KEGG   Phyllostomus discolor (pale spear-nosed bat): 114510957
Entry
114510957         CDS       T07739                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
pdic  Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic01521  EGFR tyrosine kinase inhibitor resistance
pdic01522  Endocrine resistance
pdic01524  Platinum drug resistance
pdic04010  MAPK signaling pathway
pdic04012  ErbB signaling pathway
pdic04014  Ras signaling pathway
pdic04015  Rap1 signaling pathway
pdic04022  cGMP-PKG signaling pathway
pdic04024  cAMP signaling pathway
pdic04062  Chemokine signaling pathway
pdic04066  HIF-1 signaling pathway
pdic04068  FoxO signaling pathway
pdic04071  Sphingolipid signaling pathway
pdic04072  Phospholipase D signaling pathway
pdic04140  Autophagy - animal
pdic04150  mTOR signaling pathway
pdic04151  PI3K-Akt signaling pathway
pdic04152  AMPK signaling pathway
pdic04210  Apoptosis
pdic04211  Longevity regulating pathway
pdic04213  Longevity regulating pathway - multiple species
pdic04218  Cellular senescence
pdic04261  Adrenergic signaling in cardiomyocytes
pdic04370  VEGF signaling pathway
pdic04371  Apelin signaling pathway
pdic04380  Osteoclast differentiation
pdic04510  Focal adhesion
pdic04550  Signaling pathways regulating pluripotency of stem cells
pdic04611  Platelet activation
pdic04613  Neutrophil extracellular trap formation
pdic04620  Toll-like receptor signaling pathway
pdic04625  C-type lectin receptor signaling pathway
pdic04630  JAK-STAT signaling pathway
pdic04660  T cell receptor signaling pathway
pdic04662  B cell receptor signaling pathway
pdic04664  Fc epsilon RI signaling pathway
pdic04666  Fc gamma R-mediated phagocytosis
pdic04668  TNF signaling pathway
pdic04722  Neurotrophin signaling pathway
pdic04725  Cholinergic synapse
pdic04728  Dopaminergic synapse
pdic04810  Regulation of actin cytoskeleton
pdic04910  Insulin signaling pathway
pdic04914  Progesterone-mediated oocyte maturation
pdic04915  Estrogen signaling pathway
pdic04917  Prolactin signaling pathway
pdic04919  Thyroid hormone signaling pathway
pdic04920  Adipocytokine signaling pathway
pdic04922  Glucagon signaling pathway
pdic04923  Regulation of lipolysis in adipocytes
pdic04926  Relaxin signaling pathway
pdic04929  GnRH secretion
pdic04931  Insulin resistance
pdic04932  Non-alcoholic fatty liver disease
pdic04933  AGE-RAGE signaling pathway in diabetic complications
pdic04935  Growth hormone synthesis, secretion and action
pdic04936  Alcoholic liver disease
pdic04973  Carbohydrate digestion and absorption
pdic05010  Alzheimer disease
pdic05017  Spinocerebellar ataxia
pdic05132  Salmonella infection
pdic05135  Yersinia infection
pdic05142  Chagas disease
pdic05145  Toxoplasmosis
pdic05152  Tuberculosis
pdic05160  Hepatitis C
pdic05161  Hepatitis B
pdic05162  Measles
pdic05163  Human cytomegalovirus infection
pdic05164  Influenza A
pdic05165  Human papillomavirus infection
pdic05166  Human T-cell leukemia virus 1 infection
pdic05167  Kaposi sarcoma-associated herpesvirus infection
pdic05168  Herpes simplex virus 1 infection
pdic05169  Epstein-Barr virus infection
pdic05170  Human immunodeficiency virus 1 infection
pdic05200  Pathways in cancer
pdic05205  Proteoglycans in cancer
pdic05207  Chemical carcinogenesis - receptor activation
pdic05208  Chemical carcinogenesis - reactive oxygen species
pdic05210  Colorectal cancer
pdic05211  Renal cell carcinoma
pdic05212  Pancreatic cancer
pdic05213  Endometrial cancer
pdic05214  Glioma
pdic05215  Prostate cancer
pdic05218  Melanoma
pdic05220  Chronic myeloid leukemia
pdic05221  Acute myeloid leukemia
pdic05222  Small cell lung cancer
pdic05223  Non-small cell lung cancer
pdic05224  Breast cancer
pdic05225  Hepatocellular carcinoma
pdic05226  Gastric cancer
pdic05230  Central carbon metabolism in cancer
pdic05231  Choline metabolism in cancer
pdic05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
pdic05415  Diabetic cardiomyopathy
pdic05417  Lipid and atherosclerosis
pdic05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pdic00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    114510957 (AKT2)
