KEGG   Phyllostomus discolor (pale spear-nosed bat): 114512445
Entry
114512445         CDS       T07739                                 
Symbol
RYR2
Name
(RefSeq) LOW QUALITY PROTEIN: ryanodine receptor 2
  KO
K04962  ryanodine receptor 2
Organism
pdic  Phyllostomus discolor (pale spear-nosed bat)
Pathway
pdic04020  Calcium signaling pathway
pdic04024  cAMP signaling pathway
pdic04260  Cardiac muscle contraction
pdic04261  Adrenergic signaling in cardiomyocytes
pdic04371  Apelin signaling pathway
pdic04713  Circadian entrainment
pdic04911  Insulin secretion
pdic04921  Oxytocin signaling pathway
pdic04972  Pancreatic secretion
pdic05020  Prion disease
pdic05022  Pathways of neurodegeneration - multiple diseases
pdic05410  Hypertrophic cardiomyopathy
pdic05412  Arrhythmogenic right ventricular cardiomyopathy
pdic05414  Dilated cardiomyopathy
pdic05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:pdic00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    114512445 (RYR2)
   04020 Calcium signaling pathway
    114512445 (RYR2)
   04024 cAMP signaling pathway
    114512445 (RYR2)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    114512445 (RYR2)
   04921 Oxytocin signaling pathway
    114512445 (RYR2)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    114512445 (RYR2)
   04261 Adrenergic signaling in cardiomyocytes
    114512445 (RYR2)
  09154 Digestive system
   04972 Pancreatic secretion
    114512445 (RYR2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    114512445 (RYR2)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05020 Prion disease
    114512445 (RYR2)
   05022 Pathways of neurodegeneration - multiple diseases
    114512445 (RYR2)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    114512445 (RYR2)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    114512445 (RYR2)
   05414 Dilated cardiomyopathy
    114512445 (RYR2)
   05415 Diabetic cardiomyopathy
    114512445 (RYR2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:pdic04040]
    114512445 (RYR2)
   04990 Domain-containing proteins not elsewhere classified [BR:pdic04990]
    114512445 (RYR2)
Ion channels [BR:pdic04040]
 Voltage-gated cation channels
  Ryanodine receptor
   114512445 (RYR2)
Domain-containing proteins not elsewhere classified [BR:pdic04990]
 EF-hand domain-containing proteins
  Other EF-hand domain-containing proteins
   114512445 (RYR2)
SSDB
Motif
Pfam: RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8
Other DBs
NCBI-GeneID: 114512445
NCBI-ProteinID: XP_035871944
UniProt: A0A7E6D0M9
LinkDB
Position
15:complement(4228059..4761330)
AA seq 4953 aa
MADAGEGEDEIQFLRTDDEVVLQCTAAAHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP
DLSICTFVLEQSLSVRALQEMLANTVEKSEGKFMMKTAQGGGHRTLLYGHAILLRHSYSG
MYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS
SERYLHLSYGGSSFHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTV
PSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLS
LLEDKTLLLVDKEKADVKSTAFTFRSSKEKLDGGVRKEVDGMGTSEIKYGDSVCYIQHVN
TGLWLTYQAVDVKSVRMGATQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSSVFLFN
RFIRGLDALSRKMRAAPGDLPIESVSLSLRDLIGYLHPPDEHLDHEDKQNRLRALKNRQN
LFQEEGMISLVLQCVDRLHVYSSAAHFADVAGREAGVSWKSILNSLYELLAALIRGNRKN
CAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRN
HKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGISEGS
AQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGF
DGLHLWAGCIASTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGL
FFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYT
RDLLGPTVPLTQAAFTPVPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPV
RDDNKRQHPCLVEFSQLPEQERNYNLQMSLETLKTLLALGCHVGLSDEHAEEKVKKMKLP
KNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNR
RNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGCGYGLEAPDQDHAARAEVCSGTGERFRI
FRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGADEHAFAFDGFKAQRWHQ
GNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSL
GVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEH
IEVTRIDGTVDSSPCLKVTQKSFGAQNSSTDIMFYRLSMPIECAEVFSRPAAGVLPGAGL
FGPKNDLEDYDADSDFEVLMKTAHGHLVPDRADKDKDAPKPEFNNXKDYTQEKPSRLKQR
FLLRKTKPDYSTSHSARLTEDVLADDRDDHDYLMQTSTYIYSVRIFPXQEPANVWVGWIT
SDFHQYDTCFDXDRVRTXPLLSDEKGKXKCSLKSSIKRSNCYMVCAGESMSPGQGRSSSG
LEIGCVVDAASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVM
PLSAGLFKSEHRNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRVGERQGWLVQCSDP
LQFMSLHIPEENRSVDILELTEQEELLRFHSHTLRLYSAVCALGNHRVAHALCSHVDEAQ
LLYAIQRKYMPGLLRTGYYDLLIDIHLSAYATARLMMNNEFIVPMTDETKSITLFPDEHK
EHGLPGIGLSTSLRPRMRFSSPSFVSLSHDCYQDSPEFPLDTLKAKTMQMLTEAVREGGL
RARDPVGGTTEFLFVPLIKLFYTLLTMGVFQGEDLKHILQLIEPRVFTEAAPEEQQAPPV
EPHTDDAHAPRVHVGDAAEGCCEMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDF
VAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPAEI
RDQLLDFHEDLMAHCGIELDEDGSPDGNGDLTIRGRLLSLVEKVTYLKKRQAEKPVASDP
SKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLARALPKTYTISAVS
VEDTINLLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVM
EVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASP
AMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSRGYPDIGWNP
VEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAVEEAIK
IAEDPARDGPSPTSGCSRTPDTDEEDDTVHMGNAIMTFYAALIDLLGRCAPEMHLIHAGK
GEAIRIRSILRSLIPLGDLVGVISIAFPMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLD
RVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLRRCAP
LFAGTEHHASLIDSLLHTVYRLSKGCSLTRAQRDSIEVCLLSICGQLRPSMMQHLLRRLV
FDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALS
QKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDAEGNFNPQPVETSNITI
PEKLEYFINKYAEHSHDRWSMDKLANGWIYGETYSDSSKVQPLMKPYKLLSEKEKEIYRW
PIKESLKTMLAWGWRIERTREGDSMALYSRTRRISQTSQVSVDTAHGYSPRAIDMSNVTL
SRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDIL
KFLQISGYAVSRGFKDLDLDTPSIEKRFAYSFLQQLIHYVDEAHQYILEFDGGSRSKGQH
FPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGV
LVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDSAAEDLEQTLE
NLKQGQFTHTRHQPRGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILEDVQVSCYRI
LTSLYALGTSKSIYVERQRSSLGECLAAFAGAFPVAFLETHLDKHNSYSIYNTRSSRERA
ALNLPASVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPLLCSYMSRWWEHG
PESHPGRAEACCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQ
LLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLL
IRFVDNNRAKWLKEPTPEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLIT
DTKSKMSKAAVSDQERKKMRRKGDRYSVQTSLIVAALKRLLPIGLNICAPGDQELIALAK
NRLSMKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDSSDPEKTVERVLD
IANVLFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYE
KSWIETEEHYFEDKLIEDLAKPGADPPEEDEGPKRVDPLHQLILLFSRTALTEKCKLEED
FLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHERGAAEMVLQTIS
ASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDL
NAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNN
TTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQ
GPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSM
LEGNVVNGTIGKQMVDMLVESSNNVEMILKFFNMFLKLKDLTSSDTFKEYDPDGKGVISK
RDFHKAMESHKHYTPSETEFLLSCAETDENETLDYEEFVKRFHEPAKDISFNVAVLLTNL
SEHMPNDTRLQTFLELADSVLHYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQV
KESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLSERSASKEESEKEG
PEEQGPGMGFFSILTVQAALLALRYNLLTLLRMLSLKSLKKQMKKVKKMTLRDMVSALFS
SYWGILTSLAHFVASVLRGFSRVVGGLLLGGSLVEGAKKMRVAELLANMPDPTQDEVRGD
GEEAERRTLEAALPSEDLTDLKELAEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDL
MSNPVPIPEVQEKLQEQEVKEEDKEEKENKSEPEKADGEDGEKEEKVKDEKGRQKLRSVH
THRYGEPEAPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSS
VVEGKELPHRSTSGNPRVGILDSGPDGGLDGSLDSGPLGSAAVHYVLEESSGYMEPALRI
LAVLHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLV
INTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSL
SAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLR
TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYM
FHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELR
DQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHT
GQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN
NT seq 14862 nt   +upstreamnt  +downstreamnt
atggccgatgcgggcgagggcgaggacgagatccagttcttgcggactgatgatgaggtg
gtgctgcagtgcacggcggccgcccacaaggagcagcagaagctgtgtctggcagctgaa
ggatttggcaacagactctgtttcctggagtccacctcgaattccaagaatgtgcccccc
gacctctccatctgcacctttgtgctggagcagtccctctctgtccgggccctgcaggag
atgctggcgaacacggtggagaagtcagaagggaaattcatgatgaagactgctcaaggc
ggcggtcaccggacactcctctacggccatgctatcctgctacgccactcctatagtggc
atgtacctgtgctgcctgtccacctcccggtcttccactgacaaactggccttcgatgtc
ggcttgcaagaggacacgacaggtgaggcttgctggtggaccatccaccctgcctccaag
cagcggtcagaaggagagaaggtgcgcgttggtgatgacctcatcctagtgagtgtgtcc
tctgaaaggtacttgcacctgtcctacggcggcagcagcttccacgtggacgcggctttc
cagcagactctctggagcgtggccccgatcagctcaggcagtgaagcggcccaagggtat
