Phascolarctos cinereus (koala): 110211774 Help Entry 110211774         CDS       T05867                                  Symbol SOS2 Name (RefSeq) son of sevenless homolog 2   KO K03099   son of sevenless Organism pcw  Phascolarctos cinereus (koala) Pathway pcw01521   EGFR tyrosine kinase inhibitor resistance pcw01522   Endocrine resistance pcw04010   MAPK signaling pathway pcw04012   ErbB signaling pathway pcw04014   Ras signaling pathway pcw04062   Chemokine signaling pathway pcw04068   FoxO signaling pathway pcw04072   Phospholipase D signaling pathway pcw04150   mTOR signaling pathway pcw04151   PI3K-Akt signaling pathway pcw04510   Focal adhesion pcw04540   Gap junction pcw04630   JAK-STAT signaling pathway pcw04650   Natural killer cell mediated cytotoxicity pcw04660   T cell receptor signaling pathway pcw04662   B cell receptor signaling pathway pcw04664   Fc epsilon RI signaling pathway pcw04714   Thermogenesis pcw04722   Neurotrophin signaling pathway pcw04810   Regulation of actin cytoskeleton pcw04910   Insulin signaling pathway pcw04912   GnRH signaling pathway pcw04915   Estrogen signaling pathway pcw04917   Prolactin signaling pathway pcw04926   Relaxin signaling pathway pcw04935   Growth hormone synthesis, secretion and action pcw05034   Alcoholism pcw05160   Hepatitis C pcw05161   Hepatitis B pcw05163   Human cytomegalovirus infection pcw05165   Human papillomavirus infection pcw05200   Pathways in cancer pcw05205   Proteoglycans in cancer pcw05206   MicroRNAs in cancer pcw05207   Chemical carcinogenesis - receptor activation pcw05208   Chemical carcinogenesis - reactive oxygen species pcw05210   Colorectal cancer pcw05211   Renal cell carcinoma pcw05213   Endometrial cancer pcw05214   Glioma pcw05215   Prostate cancer pcw05220   Chronic myeloid leukemia pcw05221   Acute myeloid leukemia pcw05223   Non-small cell lung cancer pcw05224   Breast cancer pcw05225   Hepatocellular carcinoma pcw05226   Gastric cancer pcw05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:pcw00001]  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     110211774 (SOS2)    04630 JAK-STAT signaling pathway     110211774 (SOS2)    04068 FoxO signaling pathway     110211774 (SOS2)    04072 Phospholipase D signaling pathway     110211774 (SOS2)    04151 PI3K-Akt signaling pathway     110211774 (SOS2)    04150 mTOR signaling pathway     110211774 (SOS2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     110211774 (SOS2)    04660 T cell receptor signaling pathway     110211774 (SOS2)    04662 B cell receptor signaling pathway     110211774 (SOS2)    04664 Fc epsilon RI signaling pathway     110211774 (SOS2)    04062 Chemokine signaling pathway     110211774 (SOS2)   09152 Endocrine system    04915 Estrogen signaling pathway     110211774 (SOS2)    04917 Prolactin signaling pathway     110211774 (SOS2)    04926 Relaxin signaling pathway     110211774 (SOS2)    04935 Growth hormone synthesis, secretion and action     110211774 (SOS2)   09156 Nervous system    04722 Neurotrophin signaling pathway     110211774 (SOS2)   09159 Environmental adaptation    04714 Thermogenesis     110211774 (SOS2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     110211774 (SOS2)    05206 MicroRNAs in cancer     110211774 (SOS2)    05205 Proteoglycans in cancer     110211774 (SOS2)    05207 Chemical carcinogenesis - receptor activation     110211774 (SOS2)    05208 Chemical carcinogenesis - reactive oxygen species     110211774 (SOS2)    05231 Choline metabolism in cancer     110211774 (SOS2)   09162 Cancer: specific types    05210 Colorectal cancer     110211774 (SOS2)    05225 Hepatocellular carcinoma     110211774 (SOS2)    05226 Gastric cancer     110211774 (SOS2)    05214 Glioma     110211774 (SOS2)    05221 Acute myeloid leukemia     110211774 (SOS2)    05220 Chronic myeloid leukemia     110211774 (SOS2)    05211 Renal cell carcinoma     110211774 (SOS2)    05215 Prostate cancer     110211774 (SOS2)    05213 Endometrial cancer     110211774 (SOS2)    05224 Breast cancer     110211774 (SOS2)    05223 Non-small cell lung cancer     110211774 (SOS2)   09172 Infectious disease: viral    05161 Hepatitis B     110211774 (SOS2)    05160 Hepatitis C     110211774 (SOS2)    05163 Human cytomegalovirus infection     110211774 (SOS2)    05165 Human papillomavirus infection     110211774 (SOS2)   09165 Substance dependence    05034 Alcoholism     110211774 (SOS2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     110211774 (SOS2)    01522 Endocrine resistance     110211774 (SOS2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH IQ_SEC7_PH PH_19 RHG20_PH PH_10 PH_13 Motif Other DBs NCBI-GeneID:  110211774 NCBI-ProteinID:  XP_020846968 UniProt:  A0A6P5KMT3 LinkDB All DBs Position Unknown AA seq 1329 aa AA seqDB search MQPPQQPYDFFSEENHPKWRGLFVPALRKVQHQVHPNLSAKEDSLYYIEELILQLLNKLC IAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRTPLLLPVDKIHPLLKEVLGY KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD IGLVSLCEDEPFSSGELNYYDLVRTEIAEERQYLRELNLIIKVFREAFLSNKKLFASSDI EGIFSNILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI LSPQFHERFNTLMAKPAVSLHFQSIADGFKEAVRYVLPRLMLVPVYHCSHYFELLEQLQE CSEEQEDRECLKQAITALLNFRCSMERICNKHSPRRRPADPVCRFYNRQLRSKHLAIKKM NEIQKNIDGWEGKDIGQCCNEFIMEGPLIRVGAKHERHIFLFDGLMISCKTNHGQSRIPG YSNAEYRLKEKFIMRKIQICDKDDTSEYKHAFELISKDENSIIFAAKSTEEKNNWMAALI SLQYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDCEENIVFEDNLQSGIPVIKGG TVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLKLLIERFEIPEPEPTEADKLAVE KGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLEKLESFISSVKGK TMKKWVESIVKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQYETFDLMTLHPIEI ARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAEN FEERVAILSRIIEILQVFQDLNNFNGVLEVVSAVNSVSVYRLDHTFEALQERKRKILDEA VELSQDHFKKYLAKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKQGKELINFSKRRKV AEITGEIQQYQNQPYCLRIESEIRRFFENLNPMGNASDKEFTDYLFNKSQEIEPRNCKQP PRFPRKTTFSLKSPGIRPHAGRHGSTSGTLRGHPTPLEREPCKISFSRINEAEHESAASA PTSPNTPSTPPVSASSDLSVFLDIDLNSSYGSNSIFAPVVLPHSKSFFSSCGSLHKLTEE PLVPPPLPPRKKFDQDVSASKGNLKYDDDPPAIPPRQPPPPKIRPRVPAYSGPFEGPLPS PPPPPPRDPLPETPPPVPLRPPEHFINYPFNLQPPPMGHTHRDPDWFREASTCPNSPNTP PSTPSPRVPRRCVLSSSQNNLAHSQAPPIPPRQNSSPHLPKLPPKTYKRDLCQPPMYRLS LLENAETPQ NT seq 3990 nt NT seq  +upstreamnt  +downstreamnt atgcagccgccgcagcagccctacgacttcttcagcgaagagaaccacccgaaatggcgg ggactcttcgtcccggccctgcggaaggttcagcatcaagttcaccccaatctctcagca aaagaagattctttatattatattgaagagttgatccttcaactgctaaataaattgtgc attgcgcagccaagaactgttcaagatgtagaggaacgtgttcaaaagacttttcctcat ccaattgacaagtgggctatcgctgatgcacagtctgccatagaaaaacgaaaacgaagg acccctctcttgttgcctgtggataaaattcatcctttattgaaggaagttttagggtat aaagtagattatcatgtctctctttatattgtggctgtattggagtatatctcagctgat attctgaaattggctggtaattatgtttttaatatcagacattatgaaatatcccagcag gacattaaagtatcaatgtgtgcagataaggttttaatggacatgtttgatcaggatgac attggtttggtttcgctctgtgaagacgaacccttttcttcaggtgaactaaattactat gatttagtcagaactgaaattgcagaagaaagacaatatctacgggaattaaatctgata