KEGG   Phyllostomus discolor (pale spear-nosed bat): 114501905
Entry
114501905         CDS       T07739                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pdic  Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic01521  EGFR tyrosine kinase inhibitor resistance
pdic01522  Endocrine resistance
pdic04010  MAPK signaling pathway
pdic04012  ErbB signaling pathway
pdic04014  Ras signaling pathway
pdic04015  Rap1 signaling pathway
pdic04022  cGMP-PKG signaling pathway
pdic04024  cAMP signaling pathway
pdic04062  Chemokine signaling pathway
pdic04068  FoxO signaling pathway
pdic04071  Sphingolipid signaling pathway
pdic04072  Phospholipase D signaling pathway
pdic04140  Autophagy - animal
pdic04150  mTOR signaling pathway
pdic04151  PI3K-Akt signaling pathway
pdic04210  Apoptosis
pdic04218  Cellular senescence
pdic04270  Vascular smooth muscle contraction
pdic04360  Axon guidance
pdic04370  VEGF signaling pathway
pdic04371  Apelin signaling pathway
pdic04510  Focal adhesion
pdic04540  Gap junction
pdic04550  Signaling pathways regulating pluripotency of stem cells
pdic04613  Neutrophil extracellular trap formation
pdic04625  C-type lectin receptor signaling pathway
pdic04630  JAK-STAT signaling pathway
pdic04650  Natural killer cell mediated cytotoxicity
pdic04660  T cell receptor signaling pathway
pdic04662  B cell receptor signaling pathway
pdic04664  Fc epsilon RI signaling pathway
pdic04666  Fc gamma R-mediated phagocytosis
pdic04720  Long-term potentiation
pdic04722  Neurotrophin signaling pathway
pdic04726  Serotonergic synapse
pdic04730  Long-term depression
pdic04810  Regulation of actin cytoskeleton
pdic04910  Insulin signaling pathway
pdic04912  GnRH signaling pathway
pdic04914  Progesterone-mediated oocyte maturation
pdic04915  Estrogen signaling pathway
pdic04916  Melanogenesis
pdic04917  Prolactin signaling pathway
pdic04919  Thyroid hormone signaling pathway
pdic04921  Oxytocin signaling pathway
pdic04926  Relaxin signaling pathway
pdic04928  Parathyroid hormone synthesis, secretion and action
pdic04929  GnRH secretion
pdic04935  Growth hormone synthesis, secretion and action
pdic05010  Alzheimer disease
pdic05022  Pathways of neurodegeneration - multiple diseases
pdic05034  Alcoholism
pdic05132  Salmonella infection
pdic05152  Tuberculosis
pdic05160  Hepatitis C
pdic05161  Hepatitis B
pdic05163  Human cytomegalovirus infection
pdic05164  Influenza A
pdic05165  Human papillomavirus infection
pdic05167  Kaposi sarcoma-associated herpesvirus infection
pdic05170  Human immunodeficiency virus 1 infection
pdic05200  Pathways in cancer
pdic05205  Proteoglycans in cancer
pdic05206  MicroRNAs in cancer
pdic05207  Chemical carcinogenesis - receptor activation
pdic05208  Chemical carcinogenesis - reactive oxygen species
pdic05210  Colorectal cancer
pdic05211  Renal cell carcinoma
pdic05212  Pancreatic cancer
pdic05213  Endometrial cancer
pdic05214  Glioma
pdic05215  Prostate cancer
pdic05218  Melanoma
pdic05219  Bladder cancer
pdic05220  Chronic myeloid leukemia
pdic05221  Acute myeloid leukemia
pdic05223  Non-small cell lung cancer
pdic05224  Breast cancer
pdic05225  Hepatocellular carcinoma
pdic05226  Gastric cancer
pdic05230  Central carbon metabolism in cancer
pdic05231  Choline metabolism in cancer
pdic05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pdic00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    114501905 (RAF1)
   04015 Rap1 signaling pathway
    114501905 (RAF1)
   04630 JAK-STAT signaling pathway
    114501905 (RAF1)
   04068 FoxO signaling pathway
    114501905 (RAF1)
   04072 Phospholipase D signaling pathway
    114501905 (RAF1)
   04071 Sphingolipid signaling pathway
    114501905 (RAF1)
   04024 cAMP signaling pathway
    114501905 (RAF1)
   04022 cGMP-PKG signaling pathway
    114501905 (RAF1)
   04151 PI3K-Akt signaling pathway
    114501905 (RAF1)
   04150 mTOR signaling pathway
    114501905 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114501905 (RAF1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    114501905 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    114501905 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    114501905 (RAF1)
   04660 T cell receptor signaling pathway
    114501905 (RAF1)
   04662 B cell receptor signaling pathway
    114501905 (RAF1)
   04664 Fc epsilon RI signaling pathway
    114501905 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    114501905 (RAF1)
   04062 Chemokine signaling pathway
    114501905 (RAF1)
  09152 Endocrine system
   04929 GnRH secretion
    114501905 (RAF1)
   04915 Estrogen signaling pathway
    114501905 (RAF1)
   04917 Prolactin signaling pathway
    114501905 (RAF1)
   04921 Oxytocin signaling pathway
    114501905 (RAF1)
   04926 Relaxin signaling pathway
    114501905 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    114501905 (RAF1)
   04919 Thyroid hormone signaling pathway
