KEGG   Phyllostomus discolor (pale spear-nosed bat): 114491735
Entry
114491735         CDS       T07739                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
pdic  Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic01521  EGFR tyrosine kinase inhibitor resistance
pdic01522  Endocrine resistance
pdic04010  MAPK signaling pathway
pdic04012  ErbB signaling pathway
pdic04014  Ras signaling pathway
pdic04015  Rap1 signaling pathway
pdic04022  cGMP-PKG signaling pathway
pdic04024  cAMP signaling pathway
pdic04062  Chemokine signaling pathway
pdic04066  HIF-1 signaling pathway
pdic04068  FoxO signaling pathway
pdic04071  Sphingolipid signaling pathway
pdic04072  Phospholipase D signaling pathway
pdic04114  Oocyte meiosis
pdic04140  Autophagy - animal
pdic04148  Efferocytosis
pdic04150  mTOR signaling pathway
pdic04151  PI3K-Akt signaling pathway
pdic04210  Apoptosis
pdic04218  Cellular senescence
pdic04270  Vascular smooth muscle contraction
pdic04370  VEGF signaling pathway
pdic04371  Apelin signaling pathway
pdic04380  Osteoclast differentiation
pdic04510  Focal adhesion
pdic04540  Gap junction
pdic04550  Signaling pathways regulating pluripotency of stem cells
pdic04613  Neutrophil extracellular trap formation
pdic04620  Toll-like receptor signaling pathway
pdic04650  Natural killer cell mediated cytotoxicity
pdic04660  T cell receptor signaling pathway
pdic04662  B cell receptor signaling pathway
pdic04664  Fc epsilon RI signaling pathway
pdic04666  Fc gamma R-mediated phagocytosis
pdic04668  TNF signaling pathway
pdic04720  Long-term potentiation
pdic04722  Neurotrophin signaling pathway
pdic04725  Cholinergic synapse
pdic04726  Serotonergic synapse
pdic04730  Long-term depression
pdic04810  Regulation of actin cytoskeleton
pdic04910  Insulin signaling pathway
pdic04912  GnRH signaling pathway
pdic04914  Progesterone-mediated oocyte maturation
pdic04915  Estrogen signaling pathway
pdic04916  Melanogenesis
pdic04917  Prolactin signaling pathway
pdic04919  Thyroid hormone signaling pathway
pdic04921  Oxytocin signaling pathway
pdic04926  Relaxin signaling pathway
pdic04928  Parathyroid hormone synthesis, secretion and action
pdic04929  GnRH secretion
pdic04934  Cushing syndrome
pdic04935  Growth hormone synthesis, secretion and action
pdic05010  Alzheimer disease
pdic05022  Pathways of neurodegeneration - multiple diseases
pdic05034  Alcoholism
pdic05132  Salmonella infection
pdic05135  Yersinia infection
pdic05160  Hepatitis C
pdic05161  Hepatitis B
pdic05163  Human cytomegalovirus infection
pdic05164  Influenza A
pdic05165  Human papillomavirus infection
pdic05166  Human T-cell leukemia virus 1 infection
pdic05167  Kaposi sarcoma-associated herpesvirus infection
pdic05170  Human immunodeficiency virus 1 infection
pdic05200  Pathways in cancer
pdic05205  Proteoglycans in cancer
pdic05206  MicroRNAs in cancer
pdic05207  Chemical carcinogenesis - receptor activation
pdic05208  Chemical carcinogenesis - reactive oxygen species
pdic05210  Colorectal cancer
pdic05211  Renal cell carcinoma
pdic05212  Pancreatic cancer
pdic05213  Endometrial cancer
pdic05214  Glioma
pdic05215  Prostate cancer
pdic05216  Thyroid cancer
pdic05218  Melanoma
pdic05219  Bladder cancer
pdic05220  Chronic myeloid leukemia
pdic05221  Acute myeloid leukemia
pdic05223  Non-small cell lung cancer
pdic05224  Breast cancer
pdic05225  Hepatocellular carcinoma
pdic05226  Gastric cancer
pdic05230  Central carbon metabolism in cancer
pdic05231  Choline metabolism in cancer
pdic05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pdic00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    114491735 (MAP2K1)
   04012 ErbB signaling pathway
    114491735 (MAP2K1)
   04014 Ras signaling pathway
    114491735 (MAP2K1)
   04015 Rap1 signaling pathway
    114491735 (MAP2K1)
   04370 VEGF signaling pathway
    114491735 (MAP2K1)
   04371 Apelin signaling pathway
    114491735 (MAP2K1)
   04668 TNF signaling pathway
    114491735 (MAP2K1)
   04066 HIF-1 signaling pathway
    114491735 (MAP2K1)
   04068 FoxO signaling pathway
    114491735 (MAP2K1)
   04072 Phospholipase D signaling pathway
    114491735 (MAP2K1)
   04071 Sphingolipid signaling pathway
    114491735 (MAP2K1)
   04024 cAMP signaling pathway
    114491735 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    114491735 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    114491735 (MAP2K1)
   04150 mTOR signaling pathway
    114491735 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114491735 (MAP2K1)
   04148 Efferocytosis
    114491735 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    114491735 (MAP2K1)
   04210 Apoptosis
    114491735 (MAP2K1)
   04218 Cellular senescence
    114491735 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    114491735 (MAP2K1)
   04540 Gap junction
    114491735 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    114491735 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    114491735 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    114491735 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    114491735 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    114491735 (MAP2K1)
