KEGG   Phyllostomus discolor (pale spear-nosed bat): 114497407
Entry
114497407         CDS       T07739                                 
Symbol
PIK3CD
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
pdic  Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic00562  Inositol phosphate metabolism
pdic01100  Metabolic pathways
pdic01521  EGFR tyrosine kinase inhibitor resistance
pdic01522  Endocrine resistance
pdic01524  Platinum drug resistance
pdic04012  ErbB signaling pathway
pdic04014  Ras signaling pathway
pdic04015  Rap1 signaling pathway
pdic04024  cAMP signaling pathway
pdic04062  Chemokine signaling pathway
pdic04066  HIF-1 signaling pathway
pdic04068  FoxO signaling pathway
pdic04070  Phosphatidylinositol signaling system
pdic04071  Sphingolipid signaling pathway
pdic04072  Phospholipase D signaling pathway
pdic04081  Hormone signaling
pdic04140  Autophagy - animal
pdic04150  mTOR signaling pathway
pdic04151  PI3K-Akt signaling pathway
pdic04152  AMPK signaling pathway
pdic04210  Apoptosis
pdic04211  Longevity regulating pathway
pdic04213  Longevity regulating pathway - multiple species
pdic04218  Cellular senescence
pdic04360  Axon guidance
pdic04370  VEGF signaling pathway
pdic04380  Osteoclast differentiation
pdic04510  Focal adhesion
pdic04550  Signaling pathways regulating pluripotency of stem cells
pdic04611  Platelet activation
pdic04613  Neutrophil extracellular trap formation
pdic04620  Toll-like receptor signaling pathway
pdic04625  C-type lectin receptor signaling pathway
pdic04630  JAK-STAT signaling pathway
pdic04650  Natural killer cell mediated cytotoxicity
pdic04660  T cell receptor signaling pathway
pdic04662  B cell receptor signaling pathway
pdic04664  Fc epsilon RI signaling pathway
pdic04666  Fc gamma R-mediated phagocytosis
pdic04668  TNF signaling pathway
pdic04670  Leukocyte transendothelial migration
pdic04722  Neurotrophin signaling pathway
pdic04725  Cholinergic synapse
pdic04750  Inflammatory mediator regulation of TRP channels
pdic04810  Regulation of actin cytoskeleton
pdic04910  Insulin signaling pathway
pdic04914  Progesterone-mediated oocyte maturation
pdic04915  Estrogen signaling pathway
pdic04917  Prolactin signaling pathway
pdic04919  Thyroid hormone signaling pathway
pdic04923  Regulation of lipolysis in adipocytes
pdic04926  Relaxin signaling pathway
pdic04929  GnRH secretion
pdic04930  Type II diabetes mellitus
pdic04931  Insulin resistance
pdic04932  Non-alcoholic fatty liver disease
pdic04933  AGE-RAGE signaling pathway in diabetic complications
pdic04935  Growth hormone synthesis, secretion and action
pdic04960  Aldosterone-regulated sodium reabsorption
pdic04973  Carbohydrate digestion and absorption
pdic05010  Alzheimer disease
pdic05017  Spinocerebellar ataxia
pdic05020  Prion disease
pdic05100  Bacterial invasion of epithelial cells
pdic05132  Salmonella infection
pdic05135  Yersinia infection
pdic05142  Chagas disease
pdic05146  Amoebiasis
pdic05160  Hepatitis C
pdic05161  Hepatitis B
pdic05162  Measles
pdic05163  Human cytomegalovirus infection
pdic05164  Influenza A
pdic05165  Human papillomavirus infection
pdic05166  Human T-cell leukemia virus 1 infection
pdic05167  Kaposi sarcoma-associated herpesvirus infection
pdic05168  Herpes simplex virus 1 infection
pdic05169  Epstein-Barr virus infection
pdic05170  Human immunodeficiency virus 1 infection
pdic05171  Coronavirus disease - COVID-19
pdic05200  Pathways in cancer
pdic05203  Viral carcinogenesis
pdic05205  Proteoglycans in cancer
pdic05206  MicroRNAs in cancer
pdic05207  Chemical carcinogenesis - receptor activation
pdic05208  Chemical carcinogenesis - reactive oxygen species
pdic05210  Colorectal cancer
pdic05211  Renal cell carcinoma
pdic05212  Pancreatic cancer
pdic05213  Endometrial cancer
pdic05214  Glioma
pdic05215  Prostate cancer
