KEGG   Phyllostomus discolor (pale spear-nosed bat): 114490993
Entry
114490993         CDS       T07739                                 
Symbol
PIK3CA
Name
(RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pdic  Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic00562  Inositol phosphate metabolism
pdic01100  Metabolic pathways
pdic01521  EGFR tyrosine kinase inhibitor resistance
pdic01522  Endocrine resistance
pdic01524  Platinum drug resistance
pdic04012  ErbB signaling pathway
pdic04014  Ras signaling pathway
pdic04015  Rap1 signaling pathway
pdic04024  cAMP signaling pathway
pdic04062  Chemokine signaling pathway
pdic04066  HIF-1 signaling pathway
pdic04068  FoxO signaling pathway
pdic04070  Phosphatidylinositol signaling system
pdic04071  Sphingolipid signaling pathway
pdic04072  Phospholipase D signaling pathway
pdic04081  Hormone signaling
pdic04140  Autophagy - animal
pdic04150  mTOR signaling pathway
pdic04151  PI3K-Akt signaling pathway
pdic04152  AMPK signaling pathway
pdic04210  Apoptosis
pdic04211  Longevity regulating pathway
pdic04213  Longevity regulating pathway - multiple species
pdic04218  Cellular senescence
pdic04360  Axon guidance
pdic04370  VEGF signaling pathway
pdic04380  Osteoclast differentiation
pdic04510  Focal adhesion
pdic04550  Signaling pathways regulating pluripotency of stem cells
pdic04611  Platelet activation
pdic04613  Neutrophil extracellular trap formation
pdic04620  Toll-like receptor signaling pathway
pdic04625  C-type lectin receptor signaling pathway
pdic04630  JAK-STAT signaling pathway
pdic04650  Natural killer cell mediated cytotoxicity
pdic04660  T cell receptor signaling pathway
pdic04662  B cell receptor signaling pathway
pdic04664  Fc epsilon RI signaling pathway
pdic04666  Fc gamma R-mediated phagocytosis
pdic04668  TNF signaling pathway
pdic04670  Leukocyte transendothelial migration
pdic04722  Neurotrophin signaling pathway
pdic04725  Cholinergic synapse
pdic04750  Inflammatory mediator regulation of TRP channels
pdic04810  Regulation of actin cytoskeleton
pdic04910  Insulin signaling pathway
pdic04914  Progesterone-mediated oocyte maturation
pdic04915  Estrogen signaling pathway
pdic04917  Prolactin signaling pathway
pdic04919  Thyroid hormone signaling pathway
pdic04923  Regulation of lipolysis in adipocytes
pdic04926  Relaxin signaling pathway
pdic04929  GnRH secretion
pdic04930  Type II diabetes mellitus
pdic04931  Insulin resistance
pdic04932  Non-alcoholic fatty liver disease
pdic04933  AGE-RAGE signaling pathway in diabetic complications
pdic04935  Growth hormone synthesis, secretion and action
pdic04960  Aldosterone-regulated sodium reabsorption
pdic04973  Carbohydrate digestion and absorption
pdic05010  Alzheimer disease
pdic05017  Spinocerebellar ataxia
pdic05020  Prion disease
pdic05100  Bacterial invasion of epithelial cells
pdic05132  Salmonella infection
pdic05135  Yersinia infection
pdic05142  Chagas disease
pdic05146  Amoebiasis
pdic05160  Hepatitis C
pdic05161  Hepatitis B
pdic05162  Measles
pdic05163  Human cytomegalovirus infection
pdic05164  Influenza A
pdic05165  Human papillomavirus infection
pdic05166  Human T-cell leukemia virus 1 infection
pdic05167  Kaposi sarcoma-associated herpesvirus infection
pdic05168  Herpes simplex virus 1 infection
pdic05169  Epstein-Barr virus infection
pdic05170  Human immunodeficiency virus 1 infection
pdic05171  Coronavirus disease - COVID-19
pdic05200  Pathways in cancer
pdic05203  Viral carcinogenesis
pdic05205  Proteoglycans in cancer
pdic05206  MicroRNAs in cancer
pdic05207  Chemical carcinogenesis - receptor activation
pdic05208  Chemical carcinogenesis - reactive oxygen species
pdic05210  Colorectal cancer
pdic05211  Renal cell carcinoma
pdic05212  Pancreatic cancer
pdic05213  Endometrial cancer
pdic05214  Glioma
pdic05215  Prostate cancer
pdic05218  Melanoma
pdic05220  Chronic myeloid leukemia
pdic05221  Acute myeloid leukemia
pdic05222  Small cell lung cancer
pdic05223  Non-small cell lung cancer
pdic05224  Breast cancer
pdic05225  Hepatocellular carcinoma
pdic05226  Gastric cancer
pdic05230  Central carbon metabolism in cancer
pdic05231  Choline metabolism in cancer
pdic05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pdic05415  Diabetic cardiomyopathy
pdic05417  Lipid and atherosclerosis
pdic05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pdic00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    114490993 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    114490993 (PIK3CA)
   04014 Ras signaling pathway
    114490993 (PIK3CA)
   04015 Rap1 signaling pathway
    114490993 (PIK3CA)
   04370 VEGF signaling pathway
    114490993 (PIK3CA)
   04630 JAK-STAT signaling pathway
    114490993 (PIK3CA)
   04668 TNF signaling pathway
    114490993 (PIK3CA)
   04066 HIF-1 signaling pathway
    114490993 (PIK3CA)
   04068 FoxO signaling pathway
