Phyllostomus discolor (pale spear-nosed bat): 114488244
Help
Entry
114488244 CDS
T07739
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
pdic
Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic00562
Inositol phosphate metabolism
pdic01100
Metabolic pathways
pdic01521
EGFR tyrosine kinase inhibitor resistance
pdic04012
ErbB signaling pathway
pdic04014
Ras signaling pathway
pdic04020
Calcium signaling pathway
pdic04062
Chemokine signaling pathway
pdic04064
NF-kappa B signaling pathway
pdic04066
HIF-1 signaling pathway
pdic04070
Phosphatidylinositol signaling system
pdic04072
Phospholipase D signaling pathway
pdic04360
Axon guidance
pdic04370
VEGF signaling pathway
pdic04380
Osteoclast differentiation
pdic04611
Platelet activation
pdic04613
Neutrophil extracellular trap formation
pdic04625
C-type lectin receptor signaling pathway
pdic04650
Natural killer cell mediated cytotoxicity
pdic04662
B cell receptor signaling pathway
pdic04664
Fc epsilon RI signaling pathway
pdic04666
Fc gamma R-mediated phagocytosis
pdic04670
Leukocyte transendothelial migration
pdic04722
Neurotrophin signaling pathway
pdic04750
Inflammatory mediator regulation of TRP channels
pdic04919
Thyroid hormone signaling pathway
pdic04933
AGE-RAGE signaling pathway in diabetic complications
pdic04935
Growth hormone synthesis, secretion and action
pdic05167
Kaposi sarcoma-associated herpesvirus infection
pdic05169
Epstein-Barr virus infection
pdic05170
Human immunodeficiency virus 1 infection
pdic05171
Coronavirus disease - COVID-19
pdic05200
Pathways in cancer
pdic05205
Proteoglycans in cancer
pdic05206
MicroRNAs in cancer
pdic05214
Glioma
pdic05223
Non-small cell lung cancer
pdic05225
Hepatocellular carcinoma
Module
pdic_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
pdic00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
114488244 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
114488244 (PLCG2)
04014 Ras signaling pathway
114488244 (PLCG2)
04370 VEGF signaling pathway
114488244 (PLCG2)
04064 NF-kappa B signaling pathway
114488244 (PLCG2)
04066 HIF-1 signaling pathway
114488244 (PLCG2)
04020 Calcium signaling pathway
114488244 (PLCG2)
04070 Phosphatidylinositol signaling system
114488244 (PLCG2)
04072 Phospholipase D signaling pathway
114488244 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
114488244 (PLCG2)
04613 Neutrophil extracellular trap formation
114488244 (PLCG2)
04625 C-type lectin receptor signaling pathway
114488244 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
114488244 (PLCG2)
04662 B cell receptor signaling pathway
114488244 (PLCG2)
04664 Fc epsilon RI signaling pathway
114488244 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
114488244 (PLCG2)
04670 Leukocyte transendothelial migration
114488244 (PLCG2)
04062 Chemokine signaling pathway
114488244 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
114488244 (PLCG2)
04919 Thyroid hormone signaling pathway
114488244 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
114488244 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
114488244 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
114488244 (PLCG2)
04380 Osteoclast differentiation
114488244 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
114488244 (PLCG2)
05206 MicroRNAs in cancer
114488244 (PLCG2)
05205 Proteoglycans in cancer
114488244 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
114488244 (PLCG2)
05214 Glioma
114488244 (PLCG2)
05223 Non-small cell lung cancer
114488244 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
114488244 (PLCG2)
05171 Coronavirus disease - COVID-19
114488244 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
114488244 (PLCG2)
05169 Epstein-Barr virus infection
114488244 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
114488244 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
114488244 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
pdic04131
]
114488244 (PLCG2)
Enzymes [BR:
pdic01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
114488244 (PLCG2)
Membrane trafficking [BR:
pdic04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
114488244 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
114488244 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
C2
SH3_1
PH
SH3_9
PH_12
EF-hand_PLCG1
SH2_1
PH_14
SH3_2
Adhesin_E
GDPD
EF-hand_like
Motif
Other DBs
NCBI-GeneID:
114488244
NCBI-ProteinID:
XP_028357729
UniProt:
A0A6J2KSU8
LinkDB
All DBs
Position
12:71129691..71274563
Genome browser
AA seq
1265 aa
AA seq
DB search
MTTMVNVDGLPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKCSKDFERAKAVRQKEDCCFTILYGTQFTLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRKNSISLRELKTVLPLVNFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VHLHDFQRFLLHEQQELWAQDLNRVRKRMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVVLSIEEHCGVEQQRYMARV
FKEVFGDMLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVDMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDTPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCSEMGGKDGTFLVRESERFPNDYTLSFWRSGRVQHCRIRSTMEDGVMKYY
LTDNLMFPSIYALIQYYRGTHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRKREGSDSYAITFRAKGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
KKHALYRKMKLRYPVTPELLERYSMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKQSDELSFYRGALIHNVSKEPGGWWKGDYGTKIQQYFPSNYVEDISSADVEDLEKQII
EDNPLGSLCRGILDLNAYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIRQITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSVVRQKPIDLLKYNQKALTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNQALFSLNGRTGYVLQPESMRTDKYDPMPPESQRKIQMTLTVKVLGARHLPKPGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALIKEFNVNENQLQLYQEKCNRRLREKRVSN
SKFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgaccaccatggtcaatgtggacggccttccggagtatgagaagagtcagatcaagaga
gccctggagctgggcacagtgatgaccgtgttcagcttccgcaagtccaccccggagcgc
aggaccgtccaggtgatcatggagacacggcaggtggcctggagtaagacggccgacaag
atcgaaggtttcctggatatcatggaaataaaggaaatccgcccggggaagtgctccaag
gattttgagcgtgccaaagcagtgcgccagaaggaagactgctgcttcaccatcctgtac
ggcacccagttcaccctcagcacgctcagtttagcagctgactctaaggaagatgcaacc
aagtggctctccggcttgaaaatcttacaccaagaagcaatgagtgcgtccacacccacc
attattgagagttggctgagaaagcagatttattcagtggaccaaaccagaaaaaacagc
atcagcctccgagagctgaagactgtcttgcccctggtcaacttcaaagtgagcagtgcc
aagttcctcaaggacaagtttgtggaaataggcgcgcacaaagatgaactcagctttgaa
cagttccatctcttctataaaaaactaatgtttgaacagcaaaaatcgattctggacgaa
ttcaaaaaagactcctccgtgttcatcttggggaacactgaccggccggacgcctccgct
gttcacctgcacgacttccagcgctttctcttacatgagcagcaggagctctgggcccag
gatctgaacagagtccgcaagaggatgacaaagtttatcgacgacacaatgagggaaact
gcggagcccttcctgttcgttgatgagttcctcacgtacctgttttcacgggagaacagc
atttgggatgagaagtatgacgtggtggacatgcaggacatgaacaaccccttgtctcat
tactggatctcctcatcacataacacgtacctcacaggtgaccagctgcggagtgagtcg
tccacagaggcatacatccgctgcctgcgcatgggctgtcgctgcattgagttggactgc
tgggacgggcccgacgggaagcccatcatctaccacggctggacacggaccaccaagatc
aagtttgatgatgtcgtgcaggccatcaaagaccacgcctttgtcacctcgagcttccct
gtggtcctgtccatcgaggagcactgtggcgtggaacagcagcgctacatggccagagtg
ttcaaggaggtgtttggcgacatgctgctgatgaagcccacagaggcaagtgccgaccag
ctgccctcacccagccagcttcgggaaaagatcatcatcaagcataagaagctgggcccc
cgcggcgacgtggatgtcgacatggaggacaagaaagatgagcacaagcaacagggcgaa
ctgtacatgtgggactccatcgaccagaagtggactcggcactattgcgccatcgccgat
gccaagctgtccttcagtgacgacattgaacagaccatggaagaagaagtgccccaggat
acgccccccaccgagctgcattttggagagaagtggttccacaagaaggtggagaagagg
acgagtgctgagaagctgctgcaggagtactgctccgagatggggggcaaggacgggacc
ttcttggtgcgggagagcgagaggttccccaacgactacaccctgtccttctggcggtca
ggccgcgtccagcactgccggatccgctccaccatggaggacggggtcatgaagtactac
ctgactgacaacctcatgttccccagcatctacgccctcatccagtactaccgcgggacg
cacctgcgctgcgccgagttcgagctgcgcctcacggaccctgtgcccaaccccaacccc
cacgagtcaaagccgtggtactatgacgggctgagccgtggagaagcggaggacatgctg
atgagagttccccgggacggcgccttcctcatccggaagcgggaaggcagcgactcctac
gccatcaccttcagggccaagggcaaggtgaagcactgtcgcatcaaccgggacggccgg
cacttcgtgctggggacctccgcctactttgagagcctggtggagctcgtcagttactac
aagaagcacgcgctgtaccggaagatgaaactgcgctaccctgtgactcccgaactcctg
gagcgctacagcatggaaagagacataaactccctgtatgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccttctatgcctcagagaactgtgaaagctctgtatgactac
aaagccaagcagagtgatgagctgagcttctaccgtggcgccctcattcacaacgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaaaatccagcagtacttcccg
tccaattacgtcgaggacatttcatcggctgatgtggaggatctggagaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatactggatctcaatgcctataacgtt
gtgaaagccccacagggcaaaaaccagaagcctttcgtctttatcctggaacccaagaag
cagggggaccctccagtggagtttgccacggacagggtggaggagctcttcgaatggttc
cagagcatccggcagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtcgatcgccattgagctgtcggacctggtcgtctactgcaagccaacc
agcaagaccaaagacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acgaaggctgacagcgtcgtcaggcagaagcccatcgatctcctgaagtacaatcagaag
gccctgacccgcgtgtacccgaagggacagagggtggactcctccaactacgatcccttc
cgcctctggctgtgtggctcccaaatggtggcactcaatttccagactgcagacaagtac
atgcagatgaatcaggccttgttctctctcaatgggaggaccggctatgtcctacagccc
gagagcatgaggacggataagtatgaccccatgccacccgagtcccagaggaagattcag
atgaccttgacggtcaaggttctcggggcacgccatcttcccaagcctggacgaagcatc
gcatgtccctttgtggaggtggaaatatgtggagctgaatatgacaacaacaagtttaag
acgacggttgtgaatgacaatggcctaagccccgtctgggctccaacacaggagaaggtg
acattcgaaatttacgatccaaacctcgcgttcctgcgcttcgtggtgtacgaggaagat
atgttcagcgatcccaactttctcgctcacgccacttaccccattaaaggaatcaaatca
ggatttagatctgttcctctgaagaatgggtacagcgaagacattgagctggcttccctc
ctggttttctgtgagatgcggccagtcctggagagcgaagaggaactctactcctcctgt
cgccagctgcggaggcggcaagaagaactgaacaaccagctctttctatacgacacacac
cagaacttgcgcaatgccaaccgggatgccctcattaaagaattcaatgtcaacgagaac
cagctccagctgtaccaggagaagtgcaaccggaggttaagagagaagagagtcagcaac
agcaagttttactcatag
DBGET
integrated database retrieval system
