KEGG   Phascolarctos cinereus (koala): 110212891
Entry
110212891         CDS       T05867                                 
Symbol
JAK1
Name
(RefSeq) tyrosine-protein kinase JAK1 isoform X1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
pcw  Phascolarctos cinereus (koala)
Pathway
pcw01521  EGFR tyrosine kinase inhibitor resistance
pcw04151  PI3K-Akt signaling pathway
pcw04217  Necroptosis
pcw04380  Osteoclast differentiation
pcw04550  Signaling pathways regulating pluripotency of stem cells
pcw04620  Toll-like receptor signaling pathway
pcw04621  NOD-like receptor signaling pathway
pcw04630  JAK-STAT signaling pathway
pcw04658  Th1 and Th2 cell differentiation
pcw04659  Th17 cell differentiation
pcw05140  Leishmaniasis
pcw05145  Toxoplasmosis
pcw05152  Tuberculosis
pcw05160  Hepatitis C
pcw05161  Hepatitis B
pcw05162  Measles
pcw05163  Human cytomegalovirus infection
pcw05164  Influenza A
pcw05165  Human papillomavirus infection
pcw05166  Human T-cell leukemia virus 1 infection
pcw05167  Kaposi sarcoma-associated herpesvirus infection
pcw05168  Herpes simplex virus 1 infection
pcw05169  Epstein-Barr virus infection
pcw05171  Coronavirus disease - COVID-19
pcw05200  Pathways in cancer
pcw05203  Viral carcinogenesis
pcw05212  Pancreatic cancer
pcw05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pcw00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    110212891 (JAK1)
   04151 PI3K-Akt signaling pathway
    110212891 (JAK1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    110212891 (JAK1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    110212891 (JAK1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    110212891 (JAK1)
   04621 NOD-like receptor signaling pathway
    110212891 (JAK1)
   04658 Th1 and Th2 cell differentiation
    110212891 (JAK1)
   04659 Th17 cell differentiation
    110212891 (JAK1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    110212891 (JAK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110212891 (JAK1)
   05203 Viral carcinogenesis
    110212891 (JAK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110212891 (JAK1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    110212891 (JAK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110212891 (JAK1)
   05161 Hepatitis B
    110212891 (JAK1)
   05160 Hepatitis C
    110212891 (JAK1)
   05171 Coronavirus disease - COVID-19
    110212891 (JAK1)
   05164 Influenza A
    110212891 (JAK1)
   05162 Measles
    110212891 (JAK1)
   05168 Herpes simplex virus 1 infection
    110212891 (JAK1)
   05163 Human cytomegalovirus infection
    110212891 (JAK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110212891 (JAK1)
   05169 Epstein-Barr virus infection
    110212891 (JAK1)
   05165 Human papillomavirus infection
    110212891 (JAK1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    110212891 (JAK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    110212891 (JAK1)
   05140 Leishmaniasis
    110212891 (JAK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110212891 (JAK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcw01001]
    110212891 (JAK1)
Enzymes [BR:pcw01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     110212891 (JAK1)
Protein kinases [BR:pcw01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   110212891 (JAK1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 RIO1 FERM_C_FAK1
Other DBs
NCBI-GeneID: 110212891
NCBI-ProteinID: XP_020848682
UniProt: A0A6P5KSF4
LinkDB
Position
Unknown
AA seq 1153 aa
MQYLNFKEDCNAMAFCAKMRSYKKNEVNLDVLEPGVQVVFYLPDRKPLHILSGEYTVEDL
SIRAAQECCISPLCHNLFALYDEKTKLWYAPNHCIKIEDKTSLRLHYRMRFYFTNWHGTN
ENEQSVWRHSPKKQKSGYERRRVLDATPLLDANSLEYLFAQGQYDLVKCLAPVRDPKTDQ
EVHEIENECLGMAVLAISHYAMMNNIQLPDLPKDVSYKRYIPETLNRTIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVTPHDLKVKYLSTLETLTKHYGAEIFETSLLLISSENEMN
KLNSKDCGNVIRYEVMVTGNLGIQWRQKPNVVSVEKEKNKLKRKKQESKHRKEEEKNKAR
EEWNNFSYFPEITHVVIKESMVSINKQDNKKMELSLASHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIENGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CLEKSEQMLTSQKQYKNFQIEVKKGKYSLHGSDRVFPSLRGLMDHLKKQILKTDNISFVL
KKCCQPKPREISNLLVATKKAQECLPVYTMSQLSFHRILKEDIIQGEHMGRGTRTQIYSG
TLDYKDEEGSSDEKKMKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFMEFGPLDLFMHRKSELLTTPWKFKVAKQLASALSYLEDKDLVHGNVCAKNVL
LAREGLDGECSPFIKLSDPGIPITVLSRQECVERIPWIAPECVDDSKNLSVAADKWSFGT
TLWEICYNGEIPLKDKTLAEKERFYEGRVMPVTPSCKELADLMTQCMNYDPSQRPFFRAI
MRDINKLEEQNPDILSEKQPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT
GEQVAVKSLKPESGGNQIADLKKEIEILKNLYHENIVKYKGICTEDGGNRIKLIMEFLPS
GSLKEYLPRNKNKINLKQQLKYAVQICKGMDYLGSCQYVHRDLAARNVLVENEHRVKIGD
FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLVQCKFYIASDVWSFGVTLHELLTYCDSE
SSPMAMFLKMIGPTQGQMTVTRLVRALKDGKRLQCPPNCPEEVYQLMKKCWEYQPNSRTS
FQNLIRGFEALIK
NT seq 3462 nt   +upstreamnt  +downstreamnt
atgcagtatctaaatttcaaagaggactgcaatgccatggcgttctgtgcaaaaatgagg
agctacaaaaagaacgaggtgaatctggatgtgctggagcctggggtgcaggtggtgttc
tatctgcctgacaggaaacccctccacatactcagtggggagtacactgtggaagacctg
agcatcagagctgcgcaggagtgctgcatctctccactgtgccacaacctctttgccctg
tacgatgagaagaccaagctgtggtacgccccgaatcactgcatcaagatcgaagacaaa
acgtcgctacggctgcattatcgaatgagattctatttcaccaactggcacgggaccaat
gagaacgagcagtcggtgtggagacactccccaaagaagcagaaaagtggctatgaaagg
agacgcgtcctggacgccacgcccctccttgatgccaattcgctggagtatctgtttgcc
cagggacaatatgatttagtgaagtgcttggctcctgtgcgagacccaaagaccgatcag
gaagtacatgagattgaaaatgaatgtctggggatggcagtgctggccatatcccattat
gccatgatgaataatatacaacttccagacctgccgaaggacgtcagttacaagcgatat
attccagaaacactgaacaggaccatcagacaaaggaatctcttaaccagaatgcgaata
aataatgtcttcaaggatttccttaaggaatttaataacaagaccatttgtgacagtagt
gtgactccccatgatctaaaggtgaaatatctgtcgaccttggagacgctaaccaaacat
tatggagctgaaatttttgagacttcgctcttgttgatttcatctgaaaatgaaatgaat
aagttaaactcaaaagactgtggaaacgtcatacgttatgaagtgatggtgaccggaaat
cttggaatacagtggaggcaaaaaccaaatgtggtttctgttgagaaggagaaaaacaag
ctgaagaggaagaagcaggagagcaaacacaggaaagaggaagagaagaacaaagcccgg
gaggaatggaataacttctcctacttccccgaaatcacccatgttgtcatcaaggagtcc
atggtcagcatcaataagcaggacaacaagaagatggagttaagcctggcttcccacgag
gaagccttgtctttcgtgtctctggtggatggctatttccggctcacggcagatgcccat
cattacctctgcacggatgtcgcacctccgttgattgtgcacaacatagaaaatggttgt
catggccccatctgtactgagtatgcaatcaacaagctgagacaagaagggagcgaggag
ggcatgtacgtcctgcgctggagctgcacagactttgacaacatcctcatgactgtgacc
tgcttggagaagtcagagcagatgttaacgagccagaaacagtacaagaatttccagatt
gaagtgaagaaggggaaatactccctgcatggctccgatcgagtgttcccctctctcaga
ggcctgatggaccatctgaaaaagcagatcctgaaaacagacaacatcagcttcgtcctg
aagaaatgctgtcagccgaaaccaagagaaatttctaatctgcttgtggccaccaagaag
gcccaggaatgcttgccagtctatacaatgagccagctgagtttccatcgaattctcaag
gaagacatcattcagggagagcacatgggacgaggcactcggacccagatctactcaggg
accctggactacaaggatgaagaaggcagctccgatgagaaaaagatgaaagtgattctc
aaagtcttggaccctagccacagggacatttctttggctttcttcgaggccgccagcatg
atgagacaagtctcccataaacacattgtgtatctctatggcgtctgtgtccgggacgtg
gaaaacatcatggtggaggaatttatggagtttgggcccctggacctcttcatgcatcgg
aaaagtgaactcctcaccacaccttggaaattcaaggttgccaaacagctggccagtgca
ctgagttacttggaggacaaagatttggtccatgggaatgtgtgcgccaaaaatgtcctc
ttggccagagagggcctggatggtgagtgcagccccttcatcaagctcagcgatcccggg
atccccatcactgtgctctctcgacaggagtgtgtggaacggatcccgtggattgcacca
gaatgcgtggatgactccaagaacctgagcgtggctgctgataaatggagttttggcacc
accctctgggagatctgctacaatggagaaatccccttgaaagataagacgctggcagag
aaagagcggttctatgaaggtcgagttatgccggtcacgccctcgtgcaaggagctggct
gacctgatgacgcagtgcatgaactacgaccctagtcagagacccttcttccgcgccatc
atgagagacatcaataagctagaagagcagaacccagacattctttcagagaaacaaccg
acaactgaggtggatcccacccattttgaaaagcggttcttgaagaggatccgtgacttg
ggagagggccactttgggaaagttgaactctgcaggtatgaccctgagggggacaacacc
ggagagcaggttgcagtcaagtctctgaagccagagagtgggggcaaccagatagcagac
ctgaagaaggagatcgagatcttgaagaacctttatcacgaaaacattgtgaaatacaaa
gggatttgtacagaggatggaggaaataggattaaactgattatggagttcctgccttct
gggagcctgaaggaatatcttcctaggaataagaacaaaatcaacctcaaacagcagctg
aagtatgcggttcagatttgtaaggggatggactatctggggtcctgtcagtatgtccac
cgagatctggcagcgagaaatgtcctcgttgaaaacgagcaccgcgtaaagatcggagat
tttggcttaacgaaagccatcgaaacagacaaggagtactacacagtgaaggatgatcgg
gacagtcctgtcttctggtacgcgccagagtgtctagtccagtgcaaattttatatcgcc
tctgacgtctggtcattcggggtcacgctacacgaactcctcacctactgcgactcagaa
tccagtcccatggcgatgtttttaaagatgatcggcccaactcaaggtcagatgactgtc
acaagacttgtgcgtgcattaaaggatggaaaacgtttgcagtgcccacctaactgccca
gaagaggtttaccaactaatgaagaaatgctgggagtaccagccgaacagccgaacgtcc
tttcagaacctcatccgtggatttgaagcacttataaaataa

DBGET integrated database retrieval system