pdic05218  Melanoma
pdic05220  Chronic myeloid leukemia
pdic05221  Acute myeloid leukemia
pdic05222  Small cell lung cancer
pdic05223  Non-small cell lung cancer
pdic05224  Breast cancer
pdic05225  Hepatocellular carcinoma
pdic05226  Gastric cancer
pdic05230  Central carbon metabolism in cancer
pdic05231  Choline metabolism in cancer
pdic05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pdic05415  Diabetic cardiomyopathy
pdic05417  Lipid and atherosclerosis
pdic05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pdic00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    114497407 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    114497407 (PIK3CD)
   04014 Ras signaling pathway
    114497407 (PIK3CD)
   04015 Rap1 signaling pathway
    114497407 (PIK3CD)
   04370 VEGF signaling pathway
    114497407 (PIK3CD)
   04630 JAK-STAT signaling pathway
    114497407 (PIK3CD)
   04668 TNF signaling pathway
    114497407 (PIK3CD)
   04066 HIF-1 signaling pathway
    114497407 (PIK3CD)
   04068 FoxO signaling pathway
    114497407 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    114497407 (PIK3CD)
   04072 Phospholipase D signaling pathway
    114497407 (PIK3CD)
   04071 Sphingolipid signaling pathway
    114497407 (PIK3CD)
   04024 cAMP signaling pathway
    114497407 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    114497407 (PIK3CD)
   04152 AMPK signaling pathway
    114497407 (PIK3CD)
   04150 mTOR signaling pathway
    114497407 (PIK3CD)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    114497407 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114497407 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    114497407 (PIK3CD)
   04218 Cellular senescence
    114497407 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    114497407 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    114497407 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    114497407 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    114497407 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    114497407 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    114497407 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    114497407 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    114497407 (PIK3CD)
   04660 T cell receptor signaling pathway
    114497407 (PIK3CD)
   04662 B cell receptor signaling pathway
    114497407 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    114497407 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    114497407 (PIK3CD)
   04670 Leukocyte transendothelial migration
    114497407 (PIK3CD)
   04062 Chemokine signaling pathway
    114497407 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114497407 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    114497407 (PIK3CD)
   04929 GnRH secretion
    114497407 (PIK3CD)
   04915 Estrogen signaling pathway
    114497407 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    114497407 (PIK3CD)
   04917 Prolactin signaling pathway
    114497407 (PIK3CD)
   04926 Relaxin signaling pathway
    114497407 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    114497407 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    114497407 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    114497407 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    114497407 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    114497407 (PIK3CD)
   04722 Neurotrophin signaling pathway
    114497407 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    114497407 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    114497407 (PIK3CD)
   04380 Osteoclast differentiation
    114497407 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    114497407 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    114497407 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114497407 (PIK3CD)
