KEGG   Phascolarctos cinereus (koala): 110207974
Entry
110207974         CDS       T05867                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pcw  Phascolarctos cinereus (koala)
Pathway
pcw00562  Inositol phosphate metabolism
pcw01100  Metabolic pathways
pcw04015  Rap1 signaling pathway
pcw04020  Calcium signaling pathway
pcw04022  cGMP-PKG signaling pathway
pcw04062  Chemokine signaling pathway
pcw04070  Phosphatidylinositol signaling system
pcw04071  Sphingolipid signaling pathway
pcw04072  Phospholipase D signaling pathway
pcw04081  Hormone signaling
pcw04082  Neuroactive ligand signaling
pcw04261  Adrenergic signaling in cardiomyocytes
pcw04270  Vascular smooth muscle contraction
pcw04310  Wnt signaling pathway
pcw04371  Apelin signaling pathway
pcw04540  Gap junction
pcw04611  Platelet activation
pcw04613  Neutrophil extracellular trap formation
pcw04621  NOD-like receptor signaling pathway
pcw04713  Circadian entrainment
pcw04720  Long-term potentiation
pcw04723  Retrograde endocannabinoid signaling
pcw04724  Glutamatergic synapse
pcw04725  Cholinergic synapse
pcw04726  Serotonergic synapse
pcw04728  Dopaminergic synapse
pcw04730  Long-term depression
pcw04742  Taste transduction
pcw04750  Inflammatory mediator regulation of TRP channels
pcw04911  Insulin secretion
pcw04912  GnRH signaling pathway
pcw04915  Estrogen signaling pathway
pcw04916  Melanogenesis
pcw04918  Thyroid hormone synthesis
pcw04919  Thyroid hormone signaling pathway
pcw04921  Oxytocin signaling pathway
pcw04922  Glucagon signaling pathway
pcw04924  Renin secretion
pcw04925  Aldosterone synthesis and secretion
pcw04926  Relaxin signaling pathway
pcw04927  Cortisol synthesis and secretion
pcw04928  Parathyroid hormone synthesis, secretion and action
pcw04929  GnRH secretion
pcw04933  AGE-RAGE signaling pathway in diabetic complications
pcw04934  Cushing syndrome
pcw04935  Growth hormone synthesis, secretion and action
pcw04961  Endocrine and other factor-regulated calcium reabsorption
pcw04970  Salivary secretion
pcw04971  Gastric acid secretion
pcw04972  Pancreatic secretion
pcw04973  Carbohydrate digestion and absorption
pcw05010  Alzheimer disease
pcw05016  Huntington disease
pcw05017  Spinocerebellar ataxia
pcw05022  Pathways of neurodegeneration - multiple diseases
pcw05142  Chagas disease
pcw05143  African trypanosomiasis
pcw05146  Amoebiasis
pcw05163  Human cytomegalovirus infection
pcw05200  Pathways in cancer
pcw05415  Diabetic cardiomyopathy
pcw05417  Lipid and atherosclerosis
Module
pcw_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pcw00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    110207974 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    110207974 (PLCB4)
   04310 Wnt signaling pathway
    110207974 (PLCB4)
   04371 Apelin signaling pathway
    110207974 (PLCB4)
   04020 Calcium signaling pathway
    110207974 (PLCB4)
   04070 Phosphatidylinositol signaling system
    110207974 (PLCB4)
   04072 Phospholipase D signaling pathway
    110207974 (PLCB4)
   04071 Sphingolipid signaling pathway
    110207974 (PLCB4)
   04022 cGMP-PKG signaling pathway
    110207974 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    110207974 (PLCB4)
   04081 Hormone signaling
    110207974 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    110207974 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110207974 (PLCB4)
   04613 Neutrophil extracellular trap formation
    110207974 (PLCB4)
   04621 NOD-like receptor signaling pathway
    110207974 (PLCB4)
   04062 Chemokine signaling pathway
    110207974 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    110207974 (PLCB4)
   04922 Glucagon signaling pathway
    110207974 (PLCB4)
   04929 GnRH secretion
    110207974 (PLCB4)
   04912 GnRH signaling pathway
    110207974 (PLCB4)
   04915 Estrogen signaling pathway
    110207974 (PLCB4)
   04921 Oxytocin signaling pathway
    110207974 (PLCB4)
   04926 Relaxin signaling pathway
