Phyllostomus discolor (pale spear-nosed bat): 114500045
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Entry
114500045 CDS
T07739
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
pdic
Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic00790
Folate biosynthesis
pdic01100
Metabolic pathways
pdic01240
Biosynthesis of cofactors
pdic01523
Antifolate resistance
pdic04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
pdic00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
114500045 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
114500045 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
114500045 (FPGS)
Enzymes [BR:
pdic01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
114500045 (FPGS)
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
114500045
NCBI-ProteinID:
XP_028372437
UniProt:
A0A6J2LXH8
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Position
3:208826023..208844679
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AA seq
580 aa
AA seq
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MPWARSHLRAALFLAAVSPLGATPRVAGRRAWSARPAPQEPGMEYQDAVRALNTLQTNAS
YLEEAKRRRGDPATQLEAMKLYLAQSGLQVEDLDRLNIIHVTGTKGKGSTCAFTERILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKHFWRLYHHLEETKDSSSCVSMPSYFR
FLTLMAFHVFLQEKVDLAVVEVGIGGAYDSTNIIRKPVVCGVSALGIDHTSLLGDTMEKI
AWQKGGIFKHGVPAFTVLQPDGPLAVLRERAEQISCPLYLCPPLDALEEGGPPLTLGLEG
EHQRSNAALALQLARCWLQQKDHQGIGELKASRPSPLGQLPLAPMFQPTPHMRLGLQGTE
WLGRSQVLRRGSLTWYLDGAHTCSSMQACVRWFRHALHRLEKPSKVSEVCILLFNSTGDR
DAAALLKLLQPCQFDYAVFCPNLTEVSPMDNADQQNFMVTLDQVLLRCLEHQQHWGRLHE
EPAGLEPTGPGSLLLAPRPPHTHGPSSLVFSCISHALQWISQGRDPVFQTPGPPQGLLAH
PVAASGARVLREAAAVHVLVTGSLHLVGGALKLLEPSLSQ
NT seq
1743 nt
NT seq
+upstream
nt +downstream
nt
atgccctgggcgcgcagtcacctgcgcgccgctctcttcctggcagcggtttctccgctt
ggtgcaacgcccagggtcgcgggcaggcgagcgtggagtgcgaggcccgcgccgcaggag
ccgggcatggagtatcaggatgctgtgcgcgcactcaacaccctgcagaccaacgccagc
tacctggaggaggcgaagcgccggcggggcgaccccgcgacacagctggaggccatgaag
ctgtacttggcacagagtgggcttcaggtggaggacttggaccggctgaacatcatccac
gtcactgggacgaaggggaagggctccacctgtgccttcacggaacgtatcctccgaagc
tacggcctgaagacggggttctttagctctccccacctggtgcaggtacgggagcggatc
cgaatcaatgggcagcccatcagccccgagctcttcaccaagcacttctggcgcctctac
catcacctggaggagaccaaggacagcagcagctgtgtctccatgcccagctacttccgt
ttcctcacgcttatggctttccacgtcttcctccaagagaaggtggacctggccgtggtg
gaagtgggtattggtggggcttacgactccactaacatcatcaggaagcccgtagtgtgt
ggggtctccgctcttggcatcgaccacaccagccttctgggggacacgatggagaagatc
gcatggcagaaggggggcatcttcaagcacggcgtccccgccttcaccgtgctccagccg
gacggccccctggcggtgctgagggagcgagccgagcagatctcatgtcccctttacctg
tgtccaccgctggacgccctggaggaaggagggcccccgctgaccctgggcctggaggga
gaacaccagcggtccaatgccgccttggccttgcagctggcccgctgctggctgcagcag
aaggaccaccaaggcatcggggagctgaaagcgtccaggccaagccccctgggtcagctg
ccgctggcgcccatgttccagcccacaccccacatgcggctcgggcttcagggcacggag
tggctgggccggtcgcaggtgctgcggcgtgggtccctcacctggtacctggatggcgcg
cacacctgcagcagcatgcaagcctgcgttcgctggttcagacacgctctgcaccgcctg
gagaagcccagcaaggtgtctgaagtgtgcatcttgctcttcaactccaccggggaccgg
gatgccgccgccctgctgaagctgctgcagccctgccagtttgactatgccgttttctgc
cctaacctgacagaggtgtcgcccatggacaacgcagaccagcagaacttcatggtgacc
ctggaccaggtgttgctccgctgcttggagcaccagcagcactggggccgcctgcacgag
gagccggccggcctggagcccacggggcccgggtccctgctgctggcaccccgccctccc
cacacccacggccccagctccctcgtcttcagctgcatctcccacgctctgcagtggatc
agccagggccgggaccccgtctttcagacacccggtcccccacagggccttctcgcccac
cccgtggcagccagcggggcccgagtgctccgtgaggccgctgccgtccacgtgctggtc
accgggagcctgcacctggtgggcggcgccctgaagctgctggagccctccctgtcccag
tag
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