KEGG   Phascolarctos cinereus (koala): 110223673
Entry
110223673         CDS       T05867                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pcw  Phascolarctos cinereus (koala)
Pathway
pcw00562  Inositol phosphate metabolism
pcw01100  Metabolic pathways
pcw04015  Rap1 signaling pathway
pcw04020  Calcium signaling pathway
pcw04022  cGMP-PKG signaling pathway
pcw04062  Chemokine signaling pathway
pcw04070  Phosphatidylinositol signaling system
pcw04071  Sphingolipid signaling pathway
pcw04072  Phospholipase D signaling pathway
pcw04081  Hormone signaling
pcw04082  Neuroactive ligand signaling
pcw04261  Adrenergic signaling in cardiomyocytes
pcw04270  Vascular smooth muscle contraction
pcw04310  Wnt signaling pathway
pcw04371  Apelin signaling pathway
pcw04540  Gap junction
pcw04611  Platelet activation
pcw04613  Neutrophil extracellular trap formation
pcw04621  NOD-like receptor signaling pathway
pcw04713  Circadian entrainment
pcw04720  Long-term potentiation
pcw04723  Retrograde endocannabinoid signaling
pcw04724  Glutamatergic synapse
pcw04725  Cholinergic synapse
pcw04726  Serotonergic synapse
pcw04728  Dopaminergic synapse
pcw04730  Long-term depression
pcw04742  Taste transduction
pcw04750  Inflammatory mediator regulation of TRP channels
pcw04911  Insulin secretion
pcw04912  GnRH signaling pathway
pcw04915  Estrogen signaling pathway
pcw04916  Melanogenesis
pcw04918  Thyroid hormone synthesis
pcw04919  Thyroid hormone signaling pathway
pcw04921  Oxytocin signaling pathway
pcw04922  Glucagon signaling pathway
pcw04924  Renin secretion
pcw04925  Aldosterone synthesis and secretion
pcw04926  Relaxin signaling pathway
pcw04927  Cortisol synthesis and secretion
pcw04928  Parathyroid hormone synthesis, secretion and action
pcw04929  GnRH secretion
pcw04933  AGE-RAGE signaling pathway in diabetic complications
pcw04934  Cushing syndrome
pcw04935  Growth hormone synthesis, secretion and action
pcw04961  Endocrine and other factor-regulated calcium reabsorption
pcw04970  Salivary secretion
pcw04971  Gastric acid secretion
pcw04972  Pancreatic secretion
pcw04973  Carbohydrate digestion and absorption
pcw05010  Alzheimer disease
pcw05016  Huntington disease
pcw05017  Spinocerebellar ataxia
pcw05022  Pathways of neurodegeneration - multiple diseases
pcw05142  Chagas disease
pcw05143  African trypanosomiasis
pcw05146  Amoebiasis
pcw05163  Human cytomegalovirus infection
pcw05200  Pathways in cancer
pcw05415  Diabetic cardiomyopathy
pcw05417  Lipid and atherosclerosis
Module
pcw_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pcw00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    110223673 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    110223673 (PLCB2)
   04310 Wnt signaling pathway
    110223673 (PLCB2)
   04371 Apelin signaling pathway
    110223673 (PLCB2)
   04020 Calcium signaling pathway
    110223673 (PLCB2)
   04070 Phosphatidylinositol signaling system
    110223673 (PLCB2)
   04072 Phospholipase D signaling pathway
    110223673 (PLCB2)
   04071 Sphingolipid signaling pathway
    110223673 (PLCB2)
   04022 cGMP-PKG signaling pathway
    110223673 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    110223673 (PLCB2)
   04081 Hormone signaling
    110223673 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    110223673 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110223673 (PLCB2)
   04613 Neutrophil extracellular trap formation
    110223673 (PLCB2)
   04621 NOD-like receptor signaling pathway
    110223673 (PLCB2)
   04062 Chemokine signaling pathway
    110223673 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    110223673 (PLCB2)
   04922 Glucagon signaling pathway
    110223673 (PLCB2)
   04929 GnRH secretion
    110223673 (PLCB2)
   04912 GnRH signaling pathway
    110223673 (PLCB2)
   04915 Estrogen signaling pathway
    110223673 (PLCB2)
   04921 Oxytocin signaling pathway
    110223673 (PLCB2)