   04660 T cell receptor signaling pathway
    114491735 (MAP2K1)
   04662 B cell receptor signaling pathway
    114491735 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    114491735 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    114491735 (MAP2K1)
   04062 Chemokine signaling pathway
    114491735 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114491735 (MAP2K1)
   04929 GnRH secretion
    114491735 (MAP2K1)
   04912 GnRH signaling pathway
    114491735 (MAP2K1)
   04915 Estrogen signaling pathway
    114491735 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    114491735 (MAP2K1)
   04917 Prolactin signaling pathway
    114491735 (MAP2K1)
   04921 Oxytocin signaling pathway
    114491735 (MAP2K1)
   04926 Relaxin signaling pathway
    114491735 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    114491735 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    114491735 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    114491735 (MAP2K1)
   04916 Melanogenesis
    114491735 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    114491735 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    114491735 (MAP2K1)
   04726 Serotonergic synapse
    114491735 (MAP2K1)
   04720 Long-term potentiation
    114491735 (MAP2K1)
   04730 Long-term depression
    114491735 (MAP2K1)
   04722 Neurotrophin signaling pathway
    114491735 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    114491735 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114491735 (MAP2K1)
   05206 MicroRNAs in cancer
    114491735 (MAP2K1)
   05205 Proteoglycans in cancer
    114491735 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    114491735 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    114491735 (MAP2K1)
   05230 Central carbon metabolism in cancer
    114491735 (MAP2K1)
   05231 Choline metabolism in cancer
    114491735 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114491735 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114491735 (MAP2K1)
   05212 Pancreatic cancer
    114491735 (MAP2K1)
   05225 Hepatocellular carcinoma
    114491735 (MAP2K1)
   05226 Gastric cancer
    114491735 (MAP2K1)
   05214 Glioma
    114491735 (MAP2K1)
   05216 Thyroid cancer
    114491735 (MAP2K1)
   05221 Acute myeloid leukemia
    114491735 (MAP2K1)
   05220 Chronic myeloid leukemia
    114491735 (MAP2K1)
   05218 Melanoma
    114491735 (MAP2K1)
   05211 Renal cell carcinoma
    114491735 (MAP2K1)
   05219 Bladder cancer
    114491735 (MAP2K1)
   05215 Prostate cancer
    114491735 (MAP2K1)
   05213 Endometrial cancer
    114491735 (MAP2K1)
   05224 Breast cancer
    114491735 (MAP2K1)
   05223 Non-small cell lung cancer
    114491735 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114491735 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    114491735 (MAP2K1)
   05161 Hepatitis B
    114491735 (MAP2K1)
   05160 Hepatitis C
    114491735 (MAP2K1)
   05164 Influenza A
    114491735 (MAP2K1)
   05163 Human cytomegalovirus infection
    114491735 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114491735 (MAP2K1)
   05165 Human papillomavirus infection
    114491735 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    114491735 (MAP2K1)
   05135 Yersinia infection
    114491735 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114491735 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    114491735 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    114491735 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    114491735 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114491735 (MAP2K1)
   01522 Endocrine resistance
    114491735 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pdic01001]
    114491735 (MAP2K1)
Enzymes [BR:pdic01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     114491735 (MAP2K1)
Protein kinases [BR:pdic01001]
 Serine/threonine kinases: STE group
  STE7 family
   114491735 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 114491735
NCBI-ProteinID: XP_028361782
UniProt: A0A6J2L269
LinkDB
Position
1:175526483..175609232
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAIGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgccgaagaagaagccgacgcccatccagctgaacccggccccagacggctccgcggtt
aacgggaccagctcggcagagaccaacctggaggctttgcagaagaagctggaggagctg
gagctcgatgagcagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagcgagctgggtgctggcaatggtggt
gtggtgttcaaggtctcccacaagccgtccggcctggttatggccagaaagctaattcac
ctggagatcaaacctgcgattcggaaccagatcataagggagctgcaggttctacatgag
tgtaactccccatacattgtgggcttctatggtgcattttacagtgatggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagattatgcatagagatgtcaagccttccaacatcctggtgaactcc
cgtggggagatcaagctctgtgactttggggtcagtgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcgattgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcagctgagacaccacccaggccaaggacccctgggagaccccttagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaacttcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaattaaaaaccctgcagagcgagcagatttgaagcaactcatggttcatgctttc
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccgacccacgcagctggtgtctaa

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