ctgatcggtggggatgtcctccggctgctgcacggacacatggacgaatgcctcactgtc
ccctcaggagagcacggggaggaacagcgcaggactgttcattatgaaggtggagctgtg
tctgtgcacgcacggtccctgtggagactggagacgctacgagtcgcgtggagcggaagc
cacataagatggggccagcctttccgactgcgccacgtcacaacgggaaagtacctgagc
ctcctggaagacaaaaccctcctcctggtggacaaagagaaagctgatgtaaagtcaaca
gcatttaccttccggtcttccaaggaaaagctggacggaggggtgaggaaagaagttgat
ggcatggggacctctgagataaagtacggagactcggtctgctacatccagcacgtgaac
acaggcctgtggttgacctaccaggccgtggacgtgaagtccgtgcggatgggggccacg
cagcgcaaggcaatcatgcaccatgagggccacatggacgacggcatcagtctgtcccgc
tcacagcacgaggagtcgcggacggcgcgcgtcatccgcagctccgttttcctgttcaat
cggttcatcaggggcctggacgctctcagcaggaagatgagggcggcgcccggggacttg
cccatagagtctgtcagcctgagcctgcgggacctgattggctacctgcacccgccggat
gaacacctggaccacgaggacaagcagaacaggctgagagccctgaagaaccggcagaat
ctcttccaggaggaggggatgatcagccttgtgctgcagtgcgtggacaggctgcacgtc
tacagcagcgcggcccacttcgcggatgttgccgggagagaagccggcgtgtcctggaag
tcgatcctgaattctctgtatgagttgctggcggctctcattagaggaaatcgtaaaaac
tgtgcccagttttctggctccctggactggctgatcagccgactagaaagactggaagct
tcttcaggtattctggaagtcttgcactgcgtgttagtagaaagtccagaagctctgaac
atcatcaaagaagggcacattaaatccatcatttcacttctagacaagcacggaagaaat
cacaaggttctggacgtcctgtgctccctctgcgtttgccatggagtggccgtccgctcc
aaccagcacctcatctgtgacaacctccttccgggacgggatctgctgctgcagacgcgc
ctggtgaaccacgtcagcagcatgaggcccaatattttcctgggcatcagtgaggggtct
gctcagtacaagaagtggtactacgagctgatggtggaccacacggagccctttgtgaca
gcggaagccacgcacctgcgtgtgggctgggcctccacagaggggtactccccctaccct
ggcgggggcgaggagtggggcgggaacggcgttggagacgacctcttctcctacgggttt
gatggcctgcatctctgggcaggttgtatcgctagcaccgtgagctcgccgaaccagcac
ctgctgcggacggatgatgtcatcagttgctgtttagatctgagtgcgccgagcatctca
ttccgcatcaacgggcaacctgttcaagggatgtttgagaatttcaacatcgacggcctc
ttctttcccgttgttagtttctctgcaggaataaaggtgcgcttcctgcttgggggcagg
catggagaatttaagttcctccctccacctggctatgctccttgctatgaagctgttctg
ccgaaggagaagttgaaggtggagcacagccgcgagtacaagcaagaaagaacttacacc
cgggacctcctgggccccacggtgccactgactcaggccgccttcacgccggtccccgtg
gacaccagccagatcgtgttgcctccccacctggagaggatccgagaaaaactggctgag
aatatccatgagctctgggttatgaacaaaattgaacttggctggcagtatggcccggtc
agagacgacaacaagaggcagcacccgtgcctggtggagttctcccagctgcccgagcag
gaacgcaattacaacctacagatgtcactcgagaccctgaagactttgttggcattagga
tgtcatgtgggtctatcagatgaacatgccgaagaaaaggtgaaaaagatgaagttaccc
aagaattaccagctgacgagtggatacaagcctgccccgatggacctgagctttatcaaa
ctcactccgtcccaggaagcgatggtggacaagttggcagaaaacgcccacaacgtgtgg
gctcgggaccggatccggcagggctggacctacggcatccagcaggacgtaaagaacaga
agaaacccccgccttgtcccctacacacttctcgatgacagaaccaagaagtctaacaag
gacagcctgcgggaggctgtgcgcacgctgctggggtgcggctacggcctggaggctccg
gaccaggaccacgcagcccgggctgaagtgtgcagcggcaccggggagcggttccggatc
ttccgtgcagagaaaacctacgctgtgaaggccgggaggtggtacttcgagttcgaggcg
gtcacagccggagacatgcgggtcggctggagcaggccaggctgccagccggatcaggag
ctgggcgctgacgagcatgcctttgcttttgacggtttcaaggcccagcggtggcaccag
ggcaatgagcactacgggcgctcttggcaagccggtgatgtcgtgggctgtatggttgac
atgacggagcacaccatgatgttcacactgaacggcgagatcctgctggacgattcaggc
