Propithecus coquereli (Coquerel's sifaka): 105820825
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Entry
105820825 CDS
T08746
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
pcoq
Propithecus coquereli (Coquerel's sifaka)
Pathway
pcoq00230
Purine metabolism
pcoq00670
One carbon pool by folate
pcoq01100
Metabolic pathways
pcoq01523
Antifolate resistance
Module
pcoq_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
pcoq00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
105820825 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
105820825 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
105820825 (GART)
Enzymes [BR:
pcoq01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
105820825 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
105820825 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
105820825 (GART)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
CPSase_L_D2
ATP-grasp_3
ATP-grasp_2
Dala_Dala_lig_C
ATP-grasp_4
DUF498
RimK
ATP-grasp_5
Sacchrp_dh_NADP
LUD_dom
GAE_BBS1
Motif
Other DBs
NCBI-GeneID:
105820825
NCBI-ProteinID:
XP_012512843
Ensembl:
ENSPCOG00000015014
UniProt:
A0A2K6F0M4
LinkDB
All DBs
Position
Unknown
AA seq
1010 aa
AA seq
DB search
MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHAALAQ
FCKDEKIEFVVVGPEAPLAAGIVGNLSSSGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TAQWKAFTKPEEACSFIMSADFPALVVKASGLAAGKGVVVAKNKEEACKAVQEIMQEKAF
GAAGETIVIEELLEGEEVSCLCFTDGKTVAPMPAAQDHKRLLEGDGGPNTGGMGAYCPAP
QVSKDLLLKIKNMVLQRTIDGMQQEGTPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYELIQCTLDGLLCTSLPVWLENRTALTVVMASKGYPGDYTKGMEITGFPEA
RALGLEVFHAGTVLKDGKIFTNGGRVLTVTAIRENLVSALEEAKKGLAAIKFEGAIYRKD
IGFRAIAFLQQPRGLTYKESGVDIAAGNMLVKKIQPLAKATSRSGCEVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSTTEAVVAGIAKACRKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQRLP
HLERITEGDVVVGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTK
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPRKFGVDLDAQTWRIPKVFSWLQQEG
HLSEEEMARTFNCGVGAALVVSEDQTEQVLTDIQQHKEEAWVIGSVVVRPEGSPRVKVKN
LIESMQTNGSVLKNGSLKNHFSVQQKKARVAVLISGTGSNLQALIDSTREPNSSAHIVVV
ISNKAAVAGLDKAETAGIPTRVINHKLYKNRIEFDNAVDQVLEEFSTDIVCLAGFMRILS
GPFVKKWDGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVATLSERVKLSEHKIFPAALQLVASGTVQLGENGKIRWVKEE
NT seq
3033 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgagtacttataattggcagtggaggaagggaacatacactggcctggaaa
cttgcacagtctcatcatgtcaaacaagtgttggttgccccaggaaatgcgggcactgcc
tgctctgaaaagatttcaaatactgccatctccatcagtgaccacgctgcccttgctcaa
ttctgcaaagatgagaaaattgaattcgtagttgttggaccagaagcacctctggctgcc
ggaattgttgggaacctgtcatcttcaggagtgcgatgctttggccccacggcagaagca
gctcagttagagtccagcaaaaggtttgccaaagagtttatggaccgacatggaatccca
actgcacaatggaaagctttcaccaaacctgaagaggcctgcagcttcattatgagtgca
gacttccctgctttagttgtgaaggccagtggtcttgcagctggaaaaggtgtggttgta
gcaaagaacaaagaagaggcctgcaaagctgtacaggagatcatgcaggagaaagctttt
ggagcagctggagaaacaattgtcattgaagaacttcttgaaggagaagaggtgtcttgt
ctgtgtttcactgatgggaagactgtggcccccatgcccgcagcacaggaccataagcga
ttactggagggagatggcggccccaacacaggaggaatgggagcctactgcccagcacct
caggtttctaaggatttgttactaaaaattaaaaatatggttcttcagaggacaatagat
ggcatgcagcaggagggcaccccatacacaggtattctctatgctggtataatgctgacc
aaggatggcccaaaagttctggagtttaattgtcgttttggtgatccagagtgccaagta
atcctcccacttcttaaaagtgatctttatgaattgattcagtgtaccttagatggcctg
ctctgcacatctctgcctgtctggctagaaaaccgtactgccctcactgttgtcatggca
agtaaaggttatcctggagactacaccaagggcatggagataacagggtttcctgaggct
cgagctttaggactggaggtgttccatgcaggcactgtgctcaaagatggcaaaatattt
actaatgggggtagagtccttacagtaacagccatccgggaaaatctcgtatcagccctt
gaagaagccaagaaaggactagctgctataaagtttgagggagcaatttatagaaaggac
atcggctttcgggccatagctttccttcagcagcccaggggcctgacttataaggaatct
ggggtagacattgcagctggaaatatgctggtcaagaaaattcagcctttagcaaaagct
acctccagatcaggctgtgaagttgatcttggtggttttgctggtctttttgatttgaaa
gcagccggtttcaaagatcctcttctggcctctggaacagatggtgttggaactaaactg
aagattgcccagctgtgcaataaacatgataccattggtcaagatttggttgcaatgtgt
gtaaatgacattctggcacaaggagcagagcccctcttcttccttgattacttttcctgt
ggaaaacttgacctcagtacaactgaagccgttgttgctggaattgctaaagcttgtaga
aaagctggatgtgctctccttggaggtgaaacagcagaaatgcctgacatgtatcctcct
ggagagtatgacctagctggttttgcagtgggcgccatggagcgggatcagagactccct
cacctggaaagaatcactgaaggggatgttgttgttggaatagcttcatctggtcttcac
agcaatggatttagccttgttaggaaaattgtggcaaaatcttccctccagtactcctct
ccagcacctgatggttgtggtgatcagactttaggggacttacttctaactccaaccaaa
atctacagccattcactgttacctgtcctacgttcaggacatgtcaaagccttcgcccat
attactggtggtggattgctagaaaacatccccagagtcctccctcggaaatttggggtg
gatttagatgcccagacctggaggatccccaaggtcttctcatggttacagcaagaagga
cacctctctgaagaagagatggccagaacgtttaactgcggggttggggctgccctcgtg
gtatccgaggatcagacagagcaggttctgacagatattcagcagcacaaagaagaagcc
tgggtgattggcagtgtggttgttcgtcctgaaggttcccctcgtgtgaaagtcaagaat
ctgattgagagcatgcagacaaatgggtcggtgttgaagaacggctccctgaaaaatcac
ttttctgtccaacaaaaaaaggcaagagtggctgtcttaatatctggaacaggatcaaac
ctccaagcactcatagacagtactcgggaaccaaatagctctgcacacattgttgttgtt
atctccaacaaagccgcagtggctgggttagataaagcagaaacagctggtattcccacc
agagtaattaatcataaattatataaaaatcgtatagaatttgacaatgcagttgaccaa
gtccttgaagagttctccacagacatagtctgtcttgcaggattcatgagaattctatct
ggcccgtttgtcaaaaaatgggatggaaaaatgctcaatatccacccgtccttgctccct
tcttttaagggttcaaatgcccatgagcaagccctggaaactggagtcacagttactggg
tgcactgtacactttgtagctgaagacgtcgatgctggacaaattattttacaagaagct
gttcccgtgaagaggggtgacactgttgcaactctgtctgaaagagtaaaattatcagaa
cataaaatatttcctgcagccctccagctggtggccagtggaactgtacagcttggagaa
aatggcaagatccgttgggtcaaagaggaatga
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