KEGG   Propithecus coquereli (Coquerel's sifaka): 105814216
Entry
105814216         CDS       T08746                                 
Symbol
RYR3
Name
(RefSeq) ryanodine receptor 3
  KO
K04963  ryanodine receptor 3
Organism
pcoq  Propithecus coquereli (Coquerel's sifaka)
Pathway
pcoq04020  Calcium signaling pathway
pcoq04371  Apelin signaling pathway
pcoq04713  Circadian entrainment
pcoq04921  Oxytocin signaling pathway
pcoq04970  Salivary secretion
pcoq05010  Alzheimer disease
pcoq05012  Parkinson disease
pcoq05020  Prion disease
pcoq05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:pcoq00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    105814216 (RYR3)
   04020 Calcium signaling pathway
    105814216 (RYR3)
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    105814216 (RYR3)
  09154 Digestive system
   04970 Salivary secretion
    105814216 (RYR3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    105814216 (RYR3)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105814216 (RYR3)
   05012 Parkinson disease
    105814216 (RYR3)
   05020 Prion disease
    105814216 (RYR3)
   05022 Pathways of neurodegeneration - multiple diseases
    105814216 (RYR3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:pcoq04040]
    105814216 (RYR3)
Ion channels [BR:pcoq04040]
 Voltage-gated cation channels
  Ryanodine receptor
   105814216 (RYR3)
SSDB
Motif
Pfam: RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5
Other DBs
NCBI-GeneID: 105814216
NCBI-ProteinID: XP_012504569
Ensembl: ENSPCOG00000023335
LinkDB
Position
Unknown
AA seq 4747 aa
MCLSLGLAAYLIQEDEVVLQCIATVHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDLC
VCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYLTCLT
TSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHL
SISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTDQNDS
QHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLL
LQDRGKSDTKSTAFSFRPSKEIKEKLDSSHKRDIEGMGLPEIKYGDSVCFVQHVASGLWV
TYKAQDAKTPRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFVSG
NNRTAAPVTLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEGMLAL
VLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDW
LISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDVLCSL
CLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWYFEL
IIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRI
PRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMSFSAG
VKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGTTQFL
SQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPC
LVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMSNGYK
PAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYAL
LDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSYAVRS
GKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGRTWQP
GDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGRMNLG
TDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPRDHLHIEVVRIDGTMD
SPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDTEAFQKRKQMQEILSHT
TTQCYYAVRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHESVKR
SNCYMVWGGDIVASSQRSSRSNADLEIGCLVDLAMGMLSFSANGKELSTCYQVEPNTKVF
PAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLWSRMP
NSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQEDLMQFHYHTLRL
YSALCALGNSRVAYALCSHVDLSQLFHAIDNKYLPGLLRSGFYDLLISIHLANAKERKLM
MKNEYIIPITSTTRNIRLYPDKSKRHGLPGVGLRTCLKPEFRFSTPCFVTTSEEHQKQSP
EIPLETLKTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDDDDVR
QILLLIDPSVFGEHGGEMEEGAEKEEVTQVEEKAVEAGEKASKEAPIRGLLQTRLPESVK
VQMCELLNYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYDELMQALNMSAALTARKTR
EFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEEDTSWM
GKLCTLMCKIKGPPEPEKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVRMMFN
LLRRQYDSIGELLQALRKTYTISQVSVSDTINLLAALGQIRSLLSVRMGKEEELLMINGL
GDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYFCRIS
RQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVT
YLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRR
PECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVTEDNEEEEEIVHMGNAI
MSFYSALIDLLGRCAPEMHVNGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHL
LEVGFLPDLRASASLDTSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPS
GLGGYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRI
AATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKTQSGWKYGI
SLDENVRTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENE
KLRNVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGS
HPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGVIVSRGMKDMELDASSMEKRFAYKFLK
KILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSP
LKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSSTMVSCLHILAQTLDTRTVM
KSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILT
SIFEHVAQHQFGVDLLLSDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAI
PVAFLEPTLNRYNPLSVFNTKTPRERSIMGMPDTVEEMCPDIPQLEDLMKEINDLAESGA
RYMEMPHVIEVVLPMICNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGDILKIINN
NLGIEEASWMKRIAVYTQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADGRG
DTQEAELLILDEFAVLCRDLYAFYPILIRYVDNSRSNWLKSPDADSDQLFRMVAEVFILW
CKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKSKRRGDLYSI
QTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYGYRDTDEEVKEHLRNNLHLQEKSDD
PAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQ
RKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEE
EEEMEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYCSMMAKSCQSGEDEEEEEDKEK
TFEEKEMEKQKTLYQQARLHERGTAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNTG
VQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERG
EKVLQNDEFTRDLFRFLQLLCEGHNNDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESIS
DFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCVGNQQSLAHSRLWDAVVG
FLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVES
STNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFL
LSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVL
NYFEPYLGRIEIMGGAKKIERVYFEITESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKM
ELFVNFCEDTIFEMQLASQISESDSADRPEEEDEEDAIYTLEIEGEEEEDKCFESASAFA
MACASVKRSVTSFLKKATLKNLRKQYRNVKKMSAKELVKVFFSFFWTLFLGLFQLFFGIL
GGIFQVLWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHEDAVEMERAEVTEPGITAE
LAHFVKGEKGDADMMPDLFGLRPKKEGSLKHGPEVGLGDLSEIIGKDEAPTLESTVRKKR
KAQAAEMKAAHEAEGKVDSEKADAEDGEKEDRAKEEEQAEYLWAEVTKRRKRRHGQKVEK
PEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETE
DVANLWNSFNEEEEEEAMVFFVLQESTGYMAPTLRALAVVHTIISLVCVVGYYCLKVPLV
VFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYG
DLYGAERIAELLGLDKNALDFSPIEETKAEAASLVSWLSSIDTKYHIWKLGVVFTDNSFL
YLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYL
YTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYE
MYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDT
TPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRK
QYEDQLG
NT seq 14244 nt   +upstreamnt  +downstreamnt
atgtgcctgtcattagggttggcagcttacctgattcaggaagatgaagtggtactccag
tgcattgccaccgttcacaaggagcagaggaagttctgcctggctgccgagggacttggc
aatcgcctgtgcttcttggaacccacttcagaagccaagtatattcctccagatctctgc
gtctgcaattttgtgctggagcagtccctctctgtcagagccctgcaggaaatgcttgcc
aacacaggtgaaaatggcggcgaaggggcagcacaaggtggtggccacaggaccctgctc
tatggacatgcaattctcctgaggcactctttcagcggaatgtatctaacatgtttgact
acatcaagatcccagacagataaacttgccttcgatgtaggtctacgggaacatgccaca
ggagaagcctgttggtggactatacatcctgcttccaaacagaggtctgagggagagaaa
gttcgaattggcgacgatctcatcctcgtcagtgtgtcctctgaaagataccttcatctc
tcaatatcaaacggtaacatacaagtggatgcctcctttatgcaaacactctggaatgta
catcctacgtgctcaggaagtagcatcgaagaaggatacctacttggtgggcacgtagta
cgtctcttccatggtcatgatgagtgtttgacgataccatctacagatcagaatgattcc
caacacaggagaatattctatgaagctgggggagctgggacacgagccaggtctctgtgg
agagtggaaccccttcggataagctggagtggcagtaacatcagatggggccaggctttc
cgactccggcatctcaccacaggccattacctggccttgacagaggaccaaggcctactc
ctgcaagaccgggggaagtcagacaccaagtccacagccttctctttccggccatcaaag
gaaatcaaggagaaattggattccagtcataagagagatatagaaggcatgggccttcca
gagatcaagtatggagattccgtctgctttgtccagcatgtagccagtggtctgtgggtg
acgtacaaagcacaagatgccaagacaccccggctgggacctctgaaaagaaaggtcata
ctccatcaggaaggccacatggatgatggcttaacactgcagagatgccagcgggaggag
tcccaggctgctcggatcatccggaacacgacagccttgttcagccagtttgtcagtgga
aacaatcgcacagccgcccccgtgaccctgcctatagaagaggtcctacagaccctacag
gacttgattgcctacttccagcccccggaggaggagatgcggcatgaagacaagcagaac
aagctccgctcgctcaaaaacagacagaatcttttcaaggaagagggaatgttggccctt
gtcttaaattgcatcgatcgcttaaatatctacaatagcgtagcacactttgcggggatt
gccagggaagagagcggcatggcctggaaagaaatcctgaacctcctctacaaattgctg
gctgctctcattcgcggaaacagaaacaactgcgctcaattctccaataaccttgattgg
ctaatcagtaaattggacagactagaatcttcctcaggtatcttggaagttttgcactgc
atcttgattgaaagcccagaagccttaaatctgatagcagagggccacatcaagtccatc
atctccctgctggataagcatgggcggaatcacaaggttctggatgtcctgtgctcccta
tgcctctgcaatggggttgcagtgagagccaaccagaatctgatctgcgacaacttgctg
ccccggagaaacctgctcctgcaaacacgactgattaacgacgttaccagtatccggcca
aacatcttcctgggagtcgctgagggctcagcccagtataagaagtggtactttgagctg
attattgaccaagtggaccccttcctaacagcagagcccacacatctgcgggtgggctgg
gcctcttcctcaggctatgccccatacccaggaggtggagaaggatggggaggcaatggt
gttggtgatgacctgtactcctatggctttgatggacttcacctttggtcagggcggata
cccagagctgtggcctccattaaccagcacctcctgaaatcggatgatgtggtcagctgc
tgccttgaccttggagtgcccagcatctctttccgcatcaacgggcagcccgtgcaaggg