tcagaactggccttcaaggactttgacgtgggtgacggattcatacctgtgtgcagcctt
ggggtggctcaggtgggaaggatgaactttggcaaggatgtgagcaccttgaaatatttc
accatctgcggcttacaggagggctatgaaccattcgccgttaacacaaacagggacatc
accatgtggctaagcaagcgacttcctcagtttctccaggtcccgtcaaaccacgaacac
attgaggtgaccaggatcgatggcaccgtggacagctccccatgtttaaaggtcacgcag
aagtcattcggtgcccagaacagcagcactgacatcatgttctaccgcctgagcatgccc
attgagtgtgcggaggtcttctccaggccggcggctggggtgctgccgggggctggcctc
tttgggcccaagaatgatttggaggattacgatgcggactccgactttgaggttctgatg
aagacggcacatggccacctggtgcctgatcgagctgacaaagacaaagatgctccaaaa
ccagagtttaataacnccaaagattacacacaggagaagccctctcgtctgaaacaaaga
ttcctgctcaggaagacaaagccagattacagcacaagccactcggcgagactcactgaa
gacgtcctcgcagatgaccgagacgaccacgactacttgatgcagacgtccacgtacatt
tactcagtgagaatcttcccgtgacaagaacctgctaacgtctgggtgggctggatcacg
tctgatttccaccagtatgatacctgcttcgacnttgacagagttcgaacgtaaccgtta
ctctcggatgaaaaaggaaaataaaaatgttctttgaaatccagcatcaaacgcagcaac
tgctacatggtgtgcgcaggcgagagcatgagcccggggcagggacgcagcagcagcggg
ctggagattggctgcgtggtggacgccgccagtgggctgctcaccttcacggccaacggc
aaggagctgagcacgtattaccaggtggagccgagtaccaaattgtttcctgcggttttt
gcgcaagctacaagtcccaacgtctttcagtttgagttgggaagaataaagaacgtgatg
cctctctccgcgggcctcttcaagagcgagcaccggaaccctgtgccgcagtgcccgccg
cggctgcacgtgcagttcctgtcccacgtgctgtggagcaggatgcccaaccagttcctg
aaggtggacgtgtcccgggtcggtgagcgccagggctggctggtgcagtgctcggacccc
ctgcagttcatgtccctgcacatccccgaggaaaacaggtccgtggacatcctggagctg
acggagcaggaggagctgctgcgcttccactcacacaccctgcggctctactcggccgtg
tgcgccctgggcaaccaccgtgtggcgcatgccctctgcagccacgtggatgaggcgcag
ctgctttatgccatccagcgcaagtacatgcccggcctgctgcgcaccggctactacgac
ctgctcatcgatatccacctgagcgcctacgccaccgcccggctcatgatgaacaatgag
ttcatcgtgcccatgactgatgagaccaagagcatcactctctttccagatgagcacaag
gagcatgggctgcccggcatcggcctcagcacgtcactgcggccacgcatgcgcttctcc
tcacctagctttgtgagcctcagccacgactgctaccaggacagccctgagttccccctg
gacacgctcaaggccaagaccatgcagatgctgactgaggctgtgcgggagggcggactt
cgggcgcgggaccctgtagggggcaccaccgagttcctcttcgtgccactcatcaagctc
ttctacacgctgctcaccatgggtgtcttccaaggcgaggacctgaagcacatcctgcag
ctgattgagccccgggtattcacagaggccgccccggaggagcagcaggcaccgcccgtg
gagccccacaccgatgacgcccatgccccgagggtgcacgtgggggacgcagcagagggc
tgctgcgagatgaagcttcctgagcctgtgaagctgcagatgtgcctgctccttcagtac
ctctgtgactgccaggtccgacaccggatagaagccattgtggccttttcagatgacttt
gttgccaagctgcaagacaaccagcgcttccgctacaatgaggttatgcaggccctaaac
atgtcggccgcgctcacagccaggaagacaaaggagttcaggtccccgcctcaagaacag
atcaacatgcttctcaacttcaaggatgacaaaagcgaatgtccgtgtcccgcggaaatc
cgagaccagctcctggattttcatgaagacctcatggctcattgtggaattgagctggac
gaagatggctctccagatggcaacggcgacttaacaatcagaggccgcctgctgtccctg
gtggaaaaggtgacatacctgaagaagaggcaagcagaaaagccagtggcgagcgacccc
agcaagtcctccaccctgcagcagctgatctcggagaccatggtccggtgggctcaggag
tccgtcatcgaggaccccgagctggtgcgggccatgttcgtgctgctgcatcggcagtac
gatggcatcggtgggctggctcgggctctgcccaagacctacacgatcagcgccgtgtcc
gtggaggacaccatcaacctgctggcttcactcgggcagatccgctcgctgctgagtgtg
