KEGG   Phyllostomus discolor (pale spear-nosed bat): 114496029
Entry
114496029         CDS       T07739                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
pdic  Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic01522  Endocrine resistance
pdic04010  MAPK signaling pathway
pdic04012  ErbB signaling pathway
pdic04014  Ras signaling pathway
pdic04024  cAMP signaling pathway
pdic04068  FoxO signaling pathway
pdic04071  Sphingolipid signaling pathway
pdic04137  Mitophagy - animal
pdic04140  Autophagy - animal
pdic04141  Protein processing in endoplasmic reticulum
pdic04210  Apoptosis
pdic04215  Apoptosis - multiple species
pdic04217  Necroptosis
pdic04310  Wnt signaling pathway
pdic04380  Osteoclast differentiation
pdic04510  Focal adhesion
pdic04530  Tight junction
pdic04620  Toll-like receptor signaling pathway
pdic04621  NOD-like receptor signaling pathway
pdic04622  RIG-I-like receptor signaling pathway
pdic04625  C-type lectin receptor signaling pathway
pdic04657  IL-17 signaling pathway
pdic04658  Th1 and Th2 cell differentiation
pdic04659  Th17 cell differentiation
pdic04660  T cell receptor signaling pathway
pdic04664  Fc epsilon RI signaling pathway
pdic04668  TNF signaling pathway
pdic04722  Neurotrophin signaling pathway
pdic04723  Retrograde endocannabinoid signaling
pdic04728  Dopaminergic synapse
pdic04750  Inflammatory mediator regulation of TRP channels
pdic04910  Insulin signaling pathway
pdic04912  GnRH signaling pathway
pdic04914  Progesterone-mediated oocyte maturation
pdic04917  Prolactin signaling pathway
pdic04920  Adipocytokine signaling pathway
pdic04926  Relaxin signaling pathway
pdic04930  Type II diabetes mellitus
pdic04931  Insulin resistance
pdic04932  Non-alcoholic fatty liver disease
pdic04933  AGE-RAGE signaling pathway in diabetic complications
pdic04935  Growth hormone synthesis, secretion and action
pdic04936  Alcoholic liver disease
pdic05010  Alzheimer disease
pdic05012  Parkinson disease
pdic05016  Huntington disease
pdic05017  Spinocerebellar ataxia
pdic05020  Prion disease
pdic05022  Pathways of neurodegeneration - multiple diseases
pdic05132  Salmonella infection
pdic05133  Pertussis
pdic05135  Yersinia infection
pdic05142  Chagas disease
pdic05145  Toxoplasmosis
pdic05152  Tuberculosis
pdic05161  Hepatitis B
pdic05162  Measles
pdic05166  Human T-cell leukemia virus 1 infection
pdic05167  Kaposi sarcoma-associated herpesvirus infection
pdic05169  Epstein-Barr virus infection
pdic05170  Human immunodeficiency virus 1 infection
pdic05171  Coronavirus disease - COVID-19
pdic05200  Pathways in cancer
pdic05208  Chemical carcinogenesis - reactive oxygen species
pdic05210  Colorectal cancer
pdic05212  Pancreatic cancer
pdic05231  Choline metabolism in cancer
pdic05415  Diabetic cardiomyopathy
pdic05417  Lipid and atherosclerosis
pdic05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pdic00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    114496029 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    114496029 (MAPK8)
   04012 ErbB signaling pathway
    114496029 (MAPK8)
   04014 Ras signaling pathway
    114496029 (MAPK8)
   04310 Wnt signaling pathway
    114496029 (MAPK8)
   04668 TNF signaling pathway
    114496029 (MAPK8)
   04068 FoxO signaling pathway
    114496029 (MAPK8)
   04071 Sphingolipid signaling pathway
    114496029 (MAPK8)
   04024 cAMP signaling pathway
    114496029 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114496029 (MAPK8)
   04137 Mitophagy - animal
    114496029 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    114496029 (MAPK8)
   04215 Apoptosis - multiple species
    114496029 (MAPK8)
   04217 Necroptosis
    114496029 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    114496029 (MAPK8)
   04530 Tight junction
    114496029 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    114496029 (MAPK8)
   04621 NOD-like receptor signaling pathway
    114496029 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    114496029 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    114496029 (MAPK8)
   04660 T cell receptor signaling pathway
    114496029 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    114496029 (MAPK8)
   04659 Th17 cell differentiation
    114496029 (MAPK8)
   04657 IL-17 signaling pathway
    114496029 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    114496029 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114496029 (MAPK8)
   04920 Adipocytokine signaling pathway
    114496029 (MAPK8)
   04912 GnRH signaling pathway
    114496029 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    114496029 (MAPK8)
