Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1: PFREUD_08350
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Entry
PFREUD_08350 CDS
T01252
Symbol
folC
Name
(GenBank) Folylpolyglutamate synthase (bifunctionnal enzyme)
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
pfr
Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1
Pathway
pfr00790
Folate biosynthesis
pfr01100
Metabolic pathways
pfr01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
pfr00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
PFREUD_08350 (folC)
Enzymes [BR:
pfr01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
PFREUD_08350 (folC)
6.3.2.17 tetrahydrofolate synthase
PFREUD_08350 (folC)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Mur_ligase_M
CCC_C_1st_pro
Motif
Other DBs
NCBI-ProteinID:
CBL56362
UniProt:
D7GCV1
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All DBs
Position
951826..953331
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AA seq
501 aa
AA seq
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MNSTQGLPADSPRHSIVTGGFDSGDPQRHAHIVSELTGRWPENRVGPSLDRIARLCELLG
SPQRSAPVIQITGTNGKGSTAIMIDALLRAMGLRTGRFSSPHLQDLTERICIDGQPIAPD
RFDELWEQVEPLVTMVDDQRLDGIEMTFFEVMTGLAYAAFADAPVDVMIMEVGMGGRWDA
TNVADAQVAVVGPVAMDHMQYLGDTIAEIATEKAGIIKAGSTAVIAGQSADAARVLAQRC
LEVGAPMVREGIDFGLLDRQPAVSGQLLRLDTASGPIGDIFLPLLGAHMAHNAALALASV
EAFMGGKGLDPTVIEAGFGQVVAPARLETVHSEPTVVLDTAHNPHGVKATLEALREAFTF
RPLIAVVAMMADKQVDQVLAQLEAVADIIVVSHVSGSRRAMSVAELADLATGIFGANRVR
TADDVSQALSTAMGLAEQSGEGAGVLVIGSVYLAGEVRDILVGHDVTTVGQPLRLGADDL
QVGERRPAIIDADDEDVDDED
NT seq
1506 nt
NT seq
+upstream
nt +downstream
nt
atgaacagcacccaggggctccccgccgacagcccgcgacacagcattgtgaccggcggc
tttgattccggcgatccgcaacgtcacgcacatatcgtctccgagctcaccggacgctgg
ccggagaaccgcgtgggaccctccctcgaccgcattgcgcgactgtgcgagctcctgggg
tcgccccagcgcagcgccccggtgatccagatcaccggcacgaacggcaagggcagcacc
gccatcatgatcgatgccctgctgcgggccatgggcctgcgcaccggacggttcagctca
ccccacctgcaggacctcaccgaacggatctgcatcgatggccagcccatcgcccccgac
cgcttcgacgagctgtgggaacaggtcgaaccgttggtcacgatggtcgacgaccaacgc
ctggacggcatcgagatgaccttcttcgaggtgatgacggggctggcctacgcggcgttc
gccgacgcacccgttgacgtgatgatcatggaggtcggcatgggtgggcgttgggacgcc
accaatgttgccgatgcccaggtggccgtggtcggtccggtggcgatggaccacatgcag
tacctcggggacacgatcgccgagatcgccaccgagaaggcgggcatcatcaaggccggt
tcgacggccgtcatcgcgggccagagcgccgatgcggcacgcgtcctggcccaacgctgc
ctcgaggtgggggcccccatggtgcgtgagggcatcgatttcggcctgctcgaccgtcag
cccgccgtgagcgggcagctgttgcgcctggacacggcctcgggtccgatcggcgacatc
ttccttccgttgctgggtgcccacatggcccacaacgccgcactggcgttggccagtgtc
gaggcgttcatggggggcaagggccttgacccgacggtgatcgaggcgggattcggccag
gtggtggctccggcgcgcctggagacggtgcattccgagcccaccgtggtgctcgacacc
gcacacaatccccatggcgtgaaggcgaccctcgaggcgttgcgggaggccttcaccttc
cgtccgctgatcgccgtggttgcaatgatggccgacaagcaggtcgaccaggtgctcgcc
caactggaggcggttgccgacatcatcgtggtgagccatgtgtcgggcagccgtcgcgcg
atgtcggtggccgagcttgccgatctggccacgggaatcttcggtgccaaccgggtgcgc
accgccgatgacgtctcccaggcactgtccacggccatgggactggctgagcagtccggc
gagggcgccggcgtgctcgtgatcggctcggtctacctggcaggcgaggtccgcgacatc
ctggtgggccacgacgtgaccactgtcgggcagcccctgcgactgggcgccgacgacctg
caggtcggcgaacgtcgcccggccatcatcgatgccgacgacgaggacgtcgacgacgag
gattga
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