaagcagttcaagaacttccagatcgag
gtgcgcaagggccgctacagcctgcacggctcagaccgcagcttccccagcctggaggac
ctcatgagccacctgaagaagcagatcctgcgcacggacaacatcagcttcgtgttgaag
cgctgctgccagcccaagccccgagaaatctccaacctactggtggctactaagaaggcc
caggagtggcagcccgtctaccccatgagccagctgagttttgatcggatcctcaagaaa
gatattatgcaaggcgagcaccttgggagaggcacgagaacacacatctactctgggacc
ctgatggattacaaggatgatgaaggagcttccgaggagaagagaataaaagtgatcctc
aaagtcttagaccccagccacagggacatttccttggccttctttgaggcagccagcatg
atgagacaggtctcccacaagcacatcgtgtacctctacggcgtctgtgtccgagacgtg
gagaatatcatggtggaagagtttgtggaaggggggcccctggatctcttcatgcaccgg
aaaagtgatgttctcaccacaccatggaaattcaaagttgccaaacagctggccagtgcc
ctgagctacctggaggataaagacctggtccacggaaatgtgtgcaccaaaaacctcctc
ctggcccgtgagggcatcgacaccgagtgcggcccgttcatcaagctcagcgaccctggc
atccccatcaccgtgctgtccaggcaagagtgcatagaacgaatcccatggatcgctcct
gagtgtgttgaagactccaagaacctgagtgtggctgctgacaaatggagctttggaacc
acgctctgggaaatctgctacaatggcgagatccccctgaaagacaagacgctgatcgag
aaagagagattctatgaaagccggtgcaggcccgtgacaccatcttgcaaggagctggct
gacctcatgacccgttgcatgaattacgaccccaatcagagacccttcttccgagccatc
atgagagacattaataagcttgaagaacagaatccagacatcgtttcagaaaaaaagcca
gcagctgaagtggatcccacacattttgaaaagcgcttcctaaagcggatccgtgacttg
ggagagggccactttgggaaggttgagctctgcaggtatgaccctgagggtgacaacaca
ggggagcaggtggctgtgaaatctctgaagcctgagagcggaggtaaccacatagctgat
ctgaagaaggaaatagagatcttaaggaacctctatcatgagaacatcgtgaagtacaaa
ggaatctgcacagaagacggaggaaatggtattaagctcatcatggaatttctgccttcg
ggaagtcttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcagcta
aagtatgccgttcagatttgtaagggcatggactatttgggttctcggcaatacgttcac
cgggacttagcagcgagaaatgtccttgttgagagtgaacaccaagtgaaaattggagac
tttggtttaactaaagcaattgaaactgataaggagtattacacagttaaggacgaccgg
gacagccctgtgttttggtatgctccagaatgcctaattcagtgtaaattctacatcgcc
tctgacgtctggtctttcggagtgactctgcatgaactgctcacttactgtgactcagat
tctagtcccatggctttgttcctgaaaatgatcggcccaactcatggccagatgacagtc
acaagacttgtgaatacattaaaagagggaaaacgtctgccatgtccacccaactgtcca
gatgaggtttatcaacttatgagaaaatgctgggaattccaaccatccaatcggacaacc
tttcagaaccttattgaaggatttgaagcacttttaaaataa

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