atgtttgagaacttcaacacagacgggctcttctttcctgtgatgagcttttcagcaggt
gtcaaagtacgtttcctgatgggtggacgtcatggagaatttaagttcctgcctccctct
ggctacgccccttgctatgaagccttacttccaaaagagaaaatgagattggagcctgtc
aaggaatataaacgtgatgctgaaggggttagagatcttttgggcaccacccagttcctc
tcccaagcctccttcatcccctgccccatagacaccagtcaggttgttttgccacctcac
ctagagaagatccgagacagactggctgaaaacatccacgagctctggggaatgaataag
atagagctgggctggactttcggcaagatacgagatgacaacaaaagacaacacccttgc
cttgtggagttttcaaaactccccgaaactgagaagaattataacttgcaaatgtcaact
gaaaccttaaaaaccctcctggccctggggtgccacattgctcacgttaatccagctgct
gaggaggatctcaagaaggtcaaactgcccaaaaactacatgatgtccaatggctataag
ccagcccctttggacttgtctgatgtgaagctcttacctcctcaagaaattttagtggat
aagctcgcagaaaatgcacacaatgtttgggcaaaagacagaataaaacaaggatggacc
tatggcattcaacaggatttgaagaacaaaagaaatccccgtctggtgccatatgcatta
ctagatgagcgtaccaagaagtccaacagggacagcctgcgtgaagctgttcgtacattt
gttggttacgggtataatattgagccatcagaccaagaactagctgacccggctgtggag
aaagtcagcatagacaagatccgattcttccgggtagagcggtcttatgcagtgagatct
gggaagtggtattttgagtttgaggtggtgactggaggagacatgcgggttggctgggcc
aggccaggctgtcgacctgacgtcgagctgggtgctgacgaccaagccttcgtgtttgaa
ggcagcaggggccagcgttggcatcaagggagtgggtattttgggcgtacctggcagcca
ggagatgtggttggatgtatgattaacctggatgatgcttcgatgatcttcacactgaat
ggggagctgctgatcaccaacaaaggctctgaacttgcctttgctgactacgagattgag
aatggcttcgtgcccatctgctctctggggctgtctcagatcggccgcatgaatctcggg
acagacgccagtaccttcaagttttataccatgtgcggcctccaagagggctttgagcct
tttgctgtcaacatgaaccgagacgttgcaatgtggttcagcaagcgcctcccgacgttt
gtcaatgtgccaagggatcacctacacatagaggtcgtgaggattgatggcaccatggac
agcccgccttgcctcaaagtgacccacaagacgtttggcacacagaatagcaatgctgac
atgatctattgccgtctgagcatgcctgtcgagtgccactcctccttcagccacagcccc
tgtctggacactgaagctttccagaaaaggaaacagatgcaagaaatactctctcataca
acaacacagtgctactacgctgtccgcatctttgccggacaggacccctcctgcgtctgg
gtcggatgggtgactccagactaccacttgtacagtgaaaaatttgacctgaataaaaac
tgcacggtgactgtcaccctgggggatgaaagaggccgggtccatgaaagtgtgaaacgc
agcaactgctacatggtctggggtggggacattgtggccagttcccaaagatccagtcgg
agcaacgcagacctggagatcggctgtcttgtggatctggcgatgggcatgttgtccttc
tcagccaatgggaaagaactcagcacctgctaccaggtggagcccaataccaaagtattc
ccagcagtcttcctgcagcctacaagtacttctttgtttcagtttgaactgggaaagctg
aagaacgcgatgcccctgtcggcggccatattcaagagtgaagagaagaaccccgtcccg
cagtgtccgcctcggctggacgtccagaccatccagccggtgctctggagccgcatgccc
aacagcttcctgaaggtggagaccgagcgggtgagcgagcgccacggctgggtggtgcag
tgcctggagcccctacagatgatggcgctccacatccccgaggagaacaggtgtgtggat
gtcctggagctctgtgagcaggaggacctgatgcagttccattaccacacgctgcgactc
tacagcgccttgtgtgccctgggaaacagccgggtcgcctacgccctgtgcagccacgtg
gacctctcccagctcttccatgccatcgacaacaagtacctccccggcctcctccgatcg
ggtttctacgacctgctcatcagcatccacctggccaacgctaaggagaggaagctgatg
atgaagaacgagtacatcatccccattaccagcaccaccaggaatatccgcctgtacccg
gacaagtccaagaggcacgggctgcccggggtgggcctgagaacgtgcctcaagccagag
ttccggttctccacgccctgctttgtcacgaccagtgaggagcaccaaaagcagagccct
gagatccccttggagaccctcaagacgaaggcgctgagcatgctgacagaggcagtgcag
tgcagtggggcccacatccgggaccctgttggggggtccgtggagttccagtttgtgccc
gtgctcaaactcattggaaccctgctggtcatgggggtgtttgatgatgatgatgttcgg
cagatcctcctcctaatcgatccctctgtgtttggggaacatggcggggagatggaggag
