KEGG   Phyllostomus discolor (pale spear-nosed bat): 114499423
Entry
114499423         CDS       T07739                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pdic  Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic00562  Inositol phosphate metabolism
pdic01100  Metabolic pathways
pdic04015  Rap1 signaling pathway
pdic04020  Calcium signaling pathway
pdic04022  cGMP-PKG signaling pathway
pdic04062  Chemokine signaling pathway
pdic04070  Phosphatidylinositol signaling system
pdic04071  Sphingolipid signaling pathway
pdic04072  Phospholipase D signaling pathway
pdic04081  Hormone signaling
pdic04082  Neuroactive ligand signaling
pdic04261  Adrenergic signaling in cardiomyocytes
pdic04270  Vascular smooth muscle contraction
pdic04310  Wnt signaling pathway
pdic04371  Apelin signaling pathway
pdic04540  Gap junction
pdic04611  Platelet activation
pdic04613  Neutrophil extracellular trap formation
pdic04621  NOD-like receptor signaling pathway
pdic04713  Circadian entrainment
pdic04720  Long-term potentiation
pdic04723  Retrograde endocannabinoid signaling
pdic04724  Glutamatergic synapse
pdic04725  Cholinergic synapse
pdic04726  Serotonergic synapse
pdic04728  Dopaminergic synapse
pdic04730  Long-term depression
pdic04742  Taste transduction
pdic04750  Inflammatory mediator regulation of TRP channels
pdic04911  Insulin secretion
pdic04912  GnRH signaling pathway
pdic04915  Estrogen signaling pathway
pdic04916  Melanogenesis
pdic04918  Thyroid hormone synthesis
pdic04919  Thyroid hormone signaling pathway
pdic04921  Oxytocin signaling pathway
pdic04922  Glucagon signaling pathway
pdic04924  Renin secretion
pdic04925  Aldosterone synthesis and secretion
pdic04926  Relaxin signaling pathway
pdic04927  Cortisol synthesis and secretion
pdic04928  Parathyroid hormone synthesis, secretion and action
pdic04929  GnRH secretion
pdic04933  AGE-RAGE signaling pathway in diabetic complications
pdic04934  Cushing syndrome
pdic04935  Growth hormone synthesis, secretion and action
pdic04961  Endocrine and other factor-regulated calcium reabsorption
pdic04970  Salivary secretion
pdic04971  Gastric acid secretion
pdic04972  Pancreatic secretion
pdic04973  Carbohydrate digestion and absorption
pdic05010  Alzheimer disease
pdic05016  Huntington disease
pdic05017  Spinocerebellar ataxia
pdic05022  Pathways of neurodegeneration - multiple diseases
pdic05142  Chagas disease
pdic05143  African trypanosomiasis
pdic05146  Amoebiasis
pdic05163  Human cytomegalovirus infection
pdic05200  Pathways in cancer
pdic05415  Diabetic cardiomyopathy
pdic05417  Lipid and atherosclerosis
Module
pdic_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pdic00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    114499423 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    114499423 (PLCB3)
   04310 Wnt signaling pathway
    114499423 (PLCB3)
   04371 Apelin signaling pathway
    114499423 (PLCB3)
   04020 Calcium signaling pathway
    114499423 (PLCB3)
   04070 Phosphatidylinositol signaling system
    114499423 (PLCB3)
   04072 Phospholipase D signaling pathway
    114499423 (PLCB3)
   04071 Sphingolipid signaling pathway
    114499423 (PLCB3)
   04022 cGMP-PKG signaling pathway
    114499423 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    114499423 (PLCB3)
   04081 Hormone signaling
    114499423 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    114499423 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    114499423 (PLCB3)
   04613 Neutrophil extracellular trap formation
    114499423 (PLCB3)
   04621 NOD-like receptor signaling pathway
    114499423 (PLCB3)
   04062 Chemokine signaling pathway
    114499423 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    114499423 (PLCB3)
   04922 Glucagon signaling pathway
    114499423 (PLCB3)
   04929 GnRH secretion
    114499423 (PLCB3)
   04912 GnRH signaling pathway
    114499423 (PLCB3)
   04915 Estrogen signaling pathway