ataaaagtatttcgggaggctttcctttcaaacaaaaagctgtttgcatcttctgatatt gaagggatattcagcaacattttagatattcatgaattgaccgtaaagcttttgggcttg attgaagacacagttgaaatgactgatgaaagcagtcctcatcccttagctggcagttgt tttgaagatctagcagaagaacaagcatttgatccctatgaaaccttgtcacaggatatt ctttcaccacaatttcatgagcgtttcaatactttgatggccaaacctgctgtttctcta cattttcagtccattgctgatggctttaaagaggctgtacggtatgttcttccacgcctt atgctagtgccagtttaccattgttcacactactttgaattattagagcaattgcaagaa tgcagtgaagagcaagaagacagagaatgtttgaaacaagctattactgctcttctgaat ttccgttgtagcatggaacggatttgcaacaagcattcacctagacggcgacctgcggat cctgtttgtcgattttataatcgtcaattacggagcaagcacctggccattaaaaaaatg aatgaaattcaaaaaaatattgatggatgggaaggcaaagatattggccaatgttgtaat gaatttataatggaaggcccattgataagagtaggagctaagcatgaacgccatattttt ctttttgatggcttaatgattagttgtaaaactaatcatggacagtcccggattccaggt tatagcaatgcagaatacagattgaaagaaaaatttatcatgaggaaaatacaaatttgt gataaagatgacacttctgaatacaagcatgcctttgaattgatttccaaagatgaaaac agcattatatttgctgctaagtccactgaagagaaaaacaattggatggcagccttgatt tctcttcagtatcgtagtacactagatcgaatgctagattcagtattattaaaggaagaa aatgaacaaccactgaggttgccaagtccagaagtatatcgctttgttgtgaaagactgt gaggaaaacattgtttttgaagacaacttgcaaagtggaatccctgtcattaaaggagga actgtggtgaaattgattgaaaggctaacataccacatgtatgcagatcccaattttgtg cgtacttttcttacaacctatcgttcattttgtaaaccacaggaattgttgaagttattg attgaacggtttgaaatccctgagccagaacctactgaagcagataaattggcagtggag aaaggagagcaaccaatcagtgcagatctgaaacggtttcgcaaagaatatgtccaacca gtacaacttaggatactaaatgtatttcggcactgggtagaacatcatttttatgatttt gagcgagatctggagttactcgaaaaattagaatcctttatttcaagcgtaaaaggaaaa accatgaagaagtgggtagaatcaattgttaaaatcatcaagaggaaaaaacaagctcag gcaaatggaattagccataatattactttcgaaagtccaccaccaccaattgagtggcat attagcagaccaggacagtatgaaacatttgatctcatgacccttcatccaatagaaatt gcacgtcaactaacacttctggaatctgacctctacagggcagtgcagccttctgaactt gtgggaagtgtgtggactaaagaagataaagaaataaattccccaaatttattgaaaatg attcggcatactacaaatcttactctctggtttgaaaagtgcatagtagaagcagaaaac tttgaagaacgagtggcaatattaagtagaattatagaaattttgcaagtttttcaagac ttgaacaatttcaatggtgtattagaggtagtcagtgcagtgaattcagtatctgtgtac cgattggaccacacatttgaagcattacaggaaagaaaacgcaagattttagatgaagcc gtagaattaagccaagatcactttaaaaaatacctagcaaaacttaaatcaatcaaccca ccttgtgtgcctttttttggaatatatttaacaaatattctgaagactgaagaagggaat aatgatttccttaaaaaacaagggaaagaactaatcaactttagtaaaagaaggaaagta gccgaaattactggagagatacagcagtatcagaatcagccttattgtttacggatagaa tcagaaataaggaggttcttcgaaaatctcaaccctatgggaaatgcatcagacaaagaa tttacagattatttattcaataaatcacaagaaattgaaccccgaaactgtaaacagcca cctcgatttcctaggaaaacaactttctccttaaaatctcctggtataagaccacatgct ggcagacatggctctacttcaggcactttacgaggtcacccaacaccattagaaagagaa ccatgtaaaataagcttcagtcggataaatgaggctgagcatgaatcagcagcatcagca ccaacctctccaaacacaccatctactccaccagtctctgcttcttcagacctcagtgta tttttagatatagatcttaacagttcttatggaagcaacagcatctttgccccagtggtc ttaccacattcaaaatctttcttcagttcatgtggtagtttacataaattaactgaagaa ccactggttcctcctcctcttcctcctcgtaaaaagtttgatcaagatgtttcagcttct aagggaaacttgaaatatgatgatgatcctcctgctattccaccaaggcagccaccacct ccaaagataagacctcgagttcctgcttacagtggtccatttgaagggcctttgcctagc ccaccaccaccacctccacgagaccctcttcctgagactcctccacctgtaccccttcgg cctcccgaacatttcataaactatccgtttaatcttcagccaccaccaatgggacatact cacagagatccggattggttccgggaagccagtacatgtccaaactcaccgaatactcct ccaagcacaccctctccaagggtgccacgtcgctgcgtgctcagttctagtcaaaataat cttgctcattctcaagctccccctatcccaccaagacagaattcaagccctcacttacca aaactgccaccaaagacttacaaaagagatctttgtcaacctcctatgtacagattgtca ttgttagaaaatgcagaaactcctcagtga

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