ggagcagaaaaggaggaagtgacccaggtggaggagaaggcagtggaggctggagagaag
gccagcaaggaggctcccatcagaggcctgttgcagacccgcttaccagagtccgtcaaa
gtgcagatgtgtgagctcctcaactatctctgtgactgtgagctacaacaccgagtggag
gccatcgtggcatttggtgacatttatgtctccaagctacaggcaaatcagaagttccgc
tacgatgagctcatgcaggccctgaacatgtctgcagccctgaccgctcggaagaccagg
gagttccgctcacccccacaggagcagatcaacatgcttcttaactttcaactgggagag
aactgcccctgcccagaggagatccgggaggagctgtacgacttccacgaggaccttctc
cttcactgtggggttcccttggaggaagaggaagaagaggaggaggatacctcctggatg
ggaaaactgtgtaccctgatgtgtaaaatcaaaggcccacctgagccagaaaaggagcag
ccgacggaggaggaggagagatgccctacaacactgaaggaactcatctcacagacaatg
atccgctgggcccaagaggaccagatccaggatgcagagctggtccggatgatgttcaac
ctcctccggaggcagtacgacagcatcggggagctgctgcaggcattgcggaagacctac
accattagccaggtctccgtgagcgacaccatcaacctgctggctgcgctgggccagatt
cgctccctcctcagtgtcaggatgggcaaggaggaggaactactcatgatcaacgggctg
ggagatataatgaacaacaaggtgttttaccagcatcccaacctcatgagagtccttggc
atgcatgagacagtgatggaggtgatggtgaacgtgttggggacagagaagtctcagatt
gcttttccaaagatggttgctagctgctgccgcttcctttgctatttttgtcgaattagc
cggcagaatcagaaggccatgtttgagcatctgagttacctgctggagaatagcagtgtt
ggcctagcctccccgtcgatgaggggatccactccgctggacgtggccgcttcctctgtg
atggacaacaacgagttagcgctgggcttagaggaaccagacctcgagaaggtggtgacc
tacttggcaggctgtggcctgcagagctgccccatgcttctggccaaaggataccctgac
gtcggctggaaccccattgaaggggaacgctacctgtccttcctgaggtttgccgtcttc
gtgaacagtgaaagtgtggaagaaaacgcgagcgtcgtggtcaagctgctcatcagacgc
ccagagtgcttcggcccagccctgcggggtgagggaggaaacggcctcttggcagccatg
cagggggccattaagatctctgagaacccggcgctcgacctcccctctcagggatacaag
agggaagtcacggaagacaatgaagaggaagaagaaattgtgcacatgggcaatgcaatt
atgtcattttattcggcccttatagatctactgggccgctgtgctcctgaaatgcacgta
aatgggtcagtcagcgagccagacatggcagccaacttctgccctgaccacaaggcaccc
atggtgctgttcttggaccgagtttatggcattaaggatcaaacttttctgctgcactta
ctagaggttggatttttgcctgacttaagagcctctgcctctctagatacatccatgtta
cagcaactcctgcgacgtcttgtttttgatgtgccacaactcaatgaatactgcaaaatg
cctctcaagcttctgacgaatcactatgaacagtgctggaagtattactgtctgccttca
gggttggggggctatggcctcgctgtggaagaagaactgcacctaaccgagaagctcttc
tgggggatttttgactccctctcccataagaaatatgacccagatcttttccgaatggct
ctgccttgtctcagtgctatagctggggccttgccaccagattatttagataccagaatc
gcagccacattggagaaacagatctcggtggatgcagacggcaactttgaccccaaacct
atcaacaccatgaatttttccttgcctgaaaaattggaatacatcgtcaccaagtatgct
gagcattcacatgataaatgggcctgtgacaagactcagagcgggtggaagtatgggatt
tccctggatgagaatgtgaggacccacccactgataaggcctttcaagacattaacggaa
aaggagaaggaaatttatcgctggcctgccagggagtccctgaaaaccatgctggctgtg
ggctggactgtggagaggaccaaagagggggaagctttggttcaacagcgggaaaatgag
aagcttcgaaacgtgtcccaggccagccagggcaacagctacagccctgctcccctcgac
ctctcgaacgttgtgctctccagagaactccagggcatggtggaggtcgtggctgagaac
tatcataatatctgggccaagaagaaaaagctggaactggagagcaaaggtggtggcagt
caccctcttctggtgccatatgacaccttgactgccaaggaaaagttcagggaccgagag
aaggcacaggacctgtttaaattcctccaagtgaatggtgttatagtttctagaggtatg
aaggatatggagctggatgcctcctccatggaaaagagatttgcctataagtttttgaag
aagatcttgaaatatgttgattctgctcaagagtttattgcccatttggaagccattgtc
agcagtgggaaaactgaaaaatctccccatgaccaggagatcaaattctttgccaaagtc
ctcctcccactggttgaccaatacttcaccaatcaccgcctctacttcctgtcgtcccct