    114499423 (PLCB3)
   04921 Oxytocin signaling pathway
    114499423 (PLCB3)
   04926 Relaxin signaling pathway
    114499423 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    114499423 (PLCB3)
   04918 Thyroid hormone synthesis
    114499423 (PLCB3)
   04919 Thyroid hormone signaling pathway
    114499423 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    114499423 (PLCB3)
   04916 Melanogenesis
    114499423 (PLCB3)
   04924 Renin secretion
    114499423 (PLCB3)
   04925 Aldosterone synthesis and secretion
    114499423 (PLCB3)
   04927 Cortisol synthesis and secretion
    114499423 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    114499423 (PLCB3)
   04270 Vascular smooth muscle contraction
    114499423 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    114499423 (PLCB3)
   04971 Gastric acid secretion
    114499423 (PLCB3)
   04972 Pancreatic secretion
    114499423 (PLCB3)
   04973 Carbohydrate digestion and absorption
    114499423 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    114499423 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    114499423 (PLCB3)
   04725 Cholinergic synapse
    114499423 (PLCB3)
   04728 Dopaminergic synapse
    114499423 (PLCB3)
   04726 Serotonergic synapse
    114499423 (PLCB3)
   04720 Long-term potentiation
    114499423 (PLCB3)
   04730 Long-term depression
    114499423 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    114499423 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    114499423 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    114499423 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    114499423 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114499423 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    114499423 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    114499423 (PLCB3)
   05142 Chagas disease
    114499423 (PLCB3)
   05143 African trypanosomiasis
    114499423 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114499423 (PLCB3)
   05016 Huntington disease
    114499423 (PLCB3)
   05017 Spinocerebellar ataxia
    114499423 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    114499423 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114499423 (PLCB3)
   05415 Diabetic cardiomyopathy
    114499423 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    114499423 (PLCB3)
   04934 Cushing syndrome
    114499423 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pdic04131]
    114499423 (PLCB3)
Enzymes [BR:pdic01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     114499423 (PLCB3)
Membrane trafficking [BR:pdic04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    114499423 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    114499423 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 114499423
NCBI-ProteinID: XP_035885551
UniProt: A0A7E6E3C0
LinkDB
Position
6:164882040..164910516
AA seq 1223 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDSNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPRDPKIREVLGFGGPEARLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTAKVWAEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMEFINQKQRDPRLNEVLYPPLGPSQTRLLIEKYEPNQQFLERDQMSMEGFSRYL
AGDENGILPLETLDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAESAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSSGVPNS
SVRKRPLEQSNSVLSESSAATEPSSPQLGSPSSDSCPGLSNGEEAGLEKPGLEPRKSLGD
LGPADREDEEEDEEEEEQADPKKPTSDEGTASSEVNATEEMSTLVNYVEPVKFKSFEAAR
KRNKCFEMSSFVETKGMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGC
QLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRLDKSFDPFTEVIVDGIVANALR
VKVISGQFLSDRKVGIYVEVDMFGLPVDTRRGKHRTRTSQGNSFNPVWDEEPFEFPKVVL
PTLASLRIAAFEEGGKFVGHRILPVAAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYI
PDDHQDYAEALINPIKHVSLMDQRAKQLAALIGEREAQAGPETCQETQSPQLGSQMTPNP
TPSPLDTTPRRPPGPVTSPTSPSLSSPGQRGDDLVASILSEVAVTPLEELRGHKSLVKLR
SRQERDLREMLKKHQRKAVALTRRLLDNLAQARAEGRCRHRPGAPGREDEKEEEEEVKRY
