KEGG   Phyllostomus discolor (pale spear-nosed bat): 114506992
Entry
114506992         CDS       T07739                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
pdic  Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic00562  Inositol phosphate metabolism
pdic01100  Metabolic pathways
pdic04015  Rap1 signaling pathway
pdic04020  Calcium signaling pathway
pdic04022  cGMP-PKG signaling pathway
pdic04062  Chemokine signaling pathway
pdic04070  Phosphatidylinositol signaling system
pdic04071  Sphingolipid signaling pathway
pdic04072  Phospholipase D signaling pathway
pdic04081  Hormone signaling
pdic04082  Neuroactive ligand signaling
pdic04261  Adrenergic signaling in cardiomyocytes
pdic04270  Vascular smooth muscle contraction
pdic04310  Wnt signaling pathway
pdic04371  Apelin signaling pathway
pdic04540  Gap junction
pdic04611  Platelet activation
pdic04613  Neutrophil extracellular trap formation
pdic04621  NOD-like receptor signaling pathway
pdic04713  Circadian entrainment
pdic04720  Long-term potentiation
pdic04723  Retrograde endocannabinoid signaling
pdic04724  Glutamatergic synapse
pdic04725  Cholinergic synapse
pdic04726  Serotonergic synapse
pdic04728  Dopaminergic synapse
pdic04730  Long-term depression
pdic04742  Taste transduction
pdic04750  Inflammatory mediator regulation of TRP channels
pdic04911  Insulin secretion
pdic04912  GnRH signaling pathway
pdic04915  Estrogen signaling pathway
pdic04916  Melanogenesis
pdic04918  Thyroid hormone synthesis
pdic04919  Thyroid hormone signaling pathway
pdic04921  Oxytocin signaling pathway
pdic04922  Glucagon signaling pathway
pdic04924  Renin secretion
pdic04925  Aldosterone synthesis and secretion
pdic04926  Relaxin signaling pathway
pdic04927  Cortisol synthesis and secretion
pdic04928  Parathyroid hormone synthesis, secretion and action
pdic04929  GnRH secretion
pdic04933  AGE-RAGE signaling pathway in diabetic complications
pdic04934  Cushing syndrome
pdic04935  Growth hormone synthesis, secretion and action
pdic04961  Endocrine and other factor-regulated calcium reabsorption
pdic04970  Salivary secretion
pdic04971  Gastric acid secretion
pdic04972  Pancreatic secretion
pdic04973  Carbohydrate digestion and absorption
pdic05010  Alzheimer disease
pdic05016  Huntington disease
pdic05017  Spinocerebellar ataxia
pdic05022  Pathways of neurodegeneration - multiple diseases
pdic05142  Chagas disease
pdic05143  African trypanosomiasis
pdic05146  Amoebiasis
pdic05163  Human cytomegalovirus infection
pdic05200  Pathways in cancer
pdic05415  Diabetic cardiomyopathy
pdic05417  Lipid and atherosclerosis
Module
pdic_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:pdic00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    114506992 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    114506992 (PLCB4)
   04310 Wnt signaling pathway
    114506992 (PLCB4)
   04371 Apelin signaling pathway
    114506992 (PLCB4)
   04020 Calcium signaling pathway
    114506992 (PLCB4)
   04070 Phosphatidylinositol signaling system
    114506992 (PLCB4)
   04072 Phospholipase D signaling pathway
    114506992 (PLCB4)
   04071 Sphingolipid signaling pathway
    114506992 (PLCB4)
   04022 cGMP-PKG signaling pathway
    114506992 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    114506992 (PLCB4)
   04081 Hormone signaling
    114506992 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    114506992 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    114506992 (PLCB4)
   04613 Neutrophil extracellular trap formation
    114506992 (PLCB4)
   04621 NOD-like receptor signaling pathway
    114506992 (PLCB4)
   04062 Chemokine signaling pathway