   04012 ErbB signaling pathway
    114510957 (AKT2)
   04014 Ras signaling pathway
    114510957 (AKT2)
   04015 Rap1 signaling pathway
    114510957 (AKT2)
   04370 VEGF signaling pathway
    114510957 (AKT2)
   04371 Apelin signaling pathway
    114510957 (AKT2)
   04630 JAK-STAT signaling pathway
    114510957 (AKT2)
   04668 TNF signaling pathway
    114510957 (AKT2)
   04066 HIF-1 signaling pathway
    114510957 (AKT2)
   04068 FoxO signaling pathway
    114510957 (AKT2)
   04072 Phospholipase D signaling pathway
    114510957 (AKT2)
   04071 Sphingolipid signaling pathway
    114510957 (AKT2)
   04024 cAMP signaling pathway
    114510957 (AKT2)
   04022 cGMP-PKG signaling pathway
    114510957 (AKT2)
   04151 PI3K-Akt signaling pathway
    114510957 (AKT2)
   04152 AMPK signaling pathway
    114510957 (AKT2)
   04150 mTOR signaling pathway
    114510957 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    114510957 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    114510957 (AKT2)
   04218 Cellular senescence
    114510957 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    114510957 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    114510957 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    114510957 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    114510957 (AKT2)
   04613 Neutrophil extracellular trap formation
    114510957 (AKT2)
   04620 Toll-like receptor signaling pathway
    114510957 (AKT2)
   04625 C-type lectin receptor signaling pathway
    114510957 (AKT2)
   04660 T cell receptor signaling pathway
    114510957 (AKT2)
   04662 B cell receptor signaling pathway
    114510957 (AKT2)
   04664 Fc epsilon RI signaling pathway
    114510957 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    114510957 (AKT2)
   04062 Chemokine signaling pathway
    114510957 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    114510957 (AKT2)
   04922 Glucagon signaling pathway
    114510957 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    114510957 (AKT2)
   04920 Adipocytokine signaling pathway
    114510957 (AKT2)
   04929 GnRH secretion
    114510957 (AKT2)
   04915 Estrogen signaling pathway
    114510957 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    114510957 (AKT2)
   04917 Prolactin signaling pathway
    114510957 (AKT2)
   04926 Relaxin signaling pathway
    114510957 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    114510957 (AKT2)
   04919 Thyroid hormone signaling pathway
    114510957 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    114510957 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    114510957 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    114510957 (AKT2)
   04728 Dopaminergic synapse
    114510957 (AKT2)
   04722 Neurotrophin signaling pathway
    114510957 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    114510957 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    114510957 (AKT2)
   04213 Longevity regulating pathway - multiple species
    114510957 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    114510957 (AKT2)
   05205 Proteoglycans in cancer
    114510957 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    114510957 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    114510957 (AKT2)
   05230 Central carbon metabolism in cancer
    114510957 (AKT2)
   05231 Choline metabolism in cancer
    114510957 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    114510957 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    114510957 (AKT2)
   05212 Pancreatic cancer
    114510957 (AKT2)
   05225 Hepatocellular carcinoma
    114510957 (AKT2)
   05226 Gastric cancer
    114510957 (AKT2)
   05214 Glioma
    114510957 (AKT2)
   05221 Acute myeloid leukemia
    114510957 (AKT2)
   05220 Chronic myeloid leukemia
    114510957 (AKT2)
   05218 Melanoma
    114510957 (AKT2)
   05211 Renal cell carcinoma
    114510957 (AKT2)
   05215 Prostate cancer
    114510957 (AKT2)