    114490993 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    114490993 (PIK3CA)
   04072 Phospholipase D signaling pathway
    114490993 (PIK3CA)
   04071 Sphingolipid signaling pathway
    114490993 (PIK3CA)
   04024 cAMP signaling pathway
    114490993 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    114490993 (PIK3CA)
   04152 AMPK signaling pathway
    114490993 (PIK3CA)
   04150 mTOR signaling pathway
    114490993 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    114490993 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114490993 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    114490993 (PIK3CA)
   04218 Cellular senescence
    114490993 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    114490993 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    114490993 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    114490993 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    114490993 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    114490993 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    114490993 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    114490993 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    114490993 (PIK3CA)
   04660 T cell receptor signaling pathway
    114490993 (PIK3CA)
   04662 B cell receptor signaling pathway
    114490993 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    114490993 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    114490993 (PIK3CA)
   04670 Leukocyte transendothelial migration
    114490993 (PIK3CA)
   04062 Chemokine signaling pathway
    114490993 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114490993 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    114490993 (PIK3CA)
   04929 GnRH secretion
    114490993 (PIK3CA)
   04915 Estrogen signaling pathway
    114490993 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    114490993 (PIK3CA)
   04917 Prolactin signaling pathway
    114490993 (PIK3CA)
   04926 Relaxin signaling pathway
    114490993 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    114490993 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    114490993 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    114490993 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    114490993 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    114490993 (PIK3CA)
   04722 Neurotrophin signaling pathway
    114490993 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    114490993 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    114490993 (PIK3CA)
   04380 Osteoclast differentiation
    114490993 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    114490993 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    114490993 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114490993 (PIK3CA)
   05206 MicroRNAs in cancer
    114490993 (PIK3CA)
   05205 Proteoglycans in cancer
    114490993 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    114490993 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    114490993 (PIK3CA)
   05203 Viral carcinogenesis
    114490993 (PIK3CA)
   05230 Central carbon metabolism in cancer
    114490993 (PIK3CA)
   05231 Choline metabolism in cancer
    114490993 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114490993 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114490993 (PIK3CA)
   05212 Pancreatic cancer
    114490993 (PIK3CA)
   05225 Hepatocellular carcinoma
    114490993 (PIK3CA)
   05226 Gastric cancer
    114490993 (PIK3CA)
   05214 Glioma
    114490993 (PIK3CA)
   05221 Acute myeloid leukemia
    114490993 (PIK3CA)
   05220 Chronic myeloid leukemia
    114490993 (PIK3CA)
   05218 Melanoma
    114490993 (PIK3CA)
   05211 Renal cell carcinoma
    114490993 (PIK3CA)
   05215 Prostate cancer
    114490993 (PIK3CA)
   05213 Endometrial cancer
    114490993 (PIK3CA)
   05224 Breast cancer
    114490993 (PIK3CA)
   05222 Small cell lung cancer
    114490993 (PIK3CA)
   05223 Non-small cell lung cancer
    114490993 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114490993 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    114490993 (PIK3CA)
   05161 Hepatitis B
    114490993 (PIK3CA)
   05160 Hepatitis C
    114490993 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    114490993 (PIK3CA)
   05164 Influenza A
    114490993 (PIK3CA)
   05162 Measles
    114490993 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    114490993 (PIK3CA)
   05163 Human cytomegalovirus infection
    114490993 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114490993 (PIK3CA)
   05169 Epstein-Barr virus infection
    114490993 (PIK3CA)
   05165 Human papillomavirus infection
    114490993 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    114490993 (PIK3CA)
   05135 Yersinia infection
