KEGG   Propithecus coquereli (Coquerel's sifaka): 105810783
Entry
105810783         CDS       T08746                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
pcoq  Propithecus coquereli (Coquerel's sifaka)
Pathway
pcoq01521  EGFR tyrosine kinase inhibitor resistance
pcoq01522  Endocrine resistance
pcoq04010  MAPK signaling pathway
pcoq04012  ErbB signaling pathway
pcoq04014  Ras signaling pathway
pcoq04015  Rap1 signaling pathway
pcoq04022  cGMP-PKG signaling pathway
pcoq04024  cAMP signaling pathway
pcoq04062  Chemokine signaling pathway
pcoq04066  HIF-1 signaling pathway
pcoq04068  FoxO signaling pathway
pcoq04071  Sphingolipid signaling pathway
pcoq04072  Phospholipase D signaling pathway
pcoq04114  Oocyte meiosis
pcoq04140  Autophagy - animal
pcoq04148  Efferocytosis
pcoq04150  mTOR signaling pathway
pcoq04151  PI3K-Akt signaling pathway
pcoq04210  Apoptosis
pcoq04218  Cellular senescence
pcoq04270  Vascular smooth muscle contraction
pcoq04370  VEGF signaling pathway
pcoq04371  Apelin signaling pathway
pcoq04380  Osteoclast differentiation
pcoq04510  Focal adhesion
pcoq04540  Gap junction
pcoq04550  Signaling pathways regulating pluripotency of stem cells
pcoq04613  Neutrophil extracellular trap formation
pcoq04620  Toll-like receptor signaling pathway
pcoq04650  Natural killer cell mediated cytotoxicity
pcoq04660  T cell receptor signaling pathway
pcoq04662  B cell receptor signaling pathway
pcoq04664  Fc epsilon RI signaling pathway
pcoq04666  Fc gamma R-mediated phagocytosis
pcoq04668  TNF signaling pathway
pcoq04720  Long-term potentiation
pcoq04722  Neurotrophin signaling pathway
pcoq04725  Cholinergic synapse
pcoq04726  Serotonergic synapse
pcoq04730  Long-term depression
pcoq04810  Regulation of actin cytoskeleton
pcoq04910  Insulin signaling pathway
pcoq04912  GnRH signaling pathway
pcoq04914  Progesterone-mediated oocyte maturation
pcoq04915  Estrogen signaling pathway
pcoq04916  Melanogenesis
pcoq04917  Prolactin signaling pathway
pcoq04919  Thyroid hormone signaling pathway
pcoq04921  Oxytocin signaling pathway
pcoq04926  Relaxin signaling pathway
pcoq04928  Parathyroid hormone synthesis, secretion and action
pcoq04929  GnRH secretion
pcoq04934  Cushing syndrome
pcoq04935  Growth hormone synthesis, secretion and action
pcoq05010  Alzheimer disease
pcoq05022  Pathways of neurodegeneration - multiple diseases
pcoq05034  Alcoholism
pcoq05132  Salmonella infection
pcoq05135  Yersinia infection
pcoq05160  Hepatitis C
pcoq05161  Hepatitis B
pcoq05163  Human cytomegalovirus infection
pcoq05164  Influenza A
pcoq05165  Human papillomavirus infection
pcoq05166  Human T-cell leukemia virus 1 infection
pcoq05167  Kaposi sarcoma-associated herpesvirus infection
pcoq05170  Human immunodeficiency virus 1 infection
pcoq05200  Pathways in cancer
pcoq05205  Proteoglycans in cancer
pcoq05206  MicroRNAs in cancer
pcoq05207  Chemical carcinogenesis - receptor activation
pcoq05208  Chemical carcinogenesis - reactive oxygen species
pcoq05210  Colorectal cancer
pcoq05211  Renal cell carcinoma
pcoq05212  Pancreatic cancer
pcoq05213  Endometrial cancer
pcoq05214  Glioma
pcoq05215  Prostate cancer
pcoq05216  Thyroid cancer
pcoq05218  Melanoma
pcoq05219  Bladder cancer
pcoq05220  Chronic myeloid leukemia
pcoq05221  Acute myeloid leukemia
pcoq05223  Non-small cell lung cancer
pcoq05224  Breast cancer
pcoq05225  Hepatocellular carcinoma
pcoq05226  Gastric cancer
pcoq05230  Central carbon metabolism in cancer
pcoq05231  Choline metabolism in cancer
pcoq05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pcoq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    105810783 (MAP2K1)
   04015 Rap1 signaling pathway
    105810783 (MAP2K1)
   04668 TNF signaling pathway
    105810783 (MAP2K1)
   04066 HIF-1 signaling pathway
    105810783 (MAP2K1)
   04068 FoxO signaling pathway
    105810783 (MAP2K1)
   04072 Phospholipase D signaling pathway
    105810783 (MAP2K1)
   04071 Sphingolipid signaling pathway
    105810783 (MAP2K1)
   04024 cAMP signaling pathway
    105810783 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    105810783 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    105810783 (MAP2K1)
   04150 mTOR signaling pathway
    105810783 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105810783 (MAP2K1)
   04148 Efferocytosis
    105810783 (MAP2K1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    105810783 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    105810783 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    105810783 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    105810783 (MAP2K1)
   04660 T cell receptor signaling pathway
    105810783 (MAP2K1)
   04662 B cell receptor signaling pathway
    105810783 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    105810783 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    105810783 (MAP2K1)
   04062 Chemokine signaling pathway
    105810783 (MAP2K1)
  09152 Endocrine system
   04929 GnRH secretion
    105810783 (MAP2K1)
   04915 Estrogen signaling pathway