   04926 Relaxin signaling pathway
    110223673 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    110223673 (PLCB2)
   04918 Thyroid hormone synthesis
    110223673 (PLCB2)
   04919 Thyroid hormone signaling pathway
    110223673 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    110223673 (PLCB2)
   04916 Melanogenesis
    110223673 (PLCB2)
   04924 Renin secretion
    110223673 (PLCB2)
   04925 Aldosterone synthesis and secretion
    110223673 (PLCB2)
   04927 Cortisol synthesis and secretion
    110223673 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    110223673 (PLCB2)
   04270 Vascular smooth muscle contraction
    110223673 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    110223673 (PLCB2)
   04971 Gastric acid secretion
    110223673 (PLCB2)
   04972 Pancreatic secretion
    110223673 (PLCB2)
   04973 Carbohydrate digestion and absorption
    110223673 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    110223673 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    110223673 (PLCB2)
   04725 Cholinergic synapse
    110223673 (PLCB2)
   04728 Dopaminergic synapse
    110223673 (PLCB2)
   04726 Serotonergic synapse
    110223673 (PLCB2)
   04720 Long-term potentiation
    110223673 (PLCB2)
   04730 Long-term depression
    110223673 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    110223673 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    110223673 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    110223673 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    110223673 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110223673 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    110223673 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110223673 (PLCB2)
   05142 Chagas disease
    110223673 (PLCB2)
   05143 African trypanosomiasis
    110223673 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110223673 (PLCB2)
   05016 Huntington disease
    110223673 (PLCB2)
   05017 Spinocerebellar ataxia
    110223673 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    110223673 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110223673 (PLCB2)
   05415 Diabetic cardiomyopathy
    110223673 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    110223673 (PLCB2)
   04934 Cushing syndrome
    110223673 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pcw04131]
    110223673 (PLCB2)
Enzymes [BR:pcw01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     110223673 (PLCB2)
Membrane trafficking [BR:pcw04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    110223673 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    110223673 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 110223673
NCBI-ProteinID: XP_020864978
UniProt: A0A6P5M556
LinkDB
Position
Unknown
AA seq 1184 aa
MSLLNPVLLPPEVKSYLTRGERFIKWDDETSMASPVILRVDPNGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKMPKTQKLREVFNLDFPDNTFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVSKDWAEDVLALAKNPLTANAPRSRFLDKILVKLKMHLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDSINPEDFPEPVYRSFLMNLCPRPEIDEIFTSHHAKAKPYMTKEH
LTKFINQKQRDARLNSLLFPPARPDQVQCLIEKYEPSGINIQRGQLSPEGMVWFLCGPEN
SIVAQDKLILNQDMSQPLNHYFINSSHNTYLTAGQFSGPSSSEMYRQVLLSGCRCVELDC
WKGKPPEEEPIITHGFTMTTDILFKDAVEAIAESAFKTSLYPVILSFENHVDSPRQQAKM
AEYCRTIFGDTLLTEPLDRFPVKPGVPLPSPQDLLGKILIKNKKNQSPAPIPPKKELCEE
TEGFSQPSPAMGEDTVWVGEEEAELEEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYE
EMSSLVNYIQPTKFISFEFSSQKNRSYVISSFTELKAYDLLTKSPVQFVDYNKRQMSRIY
PKGTRMDSSNYSPQMFWNAGCQMVALNFQTMDMPMQQNMALFEFNGQTGYLLKHEFMRRP
DKQFDPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVEVFGLPGDPKRRYRTKLTP
NANSINPVWKEDPFVFEKIMMPELASLRVAVLEEGGKFIGHRIIPVHALQSGYHHLCLRS
ESNMPLTMPALFVFLEMKDYVPDTWADLTVALTNPIKFFNAQDKKSVKLKDTGNDPPERP
LPQRNSALGQANGALTSAGSSVAPSPNGPAAAVTWFKEEAMKEVAEPQTASLEDLQQLKG
FLKLQKRQEKELRELERRGARRWEELLQKYASLQAELTPHTGCRKLSVTKGSRKKRNVPW
