Phyllostomus discolor (pale spear-nosed bat): 114490038
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Entry
114490038 CDS
T07739
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
pdic
Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic00230
Purine metabolism
pdic00670
One carbon pool by folate
pdic01100
Metabolic pathways
pdic01523
Antifolate resistance
Module
pdic_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
pdic00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
114490038 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
114490038 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
114490038 (GART)
Enzymes [BR:
pdic01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
114490038 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
114490038 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
114490038 (GART)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
CPSase_L_D2
ATP-grasp_4
Dala_Dala_lig_C
ATP-grasp_3
ATP-grasp_2
Motif
Other DBs
NCBI-GeneID:
114490038
NCBI-ProteinID:
XP_028359740
UniProt:
A0A6J2L2B2
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All DBs
Position
2:complement(2174479..2201308)
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AA seq
1011 aa
AA seq
DB search
MAARVLVIGNGGREHTLAWKLAQSTHVKEVLVAPGNAGTACSKKISNADISISDHSALAK
FCKDEDIEFVVVGPEAPLAAGIVGNLTSSGLRCFGPTAEAALLESSKRFAKEFMDRHKIP
TARWGAFTKPELACDFIRSADFPALVVKASGLAAGKGVTVASSREEACSAVRQIMQDKTF
GAAGETVIIEELLEGEEVSCLCFTDGLSVAAMPPAQDHKRLLEGDRGPNMGGMGAYCPVP
QVSKDLLLKIKNSILQRTVDGMRQESVPYTGVLYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSALDGLLCQSPPVWLENRAALTVVMASQGYPGDYTKGVEITGFAEA
HNLGLEVFHAGTALKDRKVVTNGGRVLAVTAIRENLVLALEEARKGLAAIKFEGAVYRKD
IGHRAIAFLQQQPRGLTYKDSGVDIEAGNMLVKKIKPLAKATSRPGCDVDLGGFAGLCDL
KAARFRDPLLACGTDGVGTKLKIAQQCNKHDTVGQDLVAMCVNDILAQGAEPLFFLDYFS
CGRLDLGTAEAVVAGIAKACVQAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQQL
PRLESIEEGDVVIGVASSGLHSNGFSLVRKVVAKSSLQYSSPAPDGCGSQTLGDLLLTPT
RIYSRSLLPILRSGHVKALAHITGGGLLENIPRVLPQGLGVDLDARSWRIPAVFSWLQQQ
GHLSEEEMARTFNCGVGVALVVSAHQVGLVLSDVRLRQEEAWVIGTVVACPEGCPRVRIR
HLMDAIRADRAALKNGLADSPSSVRPKQARVAVLISGTGSNLQALIHGTREPGSAARVVV
VVSNRAAVAGLDRAERAGIPTRVIDHKLYKSRVEFDTAVDQVLEEFSTDLVCLAGFMRIL
SGPFVRKWNGKMLNIHPSLLPSFRGSNAHEQALAAGVTVTGCTVHFVAEEVDAGQIVLQE
AVPVERGDTVATLSERVKLAEHRIFPAALQLVASGTVRLGEDGKLCYAQQE
NT seq
3036 nt
NT seq
+upstream
nt +downstream
nt
atggccgcccgcgtacttgtgattggcaatggagggagagagcacacgctggcctggaaa
ctggcgcagtctactcatgtcaaagaggtgttggttgcgccgggaaatgcaggaactgcc
tgctccaaaaagatttcaaatgctgacatctccatcagcgaccacagtgccctggccaag
ttctgcaaagatgaggacattgaatttgtagttgttggaccagaggcacctctggctgct
ggaatcgtcgggaacctgacgtcctcaggattgcgctgctttggccccacggcagaagca
gccctgttagagtccagcaagaggtttgccaaagagtttatggaccggcacaaaatccca