    105810783 (MAP2K1)
   04917 Prolactin signaling pathway
    105810783 (MAP2K1)
   04921 Oxytocin signaling pathway
    105810783 (MAP2K1)
   04926 Relaxin signaling pathway
    105810783 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    105810783 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    105810783 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    105810783 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    105810783 (MAP2K1)
   04726 Serotonergic synapse
    105810783 (MAP2K1)
   04720 Long-term potentiation
    105810783 (MAP2K1)
   04730 Long-term depression
    105810783 (MAP2K1)
   04722 Neurotrophin signaling pathway
    105810783 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    105810783 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105810783 (MAP2K1)
   05206 MicroRNAs in cancer
    105810783 (MAP2K1)
   05205 Proteoglycans in cancer
    105810783 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    105810783 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    105810783 (MAP2K1)
   05230 Central carbon metabolism in cancer
    105810783 (MAP2K1)
   05231 Choline metabolism in cancer
    105810783 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105810783 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105810783 (MAP2K1)
   05212 Pancreatic cancer
    105810783 (MAP2K1)
   05225 Hepatocellular carcinoma
    105810783 (MAP2K1)
   05226 Gastric cancer
    105810783 (MAP2K1)
   05214 Glioma
    105810783 (MAP2K1)
   05216 Thyroid cancer
    105810783 (MAP2K1)
   05221 Acute myeloid leukemia
    105810783 (MAP2K1)
   05220 Chronic myeloid leukemia
    105810783 (MAP2K1)
   05218 Melanoma
    105810783 (MAP2K1)
   05211 Renal cell carcinoma
    105810783 (MAP2K1)
   05219 Bladder cancer
    105810783 (MAP2K1)
   05215 Prostate cancer
    105810783 (MAP2K1)
   05213 Endometrial cancer
    105810783 (MAP2K1)
   05224 Breast cancer
    105810783 (MAP2K1)
   05223 Non-small cell lung cancer
    105810783 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105810783 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    105810783 (MAP2K1)
   05161 Hepatitis B
    105810783 (MAP2K1)
   05160 Hepatitis C
    105810783 (MAP2K1)
   05164 Influenza A
    105810783 (MAP2K1)
   05163 Human cytomegalovirus infection
    105810783 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105810783 (MAP2K1)
   05165 Human papillomavirus infection
    105810783 (MAP2K1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    105810783 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105810783 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    105810783 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    105810783 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    105810783 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105810783 (MAP2K1)
   01522 Endocrine resistance
    105810783 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcoq01001]
    105810783 (MAP2K1)
Enzymes [BR:pcoq01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     105810783 (MAP2K1)
Protein kinases [BR:pcoq01001]
 Serine/threonine kinases: STE group
  STE7 family
   105810783 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1
Other DBs
NCBI-GeneID: 105810783
NCBI-ProteinID: XP_012500269
Ensembl: ENSPCOG00000019709
LinkDB
Position
Unknown
AA seq 424 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIACFWPRAAS
DGAGGVILGLVVRAGLSIQSAAPSLSTGANSLLLYSLFPADVKPSNILVNSRGEIKLCDF
GVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAK
ELELMFGCHVEGDAAETPPRPRTPGRPLSAYGMDSRPPMAIFELLDYIVNEPPPKLPSGV
FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTH
AAGV
NT seq 1275 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagttgaacccggcccccgacggctccgcggtt
aacgggaccagctctgcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgatgaacagcagcggaagcgccttgaggcctttcttacccagaaacagaaggtg
ggagaactgaaggatgacgacttcgagaagatcagtgagctgggggctggcaatggcgga
gtggtgtttaaggtctcccacaagccttccggtctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccaaatcataagggaactgcaggttctgcatgag
tgcaactctccatacatcgtgggcttctatggagcattctacagtgatggcgagatcagt
atctgcatggaacatatggatgggggttccttggatcaagtcctgaagaaagctggaagg
attcctgaacaaattttaggaaaagttagcattgcttgtttttggccgagggctgcctct
gatggggctgggggtgtgatcctggggctggtggtcagggctggtctgtccatccagagt
gctgccccttccctgtctaccggtgccaattccctacttctctattctctctttcctgca
gatgtcaagccctccaacatcctagtcaactcccgtggggagatcaagctctgtgacttt
ggggtcagcgggcagctcatcgactccatggccaactccttcgtgggcacaaggtcctac
atgtcgccagaaagactccaagggactcattactctgtgcagtcagacatctggagcatg
gggctctctctggtggagatggcggttgggaggtatcccatccctcctccagatgccaag
gagctggagctgatgtttggatgccacgtggagggagatgcagctgagaccccacccagg
ccaagaacccctgggaggcccctcagcgcatatggaatggacagccgacctcccatggcg
atttttgagttgttggattacatagtcaatgagcctcctccaaaactgcccagtggagta
ttcagtctggaatttcaagattttgtgaataaatgcttaataaaaaaccccgcggagaga
gcagatttgaaacaactcatggttcatgcttttatcaagagatctgatgctgaggaggta
gacttcgcaggttggctctgctcgaccatcggccttaaccagcccagcacaccaactcac
gcggctggtgtctga

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