EETSGAGPGPVEGPESTDGHVQELKEKLETELYQQGEEHYESIMKRKEQHGMEQIAKVME
LAQERQAAELKALKESAESNTKEIKKKLEAKRVERIQAMSKITSDKMAQERLKREINNSH
IQEVVHIIKQMTETLERHQERLEEKQAACLEQIREKEKKFQQEALSEYEERMRSLEAKVK
EAVRCLSFPQDSHDKKLETPSAVEEPSEEASRPTEASSQQDSHL
NT seq 3555 nt   +upstreamnt  +downstreamnt
atgtctctgctcaatccagtcctgctgccccctgaggtgaagagctatctaactcgagga
gagcgcttcatcaaatgggatgatgagacttcaatggcatccccggtcatccttcgagtg
gatcccaatggctattacttgtactggacatatcaaagcaaggaaatggagttcctggac
atcaccagcattcgggacactaggtttggaaagtttgctaagatgccaaagacccagaaa
cttcgggaggttttcaacttggatttccctgacaacaccttcctgctgaagacgctgact
gtggtgtctggcccagacatggtggacctgaccttccataactttgtctcctacaaagag
aatgtcagcaaggactgggctgaagatgttctggccttagctaagaacccattaacagcc
aatgccccccggagcaggttcctggataagatcctagtaaagctcaagatgcatctcaat
ccagaaggaaagatccccgtgaagaatttttttcagatgtttcctgcagaccggaaacga
gtagaggctgccctcagtgcctgtcaccttcccaagggcaaaaatgattccatcaatcct
gaggatttccctgagcctgtctacaggagttttctcatgaatctatgtccccgacctgaa
attgatgagatcttcacctctcaccatgccaaagcaaagccttacatgaccaaggagcat
ctgaccaagttcattaaccaaaaacaacgggatgcccgactcaactccttactcttccca
ccagcccgacctgaccaagtacaatgcctcattgaaaagtatgagcccagtggcatcaac
atccagaggggtcagctatccccagaggggatggtttggttcctatgtggtcctgagaac
agtatagtggcccaagacaagctgatactgaaccaggacatgagtcaacctctgaatcac
tacttcattaactcctcccacaatacctacctgacagctggccagttctcaggaccctca
tcctcagagatgtacagacaggtcttgctctctggctgtcgctgtgtggaacttgactgc
tggaaagggaagcctcctgaggaagagcccatcatcacccatggtttcaccatgaccaca
gacattttattcaaggatgcagtggaggccattgctgagagtgccttcaagacctcactc
taccctgtcatcctgtcctttgaaaaccatgtagactcgccccgacaacaggccaagatg
gcagaatactgccgaaccatatttggggacacgctcctcactgagcccctggacaggttc
cctgtgaagccaggggttcccttgcccagtccccaggaccttctgggcaagatcctcatc
aaaaataagaagaatcagtccccagctcccattccacccaagaaggaattgtgtgaggag
acagagggctttagccagcccagtccagccatgggtgaggacacagtgtgggttggtgaa
gaagaggctgagctggaggaagaggaagaagaggaagaatcaggtaacctggatgaagag
gaaataaagaagatgcagtcggatgagggcacagctggcctggaagtgacagcatatgaa
gagatgtctagtctggtcaactacatccagcccaccaagttcatctcctttgagttctcc
tcccagaagaatcggagttacgtcatctcttccttcacggagttgaaggcctatgaccta
ctcaccaagtcccctgtgcagttcgtggactacaataagcgtcagatgagtcggatctac
cccaagggcacccgaatggactcatctaactactctccccagatgttctggaatgcaggc
tgccaaatggttgccctcaatttccagaccatggatatgcccatgcagcagaacatggca
ctgtttgagttcaatgggcagactggctaccttctcaagcatgagttcatgcgccggcca
gacaagcaattcgaccccttctctgtggaccgtatcgatgtggtggtggccacaactctt
tccatcacggtgatttctgggcagtttctgtcagaacgaagtgtccgaacttacgtggag
gtggaggtgttcggcttgcctggagaccccaagagacgctaccgcaccaaactgacaccc
aatgccaactccataaatcccgtctggaaagaggacccctttgtctttgagaagatcatg
atgccagaactggcctctttacgagtggcagtgctggaggaaggaggcaaattcattggg
caccggattatcccagtccatgccctgcagtcaggataccatcacctgtgcctcaggagt
gaaagcaacatgcccctcaccatgcctgctctctttgttttcctggagatgaaagattat
gtgcctgacacctgggcagatctgactgtggctcttaccaaccccatcaaattctttaat
gcacaagacaagaagtcagtaaagctgaaggacacaggaaatgacccacctgagaggcct
ttgccacaaaggaactcggctctgggccaggccaatggggccctcacctctgcaggctcc
tctgtggccccatcacccaatggtcctgcagcagctgtgacctggttcaaggaagaagca
atgaaagaggtggcagaacctcagacagccagcctggaggacctgcagcagttgaaaggg
ttcctgaagcttcagaagagacaggaaaaggaacttcgggaactggagaggcggggagcc
cggcgctgggaggaactcctgcaaaagtatgccagcctacaggctgaattgaccccccac
actggatgcaggaagttgtctgtcacaaagggatcccggaaaaagagaaacgtcccttgg
gaggagaccagcggggctgggccggggccagtcgaggggccagaaagcacagatgggcat
gttcaagagctgaaggaaaagctggagacagaactgtaccagcaaggggaggagcattat
gaaagtatcatgaaacgcaaggaacagcatggcatggagcaaatcgccaaggtgatggag
ctggcccaggagagacaagcagctgagctaaaggctctcaaggaatctgcagaaagcaac
accaaagagataaagaagaagcttgaagccaaaagggtagaacggattcaggccatgagc
aagatcaccagtgacaagatggcccaagagagactgaagagagagattaacaactcacat
atacaggaagtggttcacatcatcaaacagatgacagagaccctggagagacaccaggag
aggctggaagaaaagcaggcagcctgcctggagcagatccgggagaaagagaagaagttc
cagcaagaggcattgtctgaatatgaggaacggatgaggagcctggaggccaaggtgaag
gaggcggtgagatgcctcagtttcccccaagactcccatgacaagaaactggagactccc
agtgctgtggaggaaccttcagaggaggcatctcggccaactgaggcttcttcccagcag
gatagccatctctaa

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