KEGG   Phascolarctos cinereus (koala): 110216339
Entry
110216339         CDS       T05867                                 
Symbol
BRAF
Name
(RefSeq) serine/threonine-protein kinase B-raf isoform X1
  KO
K04365  B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pcw  Phascolarctos cinereus (koala)
Pathway
pcw01521  EGFR tyrosine kinase inhibitor resistance
pcw01522  Endocrine resistance
pcw04010  MAPK signaling pathway
pcw04012  ErbB signaling pathway
pcw04015  Rap1 signaling pathway
pcw04024  cAMP signaling pathway
pcw04062  Chemokine signaling pathway
pcw04068  FoxO signaling pathway
pcw04150  mTOR signaling pathway
pcw04270  Vascular smooth muscle contraction
pcw04510  Focal adhesion
pcw04650  Natural killer cell mediated cytotoxicity
pcw04720  Long-term potentiation
pcw04722  Neurotrophin signaling pathway
pcw04726  Serotonergic synapse
pcw04730  Long-term depression
pcw04810  Regulation of actin cytoskeleton
pcw04910  Insulin signaling pathway
pcw04914  Progesterone-mediated oocyte maturation
pcw04928  Parathyroid hormone synthesis, secretion and action
pcw04934  Cushing syndrome
pcw05010  Alzheimer disease
pcw05022  Pathways of neurodegeneration - multiple diseases
pcw05034  Alcoholism
pcw05160  Hepatitis C
pcw05161  Hepatitis B
pcw05200  Pathways in cancer
pcw05205  Proteoglycans in cancer
pcw05208  Chemical carcinogenesis - reactive oxygen species
pcw05210  Colorectal cancer
pcw05211  Renal cell carcinoma
pcw05212  Pancreatic cancer
pcw05213  Endometrial cancer
pcw05214  Glioma
pcw05215  Prostate cancer
pcw05216  Thyroid cancer
pcw05218  Melanoma
pcw05219  Bladder cancer
pcw05220  Chronic myeloid leukemia
pcw05221  Acute myeloid leukemia
pcw05223  Non-small cell lung cancer
pcw05224  Breast cancer
pcw05225  Hepatocellular carcinoma
pcw05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pcw00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    110216339 (BRAF)
   04068 FoxO signaling pathway
    110216339 (BRAF)
   04024 cAMP signaling pathway
    110216339 (BRAF)
   04150 mTOR signaling pathway
    110216339 (BRAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    110216339 (BRAF)
   04062 Chemokine signaling pathway
    110216339 (BRAF)
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    110216339 (BRAF)
  09156 Nervous system
   04726 Serotonergic synapse
    110216339 (BRAF)
   04720 Long-term potentiation
    110216339 (BRAF)
   04730 Long-term depression
    110216339 (BRAF)
   04722 Neurotrophin signaling pathway
    110216339 (BRAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110216339 (BRAF)
   05205 Proteoglycans in cancer
    110216339 (BRAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    110216339 (BRAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110216339 (BRAF)
   05212 Pancreatic cancer
    110216339 (BRAF)
   05225 Hepatocellular carcinoma
    110216339 (BRAF)
   05226 Gastric cancer
    110216339 (BRAF)
   05214 Glioma
    110216339 (BRAF)
   05216 Thyroid cancer
    110216339 (BRAF)
   05221 Acute myeloid leukemia
    110216339 (BRAF)
   05220 Chronic myeloid leukemia
    110216339 (BRAF)
   05218 Melanoma
    110216339 (BRAF)
   05211 Renal cell carcinoma
    110216339 (BRAF)
   05219 Bladder cancer
    110216339 (BRAF)
   05215 Prostate cancer
    110216339 (BRAF)
   05213 Endometrial cancer
    110216339 (BRAF)
   05224 Breast cancer
    110216339 (BRAF)
   05223 Non-small cell lung cancer
    110216339 (BRAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    110216339 (BRAF)
   05160 Hepatitis C
    110216339 (BRAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110216339 (BRAF)
   05022 Pathways of neurodegeneration - multiple diseases
    110216339 (BRAF)
  09165 Substance dependence
   05034 Alcoholism
    110216339 (BRAF)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    110216339 (BRAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110216339 (BRAF)
   01522 Endocrine resistance