   05206 MicroRNAs in cancer
    114497407 (PIK3CD)
   05205 Proteoglycans in cancer
    114497407 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    114497407 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    114497407 (PIK3CD)
   05203 Viral carcinogenesis
    114497407 (PIK3CD)
   05230 Central carbon metabolism in cancer
    114497407 (PIK3CD)
   05231 Choline metabolism in cancer
    114497407 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114497407 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114497407 (PIK3CD)
   05212 Pancreatic cancer
    114497407 (PIK3CD)
   05225 Hepatocellular carcinoma
    114497407 (PIK3CD)
   05226 Gastric cancer
    114497407 (PIK3CD)
   05214 Glioma
    114497407 (PIK3CD)
   05221 Acute myeloid leukemia
    114497407 (PIK3CD)
   05220 Chronic myeloid leukemia
    114497407 (PIK3CD)
   05218 Melanoma
    114497407 (PIK3CD)
   05211 Renal cell carcinoma
    114497407 (PIK3CD)
   05215 Prostate cancer
    114497407 (PIK3CD)
   05213 Endometrial cancer
    114497407 (PIK3CD)
   05224 Breast cancer
    114497407 (PIK3CD)
   05222 Small cell lung cancer
    114497407 (PIK3CD)
   05223 Non-small cell lung cancer
    114497407 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114497407 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    114497407 (PIK3CD)
   05161 Hepatitis B
    114497407 (PIK3CD)
   05160 Hepatitis C
    114497407 (PIK3CD)
   05171 Coronavirus disease - COVID-19
    114497407 (PIK3CD)
   05164 Influenza A
    114497407 (PIK3CD)
   05162 Measles
    114497407 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    114497407 (PIK3CD)
   05163 Human cytomegalovirus infection
    114497407 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114497407 (PIK3CD)
   05169 Epstein-Barr virus infection
    114497407 (PIK3CD)
   05165 Human papillomavirus infection
    114497407 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    114497407 (PIK3CD)
   05135 Yersinia infection
    114497407 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    114497407 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    114497407 (PIK3CD)
   05142 Chagas disease
    114497407 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114497407 (PIK3CD)
   05017 Spinocerebellar ataxia
    114497407 (PIK3CD)
   05020 Prion disease
    114497407 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114497407 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    114497407 (PIK3CD)
   05415 Diabetic cardiomyopathy
    114497407 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    114497407 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    114497407 (PIK3CD)
   04931 Insulin resistance
    114497407 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    114497407 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114497407 (PIK3CD)
   01524 Platinum drug resistance
    114497407 (PIK3CD)
   01522 Endocrine resistance
    114497407 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pdic04131]
    114497407 (PIK3CD)
Enzymes [BR:pdic01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     114497407 (PIK3CD)
Membrane trafficking [BR:pdic04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    114497407 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2 DOCK-C2
Other DBs
NCBI-GeneID: 114497407
NCBI-ProteinID: XP_028368940
UniProt: A0A6J2LSP7
LinkDB
Position
5:5330559..5377131
AA seq 1044 aa
MPPGVDCPMEFWTSEENQNVAVDFLLPTGVYLNFSVSRNANLSTIKKALWHRAQYEPLFH
MLSGPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLCDPEVNDFRAKMRQFCEEAAARRQQLGWEAWLQYCFPLQLEPSARTWGA
GTLRVPNRALLVNVKFEGSEESFTFQVSTKDMPLALMTCALRKKATVFRQPLVEQPEDYT
LQVNGKHEYLYGSYPLCQFQYICSCLHRGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