actgcacgatggggcgctttcaccaagcccgaattggcctgcgacttcatcaggagtgcg
gacttcccggccctggtggtgaaggccagcggcctggccgcggggaaaggggtgaccgtc
gcctcgagccgagaggaggcctgcagcgcggtccggcagatcatgcaggataaaaccttt
ggagcagccggagaaaccgtcatcattgaagagcttctcgagggagaggaggtgtcttgt
ctgtgcttcaccgacgggctgagcgtggccgccatgccccccgcccaggaccataagcgc
ctgctggagggggaccgcggccccaacatggggggcatgggcgcctactgtccggtgcct
caggtttctaaggatttgttgctaaaaattaaaaactccattctccagaggacagtggac
ggcatgcggcaggagagtgtgccgtacacaggtgtcctctatgctggtataatgctgacc
aaggacggcccaaaggttctggagtttaattgccgtttcggtgatccggaatgccaagta
atcctcccacttctgaaaagcgatctttacgaagtgattcagtctgccctggacggcctg
ctctgccaatcgccgcctgtttggcttgaaaaccgtgcagccctgactgttgtcatggcg
agtcagggttacccaggagactacaccaagggcgtggagataacagggtttgctgaggcc
cacaatttggggctggaggtgttccatgcaggcaccgccctaaaggaccgcaaggtggtg
acaaacggagggagagtccttgcggtgactgccatccgggaaaacctcgtcttggccctt
gaagaagccaggaaaggactggctgctatcaagttcgagggcgcagtttacaggaaggac
ataggccacagagccatagcgttcctccagcagcagcccaggggcctgacttacaaggac
tctggggtagatattgaagctggaaatatgctggtcaagaaaattaaacctttagccaaa
gccacctccagaccaggctgtgatgttgaccttggaggtttcgccggtctttgtgatctg
aaggcagcccgtttccgggatcccctgctggcctgtggaacggatggcgttggaacgaaa
ctgaagattgcccagcagtgcaacaaacacgacaccgtcggccaggacttggttgctatg
tgtgtaaacgacatcctggcgcaaggcgcggagcccctcttcttcctcgattacttttcc
tgtgggagactcgacctcggcaccgcggaagctgtcgtggctggaatcgccaaagcgtgc
gtgcaagctggctgtgcgctcctcgggggagagacagcagaaatgccggacatgtaccct
cccggggaatacgacctggccggttttgccgtcggcgccatggagcgggaccagcagctc
ccccgcctggagagcatcgaagaaggggacgtcgttatcggggtagcttcatccggtctc
cacagcaacggctttagcctcgtgaggaaagtcgtggcgaagtcttcccttcagtactcc
tcccccgcgcccgacggctgcggcagccagaccttaggcgacttgctcctgacccccacc
aggatctacagccggtcgctgctgcccatcttgcgctcgggacacgtcaaggcccttgcc
cacatcactggtggggggttgctggaaaacatcccccgggtcctcccgcagggactcggg
gtcgatttagatgcccgctcctggaggatccccgccgtcttctcgtggctacagcagcaa
ggacacctctctgaggaagagatggcccggacatttaactgcggggttggcgttgccctc
gtggtatcagcgcaccaggtggggctggttctgagtgacgttcggctgcgccaggaggaa
gcctgggtgattggcacggtggtggcctgccctgaaggctgtccccgtgtgaggatcagg
cacctgatggacgccattcgcgcggacagggcagcgctgaagaacggcctggcggacagc
ccctcctccgtccgaccgaagcaggcccgagtggctgtcttaatctcgggaacagggtcc
aacctccaggcgctcatccacggcacccgggagccaggcagcgccgcccgcgtcgtggtc
gtcgtctccaacagagctgccgtggccggcctagacagagccgagagagcgggcatcccc
accagagtaatcgatcataagttatataaaagtcgtgtggaatttgacactgcagttgac
caagtccttgaagagttctccacggacttggtctgcctcgcgggattcatgaggatttta
tctggcccctttgtcagaaagtggaatgggaaaatgctcaacatccacccgtccttgctc
ccttcttttcggggttcgaacgcccacgagcaagccctggccgctggcgtcacagtgacg
gggtgcaccgtgcactttgtggctgaggaggtggacgccggacagatcgtcctgcaggaa
gctgtcccggtggagcggggcgacactgtcgccactctgtctgagcgggtgaagttggcg
gagcacagaatcttccccgcagccctgcagctggtggccagcgggactgtccggctcggg
gaggatggcaagctctgctacgcccagcaggagtga
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