KEGG   Pseudorca crassidens (false killer whale): 137229901
Entry
137229901         CDS       T12027                                 
Symbol
RPS6KB2
Name
(RefSeq) ribosomal protein S6 kinase beta-2 isoform X1
  KO
K04688  ribosomal protein S6 kinase beta [EC:2.7.11.1]
Organism
pcrs  Pseudorca crassidens (false killer whale)
Pathway
pcrs01521  EGFR tyrosine kinase inhibitor resistance
pcrs01522  Endocrine resistance
pcrs04012  ErbB signaling pathway
pcrs04066  HIF-1 signaling pathway
pcrs04140  Autophagy - animal
pcrs04150  mTOR signaling pathway
pcrs04151  PI3K-Akt signaling pathway
pcrs04152  AMPK signaling pathway
pcrs04211  Longevity regulating pathway
pcrs04213  Longevity regulating pathway - multiple species
pcrs04350  TGF-beta signaling pathway
pcrs04371  Apelin signaling pathway
pcrs04666  Fc gamma R-mediated phagosome formation
pcrs04714  Thermogenesis
pcrs04910  Insulin signaling pathway
pcrs04931  Insulin resistance
pcrs05163  Human cytomegalovirus infection
pcrs05165  Human papillomavirus infection
pcrs05170  Human immunodeficiency virus 1 infection
pcrs05200  Pathways in cancer
pcrs05205  Proteoglycans in cancer
pcrs05207  Chemical carcinogenesis - receptor activation
pcrs05210  Colorectal cancer
pcrs05212  Pancreatic cancer
pcrs05221  Acute myeloid leukemia
pcrs05224  Breast cancer
pcrs05225  Hepatocellular carcinoma
pcrs05226  Gastric cancer
pcrs05231  Choline metabolism in cancer
pcrs05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pcrs00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    137229901 (RPS6KB2)
   04350 TGF-beta signaling pathway
    137229901 (RPS6KB2)
   04371 Apelin signaling pathway
    137229901 (RPS6KB2)
   04066 HIF-1 signaling pathway
    137229901 (RPS6KB2)
   04151 PI3K-Akt signaling pathway
    137229901 (RPS6KB2)
   04152 AMPK signaling pathway
    137229901 (RPS6KB2)
   04150 mTOR signaling pathway
    137229901 (RPS6KB2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    137229901 (RPS6KB2)
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagosome formation
    137229901 (RPS6KB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    137229901 (RPS6KB2)
  09149 Aging
   04211 Longevity regulating pathway
    137229901 (RPS6KB2)
   04213 Longevity regulating pathway - multiple species
    137229901 (RPS6KB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    137229901 (RPS6KB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    137229901 (RPS6KB2)
   05205 Proteoglycans in cancer
    137229901 (RPS6KB2)
   05207 Chemical carcinogenesis - receptor activation
    137229901 (RPS6KB2)
   05231 Choline metabolism in cancer
    137229901 (RPS6KB2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    137229901 (RPS6KB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    137229901 (RPS6KB2)
   05212 Pancreatic cancer
    137229901 (RPS6KB2)
   05225 Hepatocellular carcinoma
    137229901 (RPS6KB2)
   05226 Gastric cancer
    137229901 (RPS6KB2)
   05221 Acute myeloid leukemia
    137229901 (RPS6KB2)
   05224 Breast cancer
    137229901 (RPS6KB2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    137229901 (RPS6KB2)
   05163 Human cytomegalovirus infection