ctgaagccccttagcagcagcgggtatgcctcccataaggagaaagaaatggtggccagc
ctattctgcaaactcgcagctcttgtaagacacaggatttccctatttgggagtgattct
tccacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtcatg
aagtcgggctcagagctggtgaaggctgggttgcgagcattctttgaaaatgctgcagaa
gacttagagaagacttcggaaaacctgaagcttggaaagtttacccattccaggacgcag
attaaaggcgtttcacagaatattaactataccacggtggctctgctgcccatcctgacg
tccatctttgagcacgtcgctcagcatcagtttggggtggatctgctcttgagcgacgtg
cagatttcatgctaccacatactgtgcagcctctactcccttgggacaggaaagaacatc
tatgtcgaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgccata
ccagtggcattcctggagcccacccttaaccgctacaatccactctcagtcttcaacacc
aaaacccccagagagaggtctattatggggatgccagacacggtggaagagatgtgtcct
gacatcccccagctggaagacctgatgaaggaaatcaatgacctagccgagtcaggggcc
cggtacatggagatgccacacgtcatcgaggtggtcttgcccatgatctgcaactacctg
tcctattggtgggagcgggggcccgagaacctgccccccagcacagggccctgctgcacc
aaggtcacctctgaacacctcagtctcatcctgggcgacattctgaagatcattaacaac
aacctgggcatcgaggaagcctcctggatgaagcgcatcgcagtgtacacccagccaatc
atcagcaaagccaggcctgacctgctgagaagccacttcatcccgactctggagaagctg
aagaaaaaggccgtcaagaccgtgcaggaggaggagcagctgaaagccgacggcagaggg
gacacccaggaggcggagctcctcatcctggatgagttcgcggtcctctgcagggatctc
tacgccttctaccccatattgatccgctatgtggacaacagcagatctaactggctgaaa
agccctgatgccgattctgaccagctcttccgcatggtggcagaggtcttcatcctgtgg
tgtaaatcgcacaacttcaagagggaagagcaaaattttgtgattcagaatgaaataaat
aatttggcatttttgactggcgatagcaaaagcaagatgtcaaaagccatgcaagtaaag
tctggaggacaggaccaggaacggaagaagtcaaagcgaaggggagacttgtattccatc
cagacctccctcatagtggctgctctcaagaaaatgctgcccattggtttgaacatgtgc
accccaggcgatcaggagctgatctccctagcgaaatcacgctacggctacagggacaca
gatgaagaggtcaaggaacatctgcggaataacttgcacttgcaggaaaagtctgatgac
ccggctgtaaaatggcaactgaatctctataaggatgttctgaagagtgaagaacctttt
aatccagaaaagacagtagagcgtgtgcagagaatttcagcagctgtcttccacctggag
caggtggagcagcctttgaggtccaagaaggctgtctggcacaaattgctgtcaaagcag
cggaaacgggctgtggtggcctgtttcaggatggcccctctctacaacctgcccaggcac
cgctctattaacctcttcctccatggctatcagagattttggatagaaacagaggagtat
tcctttgaagagaaactagttcaggatttggctaaatctcccaaggtggaagaggaggaa
gaggaagagatggaaaagcaacctgacccacttcatcagatcatcctccatttcagccgc
aatgctctcacagagaggagcaaattggaagacgaccctttgtacacctcctattgcagc
atgatggccaagagttgtcagagtggtgaggatgaagaagaggaggaagacaaggaaaaa
acttttgaagagaaagagatggagaaacagaaaactctctatcagcaagctcggctgcat
gagcgtggtaccgccgagatggtccttcagatgataagcgccagcaaaggtgagatgagc
cccatggtggtcgagactctgaagctggggatcgccattctgaatggaggcaacactggt
gtgcaacagaaaatgctagattacctcaaggagaaaaaggatgccggattctttcaaagc
ctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcagaac
aaagctgaaggcctggggatggtgactgaagaaggaacgctcattgttcgtgagcgtggt
gaaaaagtcctccagaatgacgagttcacgcgtgatctctttagattcctgcagttactt
tgtgagggacataacaatgactttcagaacttcctgcggactcagatgggcaacaccacc
accgtgaacatcatcatcagcaccgtggactaccttcttcgtctgcaggaatcaatcagt
gatttctactggtattattcagggaaggacatcattgatgaatctggacagcacaatttt
tccaaagctctggcagtcaccaagcagattttcaattcccttacagaatacatccagggc
ccttgtgtcgggaaccagcagagcctggctcacagcaggctgtgggacgcagtggtcggc
ttcctccatgtgtttgctaacatgcagatgaagctttctcaggattccagtcagatcgag
ctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctg
gaagggaatgtggtaaatggaactattggcaagcagatggttgacacactggtagaatca
tctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagactta
accagctcagataccttcaaagaatatgacccagatgggaaagggattatctccaaaaaa
gaattccagaaggccatggaagggcaaaaacagtacacacagtcagagattgactttctc
ctttcgtgtgcagaagctgatgagaatgacatgtttaattacatcgattttgtggaccgg
ttccatgagccggccaaggacatagggttcaatgtggcagtgttgttgacaaatctttct
gaacacatgccaaatgactctcgcctgaagtgtctgctggacccggcagaaagtgtgctg
aattactttgaaccgtacctaggaaggatcgagatcatgggtggggccaagaaaatcgag
cgtgtttattttgagatcactgaatccagtcggactcagtgggagaagccccaggtgaag
gaatctaagcgacagttcatttttgatgtcgtcaacgaaggtggggagcaggaaaagatg
gagctgtttgtgaacttttgtgaggacacgatcttcgagatgcagttagcatctcagatc
tctgaatccgactcagcagacaggccggaggaggaggatgaggaagacgctatttacaca
ttagaaattgaaggtgaagaggaggaagacaagtgttttgagtctgcctcggcatttgcc
atggcctgtgcctctgtgaaaagaagtgtcaccagctttctaaagaaggccaccctgaag
aacctcaggaagcaatacaggaacgtgaaaaagatgtctgcaaaggagctggtgaaggtg
ttcttctcttttttctggactctgttcctggggctcttccagctgttcttcggcatattg
ggagggatctttcaggtcctgtggagcacagtgtttggagggggcctagtagaaggggca
aagaacatcagagtgaccaagatcctgggtgacatgcctgacccgacccaatttggtatc
catgaggatgctgtggagatggagagggcagaagtgaccgagccagggatcacagctgaa
ctggcccacttcgtaaagggtgagaagggagatgcagacatgatgccagacctctttgga
ctgcgcccaaagaaagaaggtagcttaaagcatgggcccgaagtgggtctgggtgacctc
tctgaaattattggcaaggatgaagctcccacgttagagagtactgtacggaagaaaagg
aaagcacaggcagcagagatgaaagcagcacatgaagcagaaggaaaagtagactctgag
aaggcagacgcggaagatggagaaaaagaggacagagccaaagaggaggagcaagccgag
tacctgtgggcagaagtgacaaaaagaaggaagcgacggcacggtcagaaggttgagaag
ccagaagccttcacggccaatttctttaaagggctggaaatctatcagaccaagctactg
cattacctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttcgct
atcaacttcatcctgctcttttataaggtcactgaagaacctttagaagaagagacagag
gacgtcgcgaacctgtggaattcctttaatgaagaggaagaggaggaagcgatggtgttc
tttgttctgcaggagagcactggatacatggcacccacactgcgggccctggccgtcgtc
cacacaatcatctctctagtctgtgtggtgggctactactgcctgaaggtccctttggtg
gtattcaaaagagaaaaagaaattgccaggaagctggagtttgatggcctgtatatcaca
gaacagccatctgaagatgacatcaaggggcagtgggaccgcttggtgatcaacacaccg
tcttttcctaataactactgggacaagtttgtaaagagaaaggtgatcaacaagtatgga
gatctctacggagcagagcgcattgctgaactcctgggtttggacaaaaatgcccttgac
tttagcccaatagaagagaccaaagcagaggcagcttctctggtgtcatggctaagttcc
atcgacacgaagtaccatatttggaagctgggggttgtttttaccgacaactcctttctc
taccttgcctggtacacaaccatgtcagtcctgggccactacaacaatttcttctttgct
gctcatctactggatattgccatgggcttcaagacactgaggactattctgtcatctgta
acccacaatggcaaacagttggttctgaccgtcggtctcctggctgtggtggtttatctc
tacactgtggtcgccttcaacttcttccgcaagttctacaacaagagtgaggacgacgac
gagccggatatgaagtgtgacgacatgatgacgtgttaccttttccacatgtacgtgggc
gtgagagcaggaggcggcattggcgatgaaattgaagaccctgctggtgacccttacgaa
atgtatcgcatcgtcttcgacattacctttttcttctttgtcattgtcatcttgctggcc
atcattcaaggtcttattattgatgcttttggagagctaagagatcagcaggaacaagtg
cgagaagatatggagactaaatgtttcatctgtgggatcggcaatgactactttgacacg
acccctcatggttttgaaacacatacattacaagagcacaacttagccaactacttgttc
tttctgatgtatttgattaataaagatgaaacagagcacacgggtcaggaatcttatgtc
tggaagatgtaccaagaaaggtgttgggatttcttcccggctggtgactgctttcgtaaa
caatatgaagatcagcttggctaa

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