    114490993 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    114490993 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    114490993 (PIK3CA)
   05142 Chagas disease
    114490993 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114490993 (PIK3CA)
   05017 Spinocerebellar ataxia
    114490993 (PIK3CA)
   05020 Prion disease
    114490993 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114490993 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    114490993 (PIK3CA)
   05415 Diabetic cardiomyopathy
    114490993 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    114490993 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    114490993 (PIK3CA)
   04931 Insulin resistance
    114490993 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    114490993 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114490993 (PIK3CA)
   01524 Platinum drug resistance
    114490993 (PIK3CA)
   01522 Endocrine resistance
    114490993 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pdic04131]
    114490993 (PIK3CA)
Enzymes [BR:pdic01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     114490993 (PIK3CA)
Membrane trafficking [BR:pdic04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    114490993 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B ABC1 DUF2321
Other DBs
NCBI-GeneID: 114490993
NCBI-ProteinID: XP_028360936
UniProt: A0A6J2L0G0
LinkDB
Position
2:40210133..40295655
AA seq 1072 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
SFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKVLCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSTRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVCXQMKFLVEQMRRPDFMDGYQGFLSGPLKSPPAHQXGNLRLEECRIMSSA
KRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLP
YGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAID
LFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKFGYKRERVPFXL
TQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF
DDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3219 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acgttaataactataaagcatgaattatttaaagaagcaagaaaataccctctccatcaa
cttctccaagatgaatcttcttacatttttgtaagtgtcacccaagaagcagaaagagaa
gaattttttgatgaaacaagacgactttgtgatcttcggctctttcaaccctttttaaaa
gtaattgagcctgttggcaaccgtgaagagaagattctcaatcgagaaattggctttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaagacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaacgtagaatcttcaccagaactgccaaagcac
atatacaataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccacgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaaatacattttgaaagtgtgtggatgtgatgaatac
ttcttagaaaaatatcctctgagtcaatataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaggaaagcctttactctcaactaccaatggac
tcttttacaatgccatcttattccagacgcatctccactgctacaccatatatgaatgga
gaaacttctacaaaatccctctgggttataaatagtgcactcagaataaaagttctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttgtgtgataatgtgaacactcaaagagtaccctgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggtcgaaagggtgctaaagaggaacactgc
ccattggcgtggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaatcctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtcaagtttccagatatgtcagtgattgaagagcatgccaattggtctgtg
tcccgagaagcaggatttagttattcccatgcaggactgagtaccagactagccagagac
aatgaattaagggaaaatgataaagaacagctcagagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctatggagccacagacactattgtgtaact
atccctgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgtttggtaaaagattggcctccaatcaaacccgaacaggctatggag
ctcctggactgcaactacccagatcctatggttcgaggttttgctgttcgatgcctagaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataatctgcttgtgagatttttactcaaaaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtc
agtcagaggtttggcctgcttttggaatcctattgtcgtgcatgtgggatgtatttgaag
cacctgaacaggcaagttgaggctatggaaaagctcatcaacttaactgacattctcaag
caagagaagaaggatgaaacacaaaaggtatgttagcagatgaagtttttagttgagcaa
atgcggcgaccagatttcatggatggctaccagggctttctgtctggtcctctaaaatcc
cccccggctcatcagtagggaaatctcaggctcgaagagtgtcgcattatgtcttctgca
aaaaggccactgtggttgaattgggagaacccagacatcatgtcagagttactctttcag
aacaatgagatcatctttaaaaatggggatgatttacggcaagacatgctgacacttcaa
attattcgcattatggaaaatatctggcaaaatcaaggtcttgatcttcgaatgttacct
tacggttgtctgtcaattggtgactgtgtgggacttattgaggtggtgaggaattctcac
actatcatgcagattcagtgcaaagggggcctgaaaggcgcactgcagttcaacagccac
acgctccatcagtggctcaaagacaagaacaaaggagaaatatacgatgcagccattgac
ttgttcacacgttcatgtgctggatattgtgtcgcgaccttcattttgggaatcggagac
cgtcacaatagtaacatcatggttaaagatgatggacaactgtttcatatagattttgga
cactttttggatcacaagaaaaaatttggttataaacgggaacgtgtgccatttngtttg
acacaggatttcttaatagtgatcagtaaaggagcccaagaatgcacaaagacaagagaa
ttcgagaggtttcaggagatgtgttacaaggcttatctagctattcggcagcatgccaat
ctcttcataaatctcttctccatgatgcttggctctggaatgccagaactgcagtctttt
gatgatattgcatacattcgaaagaccctagctttagataaaactgagcaagaggctttg
gaatatttcatgaaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggac
tggatcttccacacaattaagcagcatgctttgaactga

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