    114506992 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    114506992 (PLCB4)
   04922 Glucagon signaling pathway
    114506992 (PLCB4)
   04929 GnRH secretion
    114506992 (PLCB4)
   04912 GnRH signaling pathway
    114506992 (PLCB4)
   04915 Estrogen signaling pathway
    114506992 (PLCB4)
   04921 Oxytocin signaling pathway
    114506992 (PLCB4)
   04926 Relaxin signaling pathway
    114506992 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    114506992 (PLCB4)
   04918 Thyroid hormone synthesis
    114506992 (PLCB4)
   04919 Thyroid hormone signaling pathway
    114506992 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    114506992 (PLCB4)
   04916 Melanogenesis
    114506992 (PLCB4)
   04924 Renin secretion
    114506992 (PLCB4)
   04925 Aldosterone synthesis and secretion
    114506992 (PLCB4)
   04927 Cortisol synthesis and secretion
    114506992 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    114506992 (PLCB4)
   04270 Vascular smooth muscle contraction
    114506992 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    114506992 (PLCB4)
   04971 Gastric acid secretion
    114506992 (PLCB4)
   04972 Pancreatic secretion
    114506992 (PLCB4)
   04973 Carbohydrate digestion and absorption
    114506992 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    114506992 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    114506992 (PLCB4)
   04725 Cholinergic synapse
    114506992 (PLCB4)
   04728 Dopaminergic synapse
    114506992 (PLCB4)
   04726 Serotonergic synapse
    114506992 (PLCB4)
   04720 Long-term potentiation
    114506992 (PLCB4)
   04730 Long-term depression
    114506992 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    114506992 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    114506992 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    114506992 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    114506992 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114506992 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    114506992 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    114506992 (PLCB4)
   05142 Chagas disease
    114506992 (PLCB4)
   05143 African trypanosomiasis
    114506992 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114506992 (PLCB4)
   05016 Huntington disease
    114506992 (PLCB4)
   05017 Spinocerebellar ataxia
    114506992 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    114506992 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114506992 (PLCB4)
   05415 Diabetic cardiomyopathy
    114506992 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    114506992 (PLCB4)
   04934 Cushing syndrome
    114506992 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pdic04131]
    114506992 (PLCB4)
Enzymes [BR:pdic01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     114506992 (PLCB4)
Membrane trafficking [BR:pdic04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    114506992 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    114506992 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 114506992
NCBI-ProteinID: XP_028380762
UniProt: A0A6J2MS30
LinkDB
Position
9:complement(76304799..76699077)
AA seq 1206 aa
MAKPYEFNWQKEVPYFLQEGAIFDRYEEESFLFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRLGATPKDPKILAALEAVGKSESDLEGRIVCVCSGIDLVNISFTYMVAENLE
VTKQWVDGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTFEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIEMYEPDEDLKQKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEQKQLEALKSM
MEAGESAAPVSILEDYNEEETENADQEEEAHPEYKYGNELSADDLGHKEAVANSVKKVSD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKTNVTPQ
SSSELRPTTTAALGPGMEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSM
KLQNTN
NT seq 3621 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttactttttgcaagaagga
gcaatttttgacagatatgaagaggaatcctttctgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctaacctggaaaagtgaaggcaaggaaggacaagtgcta
gaatgctccctcatcaacagtattcggttgggagccacaccaaaggatcccaaaatcctg
gctgcccttgaagctgttggaaaatcagaaagtgacctggaagggcggatagtttgtgtc
tgcagtggaatagatctggtgaacatcagtttcacttacatggtggctgaaaacctagaa
gtaactaagcaatgggtagacggcctaagatcaatcatacacaatttcagggccaacaac
gtcagtccgatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacacc
aatggtaaaatcccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cctgcagcatttacttttgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagaccctcgactgaatgaaattttattc
ccgttttacgacactaaaagggcgatgcagatcattgagatgtatgaacctgatgaagac
ttgaagcaaaaaggccttatatcaagtgatggattttgcagatatctgatgtcggatgaa
aatgcacctgtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccacaacacctatctcactggccgacaatttggcgggaaa
tcatcggtagaaatgtacagacaggttctcctggctgggtgcagatgtgtggaactcgac
tgttgggatgggaaaggcgaagaccaggaaccgataataactcacgggaaggcgatgtgc
acagacatcctcttcaaggatgttattcaagccatcaaggaaactgcattcgtcacatct
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcgcttgaatcccat
ccactcgaaccaggcaggccgttgccatcccccaatgatctcaaaagaaaaatactcatc
aaaaataaacgactgaaacctgaggttgaacaaaagcagcttgaagctttgaaaagcatg
atggaagcaggagaatccgctgctccagttagcatcttagaggattataatgaggaggaa
acagaaaatgctgaccaagaagaagaagctcaccctgaatacaaatatggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaatagtgtcaagaaggtttctgat
gaccttgaacatgaaatcaacaaaaagggcctggttactgtagaagatgagcaggcatgg
atggcatcttataaatatgtaggtgctaccactaatattcatccgtatttgtccacaatg
atcaactatgcacagcccgtaaagtttcaaggtttccatgttgctgaagaacgcaacatt
cattataacatgtcttcttttaatgagtctgtgggtctaggctacttgaagacacacgcg
attgaatttgtgaattataacaaacggcaaatgagtcgcatttaccccaagggaggccga
gtcgattccagtaattacatgccacagattttctggaacgctggctgccagatggtttca
ctgaactatcaaaccccagatttagcgatgcaattgaatcaggggaaatttgagtataat
ggatcatgcgggtaccttctcaaaccagattttatgagacggcctgatcgaacgtttgat
cctttttctgagactccagttgatggggttattgcagccacgtgctcagtgcaggtcata
tcaggtcaattcttatcagataagaaaatcggcacatatgtagaagtggacatgtatggg
ttgcccactgacactatacgtaaggaattccgaactcgcatggtgatgaacaacgggctc
aatccagtttacaatgaagaatccttcgtatttcggaaggtaatcctccctgacctggca
gtcttgagaatagcagtgtatgatgacaacaacaagctcattggccagaggattctccca
ctagatggcctccaagccggctatcgacacatttcccttcgaaatgaggggaataaacca
ttatcactgccaacaattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatattgtggatgctttatcagatccaaagaagtttctttcaattacggaaaaaaga
gcagaccaaatgagagctatgggcatcgaaactagtgacatagctgatgtgcccagtgac
acttctaagaatgacaagaaaggaaaggccaacactgccaaaacaaatgtgactccgcag
agcagctctgaactcagaccaaccaccacagccgccctggggcctggcatggaagccaag
aaaggtattgaacttatccctcaagtgaggatagaagatttaaagcagatgaaggcttac
ttgaagcatttaaagaaacaacagaaggagttaaattctttaaaaaagaaacatgcaaag
gagcacagtaccatgcaaaagttacactgcacacaagtggacaaaattgtggcacagtat
gacaaagagaagtcgactcatgaaaaaatcctggagaaggcaatgaagaagaaaggggga
agtaattgccttgaaatgaaaaaagaaacagaaattaaaattcaaacactgacatcagat
cacaaatctaaggtcaaggagattgtggctcagcacacaaaagagtggtcagagatgatc
aacacgcacagcgctgaggagcaggaaatccgggacctgcacctgagccagcagtgcgag
ctgctgagaaagctcctgatcaacgcccacgaacagcaaacccagcagctgaaactgtcc
catgacagggaaagcaaggaaatgagagcacaccaggctaagatttctatggaaaatagc
aaagccatcagccaagataaatctattaagaacaaagcagaacgggaaaggcgagtcagg
gagttaaacagcagcaacactaaaaagtttctggaagaaagaaagagactcgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctagaattcctagag
aagcagaatgagcagcttttgaaatcctgtcatgcagtgtcccaaactcaaggcgaagga
gatgcagcagatggtgaaattggaagccgagatggaccgcagaccagcaacagtagtatg
aaactccagaacacaaactga

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