    110207974 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    110207974 (PLCB4)
   04918 Thyroid hormone synthesis
    110207974 (PLCB4)
   04919 Thyroid hormone signaling pathway
    110207974 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    110207974 (PLCB4)
   04916 Melanogenesis
    110207974 (PLCB4)
   04924 Renin secretion
    110207974 (PLCB4)
   04925 Aldosterone synthesis and secretion
    110207974 (PLCB4)
   04927 Cortisol synthesis and secretion
    110207974 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    110207974 (PLCB4)
   04270 Vascular smooth muscle contraction
    110207974 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    110207974 (PLCB4)
   04971 Gastric acid secretion
    110207974 (PLCB4)
   04972 Pancreatic secretion
    110207974 (PLCB4)
   04973 Carbohydrate digestion and absorption
    110207974 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    110207974 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    110207974 (PLCB4)
   04725 Cholinergic synapse
    110207974 (PLCB4)
   04728 Dopaminergic synapse
    110207974 (PLCB4)
   04726 Serotonergic synapse
    110207974 (PLCB4)
   04720 Long-term potentiation
    110207974 (PLCB4)
   04730 Long-term depression
    110207974 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    110207974 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    110207974 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    110207974 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    110207974 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110207974 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    110207974 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110207974 (PLCB4)
   05142 Chagas disease
    110207974 (PLCB4)
   05143 African trypanosomiasis
    110207974 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110207974 (PLCB4)
   05016 Huntington disease
    110207974 (PLCB4)
   05017 Spinocerebellar ataxia
    110207974 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    110207974 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110207974 (PLCB4)
   05415 Diabetic cardiomyopathy
    110207974 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    110207974 (PLCB4)
   04934 Cushing syndrome
    110207974 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcw04131]
    110207974 (PLCB4)
Enzymes [BR:pcw01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     110207974 (PLCB4)
Membrane trafficking [BR:pcw04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    110207974 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    110207974 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like PLC-beta_C C2 EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 110207974
NCBI-ProteinID: XP_020841436
UniProt: A0A6P5K7V9
LinkDB
Position
Unknown
AA seq 1266 aa
MAKPYEFNWQKPVSPFIQEGAIFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRFGPVPKDPKILAALEAFGKSESDLEGRIVCVCSGTDLVNISFTYMVAENPD
VAKQWVEGLRAIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFRKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIETYEPDDELKTKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQILLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESATPVNILEDDNEEEIESVDQEEEAHPEFKFGSELSADDFGQKEAVANSVKKAAE
DLEHENNKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFNVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKFCSCHMI
FFFLFGFSFFLAFSSFLGEPTFFVDNACAPGMQSAQNEPPLADTNIPWRCLLPCPGSGWY
LALFLQPRGQVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSL
PTVFCNIVLKTYVPDGFGDIVDALSDPKKFLSVMEKRADQMRAMGIETSDIADVPNDTSK
NDKKGKANNAKANVTPQSSSELRPTTTSALGAGVEGKKGIELIPQVRIEDLKQMKAYLKH
LKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKLSHEKILEKAMKKKGGSNC
LEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCDLLK
KLLISAHEQQTQQLKLSHDRECKEMRANQAKISMENSKAISQDKSIKNKAERERRVRELN
SSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEVLEKQNEQLLKSCHAVSQTQGKGDAA