QEFQNRQVQSLLELREAQADAEAERRMEHLRQVLQRLREIVLDAHTTQVKKLKEMNDREK
KELQKILDRKRHNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQKQRHERVV
AGQQQVLQQLVEDEPRLLGQLAQECQEQRARLPQEIRRSLLGETPEGLGDGHLVACASNG
HAPGSIGHMSGADSESQEENTKL
NT seq 3672 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtgaccctgcgcgtggactccaatggcttcttcctgtactggacaggacccaacatggag
gtggacacactggacatcagttccatcagggacacgcggacgggccgttacgcccgcctg
cccagggaccccaaaatccgtgaggtgctgggtttcgggggccctgaagcccggctagaa
gagaagctgatgacggtggtggctgggccagacccagtgaacacgacattcttgaacttc
atggccgtgcaggatgacacagccaaggtctgggctgaggagctgttcaagctggctatg
aacatcttggcgcagaatgcctcccggaacaccttcctgcgaaaagcatacacaaagctg
aagctgcaggtgaaccaggatggacggatcccggtcaagaacatcctgaagatgttctcg
gcagacaagaagcgggtggagactgcgctggagtcctgcggcctcaattttaaccggagc
gagtccatccggcctgatgagttctccctggaaatcttcgagcggttcctgaacaagttg
tgtcttcggccagacattgacaagatcctgctggagataggtgccaagggcaagccgtac
ctgacgctggagcagctcatggaattcatcaaccagaagcaacgggacccaagactcaac
gaagtgctgtacccacccctggggccctcccagacccggctgctcattgagaagtatgag
cccaaccagcagttcctggagcgagaccagatgtccatggagggcttcagccgctacctg
gccggggacgagaatggcatcctgcccctggagaccctggatctgagcgcagacatgacc
cagccgctgagcgcctacttcatcaactcctcccataacacctatctcacagcggggcag
ctggcggggacctcgtcggtggagatgtaccgccaggcactgctgtggggctgccgctgt
gtggagctggacgtgtggaaagggcggccgccggaggaggagcccttcatcacccacggc
ttcaccatgaccacggaggtgccgctgcgggatgtgctggaggccatcgccgagagcgcc
ttcaaaacctcgccctacccagtcatcctctccttcgagaaccacgtggactcggcaaag
cagcaggccaagatggccgagtactgccgctccatctttggggacgcgctgctcatcgac
ccactggacaagtacccgctggccccgggcgtccccttgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagcggcaccggcccagcagtggcgtccccaacagc
tccgtgcgcaagcggccgctggagcagagcaactcggtcctgagcgagagctcagcagcc
acggagccctcctcgccccagcttgggtcccccagctccgatagctgcccaggcctgagc
aatggggaggaggcgggccttgagaagcccggcctggagccacggaagtctctgggtgac
cttggacctgctgaccgtgaggacgaggaggaggatgaagaagaggaggaacaggcagac
cccaaaaagccgacctcggatgagggcaccgctagcagtgaggtcaatgctactgaggaa
atgtcaaccctcgtcaactacgtggagcctgtcaagttcaagtccttcgaggctgctcga
aagaggaacaagtgcttcgagatgtcatccttcgtggagaccaagggcatggaacagctg
accaagagccccatggagtttgtggaatacaacaaacagcagctcagccgcatctacccc
aagggcacccgtgtggactcctccaactacatgccccagctcttctggaacgtgggctgc
cagctcgtggcactcaacttccagaccctggacgtggcgatgcagctcaacgcgggcgtg
ttcgagtacaacggccgcagcggctacctgctcaagcccgagttcatgaggcggctggac
aagtccttcgaccccttcaccgaggtcatcgtggacggcatcgtggccaacgccctccgg
gtcaaggtcatctccgggcagttcctgtcggacaggaaggtgggcatctacgtggaggtg
gacatgttcggcctccccgtggacacgcggcgcggcaagcaccgcactcggacctctcag
gggaactcgttcaacccggtgtgggacgaggagcccttcgagttccccaaggtggtgctg
cccacgctggcgtcactgcgtattgcagcctttgaggagggcggcaagtttgtggggcac
cggatcctgcccgttgctgccatccgctcagggtaccactacgtctgcctgaggaacgag
gccaaccagcccctgtgcctgccagccctgctcatctacacggaggcctccgactacatc
cccgacgaccaccaggactatgcagaggccctgatcaaccccatcaagcacgtcagcctg
atggaccagagggccaagcagctggctgccctcattggggagagagaggctcaggctggc
ccggagacatgccaggagacccagtctccgcagctggggtcccagatgaccccaaacccc
acacccagcccgctggacaccaccccccgacggcccccaggccctgtcacctcccccacc
agcccttcccttagcagcccaggtcagcggggggatgatctcgttgccagtatcctgtca
gaggtggctgtgaccccgctggaggagctccgaggccacaagtctctggtgaagctccgg
agtcgacaagagcgagacctgcgggagatgctcaagaagcatcaacggaaggcagttgct
ctcactcgccgattgctggacaacctggcccaggcccgggccgagggcaggtgccggcac
cgaccaggagccccaggcagggaggacgagaaggaggaggaggaggaggtgaagcggtat
caggagttccagaacagacaggtgcagagtctgttggagctgcgggaggcccaggcagat
gccgaggccgagcggaggatggagcacctgagacaggtgctgcagcgcctcagggagatt
gtcctggatgctcacacaactcaggtcaagaagctgaaggagatgaacgacagggagaag
aaggaactgcagaaaatcctggacaggaaacgccacaacagtatctcggaggccaagaca
agggagaaacataagaaggaagtggaactgacggagattaaccggcgccacatcaccgag
tccgtcaactccatccgtcggctggaggaggcccagaagcagcggcatgaacgagttgtg
gccgggcagcagcaggtcctacagcagctggtggaagacgagcccaggctgctgggccag
ctggcccaggaatgtcaggagcagcgggcgaggctgcctcaggagatccgccggagcctg
ctgggcgagacgccggaggggctgggggatggacatctggtggcttgtgccagcaacggt
cacgcgcctgggagcattgggcacatgtctggtgcggactcggagagccaagaggagaat
acgaagctctga

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