    110216339 (BRAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pcw01001]
    110216339 (BRAF)
Enzymes [BR:pcw01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     110216339 (BRAF)
Protein kinases [BR:pcw01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   110216339 (BRAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 C1_2 Pkinase_fungal FliD_N
Other DBs
NCBI-GeneID: 110216339
NCBI-ProteinID: XP_020853802
UniProt: A0A6P5L7D1
LinkDB
Position
Unknown
AA seq 803 aa
MAALSGGGGGGAEQGPALFNGDMDPEAGAGSASSAEPAIPEEVWNIKQMIKLTQEHIEAL
LDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESMGNGTDFSVSSSASTDTVTSSS
SSSLSVAPSSLAVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKA
LMMRGLIPECCAVYRRQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFT
LAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEE
ASLGESTLTSGSSPSAPPSDSIGPPILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSS
SAPNVHINTIEPVNIDDLIRDQGLRGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFD
FEPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRR
DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGV
LRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGM
DYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEV
IRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSN
CPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFS
LYACASPKTPIQAGGYGEFAAFK
NT seq 2412 nt   +upstreamnt  +downstreamnt
atggcggcgctgagcggcggcggcggcggcggcgcggagcagggccccgctctcttcaac
ggggacatggatcccgaggctggcgccggctcggcgtcctccgccgagccggccatcccc
gaggaggtgtggaacatcaagcaaatgattaaattgacacaggaacacatagaggcccta
ttggacaagttcggaggggaacataatccaccatcaatctacctggaggcctatgaagaa
tataccagcaagctagatgcacttcaacaacgggaacaacaattattagagtccatgggg
aatggaactgatttttctgtttctagctcagcttcaacagacacagttacatcttcttcc
tcttctagcctttcagtggcaccttcatctcttgcagtttttcagaatcctacagatgta
tcaagaagcaaccctaagtcaccacaaaaaccaattgttagagtcttcctgcccaacaaa
cagaggactgtggtgccagcaagatgtggggtgacagtccgagacagtctaaagaaagca
ttgatgatgagaggcctgatcccagaatgctgtgctgtgtacagaagacaggatggagag
aagaagcctattggctgggacactgatatttcctggcttactggagaagaattgcacgta
gaagttttggagaatgttcccctaacgacacacaattttgtacggaagacattttttacc
ttagcattctgtgacttttgtcgaaagttgcttttccaaggtttccgctgtcagacatgt
ggttacaaatttcaccaacgctgtagtacagaggtgccactgatgtgtgttaattatgac
cagcttgatttgctgtttgtctccaagttctttgaacaccacccaataccgcaggaggag
gcctccttaggagagagcacccttacgtcgggatcatccccttcagcacccccctcagat
tctattgggcccccaattcttaccagtccatcgccttcaaaatccattccaatcccacag
ccttttcgaccagcagatgaggatcatcggaaccagtttgggcaacgagaccggtcctca
tcggctcccaatgtgcatataaatacaatagaacctgtcaatattgatgacttgattaga
gaccaagggttacggggtgatggagcccccttgaaccaactgatgcgctgtcttcggaaa
taccaatcccggactcccagtcccctcctacattctgtccccagtgaaatagtgtttgat
tttgagcctggcccagtgttcagagggtcaaccacaggcttgtctgccacccctcctgct
tccttgcctggatctttaactaatgtgaaagcattacaaaaatctccaggacctcagcgt
gaaagaaaatcttcatcatcttctgaagacaggaatagaatgaaaacccttggtcgacgg
gactcaagtgatgattgggagattccagatgggcagattacagttggacaaaggatagga
tctggatcatttggaacagtctacaagggaaaatggcatggtgatgtagctgtgaaaatg
ttgaatgtgacagcacccacacctcagcagttacaggctttcaaaaatgaagtaggagtg
ctcaggaaaacgcgacatgtgaatatcctactctttatgggctattcaacaaaaccacag
ttggccattgttacacagtggtgtgaaggctccagtttatatcaccatctacatatcatt
gagaccaaatttgagatgatcaagctaatagatattgcacggcaaacagcacaaggcatg
gattacttacacgccaagtcaatcatccacagagacctcaagagtaataatatatttctt
catgaagacctcacagtaaaaataggggattttggtctggctacagtaaaatctcggtgg
agtggctcccatcagtttgaacagttgtctggatctatcttgtggatggcaccagaggtc
attagaatgcaagataaaaacccatatagctttcaatcagatgtatatgcgtttgggatt
gttctgtatgagttgatgacgggacaattaccttactcaaacatcaacaacagggaccag
ataatttttatggtggggcgaggatacctgtctccagatctcagtaaggtgcggagtaat
tgtccaaaagccatgaagaggttaatggcagagtgcctgaagaagaagagagatgagagg
ccactttttccccagatccttgcctccattgaacttctggcccgctcattgccaaaaatt
caccgcagtgcatctgaaccctcactgaatcgggctggcttccaaacggaggattttagt
ctgtatgcttgtgcttctccaaaaacgcccatccaggcagggggatatggagaatttgcc
gccttcaagtag

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