TKPPPIPMKKPSSVSLWSLEQPFCIELIQGSKVNADERMKLVVQAGLFHGNETLCKTVSS
SEVSVCSEPVWKQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLTLFDYKDQLKTGEYCLYMWPSVPDEKGELLNPTGTVCSNPNTESAAALIICLPEVAP
YPVYYPALDKILELGRHGEHGRFTEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE
RFPEALARLLLVTKWNKHEDVAQMLCLLCSWPELPVLSALELLDSSFPDRHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSIHHMRVLMKQGEALSKLKALNDFVKVSSQKTPKPQAKELLHVCMR
QETYLEALSHLQSPLDPSILLAEVCVEQCTFMDSKMKPLWVMYCNEEAGSNGSVGIMFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt   +upstreamnt  +downstreamnt
atgcccccgggggtggactgccccatggaattctggaccagcgaggagaatcagaatgtg
gcggttgacttcctgctgcccaccggggtctatctgaacttctccgtgtcccgaaatgcc
aacctcagcaccatcaagaaggcgctgtggcaccgcgcccagtatgagccgctcttccac
atgctcagcgggcccgaggcctacgtgttcacctgcgtcaaccagaccgcggagcagcag
gagctggaggacgagcagcggcggctctgtgacatccagcccttcctgcccgtcctgcgc
ctggtggcccgcgagggcgacagggtgaagaagctcatcaactcccagatcagcctcctc
atcggcaaaggcctgcacgagtttgactctttgtgcgacccggaagtgaatgactttcga
gccaagatgcgccagttctgcgaggaggcggcggcccgccggcagcagctgggctgggag
gcctggctgcagtactgcttccccctgcagctggagccctcggcgcggacgtggggggcg
ggcaccctgcgggtccccaaccgggccctgctggtcaacgtcaagttcgagggcagtgag
gagagcttcaccttccaggtgtccaccaaggacatgcccctggccctgatgacctgtgcc
ctccggaagaaggccacggtgttccggcagccgctggtggagcagcccgaggactacacc
ctgcaggtgaacgggaagcacgagtacctgtacggcagctaccccctctgccagttccag
tacatctgcagctgcctgcaccgcgggctgacccctcacctgaccatggtgcactcctcc
tccatcctcgccatgcgggacgagcagagcaaccccgccccccaagtccagaaaccgcgc
accaaaccgccccccattcccatgaagaagccctcgtcggtgtccctgtggtcgctggag
cagcccttctgcatcgagctcattcagggcagcaaagtgaatgccgacgagaggatgaag
ctggtggtgcaggccgggctcttccacggcaacgagacgctgtgcaagacggtgtccagc
tcggaggtgagcgtgtgctcggagcccgtgtggaagcagcgcctggagttcgacatcaac
gtctgcgacctgccgcgcatggcccgcctctgcttcgcgctgtacgccgtgatcgagaag
gccaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccatcgcctgg
gccaacctcaccctgtttgactacaaggaccagctcaagacgggcgaatactgcctgtac
atgtggccctccgtcccagatgagaaaggggagctgctgaaccccacggggactgtatgc
agcaaccccaacaccgagagtgccgcggccctcatcatctgccttccggaggtggccccc
taccctgtgtactaccccgccctggacaagatcctggagctggggcggcacggggaacac
gggcgcttcaccgaggaggagcagctgcagcttcgggagatcctggagcggcgcggctcc
ggggagctatacgagcacgagaaggacctggtgtggaagatgcgccatgaggtccaggag
cgcttccccgaggcactggctcggctgctgctggtcaccaagtggaacaagcacgaggac
gtggcccagatgctctgcctgctgtgctcctggccggagctgcctgtgctgagcgccctg
gagctgctggactccagcttccccgaccggcacgtgggctcctttgccatcaagtccctg
cggaagctgacggacgacgagcttttccagtacctgctgcagctggtgcaggtgctcaag
tacgagtcctacctcgactgcgagctgaccaagttcctgctggaccgggccctggccaac
cgcaagatcggccacttcctcttctggcacctccgctccgagatgcacgtgccgtcggtg
gccctgcgcttcggcctcatcatggaggcctactgcaggggcagcatccaccacatgagg
gtgctgatgaagcagggggaagcgctgagcaagctgaaggccctgaacgactttgtcaaa
gtgagctcccagaagacccccaagccccaggccaaggagctgctgcacgtgtgcatgcgc
caggagacctacctggaggccctctcccacctgcagtccccgctggaccccagcatcctg
ctggctgaagtctgtgtggagcagtgcaccttcatggactccaagatgaagccgctgtgg
gtcatgtactgcaacgaggaggcgggcagcaacggcagcgtgggcatcatgtttaagaac
ggggacgacctgcgccaggacatgctgaccctgcagatgatccagctcatggacgtgctg
tggaagcaggaggggctggacctgaggatgaccccttacggctgcctctccaccggggac
cgcacgggcctcatcgaggtggtgctgcactcggacaccatcgccaacatccagctgaac
aagagcaacatggcggccacagccgctttcaacaaggatgccctgctcaactggctcaag
tccaagaaccctggggaggcgctggacagagccattgaggagttcaccctgtcctgcgcc
ggctactgcgtggccacgtacgtgctgggcatcggcgatcggcacagcgacaacatcatg
atccgcgagaacgggcagctgttccacattgattttggccactttctggggaacttcaag
accaagtttggaatcaaccgggagcgagtcccgttcatcctcacctatgactttgtccac
gtgattcagcaggggaagactaataatagtgagaaatttgaaaggttccgcggctactgc
gagagagcctacaccatcctgagacgccacgggctgctcttcctgcacctcttcgccctg
atgcgcgcggcgggcctgcccgagctcagctgctccaaagacatccagtacctcaaggac
tcgctggcgctggggaagacggaggaggaggcgctgaagcacttccgcgtgaagttcaac
gaggccctccgcgagagctggaagaccaaagtgaactggctggcgcacaacgtgtccaaa
gacaacaggcagtag

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