aggatgggccgagaagaggagaagctcatgattcggggactaggggacatcatgaataat
aaagtgttctaccagcaccctaacctcatgagggcgctgggcatgcacgagacggtgatg
gaggtcatggtgaacgtcctgggtggtggggagtccaaggagatcacttttcccaagatg
gtggccaactgttgccgttttctctgttacttctgtcgtataagtcggcagaatcagaaa
gctatgtttgatcacctcagttatttattggaaaacagcagcgttggtctagcctcacca
gccatgcgggggtcgaccccgctggacgtggctgcagcctcggtgatggataacaatgag
ctggccttggcgctgcgtgagccggatctggagaaggtcgtgcgatacctggccggctgc
ggcctgcagagctgccagatgctggtgtccagggggtacccggacattgggtggaacccg
gtcgaaggggagcgatacctcgacttcctgcgattcgcggtcttctgcaacggggagagc
gtggaggagaacgccaacgtcgtggtgaggctgctcatccggaggcccgagtgttttggc
cccgccctgcggggggagggcgggaatggtcttctggcagctgtggaagaggccatcaag
atagctgaggaccctgctcgagatggtccctcgccaaccagcgggtgcagcagaacccct
gacacagatgaggaggacgacactgtgcacatggggaacgccatcatgaccttttacgct
gctctgatcgacctgctgggacgctgtgcccctgaaatgcacttgattcatgctggcaag
ggggaagccatcaggatcagatccatcctgagatccctcatcccgctgggagacttggtg
ggagtgatcagcattgcttttccgatgcccacaatagctaaggatgggaatgtggtggag
cctgacatgtctgcggggttttgcccagatcacaaggcagccatggttttgttccttgac
agggtctatggaattgaggttcaagattttctcctccaccttctagaggtcggctttctg
ccagatctccgggctgctgcttctttagatacggcggccttgagtgccacggacatggcc
ttggccctcaaccggtacctctgcacagccgtgctgcccctgctgcggaggtgcgcgccg
ctcttcgccggcaccgagcaccatgcttccctcattgactcgctgctgcacactgtgtac
aggctgtcaaagggctgctcgctgaccagggcccagcgggactccatagaagtttgcttg
ctgtccatttgtggccaactgagaccttccatgatgcagcacttactcagaagattagtg
tttgatgtcccgttgttaaatgaacatgcaaagatgcctcttaagctgctgacaaatcat
tacgaaaggtgctggaaatattactgtctgcctggagggtgggggaacttcggagctgcc
tcagaagaagaacttcatttatcaagaaaattgttctggggaatttttgatgccctgtct
caaaagaaatacgaacaggagcttttcaaactggccctgccttgcctgagtgccgtggcc
ggagctttgcctccagactacatggagtccaattacgtcagcatgatggagaagcagtcc
tccatggacgctgaaggcaactttaacccacagcctgttgaaacctcaaatatcacaatt
cccgagaaactggaatacttcatcaacaagtatgccgaacactcccatgacagatggtcc
atggacaagttggccaatggatggatttatggggaaacatattcagactcatccaaagtt
caaccattaatgaaaccatataaactactatctgaaaaggaaaaagaaatttatcgctgg
ccaatcaaagaatccttaaagacgatgctggcatggggctggaggatcgagcgcacgcgg
gagggggacagcatggcgctctacagccggacacggcgcatctcgcagaccagccaggtt
tctgtggacactgcccatgggtacagcccccgggccatcgacatgagcaacgtcacactg
tccagagacctgcatgctatggcagaaatgatggctgaaaactaccacaatatatgggca
aagaaaaagaaaatggagctggagtccaaaggagggggaaaccaccccctgctggtgcct
tatgacacgctgacagccaaggagaaagccaaggacagagagaaagctcaggacatcctc
aagttcctgcagattagcgggtacgctgtgtccaggggcttcaaggacctggacttggac
acgccgtccatcgagaagcggttcgcctacagtttccttcagcagctcatccactacgtg
gacgaggcccatcagtacatcctggagttcgatggcggcagcagaagcaaaggacagcac
ttcccttacgaacaagaaatcaagttctttgctaaagtggttcttcctttaattgatcag
tatttcaaaaaccatcgtttgtacttcttgtctgcagcgagcagaccgctctgctccggg
ggacatgcctcaaacaaggagaaagaaatggtgacgagcctgttctgcaaactcggagtt
cttgtcaggcataggatttcactgtttggaaatgatgcaacatcaattgtcaactgcctg
cacattctgggccagactctggatgcgaggacggtcatgaagacgggcctggagagcgtg
aagagcgcgctcagggcgttcctggacagcgccgctgaggacctggagcagacactggag
aacctgaagcagggccagttcactcacacccgccaccagcccaggggcgtcacccagatc