    137229901 (RPS6KB2)
   05165 Human papillomavirus infection
    137229901 (RPS6KB2)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    137229901 (RPS6KB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    137229901 (RPS6KB2)
   01522 Endocrine resistance
    137229901 (RPS6KB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcrs01001]
    137229901 (RPS6KB2)
Enzymes [BR:pcrs01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     137229901 (RPS6KB2)
Protein kinases [BR:pcrs01001]
 Serine/threonine kinases: AGC group
  RSK family [OT]
   137229901 (RPS6KB2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like Pkinase_fungal ABC1 Seadorna_VP7
Other DBs
NCBI-GeneID: 137229901
NCBI-ProteinID: XP_067604203
LinkDB
Position
9:complement(5702199..5708737)
AA seq 545 aa
MAAVFDLDLETEEGSEGEGEPEFSPAAPSPSPASPFPALASPPQSWPIACQLPFVTLSTP
GPSSPAWGEGAWHLPWLLPLGFSQDVCPLAELRAAGLEPVAHYEEVELTESSVNPGPERI
GPHCFELLRVLGKGNYGKVFQVRKVQGTNVGRIYAMKVLRKAKIVRNAKDTAHTRAERNI
LESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLSEITLAL
GHLHSQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILV
RSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLELPAYLTPDARDLVKK
FLKRNPSQRIGGGPGDAADVQRHPFFRHVNWDDLLARRVDPPFRPSLQSEEDVSQFDSHF
TRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSLQPKLRSPRRLNGSPWTPI
SPLKFSPFEGFRPSPGPPEPLEPTLPPLLLPPPPPLPPPSSTAPLPIRPPSGTKKSKKGR
GRPGR
NT seq 1638 nt   +upstreamnt  +downstreamnt
atggcggcggtgtttgacctggacctggagacggaggaaggcagcgagggcgagggcgag
ccagagttcagccccgcggcccccagcccttcccctgcgtctccctttcctgccctcgcc
tctcctccgcagtcctggcccatcgcctgccagctcccattcgtcaccctttccacgcct
gggccaagcagtccagcttggggggagggagcctggcacctcccttggctcttacccctc
ggtttctcacaggacgtgtgtccccttgccgagttgagggcggctggcctggagcctgtg
gcgcactatgaagaggtggagctgactgagagcagtgtgaacccgggccctgagcgcatc
gggccccactgcttcgagctgctgcgcgtgctgggcaaggggaactatggcaaggtgttc
caggtgcgaaaggtgcagggcaccaatgtgggcagaatatatgccatgaaagtcctgagg
aaggccaaaattgtgcgcaacgccaaggacacggcacacacgcgggctgagcggaacatt
ctagagtcagtgaagcaccccttcattgtggaactggcctatgccttccagactggtggc
aaactctacctcatcctggagtgcctcagtggcggcgagctcttcacacatctggagcga
gagggcatcttcctggaagacacggcctgtttctacttgtcagagatcacactggccctg
ggccatctccactcccaaggcatcatctaccgggatctcaaacctgagaacatcatgctc
aacagccagggtcacatcaaactgacggacttcggcctctgcaaggagtcgattcacgag
ggtgccgtcacccacaccttctgcggcaccatcgagtacatggcccctgagattctggtg
cgcagtggccacaaccgggcggtggactggtggagcttgggggccctgatgtacgacatg
ctcactggatcgccacccttcactgcagagaaccggaagaaaaccatggataagatcatc
agagggaagctggagctgcccgcctacctcaccccagatgcccgggacctcgtcaaaaag
tttctgaagcggaatcccagccaacgtatcgggggtggccctggggacgccgctgatgtg
cagaggcaccccttcttccggcacgttaattgggatgacctcctggcccgccgagtggac
ccccctttccggccgtccctgcagtcggaggaggacgtgagccagtttgactcccacttc
acgaggcagacgccggtggacagtccagacgacacggccctcagtgagagcgccaaccag
gccttcctgggcttcacgtacgtggcgccctccgtcctggacagcatcaaggagggcttc
tccctccagcccaagctgcgctcccccaggcgcctcaacggcagcccctggacccccatc
agccccctgaagttctcgccctttgagggattccggcccagccccggcccaccggagccc
ctggagcccactctaccccctctcttgctgccgccgccgccgccactaccgccgccctcg
agcactgcccccctccccatccgacccccttcagggaccaagaagtccaagaaaggccgt
gggcgccccgggcgctaa

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