DGEIGS
NT seq 3801 nt   +upstreamnt  +downstreamnt
atggccaaaccatatgaatttaactggcagaagccagtttccccatttattcaagaggga
gccatttttgacagatatgaagaggaatcctttgtatttgaacctaactgcctcttcaaa
gtggatgaatttggcttctttttgacctggaaaagtgaaggaaaggaaggacaggtatta
gagtgttccctgatcaacagcattcgttttggacctgtaccaaaggatcccaaaatccta
gcagctcttgaagcttttggaaaatcagagagtgatctggaagggaggatagtctgtgtc
tgcagtggcactgacttggtgaatatcagcttcacttatatggtggcagaaaatccggat
gttgctaagcaatgggtagaagggttaagagccatcatacataattttagagccaacaat
gttagtccaatgacatgcctcaagaaacactggatgaaattggcatttatgacaaacaca
aatggtaaaattccagttaggagtattactagaacttttgcatcaggtaaaacagaaaag
gtgatttttcaagcacttaaggagttaggtcttcccagcggaaagaatgatgaaatcgag
cctgcggcatttacatatgaaaagttttatgaactaacacaaaaaatttgtcctcggact
gacatcgaggacctctttaggaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagaccctcgactgaatgaaattttattc
ccattctatgatacaaaaagggcaatgcagataattgagacttatgagcctgatgatgag
ttgaagacaaaagggctcatatccagtgatgggttttgcagatatttgatgtcagatgaa
aatgctccagtcttccttgaccgcctggaactttaccaagaaatggatcatcctttggcc
cactactttatcagttcttcccataacacatatctaacaggacgtcaatttggtgggaaa
tcttccgtggaaatgtatagacaaatcctcttagctggatgcagatgtgttgaactagat
tgctgggatgggaaaggagaagatcaagaaccaataataactcacggaaaagcaatgtgt
acagatattctcttcaaggatgtgattcaagccatcaaggaaacagcttttgttacatca
gagtatcctgtcattctgtcctttgaaaatcattgcagcaaatatcaacagtacaagatg
tccaagtattgtgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggaagaccattaccatcccctaatgacctcaaaagaaaaatactgatc
aaaaacaaacgactgaaacctgaggtggaaaaaaaacagcttgaagctttaaaaagtatg
atggaagctggagaatcagcaaccccagtaaatatcttagaagatgacaatgaagaagaa
atagaaagtgttgaccaagaggaagaagctcacccagaattcaaatttggaagtgaactc
tctgctgatgatttcggtcaaaaggaagctgttgcaaatagtgtaaagaaggctgcagaa
gaccttgaacatgaaaacaataaaaaggggttagttactgtggaagatgagcaggcgtgg
atggcatcctacaaatacgtgggcgctacaaccaatattcacccatatttatccacaatg
atcaactatgcccagcctgtaaagtttcagggcttcaatgtagcagaagaacgtaatatt
cattacaacatgtcgtcttttaatgaatcagttggactaggttatttgaagacgcatgca
attgaatttgtgaattataataaacggcaaatgagtcggatttaccccaagggaggccga
gtggattccagtaattacatgcctcagattttctggaacgctggctgccagatggtgtca
ctgaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgaatataat
ggatcatgtggataccttctcaaaccagatttcatgcgacggccagatagaacatttgat
cctttctctgaaacacctgtagatggtgttattgcagctacttgttcagttcaggttata
tcagggcaattcttatccgataagaaaattggtacgtatgtagaagtggatatgtatggt
ttgcctacagacactatacggaaggagttccggacgcgtatggttatgaacaatggtctc
aatcctgtttacaatgaggaatcattcgtattccgaaagttctgtagctgtcatatgata
tttttttttctgtttggcttttccttctttttggctttctcctccttcttgggggaaccc
actttcttcgttgacaatgcctgtgctccaggtatgcagtctgctcagaatgagcccccg
ctggcggacaccaacattccttggagatgtcttcttccctgccctggcagtggctggtat
cttgcactattccttcagccaagagggcaggttatcctccctgatctggctgtcttgaga
atagctgtgtatgatgacaacaacaagctgattggtcaaagaatcctccccctcgatggc
cttcaggccggctacagacacatttctcttcgaaatgaagggaataaaccattatcactg
ccaactgttttctgcaacattgtgcttaaaacatatgtgccggatggttttggagatatt
gtggatgctttgtcagacccaaagaaatttctttctgtaatggaaaagagagcagatcaa
atgagagcaatgggaattgaaactagtgacatagctgatgtgccaaatgacacttcaaag
aatgacaaaaaaggaaaagccaataatgctaaagccaatgtgactcctcagagcagctct
gaactcagaccaaccactacttctgctctgggagcaggggtggaagggaagaaaggtatt
gaacttattcctcaagtgaggatagaagacttaaaacaaatgaaggcttacttgaaacac
ttaaagaaacaacagaaagagctaaattctttaaagaagaaacatgcaaaggaacacagc
accatgcagaagttacactgtacacaagttgacaaaattgtggctcaatatgacaaagag
aagttgtctcatgagaaaatcttagagaaagcaatgaagaagaagggaggaagtaattgt
ctcgaaatgaagaaagaaactgaaattaaaattcagacattaacatcagatcataaatct
aaggtgaaagagattgtagcccagcatacaaaagagtggtcagaaatgatcaatacccac
agtgctgaggagcaagaaatccgggatctgcacctcagccagcagtgtgatcttctgaaa
aaactgttgatcagtgctcacgagcagcaaactcagcagctgaagctttcccatgacaga
gaatgcaaggaaatgcgtgccaatcaggccaagatttccatggaaaatagcaaagccatc
agtcaagacaaatcaatcaaaaataaagcagaaagagagaggagagtcagggaactaaac
agcagtaacactaaaaagtttctggaagaaagaaagagacttgcaatgaaacagtcaaaa
gaaatggatcagttgaaaaaagttcaacttgaacatctagaagtcctggaaaaacagaat
gagcagcttttgaaatcctgtcatgcagtgtctcaaacacaaggcaaaggagatgcagca
gatggtgaaattggaagctga

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