atcaactacaccacagtggccctgctgcccgtgctgtcctcgctatttgagcacatcggc
cagcaccagtttggagaagacctgatattggaagatgtgcaggtgtcctgttacagaatt
ctaaccagcttgtatgctttgggaacgagcaagagtatttatgtggaaaggcagcgctcc
tcactgggggagtgtctggcagcctttgctggtgcctttcccgtggcgtttctcgaaact
catctcgacaaacataacagctactccatctacaacaccaggtcttcacgagagagagca
gctctcaatttgccagcgagtgtggaagatgtctgtccaaacataccatctttggagaag
ctcatggaggagatcgtggaactagctgagtctggtatccgctacacgcagatgccgcat
gtgatggaggtcatcctgcctctgctgtgtagctacatgtcccggtggtgggagcacggg
cccgagagccacccgggcagggcagaggcctgctgcacggccctgaactcggagcatatg
aacactctgctggggaacatcctgaagatcatctacaacaacctgggcatcgacgagggg
gcctggatgaagaggctagcagtgttttcccagcctataataaataaagtgaagccgcag
ctcttgaagactcatttcttgccattgatggagaaactgaagaagaaggcagccatggtg
gtttccgaggaagaccacctgaaagccgaggcccggggggacatgtccgaggccgaactt
ctcatcctggacgagttcaccacgctggccagggacctgtacgccttctacccgctcctg
attcgatttgtggacaataacagggcgaagtggctcaaagagcccaccccggaggctgag
gacctcttccgcatggtggccgaagtgttcatctactggtcaaagtcccacaatttcaag
agagaagagcagaattttgtcgtccagaatgaaatcaacaacatgtctttcctgattacc
gacaccaagtcaaagatgtcaaaggcggcggtctccgaccaggagcggaagaagatgagg
cggaagggtgaccgctactctgtgcagacctcgctcatcgtggccgccctgaagcggctg
ctgcccatcgggctgaacatctgtgcgcccggggaccaggagctcattgccctggccaag
aatcggctgagtatgaaagacaccgaggatgaagtccgagatataatccgcagtaacatt
cacttacaaggcaagctggaggaccctgccattaggtggcaaatggccctttacaaagac
ttacccaacaggactgaagacagttcagatcccgagaagacagtggagagagtcctggac
atagccaacgtgctcttccacctcgaacaggtggagcacccccagcgctctaagaaggct
gtctggcacaagctgctctccaagcagaggaagagggcggtggtggcctgcttccggatg
gctcctctctacaacctgccaaggcatcgggccgtcaatctcttccttcagggatatgaa
aagtcctggattgaaacagaagaacattactttgaagataaactgatagaagatttagca
aagcctggagcagaccccccagaggaagatgaaggcccaaagagagtggaccctctgcat
cagctgatcctcctgttcagtcgcacggccctaacggagaagtgcaaactggaggaagat
tttttatacatggcttatgcagatattatggcaaagagttgtcatgacgaagaagatgat
gatggtgaagaggaagtgaagagttttgaagagaaggagatggagaagcagaagcttctg
taccagcaggcccggctgcacgagcgcggcgccgcggagatggtgctgcagacgatcagt
gccagcaaaggggagaccggaccgatggtggctgctactctgaagctggggattgctatc
ctgaatggcggcaactccacagtgcagcagaaaatgctcgactacctcaaggagaagaag
gatgtgggtttcttccagagcctggctggcctgatgcagtcctgcagtgtcctcgacctg
aatgcattcgagcggcagaacaaagccgaaggacttgggatggtgacagaggaaggatca
ggagagaaggttcttcaggatgacgagttcacctgtgacctcttccgcttcctgcaactg
ctctgtgagggacacaactcagattttcagaactatctgaggacgcagaccggcaacaac
accactgtcaacatcatcatctccactgtggactacctgctgcgggttcaggaatccatc
agtgacttctactggtattactccgggaaagacgtcatcgacgagcaagggcagcggaac
ttctccaaagccatccaagtcgcaaaacaggtcttcaacacgctcacggagtacattcag
ggcccctgcaccggcaaccagcagagcctggcgcacagccgcctctgggacgccgttgtg
ggcttcctccacgtgttcgcccacatgcagatgaaactgtcgcaggactccagtcaaatc
gagctgttgaaagaactcatggacctccagaaggacatggtggtcatgctgctgtccatg
cttgaaggtaacgtcgtcaacgggacgatcggcaagcagatggtcgacatgcttgtggag
tcatccaacaacgtggagatgatcctcaagttcttcaacatgttcttaaaactgaaggac
ttgacatcttctgacacatttaaggaatatgaccctgatggcaagggggtcatttccaag