   04917 Prolactin signaling pathway
    114496029 (MAPK8)
   04926 Relaxin signaling pathway
    114496029 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    114496029 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    114496029 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    114496029 (MAPK8)
   04722 Neurotrophin signaling pathway
    114496029 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    114496029 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    114496029 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114496029 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    114496029 (MAPK8)
   05231 Choline metabolism in cancer
    114496029 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114496029 (MAPK8)
   05212 Pancreatic cancer
    114496029 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114496029 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    114496029 (MAPK8)
   05161 Hepatitis B
    114496029 (MAPK8)
   05171 Coronavirus disease - COVID-19
    114496029 (MAPK8)
   05162 Measles
    114496029 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114496029 (MAPK8)
   05169 Epstein-Barr virus infection
    114496029 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    114496029 (MAPK8)
   05135 Yersinia infection
    114496029 (MAPK8)
   05133 Pertussis
    114496029 (MAPK8)
   05152 Tuberculosis
    114496029 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    114496029 (MAPK8)
   05142 Chagas disease
    114496029 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114496029 (MAPK8)
   05012 Parkinson disease
    114496029 (MAPK8)
   05016 Huntington disease
    114496029 (MAPK8)
   05017 Spinocerebellar ataxia
    114496029 (MAPK8)
   05020 Prion disease
    114496029 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    114496029 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114496029 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    114496029 (MAPK8)
   05415 Diabetic cardiomyopathy
    114496029 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    114496029 (MAPK8)
   04936 Alcoholic liver disease
    114496029 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    114496029 (MAPK8)
   04931 Insulin resistance
    114496029 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    114496029 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    114496029 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pdic01001]
    114496029 (MAPK8)
Enzymes [BR:pdic01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     114496029 (MAPK8)
Protein kinases [BR:pdic01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   114496029 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 DUF530 Kdo
Other DBs
NCBI-GeneID: 114496029
NCBI-ProteinID: XP_028367046
UniProt: A0A6J2LI68
LinkDB
Position
5:complement(108804192..108849967)
AA seq 428 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIIGLDLKPSNIVVKSDCTLKILDFGLARTAGTS
FMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIE
QLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLS
KMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKE
VMDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAS
AGPLGCCR
NT seq 1287 nt   +upstreamnt  +downstreamnt
atgagcagaagtaagcgggacagcaatttttatagtgtagagattggagattctacattc
acagtcctgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagta
tgtgccgcttatgatgccattcttgaaagaaatgttgcaatcaagaagctaagccggcca
tttcagaatcaaactcatgctaagcgggcttacagagagctagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagcttatggatgcaaatctgtgccaagtgattcaa
atggaactagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
catcttcactctgctggaattatcatcgggttagacttaaagccaagtaatatagtagta
aaatcagactgcactttgaagattcttgactttggacttgccaggactgcaggaactagt
tttatgatgacaccttatgtagtgactcgctactacagagcacccgaagtcatcctaggg
atgggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatc
aaaggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaa
cagcttggaacaccatgtcctgaattcatgaagaaactacaaccaacagtaaggacttat
gttgaaaacagacctaaatatgctggatatagctttgagaaactcttccccgatgtactt
ttccctgctgactcagaacacaacaaacttaaagccagtcaggcaagggatttgttatcc
aaaatgctggtcattgatgcatctaaaaggatctctgtagatgaagctcttcagcaccca
tacatcaatgtctggtatgatccttctgaagcagaagctccaccaccaaagatacctgac
aagcagttagatgaaagggaacacacgatagaagaatggaaagaattaatatacaaggaa
gttatggacttggaggagagaaccaagaatggagttatacggggacagccctctccttta
ggtgcagcagtgatcaatggctctcagcatccatcgtcatcgtcatctgtcaatgatgtg
tcttcgatgtcaacagatccaactttggcctcagatacagacagcagtctagaagcctca
gcgggacctctgggctgctgtagatga

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