    114501905 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    114501905 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    114501905 (RAF1)
   04720 Long-term potentiation
    114501905 (RAF1)
   04730 Long-term depression
    114501905 (RAF1)
   04722 Neurotrophin signaling pathway
    114501905 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    114501905 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114501905 (RAF1)
   05206 MicroRNAs in cancer
    114501905 (RAF1)
   05205 Proteoglycans in cancer
    114501905 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    114501905 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    114501905 (RAF1)
   05230 Central carbon metabolism in cancer
    114501905 (RAF1)
   05231 Choline metabolism in cancer
    114501905 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114501905 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114501905 (RAF1)
   05212 Pancreatic cancer
    114501905 (RAF1)
   05225 Hepatocellular carcinoma
    114501905 (RAF1)
   05226 Gastric cancer
    114501905 (RAF1)
   05214 Glioma
    114501905 (RAF1)
   05221 Acute myeloid leukemia
    114501905 (RAF1)
   05220 Chronic myeloid leukemia
    114501905 (RAF1)
   05218 Melanoma
    114501905 (RAF1)
   05211 Renal cell carcinoma
    114501905 (RAF1)
   05219 Bladder cancer
    114501905 (RAF1)
   05215 Prostate cancer
    114501905 (RAF1)
   05213 Endometrial cancer
    114501905 (RAF1)
   05224 Breast cancer
    114501905 (RAF1)
   05223 Non-small cell lung cancer
    114501905 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    114501905 (RAF1)
   05161 Hepatitis B
    114501905 (RAF1)
   05160 Hepatitis C
    114501905 (RAF1)
   05164 Influenza A
    114501905 (RAF1)
   05163 Human cytomegalovirus infection
    114501905 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114501905 (RAF1)
   05165 Human papillomavirus infection
    114501905 (RAF1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    114501905 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114501905 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    114501905 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    114501905 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114501905 (RAF1)
   01522 Endocrine resistance
    114501905 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pdic01001]
    114501905 (RAF1)
Enzymes [BR:pdic01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     114501905 (RAF1)
Protein kinases [BR:pdic01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   114501905 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 114501905
NCBI-ProteinID: XP_028374475
UniProt: A0A6J2M874
LinkDB
Position
7:39172735..39257053
AA seq 648 aa
MEHIQGAWKTISNGFGFKDAVFDGPSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDMCQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNVRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSGSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaagacgatcagcaatggttttggattcaaagacgca
gtgtttgatggccccagctgcatttcccccacgatagttcagcagtttggctatcagcgc
cgagcatcagatgatggcaaacttacagactcatctaagacaagcaatactattcgtgtt
ttcttgccaaacaagcaaagaacggtggtcaatgtacgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggcctgcaaccagagtgctgtgcggtgttcaga
cttctccatgaacacaaaggtaaaaaagcacgtttagattggaacactgatgctgcctcg
ttgattggagaagaacttcaagtagatttcctggatcatgttcccctcacgacacacaac
tttgctcggaagacctttctgaagcttgcgttttgtgacatgtgtcagaagttcctgcta
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatgtcagacaactcttattgtttccaaattcaact
attggcgatagtggggtcccagcactgccttctttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacaccccacgccttcacgttc
aacacctccagcccctcctctgaaggttccctctcccagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagtgaatcagcctcaccttcagccctgtccggcagccccaacaatctg
agcccaacaggctggtcacagcccaaaacccctgtgccagcgcagagagagcgggcacca
ggatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctctccactcggattgggtcaggctccttt
ggaactgtttataagggcaagtggcacggagacgttgcagtcaagatcctaaaggttgtt
gaccccacacctgagcagttccaggctttcaggaacgaggtggctgtactgcgtaaaacc
cgacacgtgaacatcttgcttttcatggggtacatgacgaaggacaatctggcgatagtg
acccagtggtgtgaaggcagcagcctctacaaacacctgcatgtccaagagaccaagttc
caaatgttccagttgattgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaatatcatccacagagacatgaaatccaacaacatatttctccatgaaggcctg
actgtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacccaccggctctatcctgtggatggccccagaggtgatccgaatgcag
gataataaccctttcagcttccagtccgacgtctactcctatggcattgtgctgtatgag
cttatgacaggggagctaccttattcccacatcaacaaccgagatcagattatcttcatg
gtgggccgagggtatgcctccccagaccttagtaagctatacaagaactgccccaaagca
atgaagcggcttgttgcagactgcgtgaagaaagttaaggaagagaggcctcttttcccc
cagatcctgtcttccattgaactgctccaacactctctaccgaaaatcaaccggagcgct
tctgagccatccctgcatcgggcagcccacaccgaggacatcaatgcctgcacactgacc
acatcccctagactgcctgtcttctag

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