agggacttccacaaagccatggaaagccataagcactacacaccgtcggaaactgagttt
cttctgtcctgcgcggaaacagatgaaaacgagaccctagactatgaggaatttgtcaaa
cgcttccacgaacccgcgaaggacatcagcttcaatgtcgccgtccttttgaccaacctc
tcggagcacatgcccaacgacacgcggctgcagaccttcctggagctggcggacagcgtg
ctccactacttccagcccttcctgggccgcatcgagatcatgggcagcgccaagcgcatc
gagagggtctacttcgagatcagcgagtccagccggacgcagtgggagaagccccaggtc
aaggagtccaaaaggcagttcatcttcgatgtggtcaatgaggggggcgagaaggagaag
atggagctcttcgtgaacttctgcgaggacaccatatttgagatgcagctggcggcccag
atctcggagtcggacctgagtgagaggtcggccagcaaggaggagagtgagaaggagggg
ccagaggagcagggcccggggatgggcttcttctccatcctgaccgtccaggcggccctg
ctggccctcaggtacaacctcctgaccctgctgcgcatgctcagcctgaagagcctgaag
aagcaaatgaagaaggtgaagaagatgacgctgagggacatggtctcggccctcttctcc
tcctactggggcatcctgaccagccttgcgcacttcgtggccagcgtcctccgcggcttc
tcccgcgttgtgggtggcctgctcctggggggcagcctggtggaaggtgccaagaagatg
agagtggcagagctcctggcgaacatgccagaccccacgcaggacgaggtgaggggcgat
ggggaggaggccgagaggaggaccctggaggccgccctgccctcagaagacctcacagac
ctgaaggagctggcggaggaaagtgacctcctctcagacatatttggcctggacctgaag
agagaaggagggcagtacaaactcatccctcacaacccgaatgcgggcctcagcgacctc
atgagcaaccctgtgcccattcccgaggtgcaggagaagcttcaggaacaggaggtgaaa
gaggaagacaaggaagaaaaagaaaacaaatcggaacctgaaaaagccgatggagaagac
ggagagaaagaggagaaggtcaaggacgagaagggcaggcagaagctccggtcggtccac
acacaccggtacggggagccagaggcccccgagtcggcgttctggaagaaaatcatagct
tatcagcagaagctgctaaactattttgctcgaaacttttacaacatgagaatgttagcc
ttatttgtcgcgtttgcaatcaacttcatcctgctcttctataaggtgtccacttcttct
gtggttgaaggaaaggagctcccccatcgcagcacaagtggaaaccctagagtgggcatc
ctggacagcggccccgacggtggcctagatggcagcctggacagtggcccgctgggctcg
gcagccgtgcactacgtgctggaggagagcagcggctacatggagcccgccctgcgcatc
ctggccgtgctgcacaccgtcatctccttcttctgcatcatcggctactactgcttgaaa
gtcccactggttatttttaagcgcgaaaaggaagtagctcgaaaattggaatttgatggg
ctttatattacggaacagccttcggaagatgatattaaaggccagtgggatagactcgtg
atcaacacacagtcatttcccaacaactactgggacaaatttgttaaaagaaaggtcatg
gataagtacggagagttttatggcagggacagaattagtgagctgctcggcatggacaaa
gcggctctggacttcagtgacgcccgggagaagaagaagccaaagaaagacagctccctc
tcggccgtgctgaactccatcgacgtgaagtatcagatgtggaagctcggagtggtcttc
actgacaactccttcctctaccttgcctggtacatgaccatgtccgtccttggacactac
aacaacttcttcttcgctgctcaccttctcgacattgctatggggtttaagacgctgaga
accatcttgtcatcggtaactcacaatggcaagcagcttgtgttaaccgtcggcttgtta
gccgttgtcgtgtacctgtacactgttgtggcattcaacttcttccggaaattctacaat
aaaagtgaagacggggacaccccagacatgaagtgtgacgatatgctcacatgctacatg
ttccacatgtacgtcggcgtgcgggccggagggggcatcggcgacgagatcgaagacccg
gcgggcgatgagtacgagatctatcggatcatcttcgacatcaccttcttcttcttcgtc
atcgtcatcctcctggccataatacaaggtttgattatcgatgcgttcggagaactcaga
gaccagcaggaacaagtgaaggaagacatggagaccaaatgcttcatctgtgggataggc
aatgattacttcgacacggtgccacacggctttgagacgcacaccttacaggagcacaac
ttggccaattacctgtttttcctgatgtatctcataaacaaagacgaaacggagcacacg
ggacaggaatcttacgtctggaagatgtatcaagaaagatgctgggagttcttccccgca
ggggactgtttccggaaacagtacgaagaccagctgaactaa

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