   05213 Endometrial cancer
    114510957 (AKT2)
   05224 Breast cancer
    114510957 (AKT2)
   05222 Small cell lung cancer
    114510957 (AKT2)
   05223 Non-small cell lung cancer
    114510957 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    114510957 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    114510957 (AKT2)
   05161 Hepatitis B
    114510957 (AKT2)
   05160 Hepatitis C
    114510957 (AKT2)
   05164 Influenza A
    114510957 (AKT2)
   05162 Measles
    114510957 (AKT2)
   05168 Herpes simplex virus 1 infection
    114510957 (AKT2)
   05163 Human cytomegalovirus infection
    114510957 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    114510957 (AKT2)
   05169 Epstein-Barr virus infection
    114510957 (AKT2)
   05165 Human papillomavirus infection
    114510957 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    114510957 (AKT2)
   05135 Yersinia infection
    114510957 (AKT2)
   05152 Tuberculosis
    114510957 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    114510957 (AKT2)
   05142 Chagas disease
    114510957 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    114510957 (AKT2)
   05017 Spinocerebellar ataxia
    114510957 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    114510957 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    114510957 (AKT2)
   05415 Diabetic cardiomyopathy
    114510957 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    114510957 (AKT2)
   04932 Non-alcoholic fatty liver disease
    114510957 (AKT2)
   04931 Insulin resistance
    114510957 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    114510957 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    114510957 (AKT2)
   01524 Platinum drug resistance
    114510957 (AKT2)
   01522 Endocrine resistance
    114510957 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pdic01001]
    114510957 (AKT2)
Enzymes [BR:pdic01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     114510957 (AKT2)
Protein kinases [BR:pdic01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   114510957 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Kinase-like Pkinase_C PH_20 PH_11 ABC1 Seadorna_VP7
Other DBs
NCBI-GeneID: 114510957
NCBI-ProteinID: XP_028385300
UniProt: A0A6J2N5R8
LinkDB
Position
12:complement(7237731..7287199)
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMQAIQMVANSLKQRGLGEDPM
DYKCGSPSDSSAAEEMEVSVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLPPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLDLDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaacgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaag
acctggaggccccggtacttcctgctgaagagtgatggctccttcattggctataaggag
cgtcccgaagcacctgaccagaccctgccccccctgaacaacttctctgttgcagaatgc
cagctgatgaagactgagagaccacggcccaacacgtttgtcatacgctgcctgcagtgg
accacagtcatcgagaggaccttccacgtggactctccagatgagagggaggagtggatg
caggccatccagatggtcgccaacagcctcaagcagcggggcctgggtgaggaccccatg
gactacaagtgtggctcccctagtgactcttcggcagctgaggagatggaagtgtctgtt
agcaaggcacgggccaaggtgaccatgaatgactttgactatctcaagctcctcggcaag
ggcacctttggcaaagtcatcctggtgcgggagaaggccaccggccgctactatgccatg
aagatcctgcggaaggaggtgatcatcgccaaggatgaagtcgcccacacagtcaccgag
agccgggtcctccagaacaccaggcacccattcctcaccgcgctgaagtatgccttccag
acccacgaccgcctgtgctttgtgatggagtatgccaatggtggggagctgttcttccac
ctgtcccgggagcgggtgttcacagaagagagggcccgtttctatggcgcagagatcgtc
tcggccctggagtacctgcactcaagggacgtggtgtaccgcgacatcaagctggaaaac
ctcatgctggacaaagatggccacatcaagatcactgactttggcctgtgcaaagagggc
atcagtgacggggccaccatgaaaaccttctgtgggacccccgagtatctggcgcctgag
gtgctggaggacaacgactacggccgagccgtggactggtgggggctgggcgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgaa
ctcatcctcatggaggagatccgcttcccacgcacgctcagccccgaggccaagtccctg
cttgctgggctgcttaagaaggaccccaagcagaggctcggcggggggcccagtgatgcc
aaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtacagaag
aagctcccgccgcccttcaaacctcaggtcacgtctgaggttgacacaaggtacttcgac
gacgagttcactgcccagtccatcaccatcacacccccggaccgctatgacagcttgggc
tcgctcgacctggaccagcggactcacttcccccagttctcctactcggccagcatccga
gagtga

DBGET integrated database retrieval system